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An open-label, single-arm, phase 2 (PX-171-004) study of single-agent carfilzomib in bortezomib-naive patients with relapsed and/or refractory multiple myeloma
EVI1 is critical for the pathogenesis of a subset of MLL-AF9–rearranged AMLs
Infusion of hemolyzed red blood cells within peripheral blood stem cell grafts in patients with and without sickle cell disease
A switch in infected erythrocyte deformability at the maturation and blood circulation of Plasmodium falciparum transmission stages
Issue Archive
June 14 2012
In this Issue
Table of Contents
Inside Blood
Blood Work
Plenary Paper
PLENARY PAPER
Zebrafish screen identifies novel compound with selective toxicity against leukemia
Suzanne Ridges,Will L. Heaton,Deepa Joshi,Henry Choi,Anna Eiring,Lance Batchelor,Priya Choudhry,Elizabeth J. Manos,Hossein Sofla,Ali Sanati,Seth Welborn,Archana Agarwal,Gerald J. Spangrude,Rodney R. Miles,James E. Cox,J. Kimble Frazer,Michael Deininger,Kaveri Balan,Matthew Sigman,Markus Müschen,Tatiana Perova,Radia Johnson,Bertrand Montpellier,Cynthia J. Guidos,David A. Jones,Nikolaus S. Trede
Perspectives
Review Article
How I treat
Blood Consult
Clinical Trials and Observations
An open-label, single-arm, phase 2 (PX-171-004) study of single-agent carfilzomib in bortezomib-naive patients with relapsed and/or refractory multiple myeloma
Clinical Trials & Observations
Ravi Vij,Michael Wang,Jonathan L. Kaufman,Sagar Lonial,Andrzej J. Jakubowiak,A. Keith Stewart,Vishal Kukreti,Sundar Jagannath,Kevin T. McDonagh,Melissa Alsina,Nizar J. Bahlis,Frederic J. Reu,Nashat Y. Gabrail,Andrew Belch,Jeffrey V. Matous,Peter Lee,Peter Rosen,Michael Sebag,David H. Vesole,Lori A. Kunkel,Sandra M. Wear,Alvin F. Wong,Robert Z. Orlowski,David S. Siegel
EVI1 is critical for the pathogenesis of a subset of MLL-AF9–rearranged AMLs
Clinical Trials & Observations
Eric M. J. Bindels,Marije Havermans,Sanne Lugthart,Claudia Erpelinck,Elizabeth Wocjtowicz,Andrei V. Krivtsov,Elwin Rombouts,Scott A. Armstrong,Erdogan Taskesen,Jurgen R. Haanstra,H. Berna Beverloo,Hartmut Döhner,Wendy A. Hudson,John H. Kersey,Ruud Delwel,Ashish R. Kumar
Gene Therapy
A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of endogenous TCR
Hiroki Torikai,Andreas Reik,Pei-Qi Liu,Yuanyue Zhou,Ling Zhang,Sourindra Maiti,Helen Huls,Jeffrey C. Miller,Partow Kebriaei,Brian Rabinovitch,Dean A. Lee,Richard E. Champlin,Chiara Bonini,Luigi Naldini,Edward J. Rebar,Philip D. Gregory,Michael C. Holmes,Laurence J. N. Cooper
Hematopoiesis and Stem Cells
Immunobiology
Rapid development of exhaustion and down-regulation of eomesodermin limit the antitumor activity of adoptively transferred murine natural killer cells
Saar Gill,Adrianne E. Vasey,Alysha De Souza,Jeanette Baker,Aaron T. Smith,Holbrook E. Kohrt,Mareike Florek,Kenneth D. Gibbs, Jr,Keri Tate,David S. Ritchie,Robert S. Negrin
Lymphoid Neoplasia
Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma
Naoya Mimura,Mariateresa Fulciniti,Gullu Gorgun,Yu-Tzu Tai,Diana Cirstea,Loredana Santo,Yiguo Hu,Claire Fabre,Jiro Minami,Hiroto Ohguchi,Tanyel Kiziltepe,Hiroshi Ikeda,Yutaka Kawano,Maureen French,Martina Blumenthal,Victor Tam,Nathalie L. Kertesz,Uriel M. Malyankar,Mark Hokenson,Tuan Pham,Qingping Zeng,John B. Patterson,Paul G. Richardson,Nikhil C. Munshi,Kenneth C. Anderson
Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features
Abdel Kareem Azab,Jinsong Hu,Phong Quang,Feda Azab,Costas Pitsillides,Rana Awwad,Brian Thompson,Patricia Maiso,Jessica D. Sun,Charles P. Hart,Aldo M. Roccaro,Antonio Sacco,Hai T. Ngo,Charles P. Lin,Andrew L. Kung,Ruben D. Carrasco,Karin Vanderkerken,Irene M. Ghobrial
Molecular features of hepatosplenic T-cell lymphoma unravels potential novel therapeutic targets
Marion Travert,Yenlin Huang,Laurence de Leval,Nadine Martin-Garcia,Marie-Helene Delfau-Larue,Françoise Berger,Jacques Bosq,Josette Brière,Jean Soulier,Elizabeth MacIntyre,Teresa Marafioti,Aurélien de Reyniès,Philippe Gaulard
Bcl-2, Bcl-xL, and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells
Delphine Mérino,Seong L. Khaw,Stefan P. Glaser,Daniel J. Anderson,Lisa D. Belmont,Chihunt Wong,Peng Yue,Mikara Robati,Belinda Phipson,Walter D. Fairlie,Erinna F. Lee,Kirsteen J. Campbell,Cassandra J. Vandenberg,Suzanne Cory,Andrew W. Roberts,Mary J. C. Ludlam,David C. S. Huang,Philippe Bouillet
Prediagnostic circulating carotenoid levels and the risk of non-Hodgkin lymphoma: the Multiethnic Cohort
Nicholas J. Ollberding,Gertraud Maskarinec,Shannon M. Conroy,Yukiko Morimoto,Adrian A. Franke,Robert V. Cooney,Lynne R. Wilkens,Loïc Le Marchand,Marc T. Goodman,Brenda Y. Hernandez,Brian E. Henderson,Laurence N. Kolonel
Myeloid Neoplasia
Phagocytes, Granulocytes, and Myelopoiesis
Platelets and Thrombopoiesis
Red Cells, Iron, and Erythropoiesis
Infusion of hemolyzed red blood cells within peripheral blood stem cell grafts in patients with and without sickle cell disease
Brief Report
Courtney D. Fitzhugh,Hayato Unno,Vincent Hathaway,Wynona A. Coles,Mary E. Link,R. Patrick Weitzel,Xiongce Zhao,Elizabeth C. Wright,David F. Stroncek,Gregory J. Kato,Matthew M. Hsieh,John F. Tisdale
A switch in infected erythrocyte deformability at the maturation and blood circulation of Plasmodium falciparum transmission stages
e-blood
Marta Tibúrcio,Makhtar Niang,Guillaume Deplaine,Sylvie Perrot,Emmanuel Bischoff,Papa Alioune Ndour,Francesco Silvestrini,Ayman Khattab,Geneviève Milon,Peter H. David,Max Hardeman,Kenneth D. Vernick,Robert W. Sauerwein,Peter R. Preiser,Odile Mercereau-Puijalon,Pierre Buffet,Pietro Alano,Catherine Lavazec
Thrombosis and Hemostasis
Mitochondrial dysfunction in antiphospholipid syndrome: implications in the pathogenesis of the disease and effects of coenzyme Q10 treatment
Carlos Perez-Sanchez,Patricia Ruiz-Limon,Maria Angeles Aguirre,Maria Laura Bertolaccini,Munther A. Khamashta,Antonio Rodriguez-Ariza,Pedro Segui,Eduardo Collantes-Estevez,Nuria Barbarroja,Husam Khraiwesh,Jose Antonio Gonzalez-Reyes,Jose Manuel Villalba,Francisco Velasco,Maria Jose Cuadrado,Chary Lopez-Pedrera
Hemostatic effect of a monoclonal antibody mAb 2021 blocking the interaction between FXa and TFPI in a rabbit hemophilia model
Ida Hilden,Brian Lauritzen,Brit Binow Sørensen,Jes Thorn Clausen,Christina Jespersgaard,Berit Olsen Krogh,Andrew Neil Bowler,Jens Breinholt,Albrecht Gruhler,L. Anders Svensson,Helle Heibroch Petersen,Lars Christian Petersen,Kristoffer W. Balling,Lene Hansen,Mette Brunsgaard Hermit,Thomas Egebjerg,Birgitte Friederichsen,Mirella Ezban,Søren Erik Bjørn
Unexpected frequency of Upshaw-Schulman syndrome in pregnancy-onset thrombotic thrombocytopenic purpura
Marie Moatti-Cohen,Céline Garrec,Martine Wolf,Pierre Boisseau,Lionel Galicier,Elie Azoulay,Alain Stepanian,Yahsou Delmas,Eric Rondeau,Stéphane Bezieau,Paul Coppo,Agnès Veyradier,on behalf of the French Reference Center for Thrombotic Microangiopathies
Transplantation
Identification and expansion of highly suppressive CD8+FoxP3+ regulatory T cells after experimental allogeneic bone marrow transplantation
Renee J. Robb,Katie E. Lineburg,Rachel D. Kuns,Yana A. Wilson,Neil C. Raffelt,Stuart D. Olver,Antiopi Varelias,Kylie A. Alexander,Bianca E. Teal,Tim Sparwasser,Gunter J. Hammerling,Kate A. Markey,Motoko Koyama,Andrew D. Clouston,Christian R. Engwerda,Geoffrey R. Hill,Kelli P. A. MacDonald
Fecal calprotectin and alpha-1 antitrypsin predict severity and response to corticosteroids in gastrointestinal graft-versus-host disease
Paula Rodriguez-Otero,Raphael Porcher,Régis Peffault de Latour,Margarita Contreras,Yoram Bouhnik,Aliénor Xhaard,Annalisa Andreoli,Patricia Ribaud,Nathalie Kapel,Anne Janin,Gérard Socié,Marie Robin
Immune insufficiency during GVHD is due to defective antigen presentation within dendritic cell subsets
Kate A. Markey,Motoko Koyama,Rachel D. Kuns,Katie E. Lineburg,Yana A. Wilson,Stuart D. Olver,Neil C. Raffelt,Alistair L. J. Don,Antiopi Varelias,Renee J. Robb,Melody Cheong,Christian R. Engwerda,Raymond J. Steptoe,Hayley S. Ramshaw,Angel F. Lopez,Javier Vega-Ramos,Andrew M. Lew,Jose A. Villadangos,Geoffrey R. Hill,Kelli P. A. MacDonald
Vascular Biology
Aberrant mural cell recruitment to lymphatic vessels and impaired lymphatic drainage in a murine model of pulmonary fibrosis
Anna-Katharina Meinecke,Nadine Nagy,Gabriela D'Amico Lago,Santina Kirmse,Ralph Klose,Katrin Schrödter,Annika Zimmermann,Iris Helfrich,Helene Rundqvist,Dirk Theegarten,Olaf Anhenn,Véronique Orian-Rousseau,Randall S. Johnson,Kari Alitalo,Jens W. Fischer,Joachim Fandrey,Christian Stockmann
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Cover Image
Cover Image
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Apoptotic Tango: megakaryopoiesis in mice with a megakaryocyte-specific deletion of Mcl-1 (Mcl-1Pf4Δ/Pf4Δ) is normal. However, 2.5 hours after treatment with the BH3 mimetic ABT-737, megakaryocytes from these mice exhibit hallmarks of apoptosis with nuclear pyknosis and cytoplasmic dysmorphology evident. The image shows two megakaryocytes undergoing “a dance of death” in the bone marrow of Mcl-1Pf4Δ/Pf4Δ mice, indicating essential roles for both Bcl-xL and Mcl-1 in the viability of the megakaryocyte lineage. See the article by Debrincat et al on page 5850.
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