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Journal Articles

High Transgene Expression Rates After Extended Follow up Among Rhesus Macaque Recipients of Autologous Hematopoietic Stem Cells Transduced with a Modified HIV1-Based Lentiviral Vector

Naoya Uchida, Phillip W. Hargrove, M.S., Coen J. Lap, MD, Oswald Phang, Jr., Aylin C. Bonifacino, Allen E. Krouse, Mark E. Metzger, Anh-Dao Nguyen, Matthew M. Hsieh, MD, Tyra G. Wolfsberg, Robert E. Donahue, Derek A. Persons, MD, PhD, John F. Tisdale

Blood (2011) 118 (21): 3118.

https://doi.org/10.1182/blood.V118.21.3118.3118

Published: 2011

Journal Articles

Therapeutic levels of fetal hemoglobin in erythroid progeny of β-thalassemic CD34 + cells after lentiviral vector-mediated gene transfer

Andrew Wilber, Phillip W. Hargrove, Yoon-Sang Kim, Janice M. Riberdy, Vijay G. Sankaran, Eleni Papanikolaou, Maria Georgomanoli, Nicholas P. Anagnou, Stuart H. Orkin, Arthur W. Nienhuis, Derek A. Persons

Blood (2011) 117 (10): 2817–2826.

https://doi.org/10.1182/blood-2010-08-300723

Published: 2011

Includes: Supplemental data

Journal Articles

A zinc-finger transcriptional activator designed to interact with the γ-globin gene promoters enhances fetal hemoglobin production in primary human adult erythroblasts

Andrew Wilber, Ulrich Tschulena, Phillip W. Hargrove, Yoon-Sang Kim, Derek A. Persons, Carlos F. Barbas, III, Arthur W. Nienhuis

Blood (2010) 115 (15): 3033–3041.

https://doi.org/10.1182/blood-2009-08-240556

Published: 2010

Includes: Supplemental data

Journal Articles

High Levels of Multilineage Hematopoietic Cell Gene Marking Following Lentiviral Vector Transduction and Transplantation of Steady-State Bone Marrow CD34 + cells in a Non-Human Primate Model.

Phillip W Hargrove, M.S., Kim Yoon Sang, M.D., Ph.D., Derek Persons, MD, PhD

Blood (2009) 114 (22): 2464.

https://doi.org/10.1182/blood.V114.22.2464.2464

Published: 2009

Journal Articles

A Modified HIV1-Based Lentiviral Vector Can Transduce Rhesus Hematopoietic Repopulating Cells as Efficiently as An SIV Vector in An Autologous Transplantation Model.

Naoya Uchida, MD, PhD, Phillip W Hargrove, M.S., Kareem Washington, PhD, Coen J. Lap, MD, Matthew M. Hsieh, MD, Aylin C. Bonifacino, Sandra D. Price, Allen E. Krouse, Mark E. Metzger, Robert E. Donahue, VMD, Derek Persons, MD, PhD, John F. Tisdale, MD

Blood (2009) 114 (22): 692.

https://doi.org/10.1182/blood.V114.22.692.692

Published: 2009

Journal Articles

A Zinc-Finger Transcriptional Activator Designed to Interact with the Gamma-Globin Gene Promoters Enhances Fetal Hemoglobin Production in Erythroid Cells Derived From Normal and Beta-Thalassemic CD34 + Cells.

Andrew Wilber, PhD, Uli Tschulena, PhD, Phillip W. Hargrove, MS, Yoon-Sang Kim, MD, PhD, Carlos F. Barbas, III, PhD, Derek A. Persons, MD, PhD, Arthur W. Nienhuis, MD

Blood (2009) 114 (22): 3567.

https://doi.org/10.1182/blood.V114.22.3567.3567

Published: 2009

Journal Articles

Lentiviral Vector-Mediated Transfer of the Gamma-Globin Gene Into Normal and Beta-Thalassemic Human CD34 + Cells Results in Potentially Therapeutic Levels of Fetal Hemoglobin in Erythroid Progeny.

Andrew Wilber, Ph.D., Phillip W. Hargrove, M.S., Yoon-Sang Kim, MD, PhD, Arthur W. Nienhuis, M.D., Derek A. Persons, MD, PhD

Blood (2009) 114 (22): 3579.

https://doi.org/10.1182/blood.V114.22.3579.3579

Published: 2009

Journal Articles

Amelioration of murine β-thalassemia through drug selection of hematopoietic stem cells transduced with a lentiviral vector encoding both γ-globin and the MGMT drug-resistance gene

Huifen Zhao, Tamara I. Pestina, Md Nasimuzzaman, Perdeep Mehta, Phillip W. Hargrove, Derek A. Persons

Blood (2009) 113 (23): 5747–5756.

https://doi.org/10.1182/blood-2008-10-186684

Published: 2009

Includes: Supplemental data

Journal Articles

Evaluation of a γ-Globin Lentiviral Vector in Sickle Cell Mice and Pigtail Macaques

Phillip W Hargrove, M.S., Tamara I Pestina, Ph.D., Yoon Sang Kim, M.D., Ph.D., John Gray, Ph.D., Kelli Boyd, D.V.M., Ph.D., Derek Persons, MD, PhD

Blood (2008) 112 (11): 818.

https://doi.org/10.1182/blood.V112.11.818.818

Published: 2008

Journal Articles

Use of a Lentiviral Vector Encoding γ-Globin and the MGMT Drug Resistance Gene Coupled with In Vivo Drug Selection To Cure β-Thalassemia.

Huifen Zhao, PhD, Tamara I. Pestina, Ph.D., Phillip W. Hargrove, M.S., Derek A. Persons, M.D., Ph.D.

Blood (2007) 110 (11): 1773.

https://doi.org/10.1182/blood.V110.11.1773.1773

Published: 2007

Journal Articles

Assessment of Changes in Gene Expression Caused by Insertions of a Globin Lentiviral Vector Containing Globin Regulatory Elements or a Lentiviral Vector Containing Retroviral LTR Elements.

Phillip W. Hargrove, M.S., Steven Kepes, M.S., Hideki Hanawa, M.D., Ph.D., Cheng Cheng, Ph.D., Geoff Neale, Ph.D., Arthur W. Nienhuis, M.D., Derek A. Persons, M.D., Ph.D.

Blood (2004) 104 (11): 497.

https://doi.org/10.1182/blood.V104.11.497.497

Published: 2004

Journal Articles

Extended β-globin locus control region elements promote consistent therapeutic expression of a γ-globin lentiviral vector in murine β-thalassemia

Hideki Hanawa, Phillip W. Hargrove, Steven Kepes, Deo K. Srivastava, Arthur W. Nienhuis, Derek A. Persons

Blood (2004) 104 (8): 2281–2290.

https://doi.org/10.1182/blood-2004-03-0863

Published: 2004

Journal Articles

Successful treatment of murine β-thalassemia using in vivo selection of genetically modified, drug-resistant hematopoietic stem cells

Derek A. Persons, Esther R. Allay, Nobukuni Sawai, Phillip W. Hargrove, Thomas P. Brent, Hideki Hanawa, Arthur W. Nienhuis, Brian P. Sorrentino

Blood (2003) 102 (2): 506–513.

https://doi.org/10.1182/blood-2003-03-0677

Published: 2003

Journal Articles

The degree of phenotypic correction of murine β-thalassemia intermedia following lentiviral-mediated transfer of a human γ-globin gene is influenced by chromosomal position effects and vector copy number

Derek A. Persons, Phillip W. Hargrove, Esther R. Allay, Hideki Hanawa, Arthur W. Nienhuis

Blood (2003) 101 (6): 2175–2183.

https://doi.org/10.1182/blood-2002-07-2211

Published: 2003

Journal Articles

High-Level Globin Gene Expression Mediated by a Recombinant Adeno-Associated Virus Genome That Contains the 3′ γ Globin Gene Regulatory Element and Integrates as Tandem Copies in Erythroid Cells

Phillip W. Hargrove, Elio F. Vanin, Gary J. Kurtzman, Arthur W. Nienhuis

Blood (1997) 89 (6): 2167–2175.

https://doi.org/10.1182/blood.V89.6.2167

Published: 1997

NARROW

High Transgene Expression Rates After Extended Follow up Among Rhesus Macaque Recipients of Autologous Hematopoietic Stem Cells Transduced with a Modified HIV1-Based Lentiviral Vector

Therapeutic levels of fetal hemoglobin in erythroid progeny of β-thalassemic CD34 + cells after lentiviral vector-mediated gene transfer

A zinc-finger transcriptional activator designed to interact with the γ-globin gene promoters enhances fetal hemoglobin production in primary human adult erythroblasts

High Levels of Multilineage Hematopoietic Cell Gene Marking Following Lentiviral Vector Transduction and Transplantation of Steady-State Bone Marrow CD34 + cells in a Non-Human Primate Model.

A Modified HIV1-Based Lentiviral Vector Can Transduce Rhesus Hematopoietic Repopulating Cells as Efficiently as An SIV Vector in An Autologous Transplantation Model.

A Zinc-Finger Transcriptional Activator Designed to Interact with the Gamma-Globin Gene Promoters Enhances Fetal Hemoglobin Production in Erythroid Cells Derived From Normal and Beta-Thalassemic CD34 + Cells.

Lentiviral Vector-Mediated Transfer of the Gamma-Globin Gene Into Normal and Beta-Thalassemic Human CD34 + Cells Results in Potentially Therapeutic Levels of Fetal Hemoglobin in Erythroid Progeny.

Amelioration of murine β-thalassemia through drug selection of hematopoietic stem cells transduced with a lentiviral vector encoding both γ-globin and the MGMT drug-resistance gene

Evaluation of a γ-Globin Lentiviral Vector in Sickle Cell Mice and Pigtail Macaques

Use of a Lentiviral Vector Encoding γ-Globin and the MGMT Drug Resistance Gene Coupled with In Vivo Drug Selection To Cure β-Thalassemia.

Assessment of Changes in Gene Expression Caused by Insertions of a Globin Lentiviral Vector Containing Globin Regulatory Elements or a Lentiviral Vector Containing Retroviral LTR Elements.

Extended β-globin locus control region elements promote consistent therapeutic expression of a γ-globin lentiviral vector in murine β-thalassemia

Successful treatment of murine β-thalassemia using in vivo selection of genetically modified, drug-resistant hematopoietic stem cells

The degree of phenotypic correction of murine β-thalassemia intermedia following lentiviral-mediated transfer of a human γ-globin gene is influenced by chromosomal position effects and vector copy number

High-Level Globin Gene Expression Mediated by a Recombinant Adeno-Associated Virus Genome That Contains the 3′ γ Globin Gene Regulatory Element and Integrates as Tandem Copies in Erythroid Cells

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American Society of Hematology

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ASH Publications

American Society of Hematology

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