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miR-15a/16-1 deletion in activated B cells promotes plasma cell and mature B-cell neoplasms

Tomasz Sewastianik, Juerg R. Straubhaar, Jian-Jun Zhao, Mehmet K. Samur, Keith Adler, Helen E. Tanton, Vignesh Shanmugam, Omar Nadeem, Peter S. Dennis, Vinodh Pillai, Jianli Wang, Meng Jiang, Jianhong Lin, Ying Huang, Daniel Brooks, Mary Bouxsein, David M. Dorfman, Geraldine S. Pinkus, Davide F. Robbiani, Irene M. Ghobrial, Bogdan Budnik, Petr Jarolim, Nikhil C. Munshi, Kenneth C. Anderson, Ruben D. Carrasco
Journal: Blood
Blood (2021) 137 (14): 1905–1919.
https://doi.org/10.1182/blood.2020009088
Published: 2021
Includes: Supplemental data
Journal Articles

A clinically relevant in vivo zebrafish model of human multiple myeloma to study preclinical therapeutic efficacy

Brief Report
Jianhong Lin, Weihong Zhang, Jian-Jun Zhao, Ariel H. Kwart, Chun Yang, Dongdong Ma, Xiubao Ren, Yu-Tzu Tai, Kenneth C. Anderson, Robert I. Handin, Nikhil C. Munshi
Journal: Blood
Blood (2016) 128 (2): 249–252.
https://doi.org/10.1182/blood-2016-03-704460
Published: 2016
Journal Articles

Investigational agent MLN9708/2238 targets tumor-suppressor miR33b in MM cells

Ze Tian, Jian-jun Zhao, Yu-Tzu Tai, Samir B. Amin, Yiguo Hu, Allison J. Berger, Paul Richardson, Dharminder Chauhan, Kenneth C. Anderson
Journal: Blood
Blood (2012) 120 (19): 3958–3967.
https://doi.org/10.1182/blood-2012-01-401794
Published: 2012
Includes: Supplemental data
Journal Articles

Bruton tyrosine kinase inhibition is a novel therapeutic strategy targeting tumor in the bone marrow microenvironment in multiple myeloma

Yu-Tzu Tai, Betty Y. Chang, Sun-Young Kong, Mariateresa Fulciniti, Guang Yang, Yolanda Calle, Yiguo Hu, Jianhong Lin, Jian-Jun Zhao, Antonia Cagnetta, Michele Cea, Michael A. Sellitto, Mike Y. Zhong, Qiuju Wang, Chirag Acharya, Daniel R. Carrasco, Joseph J. Buggy, Laurence Elias, Steven P. Treon, William Matsui, Paul Richardson, Nikhil C. Munshi, Kenneth C. Anderson
Journal: Blood
Blood (2012) 120 (9): 1877–1887.
https://doi.org/10.1182/blood-2011-12-396853
Published: 2012
Includes: Supplemental data
Journal Articles

Targeting Brouton's Tyrosine Kinase with PCI-32765 Blocks Growth and Survival of Multiple Myeloma and Waldenström Macroglobulinemia Via Potent Inhibition of Osteoclastogenesis, Cytokines/Chemokine Secretion, and Myeloma Stem-Like Cells in the Bone Marrow Microenvironment

Yu-Tzu Tai, PhD, Betty Y Chang, PhD, Sun-Young Kong, MD, PhD, Mariateresa Fulciniti, PhD, Guang Yang, PhD, Yolanda Calle, PhD, Yiguo Hu, MD, PhD, Jianhong Lin, PhD, Jian-Jun Zhao, PhD, Michele Cea, MD, Antonia Cagnetta, MD, Michael A Sellitto, BS, Michelle Chen, Zachary Hunter, BS, Ruben Carrasco, MD, PhD, Joseph J. Buggy, PhD, Laurence Elias, MD, William Matsui, MD, Steven P Treon, MD, PhD, Paul G. Richardson, MD, Nikhil C. Munshi, MD, Kenneth C. Anderson, MD
Journal: Blood
Blood (2011) 118 (21): 883.
https://doi.org/10.1182/blood.V118.21.883.883
Published: 2011
Journal Articles

Investigational Agent MLN9708 Target Tumor Suppressor MicroRNA-33b in Multiple Myeloma Cells

Ze Tian, Jian-Jun Zhao, Jianhong Lin, PhD, Dharminder Chauhan, PhD, Kenneth C. Anderson, MD
Journal: Blood
Blood (2011) 118 (21): 136.
https://doi.org/10.1182/blood.V118.21.136.136
Published: 2011
Journal Articles

Mir-222-221 Induce Dexamethasone Resistance by Targeting BBC3/PUMA in Human Multiple Myeloma

Jian-Jun Zhao, M.D., Ph.D., Zhangbo Chu, M.D., Jianhong Lin, PhD, Yu-Tzu Tai, PhD, Nikhil C. Munshi, MD, Kenneth C. Anderson, MD, Ruben Carrasco, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 1419.
https://doi.org/10.1182/blood.V118.21.1419.1419
Published: 2011
Journal Articles

Microenvironment-Mediated Regulation of Micrornas In B-Lymphocytes as a Novel Mechanism for Terminal B-Cell Differentiation and Lymphomagenesis.

Jianhong Lin, M.D, Tint Lwin, MD, PhD, Wayne Tam, MD, PhD, Jian-Jun Zhao, Luis Crespo, Yong Sung Choi, Xinwei Zhang, Victoria Tannenbaum, Eduardo M. Sotomayor, MD, Lynn C. Moscinski, MD, William S. Dalton, PhD, MD, Ken Wright, PhD, Jianguo Tao, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 3853.
https://doi.org/10.1182/blood.V116.21.3853.3853
Published: 2010
Journal Articles

Bone Marrow Niche Down-Regulates Mir-30 In Multiple Myeloma Cells to Promote Cancer Progression and Cancer Initiation by Targeting BCL9/Wnt Pathway.

Jian-Jun Zhao, M.D., Ph.D., Jianhong Lin, M.D., Zhangbo Chu, M.D., Qi Wang, Ph.D., Kohichi Takada, M.D., Ph.D., Mala Mani, Ph.D., Bryan Ciccarelli, Teru Hideshima, M.D., Ph.D., Tai Yu-Tzu, Ph.D., Jianguo Tao, MD, PhD, Steven P. Treon, MD, PhD, Nikhil C. Munshi, M.D., Kenneth C. Anderson, M.D., Ruben Carrasco, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 1569.
https://doi.org/10.1182/blood.V116.21.1569.1569
Published: 2010
Journal Articles

microRNA expression profile and identification of miR-29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma

Jian-Jun Zhao, Jianhong Lin, Tint Lwin, Hua Yang, Jianping Guo, William Kong, Sophie Dessureault, Lynn C. Moscinski, Dorna Rezania, William S. Dalton, Eduardo Sotomayor, Jianguo Tao, Jin Q. Cheng
Journal: Blood
Blood (2010) 115 (13): 2630–2639.
https://doi.org/10.1182/blood-2009-09-243147
Published: 2010
Includes: Supplemental data