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Journal Articles

A Novel in-Vivo Model of Human Myelofibrosis Based on Transplantation of Thrombopoietin Overexpressing CD34+ Cells into Humanized Bone Marrows in NSG Mice Recapitulates Key Disease Hallmarks

Hongzhe Li, Alba Sierras, Anne Hultquist, Stefan Scheding

Blood (2024) 144 (Supplement 1): 1757.

https://doi.org/10.1182/blood-2024-211301

Published: 2024

Journal Articles

In Situ Spatial mRNA Analysis Implicates Increased TGFB1 and PDGFA1 Expression As Potential Drivers of Fibrosis in Pediatric Acute Lymphoblastic Leukemia

Sandro S Bräunig, Carl Dencker, Dang Nghiem Vo, Anne Hultquist, Jens Enoksson, Hongzhe Li, Stefan Scheding

Blood (2024) 144 (Supplement 1): 4227.

https://doi.org/10.1182/blood-2024-211187

Published: 2024

Journal Articles

A Phase 3, Randomized, Double-Blind, Active-Comparator-Controlled Study of Bomedemstat Versus Hydroxyurea in Patients with Essential Thrombocythemia Naïve to Cytoreductive Therapy

Blood (2024) 144 (Supplement 1): 4569.3.

https://doi.org/10.1182/blood-2024-200881

Published: 2024

Journal Articles

A Novel Approach to 3D Spatial Mapping of the Human Hematopoietic Microenvironment in Normal and Diseased Bone Marrow

Sandro Bräunig, Hongzhe Li, Isak Karmhag, Anne Hultquist, Stefan Scheding

Blood (2022) 140 (Supplement 1): 5784–5785.

https://doi.org/10.1182/blood-2022-166091

Published: 2022

Journal Articles

Single-Cell RNA Sequencing Identifies Phenotypically, Functionally, and Anatomically Distinct Stromal Niche Populations in Human Bone Marrow

Hongzhe Li, Sandro Bräunig, Parashar Dhapola, Göran Karlsson, Stefan Lang, Stefan Scheding

Blood (2022) 140 (Supplement 1): 5764–5765.

https://doi.org/10.1182/blood-2022-167740

Published: 2022

Journal Articles

Highly Reduced Survival in ET and PV Patients with Vascular Complications during Follow-up - Real World Data from the Swedish MPN Registr

Marie Lindgren, Erik Ahlstrand, MD PhD, Helna Pettersson, MD, Maria Liljeholm, Anna Ravn-Landtblom, MD, Stefan Scheding, Prof, Björn Andréasson, MD PhD, Jan Samuelsson, MD PhD

Blood (2019) 134 (Supplement_1): 1658.

https://doi.org/10.1182/blood-2019-124374

Published: 2019

Journal Articles

Transcriptome Alterations of Isolated Primary Bone Marrow Endothelial Cells Provide Insigt to MGUS and Multiple Myeloma Pathobiology

Sandro Bräunig, MSc, Dimitra Zacharaki, PhD, Hongzhe Li, PhD, Hooi Ching Lim, PhD, Stefan Lang, PhD, Thoas Fioretos, MD PhD Prof., Stefan Scheding, MD

Blood (2019) 134 (Supplement_1): 4373.

https://doi.org/10.1182/blood-2019-128024

Published: 2019

Journal Articles

Transcriptome Alterations of Prospectively Isolated Bone Marrow Stromal Cells Provide Potential Cues to MGUS and Multiple Myeloma Pathobiology

Dimitra Zacharaki, Roshanak Ghazanfari, PhD, Hongzhe Li, PhD, Hooi Ching Lim, PhD, Sofia Von Palffy, Shamit Soneji, PhD, Thoas Fioretos, MD PhD, Stefan Scheding, MD

Blood (2017) 130 (Supplement 1): 4375.

https://doi.org/10.1182/blood.V130.Suppl_1.4375.4375

Published: 2017

Journal Articles

Early Growth Response (EGR)-1 Is a Key Regulator of Human Primary Bone Marrow Stroma Cells with a Dual Role in Proliferation and Hematopoietic Stroma Support Function

Hongzhe Li, PhD, Roshanak Ghazanfari, PhD, Hooi Ching Lim, PhD, Jenny Hansson, PhD, Dimitra Zacharaki, Stefan Scheding, MD

Blood (2017) 130 (Supplement 1): 3777.

https://doi.org/10.1182/blood.V130.Suppl_1.3777.3777

Published: 2017

Journal Articles

Early Growth Response (EGR)-1 Expression Regulates Colony Forming Capacity and Hematopoietic Support Function in Human Primary Bone Marrow Stromal Stem Cells

Hongzhe Li, PhD, Roshanak Ghazanfari, Dimitra Zacharaki, Hooi Ching Lim, PhD, Stefan Scheding, MD

Blood (2016) 128 (22): 3886.

https://doi.org/10.1182/blood.V128.22.3886.3886

Published: 2016

Journal Articles

Ruxolitinib Does Not Affect Bone Marrow Stromal Cell (BMSC) Clonogenicity and Growth but Interferes with JAK Signaling Under Inflammatory Conditions - Implications for Fibrosis in Myeloproliferative Diseases?

Dimitra Zacharaki, Hongzhe Li, PhD, Roshanak Ghazanfari, Stefan Scheding, MD

Blood (2015) 126 (23): 4096.

https://doi.org/10.1182/blood.V126.23.4096.4096

Published: 2015

Journal Articles

Are MSCs Stem Cells? Demonstration of in Vitro and in Vivo Stem Cell Properties of Highly Enriched lin neg /CD45 neg /CD271 pos /CD140a low/Neg Mesenchymal Stromal Cells from Adult Human Bone Marrow

Roshanak Ghazanfari, MS, Hongzhe Li, PhD, Dimitra Zacharaki, MS, Simón Méndez-Ferrer, PhD, Stefan Scheding, MD

Blood (2014) 124 (21): 4374.

https://doi.org/10.1182/blood.V124.21.4374.4374

Published: 2014

Journal Articles

Separation of Lymphocyte Populations from Peripheral Blood Progenitor Cell Products Using Affinity Bead Acoustophoresis

Anke Urbansky, Andreas Lenshof, PhD, Josefina Dykes, MDPhD, Thomas Laurell, PhD, Stefan Scheding, MD

Blood (2014) 124 (21): 315.

https://doi.org/10.1182/blood.V124.21.315.315

Published: 2014

Journal Articles

Primary Lin neg /CD45 neg /CD271 pos /PDGFRα low/Neg Stroma Stem Cells In Adult Human Bone Marrow Show a Distinct Molecular Signature and Potent Hematopoiesis-Supporting Function

Hongzhe Li, Ph.D, Dimitra Zacharaki, MS, Roshanak Ghazanfari, MS, Marja Ekblom, MD, PhD, Simón Méndez-Ferrer, Ph.D., Stefan Scheding, MD

Blood (2013) 122 (21): 3699.

https://doi.org/10.1182/blood.V122.21.3699.3699

Published: 2013

Journal Articles

Candidate Human Primary Mesenchymal Stem/Progenitor Cells Are Highly Enriched in Lin neg /CD45 neg /CD271 pos /PDGFRα neg Bone Marrow Cells

Hongzhe Li, Ph.D, Roshanak Ghazanfari, MS, Nicholas Ditzel, MS, Moustapha Kassem, MD, PhD, Stefan Scheding, MD

Blood (2012) 120 (21): 3460.

https://doi.org/10.1182/blood.V120.21.3460.3460

Published: 2012

Journal Articles

CD146 expression on primary nonhematopoietic bone marrow stem cells is correlated with in situ localization

Ariane Tormin, Ou Li, Jan Claas Brune, Stuart Walsh, Birgit Schütz, Mats Ehinger, Nicholas Ditzel, Moustapha Kassem, Stefan Scheding

Blood (2011) 117 (19): 5067–5077.

https://doi.org/10.1182/blood-2010-08-304287

Published: 2011

Includes: Supplemental data

Journal Articles

Human Embryonic Stem Cell-Derived Mesenchymal Stroma Cells (hES-MSC) Share Basic Properties with Bone Marrow MSC, They Have Potent Stroma Support Capacities but Lack Immune-Modulatory Function. Implications for off-the Shelf ES-MSC Therapies.

Ou Li, PhD, Ariane Tormin, PhD, Jan Claas Brune, MS, Berit Sundberg, Johan Hyllner, PhD, Katarina Le Blanc, MD, PhD, Stefan Scheding, MD

Blood (2010) 116 (21): 3858.

https://doi.org/10.1182/blood.V116.21.3858.3858

Published: 2010

Journal Articles

A Novel Immunohistochemical Sequential Multi-Labelling and Erasing Technique Enables Epitope Characterization of Bone Marrow Pericytes In Primary Myelofibrosis

Ann Brinch Madelung, MD, Michael Bzorek, MT, Henrik Bondo, MD, Eva M.K. Zetterberg, MD, PhD, Ole Weis Bjerrum, MD, DMSc, Hans Carl Hasselbalch, MD, DMSc, Stefan Scheding, MD, Elisabeth Ralfkiaer, Prof., MD, DMSc

Blood (2010) 116 (21): 4108.

https://doi.org/10.1182/blood.V116.21.4108.4108

Published: 2010

Journal Articles

Human Primary CD271 + /CD45 − /CD146 −/Low and CD271 + /CD45 − /CD146 + Bone Marrow Cells Are Developmentally Closely-Related Stroma Stem Cells with Similar Functional Properties but Different In-Situ Localization.

Ariane Tormin, PhD, Ou Li, PhD, Jan Claas Brune, MS, Stuart Walsh, PhD, Mats Ehinger, MD, PhD, Nicholas Ditzel, PhD, Moustapha Kassem, PhD, Stefan Scheding, MD

Blood (2010) 116 (21): 2594.

https://doi.org/10.1182/blood.V116.21.2594.2594

Published: 2010

Journal Articles

CD146 Expression in Primary Bone Marrow MSC Progenitor/Stem Cells Is Dependent On Their In Vivo Location.

Ariane Tormin, MS, Ou Li, PhD, Stuart Walsh, BS, Mats Ehinger, MD, PhD, Jan Claas Brune, MS, Stefan Scheding, MD

Blood (2009) 114 (22): 251.

https://doi.org/10.1182/blood.V114.22.251.251

Published: 2009

NARROW

A Novel in-Vivo Model of Human Myelofibrosis Based on Transplantation of Thrombopoietin Overexpressing CD34+ Cells into Humanized Bone Marrows in NSG Mice Recapitulates Key Disease Hallmarks

In Situ Spatial mRNA Analysis Implicates Increased TGFB1 and PDGFA1 Expression As Potential Drivers of Fibrosis in Pediatric Acute Lymphoblastic Leukemia

A Phase 3, Randomized, Double-Blind, Active-Comparator-Controlled Study of Bomedemstat Versus Hydroxyurea in Patients with Essential Thrombocythemia Naïve to Cytoreductive Therapy

A Novel Approach to 3D Spatial Mapping of the Human Hematopoietic Microenvironment in Normal and Diseased Bone Marrow

Single-Cell RNA Sequencing Identifies Phenotypically, Functionally, and Anatomically Distinct Stromal Niche Populations in Human Bone Marrow

Highly Reduced Survival in ET and PV Patients with Vascular Complications during Follow-up - Real World Data from the Swedish MPN Registr

Transcriptome Alterations of Isolated Primary Bone Marrow Endothelial Cells Provide Insigt to MGUS and Multiple Myeloma Pathobiology

Transcriptome Alterations of Prospectively Isolated Bone Marrow Stromal Cells Provide Potential Cues to MGUS and Multiple Myeloma Pathobiology

Early Growth Response (EGR)-1 Is a Key Regulator of Human Primary Bone Marrow Stroma Cells with a Dual Role in Proliferation and Hematopoietic Stroma Support Function

Early Growth Response (EGR)-1 Expression Regulates Colony Forming Capacity and Hematopoietic Support Function in Human Primary Bone Marrow Stromal Stem Cells

Ruxolitinib Does Not Affect Bone Marrow Stromal Cell (BMSC) Clonogenicity and Growth but Interferes with JAK Signaling Under Inflammatory Conditions - Implications for Fibrosis in Myeloproliferative Diseases?

Are MSCs Stem Cells? Demonstration of in Vitro and in Vivo Stem Cell Properties of Highly Enriched lin neg /CD45 neg /CD271 pos /CD140a low/Neg Mesenchymal Stromal Cells from Adult Human Bone Marrow

Separation of Lymphocyte Populations from Peripheral Blood Progenitor Cell Products Using Affinity Bead Acoustophoresis

Primary Lin neg /CD45 neg /CD271 pos /PDGFRα low/Neg Stroma Stem Cells In Adult Human Bone Marrow Show a Distinct Molecular Signature and Potent Hematopoiesis-Supporting Function

Candidate Human Primary Mesenchymal Stem/Progenitor Cells Are Highly Enriched in Lin neg /CD45 neg /CD271 pos /PDGFRα neg Bone Marrow Cells

CD146 expression on primary nonhematopoietic bone marrow stem cells is correlated with in situ localization

Human Embryonic Stem Cell-Derived Mesenchymal Stroma Cells (hES-MSC) Share Basic Properties with Bone Marrow MSC, They Have Potent Stroma Support Capacities but Lack Immune-Modulatory Function. Implications for off-the Shelf ES-MSC Therapies.

A Novel Immunohistochemical Sequential Multi-Labelling and Erasing Technique Enables Epitope Characterization of Bone Marrow Pericytes In Primary Myelofibrosis

Human Primary CD271 + /CD45 − /CD146 −/Low and CD271 + /CD45 − /CD146 + Bone Marrow Cells Are Developmentally Closely-Related Stroma Stem Cells with Similar Functional Properties but Different In-Situ Localization.

CD146 Expression in Primary Bone Marrow MSC Progenitor/Stem Cells Is Dependent On Their In Vivo Location.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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