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Journal Articles

Complement Inhibition Using Eculizumab Overcomes Platelet Transfusion Refractoriness in Allo-Immunized Patients Receiving HLA Mismatched Platelets

Phuong T. Vo, MD, Enkhtsetseg Purev, Kamille A West, MD, Michael Hochman, Emily C. McDuffee, PhD DO, Tatyana Worthy, Lisa Cook, Catalina Ramos, Brian Wells, Willy A. Flegel, Sharon Adams, Robert N. Reger, Georg Aue, Richard W. Childs

Blood (2016) 128 (22): 3840.

https://doi.org/10.1182/blood.V128.22.3840.3840

Published: 2016

Journal Articles

A Naive NK Cell Repertoire in the Circulation of Haploidentical Stem Cell Donors Pre Mobilization Predicts Rejection of Cord Myeloid Cells in Patients Undergoing Combined Haploidentical and Unrelated Cord Blood HSCT

Mattias Carlsten, MD, PhD, Robert N. Reger, Ritesh Kotecha, Enkhtsetseg Purev, Xin Tian, Roger Kurlander, Georg Aue, Richard W. Childs

Blood (2016) 128 (22): 2199.

https://doi.org/10.1182/blood.V128.22.2199.2199

Published: 2016

Journal Articles

Excellent Outcomes of Combined Haploidentical and Cord-Blood (Haplo-Cord) Transplantation and HLA-Matched Sibling (Matched-Sib) Donor Transplantation for High-Risk Patients with Severe Aplastic Anemia (SAA) Refractory to Immunosuppressive Therapy

Blood (2016) 128 (22): 4689.

https://doi.org/10.1182/blood.V128.22.4689.4689

Published: 2016

Journal Articles

mRNA Transfection of NK Cells with Gain-of-Function CXCR4 As a Novel Method to Enhance the Homing of Adoptively Transferred NK Cells to the Bone Marrow for the Treatment of Hematological Malignancies

Emily R. Levy, Robert N. Reger, B.S., Mattias Carlsten, MD, PhD, Richard W. Childs, MD

Blood (2015) 126 (23): 3089.

https://doi.org/10.1182/blood.V126.23.3089.3089

Published: 2015

Journal Articles

ER-Stress-Induced Suppression of HLA-E on Bortezomib-Evading Malignant Plasma Cells Dramatically Enhances Their Susceptibility to NK Cell Killing: Identification of an Achilles Heel in Myeloma Cells That Can be Utilized to Prevent Disease Relapse Following Bortezomib Treatment

Mattias Carlsten, MD, PhD, Ali Namazi, MD, Robert N. Reger, B.S., Maria Berg, Richard W. Childs, MD

Blood (2015) 126 (23): 4296.

https://doi.org/10.1182/blood.V126.23.4296.4296

Published: 2015

Journal Articles

Identification and Ex Vivo Expansion of a Circulating NK Cell Progenitor Population That Leads to Sustained Production of CD56+ NK Cells

Jan K. Davidson-Moncada, MD PhD, Taylor Harrison Wand, BA, Robert N. Reger, B.S., Chuanfeng Wu, PhD, Cynthia E. Dunbar, MD, Richard W. Childs, MD

Blood (2015) 126 (23): 850.

https://doi.org/10.1182/blood.V126.23.850.850

Published: 2015

Journal Articles

Treatment of Ex Vivo Expanded NK Cells with Daratumumab F(ab')2 Fragments Protects Adoptively Transferred NK Cells from Daratumumab-Mediated Killing and Augments Daratumumab-Induced Antibody Dependent Cellular Toxicity (ADCC) of Myeloma

Elena Cherkasova, PhD, Luis Espinoza, MD PhD, Ritesh Kotecha, Robert N. Reger, B.S., Maria Berg, Georg Aue, Ricardo M. Attar, PhD, A Kate Sasser, Mattias Carlsten, MD, PhD, Richard W. Childs, MD

Blood (2015) 126 (23): 4244.

https://doi.org/10.1182/blood.V126.23.4244.4244

Published: 2015

Journal Articles

Ex Vivo Expanded NK Cells Mediate Highly Efficient and Rapid Killing of Ewing Sarcoma Cells Through Degranulation with Tumor Cytotoxicity Controlled by the NKG2D, DNAM-1, and NKp30 NK Receptors

Amrita D. Karambelkar, B.S., Robert N. Reger, B.S., Mattias Carlsten, MD, PhD, Richard W. Childs, MD

Blood (2015) 126 (23): 1894.

https://doi.org/10.1182/blood.V126.23.1894.1894

Published: 2015

Journal Articles

Excellent Engraftment and Long-Term Survival in Patients with Severe Aplastic Anemia (SAA) Undergoing Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) with Haplo-Identical CD34+ Cells Combined with a Single Umbilical Cord Blood Unit

Enkhtsetseg Purev, Georg Aue, Ritesh Kotecha, Jennifer Wilder, Hahn M. Khuu, David F. Stroncek, MD, Roger Kurlander, Robert N. Reger, B.S., Willy A. Flegel, Sharon Adams, Lisa Cook, Catalina Ramos, Elena Cho, Richard W. Childs, MD

Blood (2015) 126 (23): 5516.

https://doi.org/10.1182/blood.V126.23.5516.5516

Published: 2015

Journal Articles

High Incidence of Late, Sustained and Clinically Inconsequential Epstein Barr Virus (EBV) Reactivation Following Combined Unrelated Cord Blood and Haploidentical CD34+ Cell Transplantation

Sneha Purvey, Enkhtsetseg Purev, Xin Tian, Jennifer Wilder, Lisa Cook, Catalina Ramos, Elena Cho, Patricia Prince, Susan F. Leitman, Hanh Khuu, David Stroncek, Robert N Reger, Georg Aue, Richard W. Childs, MD

Blood (2014) 124 (21): 1180.

https://doi.org/10.1182/blood.V124.21.1180.1180

Published: 2014

Journal Articles

A Novel Method to Study the in Vivo Trafficking and Homing of Adoptively Transferred NK Cells in Rhesus Macaques and Humans

Jan Davidson-Moncada, MD PhD MSc, Noriko Sato, MD PhD, Robert F Hoyt, DVM, Robert N Reger, Marvin Thomas, DVM, MS, Randy Clevenger, Mark E. Metzger, Robert E. Donahue, Philip C Eclarinal, BS, CNMT, Lawrence Szajek, Gary L Griffiths, PhD, Cynthia E. Dunbar, MD, Peter Choyke, MD, Richard Childs, MD

Blood (2014) 124 (21): 659.

https://doi.org/10.1182/blood.V124.21.659.659

Published: 2014

Journal Articles

Excellent Engraftment and Reduced Acute and Chronic Graft Versus Host Disease (GVHD) in ATG-Refractory Severe Aplastic Anemia (SAA) Following Transplantation of a PBSC Allograft Containing CD34+ Selected Cells Combined with Non-Mobilized Donor T-Cells

Enkhtsetseg Purev, Xin Tian, Jeremy M Pantin, Robert N Reger, Lisa Cook, Catalina Ramos, Elena Cho, Sneha Purvey, Patricia Prince, Hahn Khuu, David Stroncek, Susan Leitman, Danielle M. Townsley, MD, Neal S. Young, MD, Georg Aue, Richard W. Childs, MD

Blood (2014) 124 (21): 3882.

https://doi.org/10.1182/blood.V124.21.3882.3882

Published: 2014

Journal Articles

Improved Homing To Bone Marrow, Spleen and Lung Of Adoptively Infused NK Cells Expanded Ex Vivo With The Small Molecule Nicotinamide Using Feeder-Free Conditions

Gabi M. Frei, Maria Berg, Tony Peled, MSc, Robert N. Reger, Ritesh Kotecha, Toshihiro Onishi, MD, Luis Espinoza-Calderon, Nurit Persi, Chana Lador, Amnon Peled, Richard W. Childs, MD

Blood (2013) 122 (21): 897.

https://doi.org/10.1182/blood.V122.21.897.897

Published: 2013

Journal Articles

Identification of a Human Endogenous Retrovirus Type-E (HERV-E) Envelope with Selective Expression in Clear Cell Kidney Cancer That Is Immunogenic in Vitro.

Elena Cherkasova, Quinn Weisman, BS, Sachiko Kajigaya, PhD, Yoshiyuki Takahashi, MD, PhD, Robert N Reger, Nanae Harashima

Blood (2012) 120 (21): 3015.

https://doi.org/10.1182/blood.V120.21.3015.3015

Published: 2012

Journal Articles

A Phase I Trial of Adoptively Transferred Ex-Vivo Expanded Autologous Natural Killer (NK) Cells Following Treatment with Bortezomib to Sensitize Tumors to NK Cell Cytotoxicity

Robert N Reger, Maria Berg, Andreas Lundqvist, PhD, Theresa Donohue, MHS, PA-C, Mattias Carlsten, MD Ph.D, Dawn M Betters, Ph.D, Lisa Cook, RN, BSN, Catalina Ramos, RN, BSN, Sophia Grasmeder, RN, BSN, OCN, Su Su, MD, PhD, David Stroncek, MD, Jeremy Pantin, MD, Keyvan Keyvanfar, BS, Cristian A. Carvallo, MD, Hahn Khuu, MD, Richard Childs, MD

Blood (2011) 118 (21): 1001.

https://doi.org/10.1182/blood.V118.21.1001.1001

Published: 2011

NARROW

Complement Inhibition Using Eculizumab Overcomes Platelet Transfusion Refractoriness in Allo-Immunized Patients Receiving HLA Mismatched Platelets

A Naive NK Cell Repertoire in the Circulation of Haploidentical Stem Cell Donors Pre Mobilization Predicts Rejection of Cord Myeloid Cells in Patients Undergoing Combined Haploidentical and Unrelated Cord Blood HSCT

Excellent Outcomes of Combined Haploidentical and Cord-Blood (Haplo-Cord) Transplantation and HLA-Matched Sibling (Matched-Sib) Donor Transplantation for High-Risk Patients with Severe Aplastic Anemia (SAA) Refractory to Immunosuppressive Therapy

mRNA Transfection of NK Cells with Gain-of-Function CXCR4 As a Novel Method to Enhance the Homing of Adoptively Transferred NK Cells to the Bone Marrow for the Treatment of Hematological Malignancies

ER-Stress-Induced Suppression of HLA-E on Bortezomib-Evading Malignant Plasma Cells Dramatically Enhances Their Susceptibility to NK Cell Killing: Identification of an Achilles Heel in Myeloma Cells That Can be Utilized to Prevent Disease Relapse Following Bortezomib Treatment

Identification and Ex Vivo Expansion of a Circulating NK Cell Progenitor Population That Leads to Sustained Production of CD56+ NK Cells

Treatment of Ex Vivo Expanded NK Cells with Daratumumab F(ab')2 Fragments Protects Adoptively Transferred NK Cells from Daratumumab-Mediated Killing and Augments Daratumumab-Induced Antibody Dependent Cellular Toxicity (ADCC) of Myeloma

Ex Vivo Expanded NK Cells Mediate Highly Efficient and Rapid Killing of Ewing Sarcoma Cells Through Degranulation with Tumor Cytotoxicity Controlled by the NKG2D, DNAM-1, and NKp30 NK Receptors

Excellent Engraftment and Long-Term Survival in Patients with Severe Aplastic Anemia (SAA) Undergoing Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) with Haplo-Identical CD34+ Cells Combined with a Single Umbilical Cord Blood Unit

High Incidence of Late, Sustained and Clinically Inconsequential Epstein Barr Virus (EBV) Reactivation Following Combined Unrelated Cord Blood and Haploidentical CD34+ Cell Transplantation

A Novel Method to Study the in Vivo Trafficking and Homing of Adoptively Transferred NK Cells in Rhesus Macaques and Humans

Excellent Engraftment and Reduced Acute and Chronic Graft Versus Host Disease (GVHD) in ATG-Refractory Severe Aplastic Anemia (SAA) Following Transplantation of a PBSC Allograft Containing CD34+ Selected Cells Combined with Non-Mobilized Donor T-Cells

Improved Homing To Bone Marrow, Spleen and Lung Of Adoptively Infused NK Cells Expanded Ex Vivo With The Small Molecule Nicotinamide Using Feeder-Free Conditions

Identification of a Human Endogenous Retrovirus Type-E (HERV-E) Envelope with Selective Expression in Clear Cell Kidney Cancer That Is Immunogenic in Vitro.

A Phase I Trial of Adoptively Transferred Ex-Vivo Expanded Autologous Natural Killer (NK) Cells Following Treatment with Bortezomib to Sensitize Tumors to NK Cell Cytotoxicity

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American Society of Hematology

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ASH Publications

American Society of Hematology

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