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INSIDE BLOOD

AIDS lymphomas: beginning of an EPOCH?

David T. Scadden

View Articletitled, AIDS lymphomas: beginning of an EPOCH?

Major link between mast cells and the idiopathic hypereosinophilic syndrome

Marc E. Rothenberg

View Articletitled, Major link between mast cells and the idiopathic hypereosinophilic syndrome

Progress with unrelated cord blood transplants in adults

Joanne Kurtzberg

View Articletitled, Progress with unrelated cord blood transplants in adults

New targets for antiadhesion therapy of human multiple sclerosis

Paul Kubes,Steven M. Kerfoot

View Articletitled, New targets for antiadhesion therapy of human multiple sclerosis

Factor XI inhibitors

David Gailani

View Articletitled, Factor XI inhibitors

Targeting DCs to induce regulatory T cells in vivo

Robert L. Truitt

View Articletitled, Targeting DCs to induce regulatory T cells in vivo

Gene expression profiling illuminates myeloma biology

A. Keith Stewart

View Articletitled, Gene expression profiling illuminates myeloma biology

Cryptic malaria parasites unveiled

Alister Craig

View Articletitled, Cryptic malaria parasites unveiled

Diamond-Blackfan anemia and nucleolar transport

Alan D. D'Andrea

View Articletitled, Diamond-Blackfan anemia and nucleolar transport

Additional alpha applications

David A. Scheinberg

View Articletitled, Additional alpha applications

PLENARY PAPERS

Highly effective treatment of acquired immunodeficiency syndrome–related lymphoma with dose-adjusted EPOCH: impact of antiretroviral therapy suspension and tumor biology
Clinical Trials & Observations

Richard F. Little,Stefania Pittaluga,Nicole Grant,Seth M. Steinberg,Mark F. Kavlick,Hiroaki Mitsuya,Genoveffa Franchini,Martin Gutierrez,Mark Raffeld,Elaine S. Jaffe,Gene Shearer,Robert Yarchoan,Wyndham H. Wilson

View Articletitled, Highly effective treatment of acquired immunodeficiency syndrome–related lymphoma with dose-adjusted EPOCH: impact of antiretroviral therapy suspension and tumor biology

Elevated serum tryptase levels identify a subset of patients with a myeloproliferative variant of idiopathic hypereosinophilic syndrome associated with tissue fibrosis, poor prognosis, and imatinib responsiveness
Clinical Trials & Observations

Amy D. Klion,Pierre Noel,Cem Akin,Melissa A. Law,D. Gary Gilliland,Jan Cools,Dean D. Metcalfe,Thomas B. Nutman

View Articletitled, Elevated serum tryptase levels identify a subset of patients with a myeloproliferative variant of idiopathic hypereosinophilic syndrome associated with tissue fibrosis, poor prognosis, and imatinib responsiveness

REVIEW IN TRANSLATIONAL HEMATOLOGY

Map kinase signaling pathways and hematologic malignancies

Leonidas C. Platanias

View Articletitled, Map kinase signaling pathways and hematologic malignancies

CHEMOKINES

Cell surface peptidase CD26/DPPIV mediates G-CSF mobilization of mouse progenitor cells

Kent W. Christopherson, II,Scott Cooper,Hal E. Broxmeyer

View Articletitled, Cell surface peptidase CD26/DPPIV mediates G-CSF mobilization of mouse progenitor cells

Platelet factor 4 promotes adhesion of hematopoietic progenitor cells and binds IL-8: novel mechanisms for modulation of hematopoiesis

Arkadiusz Z. Dudek,Irina Nesmelova,Kevin Mayo,Catherine M. Verfaillie,Simon Pitchford,Arne Slungaard

View Articletitled, Platelet factor 4 promotes adhesion of hematopoietic progenitor cells and binds IL-8: novel mechanisms for modulation of hematopoiesis

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Minimal residual disease in adolescent (older than 14 years) and adult acute lymphoblastic leukemias: early immunophenotypic evaluation has high clinical value
Clinical Trials & Observations

María-Belén Vidriales,José J. Pérez,Maria Consuelo López-Berges,Norma Gutiérrez,Juana Ciudad,Paulo Lucio,Lourdes Vazquez,Ramón García-Sanz,Maria Consuelo del Cañizo,Javier Fernández-Calvo,Fernando Ramos,M. Jesús Rodríguez,M. José Calmuntia,Ana Porwith,Alberto Orfao,Jesús F. San-Miguel

View Articletitled, Minimal residual disease in adolescent (older than 14 years) and adult acute lymphoblastic leukemias: early immunophenotypic evaluation has high clinical value

Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment
Clinical Trials & Observations

Ravi Bhatia,Melissa Holtz,Ning Niu,Rachel Gray,David S. Snyder,Charles L. Sawyers,Daniel A. Arber,Marilyn L. Slovak,Stephen J. Forman

View Articletitled, Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment

A unique atrial primary cardiac lymphoma mimicking myxoma presenting with embolic stroke: a case report
Clinical Trials & Observations Brief Report

Michael M. Quigley,Eric Schwartzman,Pamela D. Boswell,Rebecca L. Christensen,Lisa A. Gleason,Robert W. Sharpe,Thomas A. d'Amato

View Articletitled, A unique atrial primary cardiac lymphoma mimicking myxoma presenting with embolic stroke: a case report

Unrelated cord blood transplantation for adult patients with advanced myelodysplastic syndrome
Clinical Trials & Observations Brief Report

Jun Ooi,Tohru Iseki,Satoshi Takahashi,Akira Tomonari,Koji Ishii,Kashiya Takasugi,Yoko Shimohakamada,Nobuhiro Ohno,Kaoru Uchimaru,Fumitaka Nagamura,Arinobu Tojo,Shigetaka Asano

View Articletitled, Unrelated cord blood transplantation for adult patients with advanced myelodysplastic syndrome

Efficacy of imatinib mesylate in the treatment of idiopathic hypereosinophilic syndrome
Clinical Trials & Observations Brief Report

Jorge Cortes,Patricia Ault,Charles Koller,Deborah Thomas,Alessandra Ferrajoli,William Wierda,Mary B. Rios,Laurie Letvak,Elizabeth S. Kaled,Hagop Kantarjian

View Articletitled, Efficacy of imatinib mesylate in the treatment of idiopathic hypereosinophilic syndrome

GENE THERAPY

Performance- and safety-enhanced lentiviral vectors containing the human interferon-β scaffold attachment region and the chicken β-globin insulator

Ali Ramezani,Teresa S. Hawley,Robert G. Hawley

View Articletitled, Performance- and safety-enhanced lentiviral vectors containing the human interferon-β scaffold attachment region and the chicken β-globin insulator

HEMATOPOIESIS

Genetic evidence for convergence of c-Kit– and α₄ integrin–mediated signals on class I_A PI-3kinase and the Rac pathway in regulating integrin-directed migration in mast cells

Bai Lin Tan,Mustafa N. Yazicioglu,David Ingram,Jennifer McCarthy,Jovencio Borneo,David A. Williams,Reuben Kapur

View Articletitled, Genetic evidence for convergence of c-Kit– and α4 integrin–mediated signals on class IA PI-3kinase and the Rac pathway in regulating integrin-directed migration in mast cells

Erythropoiesis from acetyl LDL incorporating endothelial cells at the preliver stage

Daisuke Sugiyama,Minetaro Ogawa,Imiko Hirose,Thierry Jaffredo,Ken-ichi Arai,Kohichiro Tsuji

View Articletitled, Erythropoiesis from acetyl LDL incorporating endothelial cells at the preliver stage

The role of G-protein signaling in hematopoietic stem/progenitor cell mobilization

Thalia Papayannopoulou,Gregory V. Priestley,Halvard Bonig,Betty Nakamoto

View Articletitled, The role of G-protein signaling in hematopoietic stem/progenitor cell mobilization

Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene

Yoshiaki Okada,Ryohei Nagai,Takahiro Sato,Eri Matsuura,Takashi Minami,Ikuo Morita,Takefumi Doi

View Articletitled, Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene

A PAR domain transcription factor is involved in the expression from a hematopoietic-specific promoter for the human LMO2 gene

Scott C. Crable,Kathleen P. Anderson

View Articletitled, A PAR domain transcription factor is involved in the expression from a hematopoietic-specific promoter for the human LMO2 gene

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Oxidized phospholipids in oxidized low-density lipoprotein down-regulate thrombomodulin transcription in vascular endothelial cells through a decrease in the binding of RARβ-RXRα heterodimers and Sp1 and Sp3 to their binding sequences in the TM promoter

Hidemi Ishii,Tsuyoshi Tezuka,Hiroyuki Ishikawa,Kimihiko Takada,Koji Oida,Shuichi Horie

View Articletitled, Oxidized phospholipids in oxidized low-density lipoprotein down-regulate thrombomodulin transcription in vascular endothelial cells through a decrease in the binding of RARβ-RXRα heterodimers and Sp1 and Sp3 to their binding sequences in the TM promoter

CD8⁺ T cells from patients with acute multiple sclerosis display selective increase of adhesiveness in brain venules: a critical role for P-selectin glycoprotein ligand-1

Luca Battistini,Laura Piccio,Barbara Rossi,Simona Bach,Simona Galgani,Claudio Gasperini,Linda Ottoboni,Donatella Ciabini,Maria D. Caramia,Giorgio Bernardi,Carlo Laudanna,Elio Scarpini,Rodger P. McEver,Eugene C. Butcher,Giovanna Borsellino,Gabriela Constantin

View Articletitled, CD8+ T cells from patients with acute multiple sclerosis display selective increase of adhesiveness in brain venules: a critical role for P-selectin glycoprotein ligand-1

Supplemental data

Prevalence, causes, and characterization of factor XI inhibitors in patients with inherited factor XI deficiency
Clinical Trials & Observations

Ophira Salomon,Ariella Zivelin,Tami Livnat,Rima Dardik,Ron Loewenthal,Ophelia Avishai,David M. Steinberg,Michael H. Rosove,Niamh O'Connell,Christine A. Lee,Uri Seligsohn

View Articletitled, Prevalence, causes, and characterization of factor XI inhibitors in patients with inherited factor XI deficiency

Mechanisms and implications of platelet discoid shape

Joseph E. Italiano, Jr,Wolfgang Bergmeier,Sanjay Tiwari,Hervé Falet,John H. Hartwig,Karin M. Hoffmeister,Patrick André,Denisa D. Wagner,Ramesh A. Shivdasani

View Articletitled, Mechanisms and implications of platelet discoid shape

Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1

Eszter Dömötör,Omar Benzakour,John H. Griffin,David Yule,Kenji Fukudome,Berislav V. Zlokovic

View Articletitled, Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1

Exosite-dependent regulation of factor VIIIa by activated protein C

Chandrashekhara Manithody,Philip J. Fay,Alireza R. Rezaie

View Articletitled, Exosite-dependent regulation of factor VIIIa by activated protein C

Major mutations in calf-1 and calf-2 domains of glycoprotein IIb in patients with Glanzmann thrombasthenia enable GPIIb/IIIa complex formation, but impair its transport from the endoplasmic reticulum to the Golgi apparatus

Nurit Rosenberg,Rivka Yatuv,Vladimir Sobolev,Hava Peretz,Ariella Zivelin,Uri Seligsohn

View Articletitled, Major mutations in calf-1 and calf-2 domains of glycoprotein IIb in patients with Glanzmann thrombasthenia enable GPIIb/IIIa complex formation, but impair its transport from the endoplasmic reticulum to the Golgi apparatus

HGF receptor up-regulation contributes to the angiogenic phenotype of human endothelial cells and promotes angiogenesis in vitro

Shunli Ding,Tatyana Merkulova-Rainon,Zhong Chao Han,Gérard Tobelem

View Articletitled, HGF receptor up-regulation contributes to the angiogenic phenotype of human endothelial cells and promotes angiogenesis in vitro

Aggravation of endotoxin-induced disseminated intravascular coagulation and cytokine activation in heterozygous protein-C–deficient mice

Marcel Levi,Janine Dörffler-Melly,Pieter Reitsma,Harry Büller,Sandrine Florquin,Tom van der Poll,Peter Carmeliet

View Articletitled, Aggravation of endotoxin-induced disseminated intravascular coagulation and cytokine activation in heterozygous protein-C–deficient mice

Evidence for a role for Gα_i1 in mediating weak agonist-induced platelet aggregation in human platelets: reduced Gα_i1 expression and defective G_i signaling in the platelets of a patient with a chronic bleeding disorder
Clinical Trials & Observations

Yatin M. Patel,Kirti Patel,Salman Rahman,Mark P. Smith,Gillian Spooner,Rushika Sumathipala,Michael Mitchell,Geraldine Flynn,Alexandra Aitken,Geoffrey Savidge

View Articletitled, Evidence for a role for Gαi1 in mediating weak agonist-induced platelet aggregation in human platelets: reduced Gαi1 expression and defective Gi signaling in the platelets of a patient with a chronic bleeding disorder

Involvement of a CD47-dependent pathway in platelet adhesion on inflamed vascular endothelium under flow

Patricia Lagadec,Olivier Dejoux,Michel Ticchioni,Françoise Cottrez,Mette Johansen,Eric J. Brown,Alain Bernard

View Articletitled, Involvement of a CD47-dependent pathway in platelet adhesion on inflamed vascular endothelium under flow

Identification of thrombin activatable fibrinolysis inhibitor (TAFI) in human platelets
Brief Report

Laurent O. Mosnier,Paula Buijtenhuijs,Pauline F. Marx,Joost C. M. Meijers,Bonno N. Bouma

View Articletitled, Identification of thrombin activatable fibrinolysis inhibitor (TAFI) in human platelets

Oxidized low-density lipoprotein (oxLDL) triggers hypoxia-inducible factor-1α (HIF-1α) accumulation via redox-dependent mechanisms
Brief Report

Vladimir A. Shatrov,Vadim V. Sumbayev,Jie Zhou,Bernhard Brüne

View Articletitled, Oxidized low-density lipoprotein (oxLDL) triggers hypoxia-inducible factor-1α (HIF-1α) accumulation via redox-dependent mechanisms

Anti–protein Z antibodies in women with pathologic pregnancies
Brief Report

Jean-Christophe Gris,Cécile Amadio,Eric Mercier,Géraldine Lavigne-Lissalde,Hervé Déchaud,Médéric Hoffet,Isabelle Quéré,Jean Amiral,Michel Dauzat,Pierre Marès

View Articletitled, Anti–protein Z antibodies in women with pathologic pregnancies

IMMUNOBIOLOGY

Generation of low-toxicity interleukin-2 fusion proteins devoid of vasopermeability activity

Peisheng Hu,Myra Mizokami,Gina Ruoff,Leslie A. Khawli,Alan L. Epstein

View Articletitled, Generation of low-toxicity interleukin-2 fusion proteins devoid of vasopermeability activity

Induction of CD4⁺/CD25⁺ regulatory T cells by targeting of antigens to immature dendritic cells

Karsten Mahnke,Yingjie Qian,Jürgen Knop,Alexander H. Enk

View Articletitled, Induction of CD4+/CD25+ regulatory T cells by targeting of antigens to immature dendritic cells

Human cytomegalovirus protein pp65 mediates accumulation of HLA-DR in lysosomes and destruction of the HLA-DR α-chain

Jenny Odeberg,Bodo Plachter,Lars Brandén,Cecilia Söderberg-Nauclér

View Articletitled, Human cytomegalovirus protein pp65 mediates accumulation of HLA-DR in lysosomes and destruction of the HLA-DR α-chain

VEGF inhibits T-cell development and may contribute to tumor-induced immune suppression

Joyce E. Ohm,Dmitry I. Gabrilovich,Gregory D. Sempowski,Ekaterina Kisseleva,Kelly S. Parman,Sorena Nadaf,David P. Carbone

View Articletitled, VEGF inhibits T-cell development and may contribute to tumor-induced immune suppression

IL-15 is an essential mediator of peripheral NK-cell homeostasis

Thomas Ranson,Christian A. J. Vosshenrich,Erwan Corcuff,Odile Richard,Werner Müller,James P. Di Santo

View Articletitled, IL-15 is an essential mediator of peripheral NK-cell homeostasis

Human IL-12(p35) gene activation involves selective remodeling of a single nucleosome within a region of the promoter containing critical Sp1-binding sites

Stanislas Goriely,Dominique Demonté,Séverine Nizet,Dominique De Wit,Fabienne Willems,Michel Goldman,Carine Van Lint

View Articletitled, Human IL-12(p35) gene activation involves selective remodeling of a single nucleosome within a region of the promoter containing critical Sp1-binding sites

High expression of activation-induced cytidine deaminase (AID) and splice variants is a distinctive feature of poor-prognosis chronic lymphocytic leukemia

Helen McCarthy,William G. Wierda,Lynn L. Barron,Candy C. Cromwell,Jing Wang,Kevin R. Coombes,Roberto Rangel,Kojo S. J. Elenitoba-Johnson,Michael J. Keating,Lynne V. Abruzzo

View Articletitled, High expression of activation-induced cytidine deaminase (AID) and splice variants is a distinctive feature of poor-prognosis chronic lymphocytic leukemia

Sphingosine 1-phosphate is a novel inhibitor of T-cell proliferation

Yixin Jin,Eirunn Knudsen,Ling Wang,Yenan Bryceson,Bassam Damaj,Sandra Gessani,Azzam A. Maghazachi

View Articletitled, Sphingosine 1-phosphate is a novel inhibitor of T-cell proliferation

LFA-1 is required for retention of effector CD8 T cells in mouse lungs

Jayant Thatte,Vrushali Dabak,Mark B. Williams,Thomas J. Braciale,Klaus Ley

View Articletitled, LFA-1 is required for retention of effector CD8 T cells in mouse lungs

CCR7 ligands induce rapid endocytosis in mature dendritic cells with concomitant up-regulation of Cdc42 and Rac activities

Yoshiki Yanagawa,Kazunori Onoé

View Articletitled, CCR7 ligands induce rapid endocytosis in mature dendritic cells with concomitant up-regulation of Cdc42 and Rac activities

NEOPLASIA

T-cell epitopes within the complementarity-determining and framework regions of the tumor-derived immunoglobulin heavy chain in multiple myeloma

Lotta Hansson,Hodjattallah Rabbani,Jan Fagerberg,Anders Österborg,Håkan Mellstedt

View Articletitled, T-cell epitopes within the complementarity-determining and framework regions of the tumor-derived immunoglobulin heavy chain in multiple myeloma

Jak1 deficiency leads to enhanced Abelson-induced B-cell tumor formation

Veronika Sexl,Boris Kovacic,Roland Piekorz,Richard Moriggl,Dagmar Stoiber,Angelika Hoffmeyer,Rita Liebminger,Oliver Kudlacek,Eva Weisz,Kristen Rothammer,James N. Ihle

View Articletitled, Jak1 deficiency leads to enhanced Abelson-induced B-cell tumor formation

ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profile
Clinical Trials & Observations

Adrian Wiestner,Andreas Rosenwald,Todd S. Barry,George Wright,R. Eric Davis,Sarah E. Henrickson,Hong Zhao,Rachel E. Ibbotson,Jenny A. Orchard,Zadie Davis,Maryalice Stetler-Stevenson,Mark Raffeld,Diane C. Arthur,Gerald E. Marti,Wyndham H. Wilson,Terry J. Hamblin,David G. Oscier,Louis M. Staudt

View Articletitled, ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profile

Chronic lymphocytic leukemias utilizing the V_H3-21 gene display highly restricted V_λ2-14 gene use and homologous CDR3s: implicating recognition of a common antigen epitope

Gerard Tobin,Ulf Thunberg,Anna Johnson,Inger Eriksson,Ola Söderberg,Karin Karlsson,Mats Merup,Gunnar Juliusson,Juhani Vilpo,Gunilla Enblad,Christer Sundström,Göran Roos,Richard Rosenquist

View Articletitled, Chronic lymphocytic leukemias utilizing the VH3-21 gene display highly restricted Vλ2-14 gene use and homologous CDR3s: implicating recognition of a common antigen epitope

Induction of apoptosis in IL-3–dependent hematopoietic cell lines by guanine nucleotide depletion

Jing Jin Gu,Karen Gathy,Lalaine Santiago,Eric Chen,Min Huang,Lee M. Graves,Beverly S. Mitchell

View Articletitled, Induction of apoptosis in IL-3–dependent hematopoietic cell lines by guanine nucleotide depletion

Specific homeodomain-DNA interactions are required for HOX11-mediated transformation

Bronwyn M. Owens,Yuan-Xiao Zhu,Ting-Chung Suen,Pei-Xiang Wang,Jack F. Greenblatt,Paul E. Goss,Robert G. Hawley

View Articletitled, Specific homeodomain-DNA interactions are required for HOX11-mediated transformation

A subset of t(11;14) lymphoma with mantle cell features displays mutated IgV_H genes and includes patients with good prognosis, nonnodal disease
Clinical Trials & Observations

Jenny Orchard,Richard Garand,Zadie Davis,Gavin Babbage,Surinder Sahota,Estella Matutes,Daniel Catovsky,Peter W. Thomas,Hervé Avet-Loiseau,David Oscier

View Articletitled, A subset of t(11;14) lymphoma with mantle cell features displays mutated IgVH genes and includes patients with good prognosis, nonnodal disease

Telomerase and telomere length in multiple myeloma: correlations with disease heterogeneity, cytogenetic status, and overall survival
Clinical Trials & Observations

Kai-Da Wu,Lisa M. Orme,John Shaughnessy, Jr,Joth Jacobson,Bart Barlogie,Malcolm A. S. Moore

View Articletitled, Telomerase and telomere length in multiple myeloma: correlations with disease heterogeneity, cytogenetic status, and overall survival

Docosahexaenoic acid enhances arsenic trioxide–mediated apoptosis in arsenic trioxide–resistant HL-60 cells

Sanda Sturlan,Melanie Baumgartner,Erich Roth,Thomas Bachleitner-Hofmann

View Articletitled, Docosahexaenoic acid enhances arsenic trioxide–mediated apoptosis in arsenic trioxide–resistant HL-60 cells

Gene expression profiling of multiple myeloma reveals molecular portraits in relation to the pathogenesis of the disease

Florence Magrangeas,Valéry Nasser,Hervé Avet-Loiseau,Béatrice Loriod,Olivier Decaux,Samuel Granjeaud,François Bertucci,Daniel Birnbaum,Catherine Nguyen,Jean-Luc Harousseau,Régis Bataille,Rémi Houlgatte,Stéphane Minvielle

View Articletitled, Gene expression profiling of multiple myeloma reveals molecular portraits in relation to the pathogenesis of the disease

TCL1 expression in plasmacytoid dendritic cells (DC2s) and the related CD4⁺ CD56⁺ blastic tumors of skin
Brief Report

Marco Herling,Michael A. Teitell,Rhine R. Shen,L. Jeffrey Medeiros,Dan Jones

View Articletitled, TCL1 expression in plasmacytoid dendritic cells (DC2s) and the related CD4+ CD56+ blastic tumors of skin

The CNS is a sanctuary for leukemic cells in mice receiving imatinib mesylate for Bcr/Abl-induced leukemia
Brief Report

Nicholas C. Wolff,James A. Richardson,Merrill Egorin,Robert L. Ilaria, Jr

View Articletitled, The CNS is a sanctuary for leukemic cells in mice receiving imatinib mesylate for Bcr/Abl-induced leukemia

PHAGOCYTES

Ligation of Siglec-8: a selective mechanism for induction of human eosinophil apoptosis

Esra Nutku,Hideyuki Aizawa,Sherry A. Hudson,Bruce S. Bochner

View Articletitled, Ligation of Siglec-8: a selective mechanism for induction of human eosinophil apoptosis

Apoptotic neutrophils in the circulation of patients with glycogen storage disease type 1b (GSD1b)
Brief Report

Taco W. Kuijpers,Nikolai A. Maianski,Anton T. J. Tool,G. Peter A. Smit,Jan Peter Rake,Dirk Roos,Gepke Visser

View Articletitled, Apoptotic neutrophils in the circulation of patients with glycogen storage disease type 1b (GSD1b)

RED CELLS

Adhesion of normal and Plasmodium falciparum ring–infected erythrocytes to endothelial cells and the placenta involves the rhoptry-derived ring surface protein-2

Jean-Bernard Lekana Douki,Yvon Sterkers,Catherine Lépolard,Boubacar Traoré,Fabio T. M. Costa,Artur Scherf,Jürg Gysin

View Articletitled, Adhesion of normal and Plasmodium falciparum ring–infected erythrocytes to endothelial cells and the placenta involves the rhoptry-derived ring surface protein-2

Peroxiredoxin II is essential for sustaining life span of erythrocytes in mice

Tae-Hoon Lee,Sun-Uk Kim,Seong-Lan Yu,Sue Hee Kim,Do Sim Park,Hyung-Bae Moon,So Hee Dho,Ki-Sun Kwon,Hyun Jeong Kwon,Ying-Hao Han,Sangkyun Jeong,Sang Won Kang,Hee-Sup Shin,Kyung-Kwang Lee,Sue Goo Rhee,Dae-Yeul Yu

View Articletitled, Peroxiredoxin II is essential for sustaining life span of erythrocytes in mice

Nucleolar localization of RPS19 protein in normal cells and mislocalization due to mutations in the nucleolar localization signals in 2 Diamond-Blackfan anemia patients: potential insights into pathophysiology

Lydie Da Costa,Gil Tchernia,Philippe Gascard,Annie Lo,Joerg Meerpohl,Charlotte Niemeyer,Joel-Anne Chasis,Jason Fixler,Narla Mohandas

View Articletitled, Nucleolar localization of RPS19 protein in normal cells and mislocalization due to mutations in the nucleolar localization signals in 2 Diamond-Blackfan anemia patients: potential insights into pathophysiology

TRANSFUSION MEDICINE

Complement receptor 1 inhibitors for prevention of immune-mediated red cell destruction: potential use in transfusion therapy

Karina Yazdanbakhsh,Stanley Kang,Daniel Tamasauskas,Dorothy Sung,Andromachi Scaradavou

View Articletitled, Complement receptor 1 inhibitors for prevention of immune-mediated red cell destruction: potential use in transfusion therapy

TRANSPLANTATION

Human cytomegalovirus immediate-early mRNAemia versus pp65 antigenemia for guiding pre-emptive therapy in children and young adults undergoing hematopoietic stem cell transplantation: a prospective, randomized, open-label trial
Clinical Trials & Observations

Giuseppe Gerna,Daniele Lilleri,Fausto Baldanti,Maria Torsellini,Giovanna Giorgiani,Marco Zecca,Piero De Stefano,Jaap Middeldorp,Franco Locatelli,M. Grazia Revello

View Articletitled, Human cytomegalovirus immediate-early mRNAemia versus pp65 antigenemia for guiding pre-emptive therapy in children and young adults undergoing hematopoietic stem cell transplantation: a prospective, randomized, open-label trial

Augmentation of umbilical cord blood (UCB) transplantation with ex vivo–expanded UCB cells: results of a phase 1 trial using the AastromReplicell System
Clinical Trials & Observations

Jennifer Jaroscak,Kristin Goltry,Alan Smith,Barbara Waters-Pick,Paul L. Martin,Timothy A. Driscoll,Richard Howrey,Nelson Chao,Judy Douville,Sue Burhop,Pingfu Fu,Joanne Kurtzberg

View Articletitled, Augmentation of umbilical cord blood (UCB) transplantation with ex vivo–expanded UCB cells: results of a phase 1 trial using the AastromReplicell System

Selective T-cell ablation with bismuth-213–labeled anti-TCRαβ as nonmyeloablative conditioning for allogeneic canine marrow transplantation

Wolfgang A. Bethge,D. Scott Wilbur,Rainer Storb,Donald K. Hamlin,Erlinda B. Santos,Martin W. Brechbiel,Darrell R. Fisher,Brenda M. Sandmaier

View Articletitled, Selective T-cell ablation with bismuth-213–labeled anti-TCRαβ as nonmyeloablative conditioning for allogeneic canine marrow transplantation

IL-10 and TGF-β induce alloreactive CD4⁺CD25^– T cells to acquire regulatory cell function

Zong-ming Chen,Matthew J. O'Shaughnessy,Irene Gramaglia,Angela Panoskaltsis-Mortari,William J. Murphy,Satwant Narula,Maria G. Roncarolo,Bruce R. Blazar

View Articletitled, IL-10 and TGF-β induce alloreactive CD4+CD25– T cells to acquire regulatory cell function

CORRESPONDENCE

Monitoring CML after nonmyeloablative transplantations: how negative is negative?

Jaspal Kaeda,Jane Apperley,Junia Melo,Nicolas Cross,John Goldman

View Articletitled, Monitoring CML after nonmyeloablative transplantations: how negative is negative?

Rapid identification of CBFB-MYH11–positive acute myeloid leukemia (AML) cases by one single MYH11 real-time RT-PCR

Bert A. van der Reijden,Marion Massop,Evelyn Tönnissen,Louis van de Locht,Petra Muus,Theo de Witte,Joop H. Jansen

View Articletitled, Rapid identification of CBFB-MYH11–positive acute myeloid leukemia (AML) cases by one single MYH11 real-time RT-PCR

No exon 4 polymorphism of cytochrome P450 CYP2C9 in Taiwanese

Jan-Gowth Chang

View Articletitled, No exon 4 polymorphism of cytochrome P450 CYP2C9 in Taiwanese

Lack of alteration in GATA-1 expression in CD34⁺ hematopoietic progenitors from patients with idiopathic myelofibrosis

Marie-Claire Martyré,Virginie Steunou,Marie-Caroline LeBousse-Kerdilès,Juana Wietzerbin

View Articletitled, Lack of alteration in GATA-1 expression in CD34+ hematopoietic progenitors from patients with idiopathic myelofibrosis

Deferiprone and hepatic fibrosis

Gary M. Brittenham,David G. Nathan,Nancy F. Olivieri,John B. Porter,Martin Pippard,Elliott P. Vichinsky,David J. Weatherall

View Articletitled, Deferiprone and hepatic fibrosis

Donor serostatus and CMV infection and disease among recipients of prophylactic granulocyte transfusions

W. Garrett Nichols,Thomas Price,Michael Boeckh

View Articletitled, Donor serostatus and CMV infection and disease among recipients of prophylactic granulocyte transfusions

Issue Archive

Table of Contents

INSIDE BLOOD

PLENARY PAPERS

Highly effective treatment of acquired immunodeficiency syndrome–related lymphoma with dose-adjusted EPOCH: impact of antiretroviral therapy suspension and tumor biology Clinical Trials & Observations

Elevated serum tryptase levels identify a subset of patients with a myeloproliferative variant of idiopathic hypereosinophilic syndrome associated with tissue fibrosis, poor prognosis, and imatinib responsiveness Clinical Trials & Observations

REVIEW IN TRANSLATIONAL HEMATOLOGY

CHEMOKINES

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Minimal residual disease in adolescent (older than 14 years) and adult acute lymphoblastic leukemias: early immunophenotypic evaluation has high clinical value Clinical Trials & Observations

Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment Clinical Trials & Observations

A unique atrial primary cardiac lymphoma mimicking myxoma presenting with embolic stroke: a case report Clinical Trials & Observations Brief Report

Unrelated cord blood transplantation for adult patients with advanced myelodysplastic syndrome Clinical Trials & Observations Brief Report

Efficacy of imatinib mesylate in the treatment of idiopathic hypereosinophilic syndrome Clinical Trials & Observations Brief Report

GENE THERAPY

HEMATOPOIESIS

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Prevalence, causes, and characterization of factor XI inhibitors in patients with inherited factor XI deficiency Clinical Trials & Observations

Evidence for a role for Gαi1 in mediating weak agonist-induced platelet aggregation in human platelets: reduced Gαi1 expression and defective Gi signaling in the platelets of a patient with a chronic bleeding disorder Clinical Trials & Observations

Identification of thrombin activatable fibrinolysis inhibitor (TAFI) in human platelets Brief Report

Oxidized low-density lipoprotein (oxLDL) triggers hypoxia-inducible factor-1α (HIF-1α) accumulation via redox-dependent mechanisms Brief Report

Anti–protein Z antibodies in women with pathologic pregnancies Brief Report

IMMUNOBIOLOGY

NEOPLASIA

ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profile Clinical Trials & Observations

A subset of t(11;14) lymphoma with mantle cell features displays mutated IgVH genes and includes patients with good prognosis, nonnodal disease Clinical Trials & Observations

Telomerase and telomere length in multiple myeloma: correlations with disease heterogeneity, cytogenetic status, and overall survival Clinical Trials & Observations

TCL1 expression in plasmacytoid dendritic cells (DC2s) and the related CD4+ CD56+ blastic tumors of skin Brief Report

The CNS is a sanctuary for leukemic cells in mice receiving imatinib mesylate for Bcr/Abl-induced leukemia Brief Report