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Journal Articles

TR4 and BCL11A Repress γ-globin Transcription via Independent Mechanisms

Yu Wang, Greggory Myers, Lei Yu, Kaiwen Deng, Ginette Balbin-Cuesta, Sharon A. Singh, Yuanfang Guan, Rami Khoriaty, James Douglas Engel

Blood blood.2024024599.

https://doi.org/10.1182/blood.2024024599

Published: 2024

Includes: Supplemental data

Journal Articles

p53-Independent Pathways in Diamond Blackfan Anemia

Kaiwen Deng, Lei Yu, Susan Hammoud, Alejandra Sanchez-Martinez, Xiaofang Liu, Ghazi-Abullah Saroya, Greggory Myers, Yu Wang, Ginette Balbin-Cuesta, Yuanfang Guan, Vesa Kaartinen, Rami Khoriaty, James Douglas Engel, Sharon A Singh

Blood (2022) 140 (Supplement 1): 11474.

https://doi.org/10.1182/blood-2022-165705

Published: 2022

Journal Articles

Identification of Novel Regulators of Erythropoiesis Using Whole-Genome CRISPR-Cas9 Screening

Greggory Myers, Lei Yu, Ginette Balbin-Cuesta, Ayse Bilge Ozel, James Douglas Engel, Rami Khoriaty

Blood (2022) 140 (Supplement 1): 8155–8156.

https://doi.org/10.1182/blood-2022-170101

Published: 2022

Journal Articles

An erythroid-to-myeloid cell fate conversion is elicited by LSD1 inactivation

Lei Yu, Greggory Myers, Chia-Jui Ku, Emily Schneider, Yu Wang, Sharon A. Singh, Natee Jearawiriyapaisarn, Andrew White, Takashi Moriguchi, Rami Khoriaty, Masayuki Yamamoto, Michael G. Rosenfeld, Julien Pedron, John H. Bushweller, Kim-Chew Lim, James Douglas Engel

Blood (2021) 138 (18): 1691–1704.

https://doi.org/10.1182/blood.2021011682

Published: 2021

Includes: Supplemental data

Journal Articles

In Situ Fate Mapping of Native and Stress Myelopoiesis Reveals a Unique Niche for Mono- and Dendritic Cell -Poiesis

Blood (2020) 136 (Supplement 1): 38–39.

https://doi.org/10.1182/blood-2020-143123

Published: 2020

Journal Articles

Mutation of Murine Rpl5 reveals a New Model for Diamond Blackfan Anemia Characterized By Defective Erythropoiesis

Philippe Lemay, PhD, Morgan A Jones, MD PhD BS, MS, Fatma Mohamed, Marie-Claude Guyot, Alexander Ludlow, Qing Li, MD, James Douglas Engel, PhD, Renny Franceschi, PhD, Thomas L. Rothstein, MD PhD, Vesa Kaartinen, PhD, Zoha Kibar, PhD, Sharon A Singh, MD

Blood (2019) 134 (Supplement_1): 2495.

https://doi.org/10.1182/blood-2019-131526

Published: 2019

Journal Articles

Spatial Mapping of Myelopoiesis Reveals the Bone Marrow Niche for Monocyte Dendritic Cell Progenitors

Jizhou Zhang, Qingqing Wu, PhD, Courtney Johnson, BS, André Olsson, MS, PhD, Anastasiya Slaughter, BA, Margot Lindsay May, BS, Benjamin Weinhaus, BS, Emily Bowers, PhD, James Douglas Engel, PhD, Jean X. Jiang, PhD, Sherry L. Abboud-Werner, PhD, Nathan Salomonis, PhD, H. Leighton Grimes, PhD, Daniel Lucas-Alcaraz, PhD

Blood (2019) 134 (Supplement_1): 528.

https://doi.org/10.1182/blood-2019-128809

Published: 2019

Journal Articles

Inhibition of LSD1 by small molecule inhibitors stimulates fetal hemoglobin synthesis

Cuong Quang Le, Greggory Myers, Alawi Habara, Natee Jearawiriyapaisarn, George J. Murphy, David H. K. Chui, Martin H. Steinberg, James Douglas Engel, Shuaiying Cui

Blood (2019) 133 (22): 2455–2459.

https://doi.org/10.1182/blood.2018892737

Published: 2019

Includes: Supplemental data

Journal Articles

The LSD1 Inhibitor RN-1 Increases γ-Globin Expression in Baboons By Targeting an Early Event Responsible for γ-Globin Repression

Kestis Vaitkus, Vinzon Ibanez, B.S., Maria Armila Ruiz, B.S., Ramasamy Jagadeeswaran, PhD, Yogenthiran Saunthararajah, MD, James Douglas Engel, PhD, Joseph DeSimone, PhD, Angela Rivers, MD, Donald Lavelle, PhD

Blood (2018) 132 (Supplement 1): 1054.

https://doi.org/10.1182/blood-2018-99-113539

Published: 2018

Journal Articles

LSD1 Inhibitors Induce Fetal Hemoglobin in Primary Human Erythroid Cells

Cuong LE, PhD, Greggory Myers, Alawi Habara, MBBS, MSc, David H.K. Chui, MD, Martin H. Steinberg, MD, James Douglas Engel, PhD, Shuaiying Cui, PhD

Blood (2018) 132 (Supplement 1): 1066.

https://doi.org/10.1182/blood-2018-99-117675

Published: 2018

Journal Articles

Stage-specific roles for Zmiz1 in Notch-dependent steps of early T-cell development

Qing Wang, Ran Yan, Nancy Pinnell, Anna C. McCarter, Yeonjoo Oh, Yiran Liu, Cher Sha, Noah F. Garber, Yitong Chen, Qingqing Wu, Chia-Jui Ku, Ivy Tran, Amparo Serna Alarcon, Rork Kuick, James Douglas Engel, Ivan Maillard, Tomasz Cierpicki, Mark Y. Chiang

Blood (2018) 132 (12): 1279–1292.

https://doi.org/10.1182/blood-2018-02-835850

Published: 2018

Includes: Supplemental data

Journal Articles

The orphan nuclear receptor TR4 regulates erythroid cell proliferation and maturation

Mary P. Lee, Osamu Tanabe, Lihong Shi, Natee Jearawiriyapaisarn, Daniel Lucas, James Douglas Engel

Blood (2017) 130 (23): 2537–2547.

https://doi.org/10.1182/blood-2017-05-783159

Published: 2017

Journal Articles

GATA2 haploinsufficiency accelerates EVI1-driven leukemogenesis

Saori Katayama, Mikiko Suzuki, Ayaka Yamaoka, Nadine Keleku-Lukwete, Fumiki Katsuoka, Akihito Otsuki, Shigeo Kure, James Douglas Engel, Masayuki Yamamoto

Blood (2017) 130 (7): 908–919.

https://doi.org/10.1182/blood-2016-12-756767

Published: 2017

Includes: Supplemental data

Journal Articles

Efficacy and safety of long-term RN-1 treatment to increase HbF in baboons

Vinzon Ibanez, Kestis Vaitkus, Angela Rivers, Robert Molokie, Shuaiying Cui, James Douglas Engel, Joseph DeSimone, Donald Lavelle

Blood (2017) 129 (2): 260–263.

https://doi.org/10.1182/blood-2016-10-746727

Published: 2017

Journal Articles

The LSD1 inhibitor RN-1 induces fetal hemoglobin synthesis and reduces disease pathology in sickle cell mice

Shuaiying Cui, Kim-Chew Lim, Lihong Shi, Mary Lee, Natee Jearawiriyapaisarn, Greggory Myers, Andrew Campbell, David Harro, Shigeki Iwase, Raymond C. Trievel, Angela Rivers, Joseph DeSimone, Donald Lavelle, Yogen Saunthararajah, James Douglas Engel

Blood (2015) 126 (3): 386–396.

https://doi.org/10.1182/blood-2015-02-626259

Published: 2015

Includes: Supplemental data

Journal Articles

Compound loss of function of nuclear receptors Tr2 and Tr4 leads to induction of murine embryonic β-type globin genes

Shuaiying Cui, Osamu Tanabe, Michael Sierant, Lihong Shi, Andrew Campbell, Kim-Chew Lim, James Douglas Engel

Blood (2015) 125 (9): 1477–1487.

https://doi.org/10.1182/blood-2014-10-605022

Published: 2015

Includes: Supplemental data

Journal Articles

TRIM28 is essential for erythroblast differentiation in the mouse

Tomonori Hosoya, Mary Clifford, Régine Losson, Osamu Tanabe, James Douglas Engel

Blood (2013) 122 (23): 3798–3807.

https://doi.org/10.1182/blood-2013-04-496166

Published: 2013

Includes: Supplemental data

Journal Articles

GATA-3 regulates hematopoietic stem cell maintenance and cell-cycle entry

Chia-Jui Ku, Tomonori Hosoya, Ivan Maillard, James Douglas Engel

Blood (2012) 119 (10): 2242–2251.

https://doi.org/10.1182/blood-2011-07-366070

Published: 2012

Journal Articles

Transcriptional interference among the murine β-like globin genes

Xiao Hu, Susan Eszterhas, Nicolas Pallazzi, Eric E. Bouhassira, Jennifer Fields, Osamu Tanabe, Scott A. Gerber, Michael Bulger, James Douglas Engel, Mark Groudine, Steven Fiering

Blood (2006) 109 (5): 2210–2216.

https://doi.org/10.1182/blood-2006-06-029868

Published: 2006

Includes: Supplemental data

Journal Articles

Transgenic rescue of GATA-1–deficient mice with GATA-1 lacking a FOG-1 association site phenocopies patients with X-linked thrombocytopenia

Ritsuko Shimizu, Kinuko Ohneda, James Douglas Engel, Cecelia D. Trainor, Masayuki Yamamoto

Blood (2004) 103 (7): 2560–2567.

https://doi.org/10.1182/blood-2003-07-2514

Published: 2004

NARROW

TR4 and BCL11A Repress γ-globin Transcription via Independent Mechanisms

p53-Independent Pathways in Diamond Blackfan Anemia

Identification of Novel Regulators of Erythropoiesis Using Whole-Genome CRISPR-Cas9 Screening

An erythroid-to-myeloid cell fate conversion is elicited by LSD1 inactivation

In Situ Fate Mapping of Native and Stress Myelopoiesis Reveals a Unique Niche for Mono- and Dendritic Cell -Poiesis

Mutation of Murine Rpl5 reveals a New Model for Diamond Blackfan Anemia Characterized By Defective Erythropoiesis

Spatial Mapping of Myelopoiesis Reveals the Bone Marrow Niche for Monocyte Dendritic Cell Progenitors

Inhibition of LSD1 by small molecule inhibitors stimulates fetal hemoglobin synthesis

The LSD1 Inhibitor RN-1 Increases γ-Globin Expression in Baboons By Targeting an Early Event Responsible for γ-Globin Repression

LSD1 Inhibitors Induce Fetal Hemoglobin in Primary Human Erythroid Cells

Stage-specific roles for Zmiz1 in Notch-dependent steps of early T-cell development

The orphan nuclear receptor TR4 regulates erythroid cell proliferation and maturation

GATA2 haploinsufficiency accelerates EVI1-driven leukemogenesis

Efficacy and safety of long-term RN-1 treatment to increase HbF in baboons

The LSD1 inhibitor RN-1 induces fetal hemoglobin synthesis and reduces disease pathology in sickle cell mice

Compound loss of function of nuclear receptors Tr2 and Tr4 leads to induction of murine embryonic β-type globin genes

TRIM28 is essential for erythroblast differentiation in the mouse

GATA-3 regulates hematopoietic stem cell maintenance and cell-cycle entry

Transcriptional interference among the murine β-like globin genes

Transgenic rescue of GATA-1–deficient mice with GATA-1 lacking a FOG-1 association site phenocopies patients with X-linked thrombocytopenia

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American Society of Hematology

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American Society of Hematology

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