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Journal Articles

STAG2/LMO2 Gamma-Delta (γδ) T-ALL: Identification and Characterization of an Extremely High Risk Group of T-ALL in the Very Young

Shunsuke Kimura, Petri Pölönen, Lindsey Montefiori, Kenneth Caldwell, Ilaria Iacobucci, Chelsey Chen, Anthony Brown, Katie Han, Yen-Chun Liu, Yunchao Chang, Zhongshan Cheng, Zhou Yinmei, Chun Shik Park, Sharnise Mitchell, Noemi Reyes, Allen Yeoh, Andishe Attarbaschi, Andrew Moore, Atsushi Manabe, Barbara Buldini, Kean Hui Chiew, Chi Kong Li, Ching-Hon Pui, Chunxu Qu, Daisuke Tomizawa, Elisabeth Paietta, Franco Locatelli, Gabriele Escherich, Gao Qingsong, Hannah Elisa Muhle, Hanne Vibeke Marquart, Hester A. de Groot-Kruseman, Jacob M. Rowe, Jan Stary, Jan Trka, John Kim Choi, Jules P.P. Meijerink, Junko Takita, Katarzyna Pawinska-Wasikowska, Kjeld Schmiegelow, Mariko Eguchi, Martin Schrappe, Martin Zimmermann, Masatoshi Takagi, Melissa Maybury, Michael Svaton, Michaela Reiterova, Michal Kicinski, Motohiro Kato, Orietta Spinelli, Pauline Mazilier, Paul G. Thomas, Riccardo Masetti, Rishi Sury Kotecha, Rob Pieters, Sarah Elitzur, Selina M Luger, Shuhong Shen, Sima Jeha, Steven M. Kornblau, Szymon Skoczen, Takako Miyamura, Tiffaney Vincent, Toshihiko Imamura, Valentino Conter, Yanjing Tang, Zhaohui Gu, Kathryn G. Roberts, David T. Teachey, Kristine R Crews, Cheng Cheng, Jun J. Yang, Hiroto Inaba, Charles G. Mullighan

Blood (2023) 142 (Supplement 1): 845.

https://doi.org/10.1182/blood-2023-178688

Published: 2023

Journal Articles

A KLF4-DYRK2–mediated pathway regulating self-renewal in CML stem cells

Chun Shik Park, Andrew H. Lewis, Taylor J. Chen, Cory S. Bridges, Ye Shen, Koramit Suppipat, Monica Puppi, Julie A. Tomolonis, Paul D. Pang, Toni-Ann Mistretta, Leyuan Ma, Michael R. Green, Rachel Rau, H. Daniel Lacorazza

Blood (2019) 134 (22): 1960–1972.

https://doi.org/10.1182/blood.2018875922

Published: 2019

Includes: Supplemental data

Journal Articles

Pharmacological Inhibition of MAP2K7 Induces Apoptosis and Cell Cycle Arrest in T-Cell Acute Lymphoblastic Leukemia

Taylor J Chen, BS, Ye Shen, PhD, Cory Seth Bridges, BS, Chun Shik Park, PhD, Jacob J. Junco, PhD, Karen R. Rabin, MD PhD, H. Daniel Lacorazza, PhD

Blood (2019) 134 (Supplement_1): 3889.

https://doi.org/10.1182/blood-2019-129127

Published: 2019

Journal Articles

A Novel Short Latency, High Penetrance Model of KRAS Mutation-Driven T-Cell Acute Lymphoblastic Leukemia

Jacob J. Junco, PhD, Vincent Ulysses Gant, PhD, Maci S. Terrell, BS, Matthew Benjamin Miller, MD, Chun Shik Park, PhD, Taylor J Chen, BS, H. Daniel Lacorazza, PhD, Margaret Goodell, PhD, Rachel E. Rau, MD, Karen R. Rabin, MD PhD

Blood (2019) 134 (Supplement_1): 3792.

https://doi.org/10.1182/blood-2019-126858

Published: 2019

Journal Articles

KLF4 Controls Leukemic Stem Cell Self-Renewal in MLL-AF9-Induced Acute Myeloid Leukemia

Andrew Lewis, BS, Chun Shik Park, PhD, Monica Puppi, H. Daniel Lacorazza, PhD

Blood (2019) 134 (Supplement_1): 1231.

https://doi.org/10.1182/blood-2019-129164

Published: 2019

Journal Articles

Chemical Inhibition of the Macrophage Inhibitor Factor (MIF) Induces Cell Cycle Arrest and Apoptosis in Lymphoid and Myeloid Leukemia

Andrew Lewis, Chun Shik Park, PhD, Ye Shen, PhD, Nam Kyung Lee, B.S., H. Daniel Lacorazza, PhD

Blood (2017) 130 (Supplement 1): 1329.

https://doi.org/10.1182/blood.V130.Suppl_1.1329.1329

Published: 2017

Journal Articles

Vitamin K3 (menadione) Induces Cytotoxicity in Chronic Myeloid Leukemia Stem Cells By Upregulating DYRK2 through the Inhibition of SIAH2 Ubiquitin Ligase

Chun Shik Park, PhD, Ye Shen, PhD, Andrew H Lewis, BS, Koramit Suppipat, MD, Monica Puppi, Julie Tomolonis, Taylor J Chen, Paul Pang, Toni-Ann Mistretta, Leyuan Ma, Michael R Green, PhD, Rachel E. Rau, MD, H. Daniel Lacorazza, PhD

Blood (2017) 130 (Supplement 1): 4171.

https://doi.org/10.1182/blood.V130.Suppl_1.4171.4171

Published: 2017

Journal Articles

CRLF2 Overexpression Demonstrates Enhanced Leukemogenicity in Down Syndrome Hematopoietic Cells

Jacob J. Junco, PhD BS, Shan Liang, BS, Vishal Gokani, B.S., Vincent Ulysses Gant, PhD BS, Jaime Munoz, B.S., Allison Mayle, PhD, Chun Shik Park, PhD, H. Daniel Lacorazza, PhD, Margaret A Goodell, PhD, Karen R. Rabin, MD PhD

Blood (2016) 128 (22): 2708.

https://doi.org/10.1182/blood.V128.22.2708.2708

Published: 2016

Journal Articles

DYRK2 Inhibits the Self-Renewal of Leukemic Stem Cells in Chronic Myeloid Leukemia By Inducing Degradation of c-Myc Downstream of the Reprogramming Factor KLF4

Chun Shik Park, PhD, Ye Shen, BS, Koramit Suppipat, MD, Andrew Lewis, B.S., Julie Tomolonis, B.S., Monica Puppi, M.Sc., toni-Ann Mistretta, PhD, Leyuan Ma, Michael R Green, MD PhD, Daniel Lacorazza, PhD

Blood (2016) 128 (22): 1879.

https://doi.org/10.1182/blood.V128.22.1879.1879

Published: 2016

Journal Articles

KLF4 Regulates Self-Renewal of Leukemic Stem Cells in Chronic Myeloid Leukemia By Repressing Gbl Expression and Altering mTORC2 Activity

Chun Shik Park, PhD, Ye Shen, Takeshi Yamada, PhD, Koramit Suppipat, MD, Monica Puppi, MS, Daniel Lacorazza, PhD

Blood (2014) 124 (21): 1789.

https://doi.org/10.1182/blood.V124.21.1789.1789

Published: 2014

Journal Articles

Krüppel-like Factor 4 (KLF4) Suppresses T-Cell Acute Lymphoblastic Leukemia By Inhibiting Expression of MAP2K7 and Expansion of Leukemia Initiating Cells

Ye Shen, Chun Shik Park, PhD, Koramit Suppipat, MD, Takeshi Yamada, PhD, Toni-Ann Mistretta, PhD, Daniel Lacorazza, PhD

Blood (2014) 124 (21): 3569.

https://doi.org/10.1182/blood.V124.21.3569.3569

Published: 2014

Journal Articles

Tumor Suppressor Capacity of Krüppel Like Factor 4 (KLF4) in NOTCH1-Induced T-Cell Acute Lymphoblastic Leukemia

Ye Shen, Koramit Suppipat, MD, Chun Shik Park, PhD, Takeshi Yamada, PhD, H. Daniel Lacorazza, PhD

Blood (2012) 120 (21): 1325.

https://doi.org/10.1182/blood.V120.21.1325.1325

Published: 2012

Journal Articles

Role of DNA Methylation of the G 0 /G 1 Switch Gene 2 (G0S2) in the Proliferation of Myeloid Leukemia Cells

Takeshi Yamada, PhD, Chun Shik Park, PhD, Ye Shen, H. Daniel Lacorazza, PhD

Blood (2012) 120 (21): 3520.

https://doi.org/10.1182/blood.V120.21.3520.3520

Published: 2012

Journal Articles

Loss of Krüppel-Like Factor 4 (KLF4) Impairs the Self-Renewal of Leukemic Stem Cells

Chun Shik Park, PhD, Ye Shen, Takeshi Yamada, PhD, Koramit Suppipat, MD, H. Daniel Lacorazza, PhD

Blood (2012) 120 (21): 911.

https://doi.org/10.1182/blood.V120.21.911.911

Published: 2012

Journal Articles

Loss of Krüppel-Like Factor 4 (KLF4) Leads to Increased Self-Renewal Under Stress Conditions and Improved Survival of Hematopoietic Stem Cells

Chun Shik Park, PhD, Takeshi Yamada, PhD, Koramit Suppipat, MD, Maksim Mamonkin, H. Daniel Lacorazza, PhD

Blood (2011) 118 (21): 861.

https://doi.org/10.1182/blood.V118.21.861.861

Published: 2011

Journal Articles

The Transcription Factor ELF4 Promotes Survival of Myeloid Leukemic Stem Cells.

Chun Shik Park, PhD, Koramit Suppipat, MD, H. Daniel Lacorazza, PhD

Blood (2010) 116 (21): 1209.

https://doi.org/10.1182/blood.V116.21.1209.1209

Published: 2010

Journal Articles

Anti-Leukemic Property of Sulphoraphane In Precursor B Cell Acute Lymphoblastic Leukemia

Koramit Suppipat, MD, Xiao Zhu, Chun Shik Park, PhD, H. Daniel Lacorazza, PhD

Blood (2010) 116 (21): 3974.

https://doi.org/10.1182/blood.V116.21.3974.3974

Published: 2010

Journal Articles

Homeostatic Role of the Krüppel-Like Factor 4 (KLF4) in Proliferation and Differentiation of Primitive Hematopoietic Progenitor Cells.

Chun Shik Park, PhD, Takeshi Yamada, PhD, H. Daniel Lacorazza, PhD

Blood (2009) 114 (22): 1497.

https://doi.org/10.1182/blood.V114.22.1497.1497

Published: 2009

Journal Articles

G0/G1 Switch Gene 2 (G0S2) Is a Positive Regulator of Quiescence in Hematopoietic Stem Cells and Naïve T Cells.

Takeshi Yamada, PhD, Chun Shik Park, PhD, Leon Bae, H. Daniel Lacorazza, PhD

Blood (2009) 114 (22): 2538.

https://doi.org/10.1182/blood.V114.22.2538.2538

Published: 2009

Journal Articles

The Krüppel-Like Factor 4 (KLF4) Modulates Survival and Tissue Distribution of Natural Killer Cells.

Chun Shik Park, PhD, Ping-Hsien Lee, Takeshi Yamada, PhD, Maksim Mamonkin, H. Daniel Lacorazza, PhD

Blood (2009) 114 (22): 282.

https://doi.org/10.1182/blood.V114.22.282.282

Published: 2009

NARROW

STAG2/LMO2 Gamma-Delta (γδ) T-ALL: Identification and Characterization of an Extremely High Risk Group of T-ALL in the Very Young

A KLF4-DYRK2–mediated pathway regulating self-renewal in CML stem cells

Pharmacological Inhibition of MAP2K7 Induces Apoptosis and Cell Cycle Arrest in T-Cell Acute Lymphoblastic Leukemia

A Novel Short Latency, High Penetrance Model of KRAS Mutation-Driven T-Cell Acute Lymphoblastic Leukemia

KLF4 Controls Leukemic Stem Cell Self-Renewal in MLL-AF9-Induced Acute Myeloid Leukemia

Chemical Inhibition of the Macrophage Inhibitor Factor (MIF) Induces Cell Cycle Arrest and Apoptosis in Lymphoid and Myeloid Leukemia

Vitamin K3 (menadione) Induces Cytotoxicity in Chronic Myeloid Leukemia Stem Cells By Upregulating DYRK2 through the Inhibition of SIAH2 Ubiquitin Ligase

CRLF2 Overexpression Demonstrates Enhanced Leukemogenicity in Down Syndrome Hematopoietic Cells

DYRK2 Inhibits the Self-Renewal of Leukemic Stem Cells in Chronic Myeloid Leukemia By Inducing Degradation of c-Myc Downstream of the Reprogramming Factor KLF4

KLF4 Regulates Self-Renewal of Leukemic Stem Cells in Chronic Myeloid Leukemia By Repressing Gbl Expression and Altering mTORC2 Activity

Krüppel-like Factor 4 (KLF4) Suppresses T-Cell Acute Lymphoblastic Leukemia By Inhibiting Expression of MAP2K7 and Expansion of Leukemia Initiating Cells

Tumor Suppressor Capacity of Krüppel Like Factor 4 (KLF4) in NOTCH1-Induced T-Cell Acute Lymphoblastic Leukemia

Role of DNA Methylation of the G 0 /G 1 Switch Gene 2 (G0S2) in the Proliferation of Myeloid Leukemia Cells

Loss of Krüppel-Like Factor 4 (KLF4) Impairs the Self-Renewal of Leukemic Stem Cells

Loss of Krüppel-Like Factor 4 (KLF4) Leads to Increased Self-Renewal Under Stress Conditions and Improved Survival of Hematopoietic Stem Cells

The Transcription Factor ELF4 Promotes Survival of Myeloid Leukemic Stem Cells.

Anti-Leukemic Property of Sulphoraphane In Precursor B Cell Acute Lymphoblastic Leukemia

Homeostatic Role of the Krüppel-Like Factor 4 (KLF4) in Proliferation and Differentiation of Primitive Hematopoietic Progenitor Cells.

G0/G1 Switch Gene 2 (G0S2) Is a Positive Regulator of Quiescence in Hematopoietic Stem Cells and Naïve T Cells.

The Krüppel-Like Factor 4 (KLF4) Modulates Survival and Tissue Distribution of Natural Killer Cells.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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