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Journal Articles

Novel, potent, and orally bioavailable LSD1 inhibitors induce fetal hemoglobin synthesis in a sickle cell disease mouse model

Yu Wang, Lei Yu, Kaiwen Deng, Mathivanan Packiarajan, Angelo Aguilar, Sojin An, Greggory Myers, Hoon Oh, Sharon A. Singh, Uhn-soo Cho, Shaomeng Wang, Yuanfang Guan, Andrew White, Rami Khoriaty, James Douglas Engel

Blood blood.2024028006.

https://doi.org/10.1182/blood.2024028006

Published: 2025

Includes: Supplemental data

Journal Articles

TR4 and BCL11A repress γ-globin transcription via independent mechanisms

Yu Wang, Greggory Myers, Lei Yu, Kaiwen Deng, Ginette Balbin-Cuesta, Sharon A. Singh, Yuanfang Guan, Rami Khoriaty, James Douglas Engel

Blood (2024) 144 (26): 2762–2772.

https://doi.org/10.1182/blood.2024024599

Published: 2024

Includes: Supplemental data

Journal Articles

The LSD1 Inhibitor RN1 Rescues Congenital Dyserythropoietic Anemia Type II

Lei Yu, Yu Wang, Richard King, Greggory Myers, Beth McGee, Ann Friedman, Ginette Balbin-Cuesta, Zesen Lin, Claire Drysdale, Xiaofang Liu, Claire Kerpet, Kaiwen Deng, Aaron Robida, James Engel, Rami Khoriaty

Blood (2024) 144 (Supplement 1): 938.

https://doi.org/10.1182/blood-2024-201649

Published: 2024

Journal Articles

p53-Independent Pathways in Diamond Blackfan Anemia

Kaiwen Deng, Lei Yu, Susan Hammoud, Alejandra Sanchez-Martinez, Xiaofang Liu, Ghazi-Abullah Saroya, Greggory Myers, Yu Wang, Ginette Balbin-Cuesta, Yuanfang Guan, Vesa Kaartinen, Rami Khoriaty, James Douglas Engel, Sharon A Singh

Blood (2022) 140 (Supplement 1): 11474.

https://doi.org/10.1182/blood-2022-165705

Published: 2022