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Journal Articles

Molecular mechanisms of leukocyte β2 integrin activation

Lai Wen, Markus Moser, Klaus Ley

Blood (2022) 139 (24): 3480–3492.

https://doi.org/10.1182/blood.2021013500

Published: 2022

Journal Articles

Kindlin-3 recruitment to the plasma membrane precedes high-affinity β 2 -integrin and neutrophil arrest from rolling

Lai Wen, Alex Marki, Payel Roy, Sara McArdle, Hao Sun, Zhichao Fan, Alexandre R. Gingras, Mark H. Ginsberg, Klaus Ley

Blood (2021) 137 (1): 29–38.

https://doi.org/10.1182/blood.2019003446

Published: 2021

Includes: Multimedia, Supplemental data

Journal Articles

Gnb isoforms control a signaling pathway comprising Rac1, Plcβ2, and Plcβ3 leading to LFA-1 activation and neutrophil arrest in vivo

Helena Block, Anika Stadtmann, Daniel Riad, Jan Rossaint, Charlotte Sohlbach, Giulia Germena, Dianqing Wu, Scott I. Simon, Klaus Ley, Alexander Zarbock

Blood (2016) 127 (3): 314–324.

https://doi.org/10.1182/blood-2015-06-651034

Published: 2016

Includes: Supplemental data

Journal Articles

Leukocytes talking to VE-cadherin

Klaus Ley

Blood (2013) 122 (14): 2300–2301.

https://doi.org/10.1182/blood-2013-08-519918

Published: 2013

Journal Articles

Inactivation of heparan sulfate 2- O -sulfotransferase accentuates neutrophil infiltration during acute inflammation in mice

Jakob Axelsson, Ding Xu, Bit Na Kang, Julia K. Nussbacher, Tracy M. Handel, Klaus Ley, P. Sriramarao, Jeffrey D. Esko

Blood (2012) 120 (8): 1742–1751.

https://doi.org/10.1182/blood-2012-03-417139

Published: 2012

Includes: Supplemental data

Journal Articles

Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation

Craig T. Lefort, Jan Rossaint, Markus Moser, Brian G. Petrich, Alexander Zarbock, Susan J. Monkley, David R. Critchley, Mark H. Ginsberg, Reinhard Fässler, Klaus Ley

Blood (2012) 119 (18): 4275–4282.

https://doi.org/10.1182/blood-2011-08-373118

Published: 2012

Includes: Multimedia, Supplemental data

Journal Articles

Leukocyte ligands for endothelial selectins: specialized glycoconjugates that mediate rolling and signaling under flow

Alexander Zarbock, Klaus Ley, Rodger P. McEver, Andrés Hidalgo

Blood (2011) 118 (26): 6743–6751.

https://doi.org/10.1182/blood-2011-07-343566

Published: 2011

Journal Articles

CD63 positions CD62P for rolling

Klaus Ley

Blood (2011) 118 (15): 4012–4013.

https://doi.org/10.1182/blood-2011-08-372318

Published: 2011

Journal Articles

Adam17 -dependent shedding limits early neutrophil influx but does not alter early monocyte recruitment to inflammatory sites

Jingjing Tang, Alexander Zarbock, Ivan Gomez, Carole L. Wilson, Craig T. Lefort, Anika Stadtmann, Bridgit Bell, Li-Chuan Huang, Klaus Ley, Elaine W. Raines

Blood (2011) 118 (3): 786–794.

https://doi.org/10.1182/blood-2010-11-321406

Published: 2011

Includes: Supplemental data

Journal Articles

Rolling on E- or P-selectin induces the extended but not high-affinity conformation of LFA-1 in neutrophils

Yoshihiro Kuwano, Oliver Spelten, Hong Zhang, Klaus Ley, Alexander Zarbock

Blood (2010) 116 (4): 617–624.

https://doi.org/10.1182/blood-2010-01-266122

Published: 2010

Includes: Multimedia, Supplemental data

Journal Articles

Identification of novel downstream targets of platelet glycoprotein VI activation by differential proteome analysis: implications for thrombus formation

Christian Schulz, Nina V. Leuschen, Thomas Fröhlich, Michael Lorenz, Susanne Pfeiler, Christian A. Gleissner, Elisabeth Kremmer, Mirjam Kessler, Alexander G. Khandoga, Bernd Engelmann, Klaus Ley, Steffen Massberg, Georg J. Arnold

Blood (2010) 115 (20): 4102–4110.

https://doi.org/10.1182/blood-2009-07-230268

Published: 2010

Includes: Supplemental data

Journal Articles

Tyrosine kinase Btk regulates E-selectin–mediated integrin activation and neutrophil recruitment by controlling phospholipase C (PLC) γ2 and PI3Kγ pathways

Helena Mueller, Anika Stadtmann, Hugo Van Aken, Emilio Hirsch, Demin Wang, Klaus Ley, Alexander Zarbock

Blood (2010) 115 (15): 3118–3127.

https://doi.org/10.1182/blood-2009-11-254185

Published: 2010

Includes: Supplemental data

Journal Articles

Gα i2 is required for chemokine-induced neutrophil arrest

Alexander Zarbock, Tracy L. Deem, Tracy L. Burcin, Klaus Ley

Blood (2007) 110 (10): 3773–3779.

https://doi.org/10.1182/blood-2007-06-094565

Published: 2007

Journal Articles

To transmigrate or not to transmigrate

Klaus Ley

Blood (2007) 109 (12): 5072–5073.

https://doi.org/10.1182/blood-2007-03-081851

Published: 2007

Journal Articles

LFA-1 is required for retention of effector CD8 T cells in mouse lungs

Jayant Thatte, Vrushali Dabak, Mark B. Williams, Thomas J. Braciale, Klaus Ley

Blood (2003) 101 (12): 4916–4922.

https://doi.org/10.1182/blood-2002-10-3159

Published: 2003

Journal Articles

Sialyltransferase specificity in selectin ligand formation

Lesley G. Ellies, Markus Sperandio, Gregory H. Underhill, James Yousif, Michael Smith, John J. Priatel, Geoffrey S. Kansas, Klaus Ley, Jamey D. Marth

Blood (2002) 100 (10): 3618–3625.

https://doi.org/10.1182/blood-2002-04-1007

Published: 2002

Journal Articles

Control of leukocyte rolling velocity in TNF-α–induced inflammation by LFA-1 and Mac-1

Jessica L. Dunne, Christie M. Ballantyne, Arthur L. Beaudet, Klaus Ley

Blood (2002) 99 (1): 336–341.

https://doi.org/10.1182/blood.V99.1.336

Published: 2002

Journal Articles

Increased granulopoiesis through interleukin-17 and granulocyte colony-stimulating factor in leukocyte adhesion molecule–deficient mice

S. Bradley Forlow, Jill R. Schurr, Jay K. Kolls, Gregory J. Bagby, Paul O. Schwarzenberger, Klaus Ley

Blood (2001) 98 (12): 3309–3314.

https://doi.org/10.1182/blood.V98.12.3309

Published: 2001

Journal Articles

Dermal and pulmonary inflammatory disease in E-selectin and P-selectin double-null mice is reduced in triple-selectin–null mice

Robert G. Collins, Unsu Jung, Maricela Ramirez, Daniel C. Bullard, M. John Hicks, C. Wayne Smith, Klaus Ley, Arthur L. Beaudet

Blood (2001) 98 (3): 727–735.

https://doi.org/10.1182/blood.V98.3.727

Published: 2001

Journal Articles

Severe impairment of leukocyte rolling in venules of core 2 glucosaminyltransferase–deficient mice

Markus Sperandio, Aravinda Thatte, Dan Foy, Lesley G. Ellies, Jamey D. Marth, Klaus Ley

Blood (2001) 97 (12): 3812–3819.

https://doi.org/10.1182/blood.V97.12.3812

Published: 2001

Includes: Multimedia, Supplemental data

NARROW

Molecular mechanisms of leukocyte β2 integrin activation

Kindlin-3 recruitment to the plasma membrane precedes high-affinity β 2 -integrin and neutrophil arrest from rolling

Gnb isoforms control a signaling pathway comprising Rac1, Plcβ2, and Plcβ3 leading to LFA-1 activation and neutrophil arrest in vivo

Leukocytes talking to VE-cadherin

Inactivation of heparan sulfate 2- O -sulfotransferase accentuates neutrophil infiltration during acute inflammation in mice

Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation

Leukocyte ligands for endothelial selectins: specialized glycoconjugates that mediate rolling and signaling under flow

CD63 positions CD62P for rolling

Adam17 -dependent shedding limits early neutrophil influx but does not alter early monocyte recruitment to inflammatory sites

Rolling on E- or P-selectin induces the extended but not high-affinity conformation of LFA-1 in neutrophils

Identification of novel downstream targets of platelet glycoprotein VI activation by differential proteome analysis: implications for thrombus formation

Tyrosine kinase Btk regulates E-selectin–mediated integrin activation and neutrophil recruitment by controlling phospholipase C (PLC) γ2 and PI3Kγ pathways

Gα i2 is required for chemokine-induced neutrophil arrest

To transmigrate or not to transmigrate

LFA-1 is required for retention of effector CD8 T cells in mouse lungs

Sialyltransferase specificity in selectin ligand formation

Control of leukocyte rolling velocity in TNF-α–induced inflammation by LFA-1 and Mac-1

Increased granulopoiesis through interleukin-17 and granulocyte colony-stimulating factor in leukocyte adhesion molecule–deficient mice

Dermal and pulmonary inflammatory disease in E-selectin and P-selectin double-null mice is reduced in triple-selectin–null mice

Severe impairment of leukocyte rolling in venules of core 2 glucosaminyltransferase–deficient mice

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American Society of Hematology

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ASH Publications

American Society of Hematology

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