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Journal Articles

Landscape of driver mutations and their clinical effects on Down syndrome–related myeloid neoplasms

Tomohiko Sato, Kenichi Yoshida, Tsutomu Toki, Rika Kanezaki, Kiminori Terui, Ryunosuke Saiki, Masami Ojima, Yotaro Ochi, Seiya Mizuno, Masaharu Yoshihara, Tamayo Uechi, Naoya Kenmochi, Shiro Tanaka, Jun Matsubayashi, Kenta Kisai, Ko Kudo, Kentaro Yuzawa, Yuka Takahashi, Tatsuhiko Tanaka, Yohei Yamamoto, Akie Kobayashi, Takuya Kamio, Shinya Sasaki, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Hideki Muramatsu, Asahito Hama, Daisuke Hasegawa, Atsushi Sato, Katsuyoshi Koh, Shuhei Karakawa, Masao Kobayashi, Junichi Hara, Yuichi Taneyama, Chihaya Imai, Daiichiro Hasegawa, Naoto Fujita, Masahiro Yoshitomi, Shotaro Iwamoto, Genki Yamato, Satoshi Saida, Nobutaka Kiyokawa, Takao Deguchi, Masafumi Ito, Hidemasa Matsuo, Souichi Adachi, Yasuhide Hayashi, Takashi Taga, Akiko M. Saito, Keizo Horibe, Kenichiro Watanabe, Daisuke Tomizawa, Satoru Miyano, Satoru Takahashi, Seishi Ogawa, Etsuro Ito

Blood (2024) 143 (25): 2627–2643.

https://doi.org/10.1182/blood.2023022247

Published: 2024

Includes: Supplemental data

Journal Articles

BRAF V600E-Positive Precursors As Molecular Markers of Bone Marrow Involvement in Pediatric Langerhans Cell Histiocytosis

Ko Kudo, MD, Rika Kanezaki, PhD, Akie Kobayashi, MD, Tomohiko Sato, MD PhD, Takuya Kamio, MD PhD, Shinya Sasaki, MD PhD, Imamura Masaru, MD PhD, Chihaya Imai, MD PhD, Masahiro Irie, MD PhD, Yoji Sasahara, MD PhD, Kumiko Ando, MD, Harumi Kakuda, MD PhD, Takehiko Doi, MD PhD, Hiroshi Kawaguchi, MD PhD, Kazuko Kudo, MD PhD, Hirokazu Kanegane, MD PhD, Kiminori Terui, MD PhD, Tsutomu Toki, PhD, Etsuro Ito, MD PhD

Blood (2019) 134 (Supplement_1): 3588.

https://doi.org/10.1182/blood-2019-127536

Published: 2019

Journal Articles

RAS Pathway Mutations in Down Syndrome-Associated Acute Lymphoblastic Leukemia in Japan

Tatsuya Ito, MD, Kiminori Terui, MDPhD, Isamu Hanada, MD PhD, Fumika Ikeda, MD, Tsutomu Toki, PhD, Rika Kanezaki, PhD, Tomohiko Sato, MD PhD, Takuya Kamio, MDPhD, Ko Kudo, MD, Shinya Sasaki, MD PhD, Yoshihiro Takahashi, MD PhD, Yasuhide Hayashi, MD PhD, Takeshi Inukai, MD PhD, Hiroki Hori, MD PhD, Etsuro Ito, MD PhD

Blood (2015) 126 (23): 4986.

https://doi.org/10.1182/blood.V126.23.4986.4986

Published: 2015

Journal Articles

Naturally occurring oncogenic GATA1 mutants with internal deletions in transient abnormal myelopoiesis in Down syndrome

Tsutomu Toki, Rika Kanezaki, Eri Kobayashi, Hiroshi Kaneko, Mikiko Suzuki, RuNan Wang, Kiminori Terui, Hirokazu Kanegane, Miho Maeda, Mikiya Endo, Tatsuki Mizuochi, Souichi Adachi, Yasuhide Hayashi, Masayuki Yamamoto, Ritsuko Shimizu, Etsuro Ito

Blood (2013) 121 (16): 3181–3184.

https://doi.org/10.1182/blood-2012-01-405746

Published: 2013

Includes: Supplemental data

Journal Articles

Genetic Basis of Myeloid Proliferation Related to Down Syndrome

Blood (2012) 120 (21): 535.

https://doi.org/10.1182/blood.V120.21.535.535

Published: 2012

Journal Articles

Identification of TRIB1 R107L gain-of-function mutation in human acute megakaryocytic leukemia

Takashi Yokoyama, Tsutomu Toki, Yoshihiro Aoki, Rika Kanezaki, Myoung-ja Park, Yohei Kanno, Tomoko Takahara, Yukari Yamazaki, Etsuro Ito, Yasuhide Hayashi, Takuro Nakamura

Blood (2012) 119 (11): 2608–2611.

https://doi.org/10.1182/blood-2010-12-324806

Published: 2012

Includes: Supplemental data

Journal Articles

GATA1 Mutants Lacking Rb-Binding Motif Observed in Transient Abnormal Myelopoiesis in Down Syndrome

Tsutomu Toki, PhD, Eri Kobayashi, MS, Rika Kanezaki, MS, RuNan Wang, MD, Kiminori Terui, MD, PhD, Hirokazu Kanegane, MD, PhD, Miho Maeda, MD, PhD, Mikiya Endo, MD, PhD, Tatsuki Mizuochi, MD, PhD, Souichi Adachi, MD, PhD, Yasuhide Hayashi, MD, PhD, Ritsuko Shimizu, MD, PhD, Masayuki Yamamoto, MD, PhD, Etsuro Ito, MD, PhD

Blood (2011) 118 (21): 1491.

https://doi.org/10.1182/blood.V118.21.1491.1491

Published: 2011

Journal Articles

Down syndrome and GATA1 mutations in transient abnormal myeloproliferative disorder: mutation classes correlate with progression to myeloid leukemia

Blood (2010) 116 (22): 4631–4638.

https://doi.org/10.1182/blood-2010-05-282426

Published: 2010

Includes: Supplemental data

Journal Articles

The Essential Role of Stem Cell Factor/KIT Signaling in the Proliferation and Survival of Blast Cells from Transient Leukemia in Neonates with Down Syndrome.

Tsutomu Toki, PhD, Rika Kanezaki, Souichi Adachi, MD, PhD, Hisanori Fujino, MD, PhD, Gang Xu, Tomohiko Sato, Kahori Suzuki, Hisamichi Tauchi, MD, PhD, Mikiya Endo, MD, PhD, Etsuro Ito

Blood (2008) 112 (11): 1807.

https://doi.org/10.1182/blood.V112.11.1807.1807

Published: 2008

Journal Articles

Activating JAK3 Mutations in Transient Myeloproliferative Disorder and Acute Megakaryoblastic Leukemia Accompanying Down Syndrome.

Tomohiko Sato, MD, Tsutomu Toki, PhD, Rika Kanezaki, M.S., Gang Xu, MD, PhD, Kiminori Terui, MD, PhD, Takuya Kamio, MD, PhD, Seiji Kojima, MD, PhD, Hitoshi Kiyoi, MD, PhD, Hiroyuki Mano, MD, PhD, Etsuro Ito, MD, PhD

Blood (2007) 110 (11): 1620.

https://doi.org/10.1182/blood.V110.11.1620.1620

Published: 2007

Journal Articles

Transgenic expression of BACH1 transcription factor results in megakaryocytic impairment

Tsutomu Toki, Fumiki Katsuoka, Rika Kanezaki, Gang Xu, Hidekachi Kurotaki, Jiying Sun, Takuya Kamio, Seiji Watanabe, Satoru Tandai, Kiminori Terui, Soroku Yagihashi, Norio Komatsu, Kazuhiko Igarashi, Masayuki Yamamoto, Etsuro Ito

Blood (2005) 105 (8): 3100–3108.

https://doi.org/10.1182/blood-2004-07-2826

Published: 2005

Journal Articles

Transgenic Expression of Bach1 Transcription Factor Results in Down-Regulation of the p45 Target Genes in Megakaryocytic Lineage Cells.

Tsutomu Toki, PhD, Fumiki Katsuoka, MD, Rika Kanezaki, MS, Seiji Watanabe, PhD, Takuya Kamio, MD, Satoru Tandai, MD, Hidekachi Kurotaki, MD, Soroku Yagihashi, MD, Jiying Sun, PhD, Norio Komatsu, MD, PhD, Kazuhiko Igarashi, MD, PhD, Masayuki Yamamoto, MD, PhD, Etsuro Ito, MD, PhD

Blood (2004) 104 (11): 1605.

https://doi.org/10.1182/blood.V104.11.1605.1605

Published: 2004

Journal Articles

B-cell–specific transcription factor BACH2 modifies the cytotoxic effects of anticancer drugs

Takuya Kamio, Tsutomu Toki, Rika Kanezaki, Shinya Sasaki, Satoru Tandai, Kiminori Terui, Dai Ikebe, Kazuhiko Igarashi, Etsuro Ito

Blood (2003) 102 (9): 3317–3322.

https://doi.org/10.1182/blood-2002-12-3656

Published: 2003

Journal Articles

Frequent mutations in the GATA-1 gene in the transient myeloproliferative disorder of Down syndrome

Blood (2003) 102 (8): 2960–2968.

https://doi.org/10.1182/blood-2003-02-0390

Published: 2003

NARROW

Landscape of driver mutations and their clinical effects on Down syndrome–related myeloid neoplasms

BRAF V600E-Positive Precursors As Molecular Markers of Bone Marrow Involvement in Pediatric Langerhans Cell Histiocytosis

RAS Pathway Mutations in Down Syndrome-Associated Acute Lymphoblastic Leukemia in Japan

Naturally occurring oncogenic GATA1 mutants with internal deletions in transient abnormal myelopoiesis in Down syndrome

Genetic Basis of Myeloid Proliferation Related to Down Syndrome

Identification of TRIB1 R107L gain-of-function mutation in human acute megakaryocytic leukemia

GATA1 Mutants Lacking Rb-Binding Motif Observed in Transient Abnormal Myelopoiesis in Down Syndrome

Down syndrome and GATA1 mutations in transient abnormal myeloproliferative disorder: mutation classes correlate with progression to myeloid leukemia

The Essential Role of Stem Cell Factor/KIT Signaling in the Proliferation and Survival of Blast Cells from Transient Leukemia in Neonates with Down Syndrome.

Activating JAK3 Mutations in Transient Myeloproliferative Disorder and Acute Megakaryoblastic Leukemia Accompanying Down Syndrome.

Transgenic expression of BACH1 transcription factor results in megakaryocytic impairment

Transgenic Expression of Bach1 Transcription Factor Results in Down-Regulation of the p45 Target Genes in Megakaryocytic Lineage Cells.

B-cell–specific transcription factor BACH2 modifies the cytotoxic effects of anticancer drugs

Frequent mutations in the GATA-1 gene in the transient myeloproliferative disorder of Down syndrome

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American Society of Hematology

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American Society of Hematology

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