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Journal Articles

A factor VIIIa–mimetic bispecific antibody, Mim8, ameliorates bleeding upon severe vascular challenge in hemophilia A mice

Henrik Østergaard, Jacob Lund, Per J. Greisen, Stine Kjellev, Anette Henriksen, Nikolai Lorenzen, Eva Johansson, Gustav Røder, Morten G. Rasch, Laust B. Johnsen, Thomas Egebjerg, Søren Lund, Henrik Rahbek-Nielsen, Prafull S. Gandhi, Kasper Lamberth, Mette Loftager, Lisbeth M. Andersen, Amalie C. Bonde, Fabian Stavenuiter, Daniel E. Madsen, Xun Li, Thomas L. Holm, Carsten D. Ley, Peter Thygesen, Haisun Zhu, Rong Zhou, Karina Thorn, Zhiru Yang, Mette B. Hermit, Jais R. Bjelke, Bjarne G. Hansen, Ida Hilden
Journal: Blood
Blood (2021) 138 (14): 1258–1268.
https://doi.org/10.1182/blood.2020010331
Published: 2021
Includes: Supplemental data
Journal Articles

Mim8 - a Next-Generation FVIII Mimetic Bi-Specific Antibody - Potently Restores the Hemostatic Capacity in Hemophilia a Settings in Vitro and In Vivo

Stine L Kjellev, PhDDVM, Henrik Østergaard, PhD, Per Jr Greisen, PhD, Mette B Hermit, PhD, Karina Thorn, PhD, Bjarne G Hansen, PhD, Rong Zhou, PhD, Jais Rose Bjelke, PhD, Marianne Kjalke, PhD, Jacob Lund, PhD, Thomas L Holm, PhD, Carsten Dan Ley, PhD, Daniel Elenius, PhD, Peter Thygesen, PhD, Mette Loftager, PhD, Morten G Rasch, PhD, Nikolai Lorenzen, PhD, Prafull S Gandhi, PhD, Kasper Lamberth, PhD, Thomas Egebjerg, Søren Lund, PhD, Anette Henriksen, PhD, Henrik Rahbek-Nielsen, PhD, Zhiru Yang, Ida Hilden
Journal: Blood
Blood (2019) 134 (Supplement_1): 96.
https://doi.org/10.1182/blood-2019-122817
Published: 2019
Journal Articles

Evaluation of a Next-Generation FVIII Mimetic Antibody, Mim8, in Combination with Recombinant FVIIa, FVIII and Activated Prothrombin Complex Concentrate

Laurent Burnier, PhD, Mette B Hermit, PhD, Ida Hilden, Mirella Ezban, PhD, Stine L Kjellev, PhDDVM
Journal: Blood
Blood (2019) 134 (Supplement_1): 2388.
https://doi.org/10.1182/blood-2019-123340
Published: 2019
Journal Articles

Thrombin Generation Assay in Plasma from Hemophilia a Patients with or without Inhibitors on Concizumab Prophylaxis: Spiking with rFVIIa or aPCC

Marianne Kjalke, PhD, Mads Kjelgaard-Hansen, Søren Andersen, Ida Hilden
Journal: Blood
Blood (2019) 134 (Supplement_1): 3639.
https://doi.org/10.1182/blood-2019-122301
Published: 2019
Journal Articles

Next-Generation FVIII Mimetic Shows Superior Effect in a FIX- and Fx-Humanized Mouse Model In Vivo

Carsten Dan Ley, PhD, Thomas Lindebo Holm, PhD, Daniel Elenius, PhD, Heidi Lindgreen Holmberg, PhD, Jais Rose Bjelke, PhD, Mette Loftager, PhD, Mette B Hermit, PhD, Ida Hilden, Stine L Kjellev, PhDDVM
Journal: Blood
Blood (2019) 134 (Supplement_1): 3631.
https://doi.org/10.1182/blood-2019-128159
Published: 2019
Journal Articles

Concizumab Promotes Hemostasis Via a TF-FVIIa Dependent Mechanism As Shown in a Rabbit Hemophilia Bleeding Model

Brian Lauritzen, Ida Hilden
Journal: Blood
Blood (2016) 128 (22): 1401.
https://doi.org/10.1182/blood.V128.22.1401.1401
Published: 2016
Journal Articles

Kunitz 3-Selective but Not Kunitz 2-Selective TFPI Inhibitors Cause Release of Tfpiα from Endothelial Cells: Insights into the Release Mechanism

Julie A. Peterson, PhD, Cecilia Augustsson, PhD, Susan A Maroney, DVM, PhD, Helle Heibroch Petersen, Ida Hilden, Alan Mast, Wes Zwifelhofer, BS
Journal: Blood
Blood (2016) 128 (22): 2558.
https://doi.org/10.1182/blood.V128.22.2558.2558
Published: 2016
Journal Articles

Plasma and Platelet Tissue Factor Pathway Inhibitor (TFPI) in Blood Donors and in People with Hemophilia

Paul E. R. Ellery, PhD, Cecilia Augustsson, PhD, Soren Andersen, PhD, Susan A. Maroney, DVM, PhD, Jeremy P Wood, PhD, Joan Cox Gill, MD, Ida Hilden, PhD, Alan E. Mast, MD PhD
Journal: Blood
Blood (2014) 124 (21): 4241.
https://doi.org/10.1182/blood.V124.21.4241.4241
Published: 2014
Journal Articles

A novel B-domain O -glycoPEGylated FVIII (N8-GP) demonstrates full efficacy and prolonged effect in hemophilic mice models

Henning R. Stennicke, Marianne Kjalke, Ditte M. Karpf, Kristoffer W. Balling, Peter B. Johansen, Torben Elm, Kristine Øvlisen, Flemming Möller, Heidi L. Holmberg, Charlotte N. Gudme, Egon Persson, Ida Hilden, Hermann Pelzer, Henrik Rahbek-Nielsen, Christina Jespersgaard, Are Bogsnes, Anette A. Pedersen, Anne K. Kristensen, Bernd Peschke, Wendy Kappers, Frederik Rode, Lars Thim, Mikael Tranholm, Mirella Ezban, Eva H. N. Olsen, Søren E. Bjørn
Journal: Blood
Blood (2013) 121 (11): 2108–2116.
https://doi.org/10.1182/blood-2012-01-407494
Published: 2013
Includes: Supplemental data
Journal Articles

Hemostatic effect of a monoclonal antibody mAb 2021 blocking the interaction between FXa and TFPI in a rabbit hemophilia model

Ida Hilden, Brian Lauritzen, Brit Binow Sørensen, Jes Thorn Clausen, Christina Jespersgaard, Berit Olsen Krogh, Andrew Neil Bowler, Jens Breinholt, Albrecht Gruhler, L. Anders Svensson, Helle Heibroch Petersen, Lars Christian Petersen, Kristoffer W. Balling, Lene Hansen, Mette Brunsgaard Hermit, Thomas Egebjerg, Birgitte Friederichsen, Mirella Ezban, Søren Erik Bjørn
Journal: Blood
Blood (2012) 119 (24): 5871–5878.
https://doi.org/10.1182/blood-2012-01-401620
Published: 2012
Includes: Supplemental data
Journal Articles

High Affinity Binding of FVIII to VWF Is Not Required for the Haemostatic Effect of FVIII In Vivo

Heidi L Holmberg, PhD, Marianne Kjalke, PhD, Ditte Karpf, PhD, Ida Hilden, PhD, Hermann Pelzer, Mikael Koefoed-Hansen, PhD, Laust Johnsen, PhD, Lars Thim, PhD, Johan Karlsson, PhD, Christina Jespersgaard, PhD, Gert Bolt, PhD, Henning Stennicke, MSc, PhD
Journal: Blood
Blood (2011) 118 (21): 1182.
https://doi.org/10.1182/blood.V118.21.1182.1182
Published: 2011