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Journal Articles

Multi-omics single-cell spatial profiling of paediatric and adult acute myeloid leukaemia links spatial organization, molecular genetics and microenvironmental interactions

Free
Merel van der Meulen, Joost Koedijk, Emma Pool, Eva Argiro, Marijn Scheijde-Vermeulen, Livius Penter, Jana Ihlow, Andrej Lissat, Marieke Griffioen, Jennifer Tjon, Erik Van Den Akker, David Horst, Hendrik Veelken, Bianca Goemans, Wim De Jonge, Thanasis Margaritis, C. Zwaan, Olaf Heidenreich
Journal: Blood
Blood (2025) 146 (Supplement 1): 860.
https://doi.org/10.1182/blood-2025-860
Published: 2025
Journal Articles

A novel intercontinental external quality assessment program for flow cytometric measurable residual disease assessment in pediatric AML

Free
Margarita Maurer-Granofszky, Flavia Battistutta, Boutheina Bouslama, Lisa Brodersen, Chad Hudson, Christel Katerkamp, Pamela Scarparo, Anastasia Soboli, Jeroen te Marvelde, Barbara Buldini, Linda Fogelstrand, David Gillis, Hélène Lapillonne, Michael Loken, Vincent van der Velden, Nils Von Neuhoff, Lucy Wheeler, Todd Cooper, Sarah Tasian, Dirk Reinhardt, Gwen Nichols, C. Zwaan, Michael Dworzak
Journal: Blood
Blood (2025) 146 (Supplement 1): 3514.
https://doi.org/10.1182/blood-2025-3514
Published: 2025
Journal Articles

HEM-ismart: An international proof-of-concept therapeutic stratification trial of molecular anomalies in relapsed or refractory hematological malignancies in children

Free
Andrej Lissat, Francisco Bautista, Olli Lohi, Uri Ilan, Judith Boer, Monique Den Boer, Cornelia Eckert, Anne Elsinghorst, Ellis van Liempt, Britta Vormoor, Birgit Burkhardt, Jean Pierre Bourquin, Marie-Emilie Dourthe, Martha Grootenhuis, Frederick van Delft, Alwin Huitema, Shai Izraeli, Franco Locatelli, Marion Mateos, Denis Schewe, Arend von Stackelberg, Sarah Tasian, David Teachey, Harm Van Tinteren, C. Zwaan
Journal: Blood
Blood (2025) 146 (Supplement 1): 1582.
https://doi.org/10.1182/blood-2025-1582
Published: 2025
Journal Articles

ITCC-101/APAL2020D: A randomized Phase 3 trial of fludarabine/cytarabine/gemtuzumab ozogamycin with or without venetoclax in children with relapsed Acute Myeloid Leukemia

Free
Sae Ishimaru, Gwenaëlle Gueguen, Seth Karol, Francisco Bautista, Marjolein Mijnders-Remers, Jurren Sluijs, Jesse Anderson, Jennifer Lukin, Ann Collins, Harm Van Tinteren, Faith Galderisi, Mazaher Dhalla, Maika Onishi, Frank Scherer, Kristina Unnebrink, Daisuke Tomizawa, Dirk Reinhardt, Franco Locatelli, Alba Rubio-San-Simón, Gwen Nichols, Todd Cooper, Sarah Tasian, C. Zwaan
Journal: Blood
Blood (2025) 146 (Supplement 1): 1656.
https://doi.org/10.1182/blood-2025-1656
Published: 2025
Journal Articles

Revumenib for patients with relapsed or refractory (R/R) KMT2Ar acute leukemia: Outcomes by leukemia type in the phase 2 AUGMENT-101 study

Free
Ibrahim Aldoss, Ghayas Issa, James Blachly, Michael Thirman, Gabriel Mannis, Martha Arellano, John DiPersio, Elie Traer, C. Zwaan, Neerav Shukla, Branko Cuglievan, Carolyn Grove, Matthew Greenwood, Christine McMahon, Alexander Perl, Richard Stone, Cristina Papayannidis, David Dickens, Mael Heiblig, Andrius Zucenka, Pau Montesinos, Ioannis Mantzaris, Tibor Kovacsovics, Paul Shami, Li Yu, Rebecca Bagley, Angela R. Smith, Eytan Stein
Journal: Blood
Blood (2025) 146 (Supplement 1): 1001.
https://doi.org/10.1182/blood-2025-1001
Published: 2025
Journal Articles

Pediatric AML blasts drive immunosuppressive reprogramming and metabolic adaptation in macrophages, impairing T cell activation and anti-leukemic immunity

Free
Alicia Perzolli, Farah Massaoudi, Joost Koedijk, Elizabeth Schweighart, Lennart Kester, Bianca Goemans, C. Zwaan, Olaf Heidenreich
Journal: Blood
Blood (2025) 146 (Supplement 1): 5282.
https://doi.org/10.1182/blood-2025-5282
Published: 2025
Journal Articles

Molecular characterization of pediatric acute myeloid leukemia treated under the NOPHO-DBH-2012 protocol in the Netherlands

Free
Elizabeth Schweighart, Maaike Luesink, Milad Rasouli, Gertjan Kaspers, Olaf Heidenreich, C. Zwaan, Lennart Kester, Bianca Goemans
Journal: Blood
Blood (2025) 146 (Supplement 1): 445.
https://doi.org/10.1182/blood-2025-445
Published: 2025
Journal Articles

Spatial Technologies Reveal the Immune Landscape of Pediatric Acute Myeloid Leukemia

Free
Joost B. Koedijk, Inge Van Der Werf, Marijn A. Vermeulen, Alicia Perzolli, Marta F. Fiocco, Hester A. de Groot-Kruseman, Rubina Moeniralam, Kristina B. Christensen, Henrik Hasle, Stefan Nierkens, Mirjam E. Belderbos, Michel C. Zwaan, Olaf Heidenreich
Journal: Blood
Blood (2023) 142 (Supplement 1): 2959.
https://doi.org/10.1182/blood-2023-177932
Published: 2023
Journal Articles

The Effect of Immunoglobulin Prophylaxis on Infectious Morbidity in Pediatric Patients with Acute Lymphoblastic Leukemia: Results of a Randomized Controlled Trial

Free
Kirsten Thus, Hester A. de Groot-Kruseman, Pauline Winkler-Seinstra, Heidi Segers, Cor van den Bos, Inge M. Van Der Sluis, Wim Tissing, Margreet A. Veening, Michel C. Zwaan, Marta F. Fiocco, Cornelis van Tilburg, Rob Pieters, Marc Bierings
Journal: Blood
Blood (2023) 142 (Supplement 1): 2839.
https://doi.org/10.1182/blood-2023-173418
Published: 2023
Journal Articles

Non-Coding HOX Fusions in Pediatric Non-Down Syndrome Acute Megakaryoblastic Leukemia

Free
Fabienne R.S. Adriaanse, MSc, Sadie M. Sakurada, B.A., Shondra M. Pruett-Miller, PhD, Ronald W. Stam, PhD, Michel C Zwaan, MD PhD, Tanja A. Gruber, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 533.
https://doi.org/10.1182/blood-2019-127014
Published: 2019
Journal Articles

Minimal Residual Disease and IKZF1 As Predictors of Relapse, and Increased Treatment Related Mortality in Down Syndrome Acute Lymphoblastic Leukemia: A Unique and Large International Matched Case-Control Study

Free
Naomi Michels, BSc, Judith M. Boer, PhD, Marta Lopez-Yurda, PhD, Hester A. De Groot-Kruseman, PhD, Vincent van der Velden, PhD, Anthony V. Moorman, Amir Enshaei, PhD, Ajay Vora, Rosemary Sutton, BSc MSc PhD, Toby Trahair, PhD, Luciano Dalla-Pozza, MBBS FRACP, Rob Pieters, MDPhDMSc, Michel C Zwaan, MD PhD, Monique L. Den Boer, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 827.
https://doi.org/10.1182/blood-2019-124290
Published: 2019
Journal Articles

The SF3b Splicing Complex Regulates DNA Damage Response in Acute Lymphoblastic Leukemia

Free
Shalini Sankar, Miriam Guillen Navarro, Frida Ponthan, PhD, Simon Bomken, MD, Sirintra Nakjang, Vasily Grinev, PhD, Hesta McNeill, Michel C Zwaan, MD PhD, Josef Vormoor, MD PhD, Ronald W. Stam, PhD, Olaf Heidenreich
Journal: Blood
Blood (2019) 134 (Supplement_1): 1237.
https://doi.org/10.1182/blood-2019-124787
Published: 2019
Journal Articles

In-Vitro Efficacy of the Deoxyguanoside Analogs Forodesine (BCX-1777) and ARA-G in Pediatric Acute Lymphoblastic Leukemia.

Free
Irene Homminga, MD, Michel C. Zwaan, MD, PhD, Amel Seghouani, MD, Chantal Y. Manz, PhD, Shanta Bantia, PhD, Wilco Smits, Rob Pieters, MD, PhD, Jules P.P. Meijerink, PhD
Journal: Blood
Blood (2009) 114 (22): 2038.
https://doi.org/10.1182/blood.V114.22.2038.2038
Published: 2009