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Journal Articles

Nfix is a novel regulator of murine hematopoietic stem and progenitor cell survival

Per Holmfeldt, Jennifer Pardieck, Anjelica C. Saulsberry, Satish Kumar Nandakumar, David Finkelstein, John T. Gray, Derek A. Persons, Shannon McKinney-Freeman

Blood (2013) 122 (17): 2987–2996.

https://doi.org/10.1182/blood-2013-04-493973

Published: 2013

Includes: Supplemental data

Journal Articles

GATA2 Transcription Factor Mediates Myeloid Expansion Coupled with Lymphoid Block by Transcriptional Regulation of Key Target Genes.

Satish Kumar Nandakumar, MBBS, Geoffrey A. Neale, PhD, Derek A. Persons, MD, PhD

Blood (2012) 120 (21): 2317.

https://doi.org/10.1182/blood.V120.21.2317.2317

Published: 2012

Journal Articles

Hydroxyurea therapy of a murine model of sickle cell anemia inhibits the progression of pneumococcal disease by down-modulating E-selectin

Jeffrey D. Lebensburger, Thad Howard, Yunming Hu, Tamara I. Pestina, Geli Gao, Melissa Johnson, Stanislav S. Zakharenko, Russell E. Ware, Elaine I. Tuomanen, Derek A. Persons, Jason W. Rosch

Blood (2012) 119 (8): 1915–1921.

https://doi.org/10.1182/blood-2011-08-374447

Published: 2012

Includes: Multimedia, Supplemental data

Journal Articles

High Transgene Expression Rates After Extended Follow up Among Rhesus Macaque Recipients of Autologous Hematopoietic Stem Cells Transduced with a Modified HIV1-Based Lentiviral Vector

Naoya Uchida, Phillip W. Hargrove, M.S., Coen J. Lap, MD, Oswald Phang, Jr., Aylin C. Bonifacino, Allen E. Krouse, Mark E. Metzger, Anh-Dao Nguyen, Matthew M. Hsieh, MD, Tyra G. Wolfsberg, Robert E. Donahue, Derek A. Persons, MD, PhD, John F. Tisdale

Blood (2011) 118 (21): 3118.

https://doi.org/10.1182/blood.V118.21.3118.3118

Published: 2011

Journal Articles

Transcriptional regulation of fetal to adult hemoglobin switching: new therapeutic opportunities

Andrew Wilber, Arthur W. Nienhuis, Derek A. Persons

Blood (2011) 117 (15): 3945–3953.

https://doi.org/10.1182/blood-2010-11-316893

Published: 2011

Journal Articles

Therapeutic levels of fetal hemoglobin in erythroid progeny of β-thalassemic CD34 + cells after lentiviral vector-mediated gene transfer

Andrew Wilber, Phillip W. Hargrove, Yoon-Sang Kim, Janice M. Riberdy, Vijay G. Sankaran, Eleni Papanikolaou, Maria Georgomanoli, Nicholas P. Anagnou, Stuart H. Orkin, Arthur W. Nienhuis, Derek A. Persons

Blood (2011) 117 (10): 2817–2826.

https://doi.org/10.1182/blood-2010-08-300723

Published: 2011

Includes: Supplemental data

Journal Articles

A zinc-finger transcriptional activator designed to interact with the γ-globin gene promoters enhances fetal hemoglobin production in primary human adult erythroblasts

Andrew Wilber, Ulrich Tschulena, Phillip W. Hargrove, Yoon-Sang Kim, Derek A. Persons, Carlos F. Barbas, III, Arthur W. Nienhuis

Blood (2010) 115 (15): 3033–3041.

https://doi.org/10.1182/blood-2009-08-240556

Published: 2010

Includes: Supplemental data

Journal Articles

A Zinc-Finger Transcriptional Activator Designed to Interact with the Gamma-Globin Gene Promoters Enhances Fetal Hemoglobin Production in Erythroid Cells Derived From Normal and Beta-Thalassemic CD34 + Cells.

Andrew Wilber, PhD, Uli Tschulena, PhD, Phillip W. Hargrove, MS, Yoon-Sang Kim, MD, PhD, Carlos F. Barbas, III, PhD, Derek A. Persons, MD, PhD, Arthur W. Nienhuis, MD

Blood (2009) 114 (22): 3567.

https://doi.org/10.1182/blood.V114.22.3567.3567

Published: 2009

Journal Articles

Lentiviral Vector-Mediated Transfer of the Gamma-Globin Gene Into Normal and Beta-Thalassemic Human CD34 + Cells Results in Potentially Therapeutic Levels of Fetal Hemoglobin in Erythroid Progeny.

Andrew Wilber, Ph.D., Phillip W. Hargrove, M.S., Yoon-Sang Kim, MD, PhD, Arthur W. Nienhuis, M.D., Derek A. Persons, MD, PhD

Blood (2009) 114 (22): 3579.

https://doi.org/10.1182/blood.V114.22.3579.3579

Published: 2009

Journal Articles

Amelioration of murine β-thalassemia through drug selection of hematopoietic stem cells transduced with a lentiviral vector encoding both γ-globin and the MGMT drug-resistance gene

Huifen Zhao, Tamara I. Pestina, Md Nasimuzzaman, Perdeep Mehta, Phillip W. Hargrove, Derek A. Persons

Blood (2009) 113 (23): 5747–5756.

https://doi.org/10.1182/blood-2008-10-186684

Published: 2009

Includes: Supplemental data

Journal Articles

Sustained high-level polyclonal hematopoietic marking and transgene expression 4 years after autologous transplantation of rhesus macaques with SIV lentiviral vector–transduced CD34 + cells

Yoo-Jin Kim, Yoon-Sang Kim, Andre Larochelle, Gabriel Renaud, Tyra G. Wolfsberg, Rima Adler, Robert E. Donahue, Peiman Hematti, Bum-Kee Hong, Jean Roayaei, Keiko Akagi, Janice M. Riberdy, Arthur W. Nienhuis, Cynthia E. Dunbar, Derek A. Persons

Blood (2009) 113 (22): 5434–5443.

https://doi.org/10.1182/blood-2008-10-185199

Published: 2009

Includes: Supplemental data

Journal Articles

An experimental system for the evaluation of retroviral vector design to diminish the risk for proto-oncogene activation

Byoung Y. Ryu, Marguerite V. Evans-Galea, John T. Gray, David M. Bodine, Derek A. Persons, Arthur W. Nienhuis

Blood (2008) 111 (4): 1866–1875.

https://doi.org/10.1182/blood-2007-04-085506

Published: 2008

Includes: Supplemental data

Journal Articles

Use of a Lentiviral Vector Encoding γ-Globin and the MGMT Drug Resistance Gene Coupled with In Vivo Drug Selection To Cure β-Thalassemia.

Huifen Zhao, PhD, Tamara I. Pestina, Ph.D., Phillip W. Hargrove, M.S., Derek A. Persons, M.D., Ph.D.

Blood (2007) 110 (11): 1773.

https://doi.org/10.1182/blood.V110.11.1773.1773

Published: 2007

Journal Articles

A pill for some anemias?

Derek A. Persons

Blood (2007) 110 (6): 1709.

https://doi.org/10.1182/blood-2007-06-096719

Published: 2007

Journal Articles

Retroviral Vector Integration Site Analysis in Rhesus Macaques Transplanted with Hematopoietic Stem Cells Transduced with Simian Immunodeficiency Virus Vectors.

Yan Shou, PhD, John Gray, Ph.D, Brian A. Agricola, Zhijun Ma, M.D., Derek A. Persons, M.D., Ph.D, Brian P. Sorrentino, M.D.

Blood (2006) 108 (11): 3255.

https://doi.org/10.1182/blood.V108.11.3255.3255

Published: 2006

Journal Articles

Role of erythropoietin receptor signaling in Friend virus-induced erythroblastosis and polycythemia

Ji Zhang, Mindy S. Randall, Melanie R. Loyd, Weimin Li, Rachel L. Schweers, Derek A. Persons, Jerold E. Rehg, Constance T. Noguchi, James N. Ihle, Paul A. Ney

Blood (2006) 107 (1): 73–78.

https://doi.org/10.1182/blood-2005-05-1784

Published: 2006

Includes: Supplemental data

Journal Articles

Regulation of Primitive Hematopoietic Cell Growth and Differentiation by the Gata-2 Transcription Factor.

Stacy L. Throm, Ph.D., Derek A. Persons, M.D., Ph.D.

Blood (2004) 104 (11): 2779.

https://doi.org/10.1182/blood.V104.11.2779.2779

Published: 2004

Journal Articles

Assessment of Changes in Gene Expression Caused by Insertions of a Globin Lentiviral Vector Containing Globin Regulatory Elements or a Lentiviral Vector Containing Retroviral LTR Elements.

Phillip W. Hargrove, M.S., Steven Kepes, M.S., Hideki Hanawa, M.D., Ph.D., Cheng Cheng, Ph.D., Geoff Neale, Ph.D., Arthur W. Nienhuis, M.D., Derek A. Persons, M.D., Ph.D.

Blood (2004) 104 (11): 497.

https://doi.org/10.1182/blood.V104.11.497.497

Published: 2004

Journal Articles

Diminished Mobilization of Self-Inactivating (SIN) Lentiviral Vectors Containing Globin Regulatory Elements Compared to Those Containing a Retroviral Long Terminal Repeat.

Hideki Hanawa, MD, PhD, Derek A. Persons, MD, PhD, Takashi Shimada, MD3, Arthur W. Nienhuis, MD4

Blood (2004) 104 (11): 5271.

https://doi.org/10.1182/blood.V104.11.5271.5271

Published: 2004

Journal Articles

Extended β-globin locus control region elements promote consistent therapeutic expression of a γ-globin lentiviral vector in murine β-thalassemia

Hideki Hanawa, Phillip W. Hargrove, Steven Kepes, Deo K. Srivastava, Arthur W. Nienhuis, Derek A. Persons

Blood (2004) 104 (8): 2281–2290.

https://doi.org/10.1182/blood-2004-03-0863

Published: 2004

NARROW

Nfix is a novel regulator of murine hematopoietic stem and progenitor cell survival

GATA2 Transcription Factor Mediates Myeloid Expansion Coupled with Lymphoid Block by Transcriptional Regulation of Key Target Genes.

Hydroxyurea therapy of a murine model of sickle cell anemia inhibits the progression of pneumococcal disease by down-modulating E-selectin

High Transgene Expression Rates After Extended Follow up Among Rhesus Macaque Recipients of Autologous Hematopoietic Stem Cells Transduced with a Modified HIV1-Based Lentiviral Vector

Transcriptional regulation of fetal to adult hemoglobin switching: new therapeutic opportunities

Therapeutic levels of fetal hemoglobin in erythroid progeny of β-thalassemic CD34 + cells after lentiviral vector-mediated gene transfer

A zinc-finger transcriptional activator designed to interact with the γ-globin gene promoters enhances fetal hemoglobin production in primary human adult erythroblasts

A Zinc-Finger Transcriptional Activator Designed to Interact with the Gamma-Globin Gene Promoters Enhances Fetal Hemoglobin Production in Erythroid Cells Derived From Normal and Beta-Thalassemic CD34 + Cells.

Lentiviral Vector-Mediated Transfer of the Gamma-Globin Gene Into Normal and Beta-Thalassemic Human CD34 + Cells Results in Potentially Therapeutic Levels of Fetal Hemoglobin in Erythroid Progeny.

Amelioration of murine β-thalassemia through drug selection of hematopoietic stem cells transduced with a lentiviral vector encoding both γ-globin and the MGMT drug-resistance gene

Sustained high-level polyclonal hematopoietic marking and transgene expression 4 years after autologous transplantation of rhesus macaques with SIV lentiviral vector–transduced CD34 + cells

An experimental system for the evaluation of retroviral vector design to diminish the risk for proto-oncogene activation

Use of a Lentiviral Vector Encoding γ-Globin and the MGMT Drug Resistance Gene Coupled with In Vivo Drug Selection To Cure β-Thalassemia.

A pill for some anemias?

Retroviral Vector Integration Site Analysis in Rhesus Macaques Transplanted with Hematopoietic Stem Cells Transduced with Simian Immunodeficiency Virus Vectors.

Role of erythropoietin receptor signaling in Friend virus-induced erythroblastosis and polycythemia

Regulation of Primitive Hematopoietic Cell Growth and Differentiation by the Gata-2 Transcription Factor.

Assessment of Changes in Gene Expression Caused by Insertions of a Globin Lentiviral Vector Containing Globin Regulatory Elements or a Lentiviral Vector Containing Retroviral LTR Elements.

Diminished Mobilization of Self-Inactivating (SIN) Lentiviral Vectors Containing Globin Regulatory Elements Compared to Those Containing a Retroviral Long Terminal Repeat.

Extended β-globin locus control region elements promote consistent therapeutic expression of a γ-globin lentiviral vector in murine β-thalassemia

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American Society of Hematology

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ASH Publications

American Society of Hematology

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