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Journal Articles

Waldenstrom Macroglobulinemia Cells Modulate Mitochondrial Bioenergetics and Induce a Respiratory Hyper-Drive State upon Acquisition of Ibrutinib-Resistance

Aneel Paulus, MD, Sharoon Akhtar, MPhil, Roman Hudec, Shumail M. Paulus, MBBS, Yamima Bashir, MBBS, Thomas E. Witzig, MD, Stephen Ansell, MD PhD, Stig Linder, PhD, Sikander Ailawadhi, MD, Asher A. Chanan-Khan, MD
Journal: Blood
Blood (2016) 128 (22): 2761.
https://doi.org/10.1182/blood.V128.22.2761.2761
Published: 2016
Journal Articles

VLX1570, a First in Class Dub Inhibitor, Modulates BCR Signaling and CXCR4 Expression and Demonstrates Significant In Vivo Antitumor Activity in a Murine Model of Human Waldenstrom Macroglobulinemia

Aneel Paulus, MDMS, Sharoon Akhtar, MPhil, Kelara Samuel, Hassan Yousaf, Davitte Cogen, Jennifer Jiang, Abhisek Swaika, MBBS, Anne Novak, PhD, Stephen M Ansell, MD, PhD, Morie A Gertz, MD, Robert A. Kyle, MD, Thomas E. Witzig, MD, George J Weiner, MD, Peter Martin, MD, Morton Coleman, MD, Sikander Ailawadhi, MD, Joachim Gullbo, MD PhD, Stig Linder, PhD, Geraldo Otero-Colon, Vivek Roy, MD, Kasyapa S. Chitta, PhD, Asher Alban Chanan-Khan, MD
Journal: Blood
Blood (2015) 126 (23): 703.
https://doi.org/10.1182/blood.V126.23.703.703
Published: 2015
Journal Articles

Identification of USP14 and UCHL5 As Druggable Oncotargets in Ibrutinib-Resistant Mantle Cell Lymphoma

Aneel Paulus, MDMS, Sharoon Akhtar, MPhil, Kelara Samuel, Hassan Yousaf, Davitte Cogen, Pooja Advani, MBBS, Thomas E. Witzig, MD, George J Weiner, MD, Sikander Ailawadhi, MD, Joachim Gullbo, MD PhD, Stig Linder, PhD, Geraldo Otero-Colon, Kasyapa S. Chitta, PhD, Asher Alban Chanan-Khan, MD
Journal: Blood
Blood (2015) 126 (23): 1557.
https://doi.org/10.1182/blood.V126.23.1557.1557
Published: 2015
Journal Articles

Targeted Disruption of USP14 and UCHL5 with the Novel Deubiquitinase Enzyme (DUB) Inhibitor, VLX1570, Induces Immense Proteotoxicity and Cell Death in Malignant Plasma Cells

Aneel Paulus, MDMS, Sharoon Akhtar, MPhil, Maja Kuranz-Blake, B.S., Anne J. Novak, PhD, Stephen Ansell, MD, Morie A Gertz, MD, Robert A Kyle, MD, Peter Martin, MD, Morton Coleman, MD, Sikander Ailawadhi, MD, Stig Linder, MD PhD, Asher Chanan-Khan, MD, Kasyapa S. Chitta, PhD
Journal: Blood
Blood (2014) 124 (21): 3116.
https://doi.org/10.1182/blood.V124.21.3116.3116
Published: 2014
Journal Articles

A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance

Ze Tian, Padraig D’Arcy, Xin Wang, Arghya Ray, Yu-Tzu Tai, Yiguo Hu, Ruben D. Carrasco, Paul Richardson, Stig Linder, Dharminder Chauhan, Kenneth C. Anderson
Journal: Blood
Blood (2014) 123 (5): 706–716.
https://doi.org/10.1182/blood-2013-05-500033
Published: 2014
Includes: Supplemental data
Journal Articles

The Deubiquitinating Enzymes Of The 19S Proteasome Offer Novel Therapeutic Opportunity In Bortezomib Resistant Waldenströms Macroglobulinemia

Aneel Paulus, MD, MS, Kasyapa S. Chitta, PhD, Sharoon Akhtar, Maja Kuranz, Vivek Roy, M.D., Stephen M Ansell, M.D.Ph.D., Anne J. Novak, PhD, Peter Martin, MD, Richard R. Furman, MD, Morton Coleman, MD, Stig Linder, MD, PhD, Asher Chanan-Khan, MD
Journal: Blood
Blood (2013) 122 (21): 4426.
https://doi.org/10.1182/blood.V122.21.4426.4426
Published: 2013
Journal Articles

A Novel Small Molecule Inhibitor Of Deubiquitylating Enzyme USP14 and UCHL5 Induces Apoptosis In Myeloma Cells and Overcomes Bortezomib Resistance

Ze Tian, Ph.D, Padraig D'Arcy, Ph.D, Xin Wang, Ph.D, Arghya Ray, Yu-Tzu Tai, PhD, Yiguo Hu, PhD, Ruben Carrasco, MD, PhD, Deepika Das, Ph.D, Paul Richardson, MD, Stig Linder, MD, PhD, Dharminder Chauhan, PhD, Kenneth C. Anderson, MD
Journal: Blood
Blood (2013) 122 (21): 1923.
https://doi.org/10.1182/blood.V122.21.1923.1923
Published: 2013
Journal Articles

Inhibition Of The Deubiquitinating Enzymes UCHL5 and USP14 Is Lethal To Waldenströms Macroglobulinemia Cells

Kasyapa S. Chitta, PhD, Aneel Paulus, MD, MS, Sharoon Akhtar, Maja Kuranz, Vivek Roy, M.D., Stephen M Ansell, M.D.Ph.D., Anne J. Novak, PhD, Peter Martin, MD, Richard R. Furman, MD, Morton Coleman, MD, Stig Linder, MD, PhD, Asher Chanan-Khan, MD
Journal: Blood
Blood (2013) 122 (21): 1823.
https://doi.org/10.1182/blood.V122.21.1823.1823
Published: 2013