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Byoung Y. Ryu
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Journal Articles

In vivo CAR T-cell generation in nonhuman primates using lentiviral vectors displaying a multidomain fusion ligand

Christopher J. Nicolai, Maura H. Parker, Jim Qin, Weiliang Tang, Justin T. Ulrich-Lewis, Rebecca J. Gottschalk, Sara E. Cooper, Susana A. Hernandez Lopez, Don Parrilla, Richard S. Mangio, Nolan G. Ericson, Alissa H. Brandes, Saluwa Umuhoza, Kathryn R. Michels, Mollie M. McDonnell, Lisa Y. Park, Seungjin Shin, Wai-Hang Leung, Andrew M. Scharenberg, Hans-Peter Kiem, Ryan P. Larson, Laurie O. Beitz, Byoung Y. Ryu
Journal: Blood
Blood (2024) 144 (9): 977–987.
https://doi.org/10.1182/blood.2024024523
Published: 2024
Includes: Supplemental data
Journal Articles

Vivovec™ Surface-Engineered Lentiviral Particles Mediate In Vivo CAR T Generation with Potent and Highly Durable Activity in Non-Human Primates and Tumor-Bearing Humanized Mice

Maura Parker, Justin Ulrich-Lewis, Weiliang Tang, Chris Nicolai, Kathryn Michels, Susana Hernandez, Don Parrilla, Sara Cooper, Anai Perez, Mollie McDonnell, Greyson Hamilton, Chang-Chih Wu, Seungjin Shin, Andrew M. Scharenberg, Ryan P. Larson, Laurie Beitz, Byoung Y. Ryu
Journal: Blood
Blood (2023) 142 (Supplement 1): 765.
https://doi.org/10.1182/blood-2023-182195
Published: 2023
Journal Articles

Truncated Erythropoietin Receptors Confer an In Vivo Selective Advantage in Gene-Modified Erythroid Cells Expressing Fetal Hemoglobin Due to BCL11A Interference

Naoya Uchida, MD, Claire Drysdale, Morgan Yapundich, Jackson Gamer, Tina Nassehi, Matthew Wielgosz, Francesca Ferrara, PhD, Juan J. Haro-Mora, PhD, Selami Demirci, PhD, Aylin Bonifacino, MS, Allen Krouse, Nathaniel S. Linde, Robert E. Donahue, VMD, Byoung Y. Ryu, PhD, John F. Tisdale, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2063.
https://doi.org/10.1182/blood-2019-122770
Published: 2019
Journal Articles

CRISPR-Cas9 Genome Editing of γ-Globin Promoters in Human Hematopoietic Stem Cells to Induce Erythrocyte Fetal Hemoglobin for Treatment of β-Hemoglobinopathies

Jean-Yves Metais, PhD, Phillip A Doerfler, PhD, Thiyagaraj Mayuranathan, Daniel E. Bauer, MD PhD, Stephanie Fowler, Matthew Hsieh, MD, Varun Katta, Sagar Keriwala, Cicera Lazzarotto, Kevin Luk, Michael Neel, Scott Perry, Shaina Porter, Byoung Y. Ryu, PhD, Akshay Sharma, MBBS, Devlin Shea, Samuel Peters, John F. Tisdale, MD, Scot A. Wolfe, PhD, Kaitly Jensen Woodard, BS, Naoya Uchida, MD, Yuxuan Wu, PhD, Yu Yao, MD, Jing Zeng, MD, Shondra M. Pruett-Miller, PhD, Shengdar Q. Tsai, PhD, Mitchell J. Weiss, MD, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2066.
https://doi.org/10.1182/blood-2019-131318
Published: 2019
Journal Articles

Resveratrol trimer enhances gene delivery to hematopoietic stem cells by reducing antiviral restriction at endosomes

Stosh Ozog, Nina D. Timberlake, Kip Hermann, Olivia Garijo, Kevin G. Haworth, Guoli Shi, Christopher M. Glinkerman, Lauren E. Schefter, Saritha D’Souza, Elizabeth Simpson, Gabriella Sghia-Hughes, Raymond R. Carillo, Dale L. Boger, Hans-Peter Kiem, Igor Slukvin, Byoung Y. Ryu, Brian P. Sorrentino, Jennifer E. Adair, Scott A. Snyder, Alex A. Compton, Bruce E. Torbett
Journal: Blood
Blood (2019) 134 (16): 1298–1311.
https://doi.org/10.1182/blood.2019000040
Published: 2019
Includes: Supplemental data
Journal Articles

Fetal Hemoglobin Induction with Forced Chromatin Looping in Gene-Modified Erythroid Cells Differentiated from Rhesus Hematopoietic Progenitor Cells

Selami Demirci, PhD, Saurabh Bhardwaj, PhD, Naoya Uchida, MD PhD, Juan J. Haro Mora, PhD, Byoung Y. Ryu, PhD, Gerd A. Blobel, MD PhD, John F Tisdale, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4617.
https://doi.org/10.1182/blood.V130.Suppl_1.4617.4617
Published: 2017
Journal Articles

Interim Results from a Phase I/II Clinical Gene Therapy Study for Newly Diagnosed Infants with X-Linked Severe Combined Immunodeficiency Using a Safety-Modified Lentiviral Vector and Targeted Reduced Exposure to Busulfan

Ewelina Mamcarz, MD, Sheng Zhou, PhD, Timothy Lockey, PhD, Hossam Abdelsamed, PhD, Shane Cross, Pharm D, Zhijun Ma, MD, Jola Dowdy, Brandon Triplett, MD, Mitchell J. Weiss, MD PhD, Byoung Y. Ryu, PhD, Elif Dokmeci, MD, Juan Carlos Aldave, MD, Suk See De Ravin, MD PhD, Benjamin Youngblood, PhD, Janel R. Long-Boyle, PharmD, PhD, Michael M Meagher, PhD, Harry L Malech, MD, Jennifer Puck, MD, Morton Jerome Cowan, MD, Brian Sorrentino, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 523.
https://doi.org/10.1182/blood.V130.Suppl_1.523.523
Published: 2017
Journal Articles

A Novel and Highly Potent CAR T Cell Drug Product for Treatment of BCMA-Expressing Hematological Malignances

Alena A. Chekmasova, PhD, Holly M. Horton, PhD, Tracy E. Garrett, BA, John W. Evans, PhD, Johanna Griecci, BS, Amanda Hamel, BS, Howard J. Latimer, IV, BS, Stacie L. Seidel, MA, Byoung Y. Ryu, PhD, Michael Kuczewski, MS, Christopher J. Horvath, DVM, MS, DACVP, Kevin M. Friedman, PhD, Richard A. Morgan, PhD
Journal: Blood
Blood (2015) 126 (23): 3094.
https://doi.org/10.1182/blood.V126.23.3094.3094
Published: 2015
Journal Articles

Ubiquitous high-level gene expression in hematopoietic lineages provides effective lentiviral gene therapy of murine Wiskott-Aldrich syndrome

Alexander Astrakhan, Blythe D. Sather, Byoung Y. Ryu, Socheath Khim, Swati Singh, Stephanie Humblet-Baron, Hans D. Ochs, Carol H. Miao, David J. Rawlings
Journal: Blood
Blood (2012) 119 (19): 4395–4407.
https://doi.org/10.1182/blood-2011-03-340711
Published: 2012
Includes: Supplemental data
Journal Articles

B cell–specific lentiviral gene therapy leads to sustained B-cell functional recovery in a murine model of X-linked agammaglobulinemia

Hannah M. Kerns, Byoung Y. Ryu, Brigid V. Stirling, Blythe D. Sather, Alexander Astrakhan, Stephanie Humblet-Baron, Denny Liggitt, David J. Rawlings
Journal: Blood
Blood (2010) 115 (11): 2146–2155.
https://doi.org/10.1182/blood-2009-09-241869
Published: 2010
Includes: Supplemental data
Journal Articles

An experimental system for the evaluation of retroviral vector design to diminish the risk for proto-oncogene activation

Byoung Y. Ryu, Marguerite V. Evans-Galea, John T. Gray, David M. Bodine, Derek A. Persons, Arthur W. Nienhuis
Journal: Blood
Blood (2008) 111 (4): 1866–1875.
https://doi.org/10.1182/blood-2007-04-085506
Published: 2008
Includes: Supplemental data
Journal Articles

The Effect of a Chromatin Insulator (5′cHS4) on Enhanced Expression of the LMO2 Proto-Oncogene by an Oncoretroviral Long Terminal Repeat.

Byoung Y. Ryu, PhD, John T. Gray, PhD, David M. Bodine, PhD, Arthur W. Nienhuis, MD
Journal: Blood
Blood (2006) 108 (11): 3253.
https://doi.org/10.1182/blood.V108.11.3253.3253
Published: 2006