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Journal Articles

Landscape of driver mutations and their clinical effects on Down syndrome–related myeloid neoplasms

Tomohiko Sato, Kenichi Yoshida, Tsutomu Toki, Rika Kanezaki, Kiminori Terui, Ryunosuke Saiki, Masami Ojima, Yotaro Ochi, Seiya Mizuno, Masaharu Yoshihara, Tamayo Uechi, Naoya Kenmochi, Shiro Tanaka, Jun Matsubayashi, Kenta Kisai, Ko Kudo, Kentaro Yuzawa, Yuka Takahashi, Tatsuhiko Tanaka, Yohei Yamamoto, Akie Kobayashi, Takuya Kamio, Shinya Sasaki, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Hideki Muramatsu, Asahito Hama, Daisuke Hasegawa, Atsushi Sato, Katsuyoshi Koh, Shuhei Karakawa, Masao Kobayashi, Junichi Hara, Yuichi Taneyama, Chihaya Imai, Daiichiro Hasegawa, Naoto Fujita, Masahiro Yoshitomi, Shotaro Iwamoto, Genki Yamato, Satoshi Saida, Nobutaka Kiyokawa, Takao Deguchi, Masafumi Ito, Hidemasa Matsuo, Souichi Adachi, Yasuhide Hayashi, Takashi Taga, Akiko M. Saito, Keizo Horibe, Kenichiro Watanabe, Daisuke Tomizawa, Satoru Miyano, Satoru Takahashi, Seishi Ogawa, Etsuro Ito

Blood (2024) 143 (25): 2627–2643.

https://doi.org/10.1182/blood.2023022247

Published: 2024

Includes: Supplemental data

Journal Articles

BRAF V600E-Positive Precursors As Molecular Markers of Bone Marrow Involvement in Pediatric Langerhans Cell Histiocytosis

Ko Kudo, MD, Rika Kanezaki, PhD, Akie Kobayashi, MD, Tomohiko Sato, MD PhD, Takuya Kamio, MD PhD, Shinya Sasaki, MD PhD, Imamura Masaru, MD PhD, Chihaya Imai, MD PhD, Masahiro Irie, MD PhD, Yoji Sasahara, MD PhD, Kumiko Ando, MD, Harumi Kakuda, MD PhD, Takehiko Doi, MD PhD, Hiroshi Kawaguchi, MD PhD, Kazuko Kudo, MD PhD, Hirokazu Kanegane, MD PhD, Kiminori Terui, MD PhD, Tsutomu Toki, PhD, Etsuro Ito, MD PhD

Blood (2019) 134 (Supplement_1): 3588.

https://doi.org/10.1182/blood-2019-127536

Published: 2019

Journal Articles

RAS Pathway Mutations in Down Syndrome-Associated Acute Lymphoblastic Leukemia in Japan

Tatsuya Ito, MD, Kiminori Terui, MDPhD, Isamu Hanada, MD PhD, Fumika Ikeda, MD, Tsutomu Toki, PhD, Rika Kanezaki, PhD, Tomohiko Sato, MD PhD, Takuya Kamio, MDPhD, Ko Kudo, MD, Shinya Sasaki, MD PhD, Yoshihiro Takahashi, MD PhD, Yasuhide Hayashi, MD PhD, Takeshi Inukai, MD PhD, Hiroki Hori, MD PhD, Etsuro Ito, MD PhD

Blood (2015) 126 (23): 4986.

https://doi.org/10.1182/blood.V126.23.4986.4986

Published: 2015

Journal Articles

Mice with a Mutation in the Mdm2 Gene That Interferes with MDM2/Ribosomal Protein Binding Develop Bone Marrow Failure

Takuya Kamio, MDPhD, Bai-wei Gu, MDPhD, Timothy S. Olson, MDPhD, Yanping Zhang, PhD, Philip J Mason, PhD, Monica Bessler, MDPhD

Blood (2014) 124 (21): 4381.

https://doi.org/10.1182/blood.V124.21.4381.4381

Published: 2014

Journal Articles

JAK2 mutations and CRLF2 rearrangements in Down Syndrome-Associated Acute Lymphoblastic Leukemia in Japan

Isamu Hanada, MD, Kiminori Terui, MD, PhD, Tsutomu Toki, PhD, Ko Kudo, MD, Tomohiko Sato, MD, PhD, Takuya Kamio, MD, PhD, Shinya Sasaki, MD, PhD, Yoshihiro Takahashi, MD, PhD, Yasuhide Hayashi, MD, PhD, Kanji Sugita, MD, PhD, Seiji Kojima, MD, PhD, Kenichi Koike, MD, PhD, Yoshiyuki Kosaka, MD, PhD, Masao Kobayashi, MD, PhD, Etsuro Ito, MD, PhD

Blood (2011) 118 (21): 1451.

https://doi.org/10.1182/blood.V118.21.1451.1451

Published: 2011

Journal Articles

Relapse of Children with Aplastic Anemia after Immunosuppressive Therapy

Takuya Kamio, MD, PhD, Etsuro Ito, MD, PhD, Akira Ohara, MD, Yoshiyuki Kosaka, MD, PhD, Masahiro Tsuchida, MD, Hideo Mugishima, MD, PhD, Hiromasa Yabe, MD, Akira Morimoto, MD, PhD, Shouichi Ohga, MD, PhD, Hiroshi Yagasaki, MD, PhD, Fumio Bessho, MD, PhD, Tatsutoshi Nakahata, M.D., Ph.D., Seiji Kojima, MD, PhD

Blood (2008) 112 (11): 3098.

https://doi.org/10.1182/blood.V112.11.3098.3098

Published: 2008

Journal Articles

Activating JAK3 Mutations in Transient Myeloproliferative Disorder and Acute Megakaryoblastic Leukemia Accompanying Down Syndrome.

Tomohiko Sato, MD, Tsutomu Toki, PhD, Rika Kanezaki, M.S., Gang Xu, MD, PhD, Kiminori Terui, MD, PhD, Takuya Kamio, MD, PhD, Seiji Kojima, MD, PhD, Hitoshi Kiyoi, MD, PhD, Hiroyuki Mano, MD, PhD, Etsuro Ito, MD, PhD

Blood (2007) 110 (11): 1620.

https://doi.org/10.1182/blood.V110.11.1620.1620

Published: 2007

Journal Articles

Correction of Immunodeficiency Associated with NEMO Mutation by Umbilical Cord Stem Cell Transplantation Using a Reduced-Intensity Conditioning Regimen.

Chikako Tono, MD, PhD, Yoshihiro Takahashi, MD, PhD, Kiminori Terui, MD, PhD, Shinya Sasaki, MD, PhD, Takuya Kamio, MD, PhD, Satoru Tandai, MD, PhD, Tomohiko Sato, MD, Ko Kudo, MD, Tsutomu Toki, PhD, Naoki Tachibana, MD, PhD, Takakazu Yoshioka, MD, PhD, Tatsutoshi Nakahata, MD, PhD, Tomohiro Morio, MD, PhD, Ryuta Nishikomori, MD, PhD, Etsuro Ito, MD, PhD

Blood (2006) 108 (11): 5392.

https://doi.org/10.1182/blood.V108.11.5392.5392

Published: 2006

Journal Articles

Transgenic expression of BACH1 transcription factor results in megakaryocytic impairment

Tsutomu Toki, Fumiki Katsuoka, Rika Kanezaki, Gang Xu, Hidekachi Kurotaki, Jiying Sun, Takuya Kamio, Seiji Watanabe, Satoru Tandai, Kiminori Terui, Soroku Yagihashi, Norio Komatsu, Kazuhiko Igarashi, Masayuki Yamamoto, Etsuro Ito

Blood (2005) 105 (8): 3100–3108.

https://doi.org/10.1182/blood-2004-07-2826

Published: 2005

Journal Articles

Transgenic Expression of Bach1 Transcription Factor Results in Down-Regulation of the p45 Target Genes in Megakaryocytic Lineage Cells.

Tsutomu Toki, PhD, Fumiki Katsuoka, MD, Rika Kanezaki, MS, Seiji Watanabe, PhD, Takuya Kamio, MD, Satoru Tandai, MD, Hidekachi Kurotaki, MD, Soroku Yagihashi, MD, Jiying Sun, PhD, Norio Komatsu, MD, PhD, Kazuhiko Igarashi, MD, PhD, Masayuki Yamamoto, MD, PhD, Etsuro Ito, MD, PhD

Blood (2004) 104 (11): 1605.

https://doi.org/10.1182/blood.V104.11.1605.1605

Published: 2004

Journal Articles

B-cell–specific transcription factor BACH2 modifies the cytotoxic effects of anticancer drugs

Takuya Kamio, Tsutomu Toki, Rika Kanezaki, Shinya Sasaki, Satoru Tandai, Kiminori Terui, Dai Ikebe, Kazuhiko Igarashi, Etsuro Ito

Blood (2003) 102 (9): 3317–3322.

https://doi.org/10.1182/blood-2002-12-3656

Published: 2003

NARROW

Landscape of driver mutations and their clinical effects on Down syndrome–related myeloid neoplasms

BRAF V600E-Positive Precursors As Molecular Markers of Bone Marrow Involvement in Pediatric Langerhans Cell Histiocytosis

RAS Pathway Mutations in Down Syndrome-Associated Acute Lymphoblastic Leukemia in Japan

Mice with a Mutation in the Mdm2 Gene That Interferes with MDM2/Ribosomal Protein Binding Develop Bone Marrow Failure

JAK2 mutations and CRLF2 rearrangements in Down Syndrome-Associated Acute Lymphoblastic Leukemia in Japan

Relapse of Children with Aplastic Anemia after Immunosuppressive Therapy

Activating JAK3 Mutations in Transient Myeloproliferative Disorder and Acute Megakaryoblastic Leukemia Accompanying Down Syndrome.

Correction of Immunodeficiency Associated with NEMO Mutation by Umbilical Cord Stem Cell Transplantation Using a Reduced-Intensity Conditioning Regimen.

Transgenic expression of BACH1 transcription factor results in megakaryocytic impairment

Transgenic Expression of Bach1 Transcription Factor Results in Down-Regulation of the p45 Target Genes in Megakaryocytic Lineage Cells.

B-cell–specific transcription factor BACH2 modifies the cytotoxic effects of anticancer drugs

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American Society of Hematology

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American Society of Hematology

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