1-20 of 49
Yiguo Hu
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

Characterization of Lineage Vs. Context-Dependent Essential Genes in Multiple Myeloma Using Crispr/Cas9 Genome Editing

Geoffrey M. Matthews, PhD, Ricardo De Matos Simoes, PhD, Yiguo Hu, MD PhD, Michal Sheffer, PhD, Eugen Dhimolea, PhD, Paul J. Hengeveld, B.Sc., Megan A. Bariteau, BSc, Brian Glassner, PhD, Quinlan Sievers, BA, Benjamin L. Ebert, MD PhD, Sara Gandolfi, MD, Pallavi Awate, MSc, Huihui Tang, PhD, Franciska Vazquez, PhD, Aedin Culhane, PhD, Constantine S Mitsiades, MD PhD
Journal: Blood
Blood (2016) 128 (22): 119.
https://doi.org/10.1182/blood.V128.22.119.119
Published: 2016
Journal Articles

BET Bromodomain Degradation As a Therapeutic Strategy in Multiple Myeloma

Geoffrey M. Matthews, PhD, Sara Gandolfi, MD, Johanna Bruggentheis, Ricardo De Matos Simoes, PhD, Dennis L Buckley, PhD, Yiguo Hu, MD PhD, Michal Sheffer, PhD, Hayley Poarch, James E. Bradner, MD, Constantine S Mitsiades, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1062.
https://doi.org/10.1182/blood.V128.22.1062.1062
Published: 2016
Journal Articles

Integrated Evaluation of Results from Genome-Wide Association Studies and Crispr/Cas9-Based Functional Genomics in Myeloma: Implications for Cell-Autonomous Vs. Non-Autonomous Role of Candidate Genes in Myeloma Pathophysiology

Ricardo De Matos Simoes, PhD, Geoffrey M. Matthews, PhD, Yiguo Hu, MD PhD, Brian Glassner, PhD, Megan A. Bariteau, BSc, Michal Sheffer, PhD, Ryosuke Shirasaki, MD, Constantine S Mitsiades, MD PhD
Journal: Blood
Blood (2016) 128 (22): 486.
https://doi.org/10.1182/blood.V128.22.486.486
Published: 2016
Journal Articles

Systematic Evaluation of Preclinical Genetically Determined Vs. "Stochastic"/Transient Resistance to High-Dose Melphalan Treatment in Multiple Myeloma

Paul J. Hengeveld, B.Sc., Geoffrey M. Matthews, PhD, Yiguo Hu, MDPhD, Michal Sheffer, PhD, Megan A. Bariteau, BSc, Haley I. Poarch, Eugen Dhimolea, PhD, Constantine S Mitsiades, MD PhD
Journal: Blood
Blood (2015) 126 (23): 2484.
https://doi.org/10.1182/blood.V126.23.2484.2484
Published: 2015
Journal Articles

Constitutive Vs. Stroma-Induced Kinase Dependencies in Myeloma Cells: Functional Mapping Using Small Molecule Inhibitors As Chemical Probes

Eugen Dhimolea, PhD, Emily King, Michal Sheffer, PhD, Yiguo Hu, MDPhD, Pallavi P. Awate, Subhashis Sarkar, PhD, Geoffrey M. Matthews, PhD, Megan Murnane, Megan A. Bariteau, BSc, Blake T. Aftab, PhD, Constantine S Mitsiades, MD PhD
Journal: Blood
Blood (2015) 126 (23): 3709.
https://doi.org/10.1182/blood.V126.23.3709.3709
Published: 2015
Journal Articles

Bone Marrow Microenvironment Regulates Alternative Splicing Events in Myeloma Cells through Downregulation of RNA Binding Protein Fox2

Weihua Song, MD, Chaolin Zhang, PhD, Yiguo Hu, PhD, Maria Gkotzamanidou, MD PhD, Parantu Shah, Weisong Shan, MDPhD, Guang Yang, PhD, Yi Li, Adam Sperling, MD PhD, Naim Rashid, PhD, Mehmet Kemal Samur, PhD, Samir B. Amin, MBBS, Yu-Tzu Tai, Teru Hideshima, MDPhD, Giovanni Parmigiani, PhD, Florence Magrangeas, PhD, Stephane Minvielle, PhD, Hervé Avet-Loiseau, MD PhD, Kenneth C. Anderson, Cheng Li, PhD, Nikhil C. Munshi, MD
Journal: Blood
Blood (2014) 124 (21): 4714.
https://doi.org/10.1182/blood.V124.21.4714.4714
Published: 2014
Journal Articles

Functional Mapping of Multiple Myeloma Kinome Using a Small Molecule Inhibitor Library

Eugen Dhimolea, PhD, Emily King, Michal Sheffer, PhD, Yiguo Hu, PhD, Subhashis Sarkar, PhD, Megan Murnane, Megan A. Bariteau, B.Sc., Blake T. Aftab, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2014) 124 (21): 3642.
https://doi.org/10.1182/blood.V124.21.3642.3642
Published: 2014
Journal Articles

Temporal Dynamics of Tumor-Microenvironment Interaction and Treatment Responses Revealed through Time-Lapse Compartment-Specific Bioluminescence Imaging: Translational implications

Eugen Dhimolea, PhD, Emily King, Efstathios Kastritis, MD, Douglas W. McMillin, PhD, Jake E. Delmore, B.Sc., Joseph M. Negri, B.Sc., Hannah M. Jacobs, B.Sc., Catriona A. Hayes, MD, Michal Sheffer, PhD, Yiguo Hu, PhD, Subhashis Sarkar, PhD, Richard W.J. Groen, PhD, Megan A. Bariteau, B.Sc., Blake T. Aftab, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2014) 124 (21): 276.
https://doi.org/10.1182/blood.V124.21.276.276
Published: 2014
Journal Articles

Genome-Scale Crispr-Cas9 Knockout Studies Reveal Mutifactorial and Functionally Overlapping Mechanisms of Myeloma Cell Resistance to Proteasome Inhibition

Michal Sheffer, PhD, Yiguo Hu, PhD, Ophir Shalem, PhD, Neville Sanjana, PhD, Eugen Dhimolea, PhD, Subhashis Sarkar, PhD, Megan A. Bariteau, B.Sc., Blake T. Aftab, PhD, Richard W.J. Groen, PhD, Feng Zhang, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2014) 124 (21): 273.
https://doi.org/10.1182/blood.V124.21.273.273
Published: 2014
Journal Articles

A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance

Ze Tian, Padraig D’Arcy, Xin Wang, Arghya Ray, Yu-Tzu Tai, Yiguo Hu, Ruben D. Carrasco, Paul Richardson, Stig Linder, Dharminder Chauhan, Kenneth C. Anderson
Journal: Blood
Blood (2014) 123 (5): 706–716.
https://doi.org/10.1182/blood-2013-05-500033
Published: 2014
Includes: Supplemental data
Journal Articles

A Novel Small Molecule Inhibitor Of Deubiquitylating Enzyme USP14 and UCHL5 Induces Apoptosis In Myeloma Cells and Overcomes Bortezomib Resistance

Ze Tian, Ph.D, Padraig D'Arcy, Ph.D, Xin Wang, Ph.D, Arghya Ray, Yu-Tzu Tai, PhD, Yiguo Hu, PhD, Ruben Carrasco, MD, PhD, Deepika Das, Ph.D, Paul Richardson, MD, Stig Linder, MD, PhD, Dharminder Chauhan, PhD, Kenneth C. Anderson, MD
Journal: Blood
Blood (2013) 122 (21): 1923.
https://doi.org/10.1182/blood.V122.21.1923.1923
Published: 2013
Journal Articles

Bone Marrow Microenvironment Affects The Pathogenesis Of Multiple Myeloma Through Downregulation Of Alternative Splicing Factor Fox2 In Myeloma Cells

Weihua Song, MD, Chaolin Zhang, PhD, Yiguo Hu, PhD, Maria Gkotzamanidou, MD, Parantu Shah, PhD, Weisong Shan, MD PhD, Guang Yang, PhD, Samir B. Amin, MBBS, Yu-Tzu Tai, PhD, Yi Li, PhD, Adam Sperling, MD, PhD, Naim Rashid, PhD, Florence Magrangeas, PhD, Stephane Minvielle, PhD, Hervé Avet-Loiseau, MD, PhD, Kenneth C. Anderson, MD, Cheng Li, PhD, Nikhil C. Munshi, MD
Journal: Blood
Blood (2013) 122 (21): 3085.
https://doi.org/10.1182/blood.V122.21.3085.3085
Published: 2013
Journal Articles

CRM1 Blockade by Novel Inhibitors of Nuclear Export (SINEs) Inhibits Multiple Myeloma Cell Growth, Osteoclastogenesis, and Myeloma-Induced Osteolysis

Yu-Tzu Tai, PhD, Yosef Landesman, PhD, Chirag Acharya, M.D., Mike Y Zhong, B.S., Yolanda Calle, PhD, Michele Cea, MD, Yiguo Hu, PhD, Antonia Cagnetta, MD, Daniel Tannenbaum, B.S., Michelle Chen, Aditya Munshi, William Senapedis, PhD, Jean-Richard Saint-Martin, BS, Trinayan Kashyap, Haoqiang Ying, Dilara McCauley, PhD, Sharon Shacham, PhD MBA, Michael Kauffman, MD, PhD, Yumei Gu, Ph.D., Lizi Wu, PhD, Stephen Schey, MD, Andrew L. Kung, MD, PhD, Nikhil C. Munshi, MD, Paul G. Richardson, MD, Kenneth C. Anderson, MD
Journal: Blood
Blood (2012) 120 (21): 326.
https://doi.org/10.1182/blood.V120.21.326.326
Published: 2012
Journal Articles

Rational Combination Treatment of a Novel Selective mTOR Kinase Inhibitor AZD8055 with IGF-1R Inhibitors in Multiple Myeloma

Diana Cirstea, Teru Hideshima, MD, PhD, Loredana Santo, Homare Eda, Tyler A. Scullen, Neeharika Nemani, Anuj Mahindra, Andrew Yee, Yiguo Hu, Naoya Mimura, Jiro Minami, Hiroto Ohguchi, Rikio Suzuki, Francesca Cottini, Sylvie M Guichard, Kenneth C. Anderson, Noopur Raje
Journal: Blood
Blood (2012) 120 (21): 4023.
https://doi.org/10.1182/blood.V120.21.4023.4023
Published: 2012
Journal Articles

Investigational agent MLN9708/2238 targets tumor-suppressor miR33b in MM cells

Ze Tian, Jian-jun Zhao, Yu-Tzu Tai, Samir B. Amin, Yiguo Hu, Allison J. Berger, Paul Richardson, Dharminder Chauhan, Kenneth C. Anderson
Journal: Blood
Blood (2012) 120 (19): 3958–3967.
https://doi.org/10.1182/blood-2012-01-401794
Published: 2012
Includes: Supplemental data
Journal Articles

Bruton tyrosine kinase inhibition is a novel therapeutic strategy targeting tumor in the bone marrow microenvironment in multiple myeloma

Yu-Tzu Tai, Betty Y. Chang, Sun-Young Kong, Mariateresa Fulciniti, Guang Yang, Yolanda Calle, Yiguo Hu, Jianhong Lin, Jian-Jun Zhao, Antonia Cagnetta, Michele Cea, Michael A. Sellitto, Mike Y. Zhong, Qiuju Wang, Chirag Acharya, Daniel R. Carrasco, Joseph J. Buggy, Laurence Elias, Steven P. Treon, William Matsui, Paul Richardson, Nikhil C. Munshi, Kenneth C. Anderson
Journal: Blood
Blood (2012) 120 (9): 1877–1887.
https://doi.org/10.1182/blood-2011-12-396853
Published: 2012
Includes: Supplemental data
Journal Articles

Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma

Naoya Mimura, Mariateresa Fulciniti, Gullu Gorgun, Yu-Tzu Tai, Diana Cirstea, Loredana Santo, Yiguo Hu, Claire Fabre, Jiro Minami, Hiroto Ohguchi, Tanyel Kiziltepe, Hiroshi Ikeda, Yutaka Kawano, Maureen French, Martina Blumenthal, Victor Tam, Nathalie L. Kertesz, Uriel M. Malyankar, Mark Hokenson, Tuan Pham, Qingping Zeng, John B. Patterson, Paul G. Richardson, Nikhil C. Munshi, Kenneth C. Anderson
Journal: Blood
Blood (2012) 119 (24): 5772–5781.
https://doi.org/10.1182/blood-2011-07-366633
Published: 2012
Includes: Supplemental data
Journal Articles

Targeting Brouton's Tyrosine Kinase with PCI-32765 Blocks Growth and Survival of Multiple Myeloma and Waldenström Macroglobulinemia Via Potent Inhibition of Osteoclastogenesis, Cytokines/Chemokine Secretion, and Myeloma Stem-Like Cells in the Bone Marrow Microenvironment

Yu-Tzu Tai, PhD, Betty Y Chang, PhD, Sun-Young Kong, MD, PhD, Mariateresa Fulciniti, PhD, Guang Yang, PhD, Yolanda Calle, PhD, Yiguo Hu, MD, PhD, Jianhong Lin, PhD, Jian-Jun Zhao, PhD, Michele Cea, MD, Antonia Cagnetta, MD, Michael A Sellitto, BS, Michelle Chen, Zachary Hunter, BS, Ruben Carrasco, MD, PhD, Joseph J. Buggy, PhD, Laurence Elias, MD, William Matsui, MD, Steven P Treon, MD, PhD, Paul G. Richardson, MD, Nikhil C. Munshi, MD, Kenneth C. Anderson, MD
Journal: Blood
Blood (2011) 118 (21): 883.
https://doi.org/10.1182/blood.V118.21.883.883
Published: 2011
Journal Articles

Immunomodulatory Effects of Histone Deacetylase 6 Inhibition in Suppressor Immune Cells in Multiple Myeloma

Gullu Gorgun, PhD, Teru Hideshima, MD, PhD, Noopur S. Raje, MD, Naoya Mimura, MD, PhD, James E. Bradner, MD, Diana Cirstea, MD, Loredana Santo, MD, Yu-Tzu Tai, PhD, Michael Sellitto, Yiguo Hu, PhD, Claire Fabre, MD, PhD, Hiroto Ohguchi, MD, PhD, Jiro Minami, MD, PhD, Paul G. Richardson, MD, Nikhil C. Munshi, MD, Kenneth C. Anderson, MD
Journal: Blood
Blood (2011) 118 (21): 128.
https://doi.org/10.1182/blood.V118.21.128.128
Published: 2011
Journal Articles

Blockade of XBP1 Splicing by Inhibition of IRE1α Is a Promising Therapeutic Option in Multiple Myeloma

Naoya Mimura, MD, PhD, Mariateresa Fulciniti, PhD, Gullu Gorgun, PhD, Yu-Tzu Tai, PhD, Diana D. Cirstea, MD, Loredana Santo, MD, Yiguo Hu, PhD, Claire Fabre, MD, PhD, Jiro Minami, MD, PhD, Hiroto Ohguchi, MD, PhD, Tanyel Kiziltepe, Hiroshi Ikeda, MD, PhD, Yutaka Kawano, MD, PhD, Martina Blumenthal, Victor Tam, Nathalie L. Kertesz, Mark Hokenson, Qingping Zeng, John B. Patterson, Paul G. Richardson, MD, Nikhil C. Munshi, MD, Kenneth C. Anderson, MD
Journal: Blood
Blood (2011) 118 (21): 133.
https://doi.org/10.1182/blood.V118.21.133.133
Published: 2011