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Volume 108, Issue 10

November 15 2006

In this Issue

INSIDE BLOOD
CHEMOKINES, CYTOKINES, AND INTERLEUKINS
CLINICAL TRIALS AND OBSERVATIONS
GENE THERAPY
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
TRANSFUSION MEDICINE
TRANSPLANTATION
CORRESPONDENCE

INSIDE BLOOD

HEMOSTASIS

VWF propeptide: a useful marker in VWD

Augusto B. Federici

View Articletitled, VWF propeptide: a useful marker in VWD

PHAGOCYTES

Tickle my innards

Gregory P. Downey

View Articletitled, Tickle my innards

TRANSFUSION MEDICINE

Molecular volume and HBOC-induced vasoconstriction

Andre F. Palmer

View Articletitled, Molecular volume and HBOC-induced vasoconstriction

CLINICAL OBSERVATIONS

Older AML patients: fit for what?

Richard M. Stone

View Articletitled, Older AML patients: fit for what?

NEOPLASIA

When “the same” is really “different”

Sagar Lonial

View Articletitled, When “the same” is really “different”

NEOPLASIA

CEBPA dosage in leukemogenesis

Thomas Mercher,D. Gary Gilliland

View Articletitled, CEBPA dosage in leukemogenesis

CLINICAL OBSERVATIONS

Follicular lymphoma: chemotherapy and/or antibodies?

Michele Ghielmini

View Articletitled, Follicular lymphoma: chemotherapy and/or antibodies?

CLINICAL OBSERVATIONS

Exciting new agents in multiple myeloma

Giampaolo Merlini

View Articletitled, Exciting new agents in multiple myeloma

CHEMOKINES, CYTOKINES, AND INTERLEUKINS

Stat1 and SUMO modification

Li Song,Samita Bhattacharya,Ali A. Yunus,Christopher D. Lima,Christian Schindler

View Articletitled, Stat1 and SUMO modification

Supplemental data

SDF-1α regulation in breast cancer cells contacting bone marrow stroma is critical for normal hematopoiesis

Anabella L. Moharita,Marcelo Taborga,Kelly E. Corcoran,Margarette Bryan,Prem S. Patel,Pranela Rameshwar

View Articletitled, SDF-1α regulation in breast cancer cells contacting bone marrow stroma is critical for normal hematopoiesis

Type I interferons directly regulate lymphocyte recirculation and cause transient blood lymphopenia

Elisabeth Kamphuis,Tobias Junt,Zoe Waibler,Reinhold Forster,Ulrich Kalinke

View Articletitled, Type I interferons directly regulate lymphocyte recirculation and cause transient blood lymphopenia

CLINICAL TRIALS AND OBSERVATIONS

A phase 2 trial of the FLT3 inhibitor lestaurtinib (CEP701) as first-line treatment for older patients with acute myeloid leukemia not considered fit for intensive chemotherapy
Clinical Trials & Observations

Steven Knapper,Alan K. Burnett,Tim Littlewood,W. Jonathan Kell,Sam Agrawal,Raj Chopra,Richard Clark,Mark J. Levis,Donald Small

View Articletitled, A phase 2 trial of the FLT3 inhibitor lestaurtinib (CEP701) as first-line treatment for older patients with acute myeloid leukemia not considered fit for intensive chemotherapy

Phase 1/2 study of the combination of 5-aza-2′-deoxycytidine with valproic acid in patients with leukemia
Clinical Trials & Observations

Guillermo Garcia-Manero,Hagop M. Kantarjian,Blanca Sanchez-Gonzalez,Hui Yang,Gary Rosner,Srdan Verstovsek,Michael Rytting,William G. Wierda,Farhad Ravandi,Charles Koller,Lianchun Xiao,Stefan Faderl,Zeev Estrov,Jorge Cortes,Susan O'Brien,Elihu Estey,Carlos Bueso-Ramos,Jackie Fiorentino,Elias Jabbour,Jean-Pierre Issa

View Articletitled, Phase 1/2 study of the combination of 5-aza-2′-deoxycytidine with valproic acid in patients with leukemia

Supplemental data

Cytogenetics and age are major determinants of outcome in intensively treated acute myeloid leukemia patients older than 60 years: results from AMLSG trial AML HD98-B
Clinical Trials & Observations

Stefan Fröhling,Richard F. Schlenk,Sabine Kayser,Martina Morhardt,Axel Benner,Konstanze Döhner,Hartmut Döhner,for the German-Austrian AML Study Group

View Articletitled, Cytogenetics and age are major determinants of outcome in intensively treated acute myeloid leukemia patients older than 60 years: results from AMLSG trial AML HD98-B

Maintenance therapy with thalidomide improves survival in patients with multiple myeloma
Clinical Trials & Observations

Michel Attal,Jean-Luc Harousseau,Serge Leyvraz,Chantal Doyen,Cyrille Hulin,Lofti Benboubker,Ibrahim Yakoub Agha,Jean-Henri Bourhis,Laurent Garderet,Brigitte Pegourie,Charles Dumontet,Marc Renaud,Laurent Voillat,Christian Berthou,Gerald Marit,Mathieu Monconduit,Denis Caillot,Bernard Grobois,Herve Avet-Loiseau,Philippe Moreau,Thierry Facon,for the Inter-Groupe Francophone du Myélome (IFM)

View Articletitled, Maintenance therapy with thalidomide improves survival in patients with multiple myeloma

Rituximab maintenance improves clinical outcome of relapsed/resistant follicular non-Hodgkin lymphoma in patients both with and without rituximab during induction: results of a prospective randomized phase 3 intergroup trial
Clinical Trials & Observations

Marinus H. J. van Oers,Richard Klasa,Robert E. Marcus,Max Wolf,Eva Kimby,Randy D. Gascoyne,Andrew Jack,Mars van't Veer,Andrej Vranovsky,Harald Holte,Martine van Glabbeke,Ivana Teodorovic,Cynthia Rozewicz,Anton Hagenbeek

View Articletitled, Rituximab maintenance improves clinical outcome of relapsed/resistant follicular non-Hodgkin lymphoma in patients both with and without rituximab during induction: results of a prospective randomized phase 3 intergroup trial

Prognostic significance of CD20 expression in childhood B-cell precursor acute lymphoblastic leukemia
Clinical Trials & Observations Brief Report

Sima Jeha,Frederick Behm,Deqing Pei,John T. Sandlund,Raul C. Ribeiro,Bassem I. Razzouk,Jeffrey E. Rubnitz,Nobuko Hijiya,Scott C. Howard,Cheng Cheng,Ching-Hon Pui

View Articletitled, Prognostic significance of CD20 expression in childhood B-cell precursor acute lymphoblastic leukemia

GENE THERAPY

Lentivirus vectors expressing short hairpin RNAs against the U3-overlapping region of HIV nef inhibit HIV replication and infectivity in primary macrophages

Takuya Yamamoto,Hiroyuki Miyoshi,Norio Yamamoto,Naoki Yamamoto,Jun-ichiro Inoue,Yasuko Tsunetsugu-Yokota

View Articletitled, Lentivirus vectors expressing short hairpin RNAs against the U3-overlapping region of HIV nef inhibit HIV replication and infectivity in primary macrophages

Correction of the disease phenotype in canine leukocyte adhesion deficiency using ex vivo hematopoietic stem cell gene therapy

Thomas R. Bauer, Jr,Mehreen Hai,Laura M. Tuschong,Tanya H. Burkholder,Yu-chen Gu,Robert A. Sokolic,Cole Ferguson,Cynthia E. Dunbar,Dennis D. Hickstein

View Articletitled, Correction of the disease phenotype in canine leukocyte adhesion deficiency using ex vivo hematopoietic stem cell gene therapy

Effects of transient immunosuppression on adenoassociated, virus-mediated, liver-directed gene transfer in rhesus macaques and implications for human gene therapy

Haiyan Jiang,Linda B. Couto,Susannah Patarroyo-White,Tongyao Liu,Dea Nagy,Joseph A. Vargas,Shangzhen Zhou,Ciaran D. Scallan,Jurg Sommer,Sharmila Vijay,Federico Mingozzi,Katherine A. High,Glenn F. Pierce

View Articletitled, Effects of transient immunosuppression on adenoassociated, virus-mediated, liver-directed gene transfer in rhesus macaques and implications for human gene therapy

HEMATOPOIESIS

AML1/Runx1 rescues Notch1-null mutation-induced deficiency of para-aortic splanchnopleural hematopoiesis

Masahiro Nakagawa,Motoshi Ichikawa,Keiki Kumano,Susumu Goyama,Masahito Kawazu,Takashi Asai,Seishi Ogawa,Mineo Kurokawa,Shigeru Chiba

View Articletitled, AML1/Runx1 rescues Notch1-null mutation-induced deficiency of para-aortic splanchnopleural hematopoiesis

Negative regulation of primitive hematopoiesis by the FGF signaling pathway

Fumie Nakazawa,Hiroki Nagai,Masahiro Shin,Guojun Sheng

View Articletitled, Negative regulation of primitive hematopoiesis by the FGF signaling pathway

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Assay of the von Willebrand factor (VWF) propeptide to identify patients with type 1 von Willebrand disease with decreased VWF survival
Clinical Trials & Observations

Sandra L. Haberichter,Michael Balistreri,Pamela Christopherson,Patricia Morateck,Stefana Gavazova,Daniel B. Bellissimo,Marilyn J. Manco-Johnson,Joan Cox Gill,Robert R. Montgomery

View Articletitled, Assay of the von Willebrand factor (VWF) propeptide to identify patients with type 1 von Willebrand disease with decreased VWF survival

Lipid raft adhesion receptors and Syk regulate selectin-dependent rolling under flow conditions

Claire Abbal,Martine Lambelet,Debora Bertaggia,Carole Gerbex,Manuel Martinez,Alexandre Arcaro,Marc Schapira,Olivier Spertini

View Articletitled, Lipid raft adhesion receptors and Syk regulate selectin-dependent rolling under flow conditions

Differential effects of recombinant thrombopoietin and bone marrow stromal-conditioned media on neonatal versus adult megakaryocytes
Brief Report

Karen M. Pastos,William B. Slayton,Lisa M. Rimsza,Linda Young,Martha C. Sola-Visner

View Articletitled, Differential effects of recombinant thrombopoietin and bone marrow stromal-conditioned media on neonatal versus adult megakaryocytes

Supplemental data

IMMUNOBIOLOGY

Histone acetylation is associated with differential gene expression in the rapid and robust memory CD8⁺ T-cell response

Monchou Fann,Jason M. Godlove,Marta Catalfamo,William H. Wood, III,Francis J. Chrest,Nicholas Chun,Larry Granger,Robert Wersto,Karen Madara,Kevin Becker,Pierre A. Henkart,Nan-ping Weng

View Articletitled, Histone acetylation is associated with differential gene expression in the rapid and robust memory CD8+ T-cell response

Supplemental data

Naive regulatory T cells: a novel subpopulation defined by resistance toward CD95L-mediated cell death

Benedikt Fritzsching,Nina Oberle,Eva Pauly,Robert Geffers,Jan Buer,Johannes Poschl,Peter Krammer,Otwin Linderkamp,Elisabeth Suri-Payer

View Articletitled, Naive regulatory T cells: a novel subpopulation defined by resistance toward CD95L-mediated cell death

Supplemental data

α-Chain phosphorylation of the human leukocyte CD11b/CD18 (Mac-1) integrin is pivotal for integrin activation to bind ICAMs and leukocyte extravasation

Susanna C. Fagerholm,Minna Varis,Michael Stefanidakis,Tiina J. Hilden,Carl G. Gahmberg

View Articletitled, α-Chain phosphorylation of the human leukocyte CD11b/CD18 (Mac-1) integrin is pivotal for integrin activation to bind ICAMs and leukocyte extravasation

Pentraxin 3 protects from MCMV infection and reactivation through TLR sensing pathways leading to IRF3 activation

Silvia Bozza,Francesco Bistoni,Roberta Gaziano,Lucia Pitzurra,Teresa Zelante,Pierluigi Bonifazi,Katia Perruccio,Silvia Bellocchio,Mariella Neri,Anna Maria Iorio,Giovanni Salvatori,Rita De Santis,Mario Calvitti,Andrea Doni,Cecilia Garlanda,Alberto Mantovani,Luigina Romani

View Articletitled, Pentraxin 3 protects from MCMV infection and reactivation through TLR sensing pathways leading to IRF3 activation

Altered granulopoietic profile and exaggerated acute neutrophilic inflammation in mice with targeted deficiency in the sialyltransferase ST6Gal I

Mehrab Nasirikenari,Brahm H. Segal,Julie R. Ostberg,Ashlee Urbasic,Joseph T. Lau

View Articletitled, Altered granulopoietic profile and exaggerated acute neutrophilic inflammation in mice with targeted deficiency in the sialyltransferase ST6Gal I

Imatinib mesylate selectively impairs expansion of memory cytotoxic T cells without affecting the control of primary viral infections

Sabine Mumprecht,Matthias Matter,Viktor Pavelic,Adrian F. Ochsenbein

View Articletitled, Imatinib mesylate selectively impairs expansion of memory cytotoxic T cells without affecting the control of primary viral infections

Nef interference with HIV-1–specific CTL antiviral activity is epitope specific

Sama Adnan,Arumugam Balamurugan,Alicja Trocha,Michael S. Bennett,Hwee L. Ng,Ayub Ali,Christian Brander,Otto O. Yang

View Articletitled, Nef interference with HIV-1–specific CTL antiviral activity is epitope specific

Overlapping functions of human CD3δ and mouse CD3γ in αβ T-cell development revealed in a humanized CD3γ-deficient mouse

Edgar Fernández-Malavé,Ninghai Wang,Manuel Pulgar,Wolfgang W. A. Schamel,Balbino Alarcón,Cox Terhorst

View Articletitled, Overlapping functions of human CD3δ and mouse CD3γ in αβ T-cell development revealed in a humanized CD3γ-deficient mouse

Protein tyrosine phosphatase receptor–type O truncated (PTPROt) regulates SYK phosphorylation, proximal B-cell–receptor signaling, and cellular proliferation

Linfeng Chen,Przemyslaw Juszczynski,Kunihiko Takeyama,Ricardo C. T. Aguiar,Margaret A. Shipp

View Articletitled, Protein tyrosine phosphatase receptor–type O truncated (PTPROt) regulates SYK phosphorylation, proximal B-cell–receptor signaling, and cellular proliferation

XIAP targeting sensitizes Hodgkin lymphoma cells for cytolytic T-cell attack

Hamid Kashkar,Jens-Michael Seeger,Andreas Hombach,Anke Deggerich,Benjamin Yazdanpanah,Olaf Utermöhlen,Gerd Heimlich,Hinrich Abken,Martin Krönke

View Articletitled, XIAP targeting sensitizes Hodgkin lymphoma cells for cytolytic T-cell attack

NEOPLASIA

Aggresome induction by proteasome inhibitor bortezomib and α-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells

Laurence Catley,Ellen Weisberg,Tanyel Kiziltepe,Yu-Tzu Tai,Teru Hideshima,Paola Neri,Pierfrancesco Tassone,Peter Atadja,Dharminder Chauhan,Nikhil C. Munshi,Kenneth C. Anderson

View Articletitled, Aggresome induction by proteasome inhibitor bortezomib and α-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells

CD154 induces p73 to overcome the resistance to apoptosis of chronic lymphocytic leukemia cells lacking functional p53

Frank Dicker,Arnon P. Kater,Carlos E. Prada,Tetsuya Fukuda,Januario E. Castro,Guizhen Sun,Jean Y. Wang,Thomas J. Kipps

View Articletitled, CD154 induces p73 to overcome the resistance to apoptosis of chronic lymphocytic leukemia cells lacking functional p53

A randomized phase 2 study of lenalidomide therapy for patients with relapsed or relapsed and refractory multiple myeloma
Clinical Trials & Observations

Paul G. Richardson,Emily Blood,Constantine S. Mitsiades,Sundar Jagannath,Steven R. Zeldenrust,Melissa Alsina,Robert L. Schlossman,S. Vincent Rajkumar,K. Raman Desikan,Teru Hideshima,Nikhil C. Munshi,Kathleen Kelly-Colson,Deborah Doss,Mary L. McKenney,Svetlana Gorelik,Diane Warren,Andrea Freeman,Rebecca Rich,Anfang Wu,Marta Olesnyckyj,Kenton Wride,William S. Dalton,Jerome Zeldis,Robert Knight,Edie Weller,Kenneth C. Anderson

View Articletitled, A randomized phase 2 study of lenalidomide therapy for patients with relapsed or relapsed and refractory multiple myeloma

MIP-1α (CCL3) is a downstream target of FGFR3 and RAS-MAPK signaling in multiple myeloma

Esther Masih-Khan,Suzanne Trudel,Carla Heise,Zhihua Li,Joshua Paterson,Vincent Nadeem,Ellen Wei,David Roodman,Jaime O. Claudio,P. Leif Bergsagel,A. Keith Stewart

View Articletitled, MIP-1α (CCL3) is a downstream target of FGFR3 and RAS-MAPK signaling in multiple myeloma

Supplemental data

MPL515 mutations in myeloproliferative and other myeloid disorders: a study of 1182 patients
Clinical Trials & Observations

Animesh D. Pardanani,Ross L. Levine,Terra Lasho,Yana Pikman,Ruben A. Mesa,Martha Wadleigh,David P. Steensma,Michelle A. Elliott,Alexandra P. Wolanskyj,William J. Hogan,Rebecca F. McClure,Mark R. Litzow,D. Gary Gilliland,Ayalew Tefferi

View Articletitled, MPL515 mutations in myeloproliferative and other myeloid disorders: a study of 1182 patients

Plasma inhibitory activity (PIA): a pharmacodynamic assay reveals insights into the basis for cytotoxic response to FLT3 inhibitors

Mark Levis,Patrick Brown,B. Douglas Smith,Adam Stine,Rosalyn Pham,Richard Stone,Daniel DeAngelo,Ilene Galinsky,Frank Giles,Elihu Estey,Hagop Kantarjian,Pamela Cohen,Yanfeng Wang,Johannes Roesel,Judith E. Karp,Donald Small

View Articletitled, Plasma inhibitory activity (PIA): a pharmacodynamic assay reveals insights into the basis for cytotoxic response to FLT3 inhibitors

Expression of T-lineage-affiliated transcripts and TCR rearrangements in acute promyelocytic leukemia: implications for the cellular target of t(15;17)

Elise Chapiro,Eric Delabesse,Vahid Asnafi,Corinne Millien,Frederic Davi,Elizabeth Nugent,Kheira Beldjord,Torsten Haferlach,David Grimwade,Elizabeth A. Macintyre

View Articletitled, Expression of T-lineage-affiliated transcripts and TCR rearrangements in acute promyelocytic leukemia: implications for the cellular target of t(15;17)

Supplemental data

The effects of lestaurtinib (CEP701) and PKC412 on primary AML blasts: the induction of cytotoxicity varies with dependence on FLT3 signaling in both FLT3-mutated and wild-type cases

Steven Knapper,Kenneth I. Mills,Amanda F. Gilkes,Steve J. Austin,Val Walsh,Alan K. Burnett

View Articletitled, The effects of lestaurtinib (CEP701) and PKC412 on primary AML blasts: the induction of cytotoxicity varies with dependence on FLT3 signaling in both FLT3-mutated and wild-type cases

Newly identified c-KIT receptor tyrosine kinase ITD in childhood AML induces ligand-independent growth and is responsive to a synergistic effect of imatinib and rapamycin

Selim Corbacioglu,Mehtap Kilic,Mike-Andrew Westhoff,Dirk Reinhardt,Simone Fulda,Klaus-Michael Debatin

View Articletitled, Newly identified c-KIT receptor tyrosine kinase ITD in childhood AML induces ligand-independent growth and is responsive to a synergistic effect of imatinib and rapamycin

Prognostic significance of metallothionein in B-cell lymphomas
Clinical Trials & Observations

Christian Bjørn Poulsen,Rehannah Borup,Niels Borregaard,Finn Cilius Nielsen,Michael Boe Møller,Elisabeth Ralfkiaer

View Articletitled, Prognostic significance of metallothionein in B-cell lymphomas

The cryptic chromosomal deletion del(11)(p12p13) as a new activation mechanism of LMO2 in pediatric T-cell acute lymphoblastic leukemia

Pieter Van Vlierberghe,Martine van Grotel,H. Berna Beverloo,Charles Lee,Tryggvi Helgason,Jessica Buijs-Gladdines,Monique Passier,Elisabeth R. van Wering,Anjo J. P. Veerman,Willem A. Kamps,Jules P. P. Meijerink,Rob Pieters

View Articletitled, The cryptic chromosomal deletion del(11)(p12p13) as a new activation mechanism of LMO2 in pediatric T-cell acute lymphoblastic leukemia

Expression of interleukin-3 receptor subunits on defined subpopulations of acute myeloid leukemia blasts predicts the cytotoxicity of diphtheria toxin interleukin-3 fusion protein against malignant progenitors that engraft in immunodeficient mice

Leman Yalcintepe,Arthur E. Frankel,Donna E. Hogge

View Articletitled, Expression of interleukin-3 receptor subunits on defined subpopulations of acute myeloid leukemia blasts predicts the cytotoxicity of diphtheria toxin interleukin-3 fusion protein against malignant progenitors that engraft in immunodeficient mice

The CML-related oncoprotein BCR/ABL induces expression of histidine decarboxylase (HDC) and the synthesis of histamine in leukemic cells

Karl J. Aichberger,Matthias Mayerhofer,Anja Vales,Maria-Theresa Krauth,Karoline V. Gleixner,Martin Bilban,Harald Esterbauer,Karoline Sonneck,Stefan Florian,Sophia Derdak,Winfried F. Pickl,Hermine Agis,Andras Falus,Christian Sillaber,Peter Valent

View Articletitled, The CML-related oncoprotein BCR/ABL induces expression of histidine decarboxylase (HDC) and the synthesis of histamine in leukemic cells

Mutation of JAK2 in the myeloproliferative disorders: timing, clonality studies, cytogenetic associations, and role in leukemic transformation
Clinical Trials & Observations

Peter J. Campbell,E. Joanna Baxter,Philip A. Beer,Linda M. Scott,Anthony J. Bench,Brian J. P. Huntly,Wendy N. Erber,Rajko Kusec,Thomas Stauffer Larsen,Stéphane Giraudier,Marie-Caroline Le Bousse-Kerdilès,Martin Griesshammer,John T. Reilly,Betty Y. Cheung,Claire N. Harrison,Anthony R. Green

View Articletitled, Mutation of JAK2 in the myeloproliferative disorders: timing, clonality studies, cytogenetic associations, and role in leukemic transformation

NUP214-ABL1 in adult T-ALL: the GMALL study group experience
Clinical Trials & Observations

Thomas Burmeister,Nicola Gökbuget,Richard Reinhardt,Harald Rieder,Dieter Hoelzer,Stefan Schwartz

View Articletitled, NUP214-ABL1 in adult T-ALL: the GMALL study group experience

Overexpression of CEBPA resulting from the translocation t(14;19)(q32;q13) of human precursor B acute lymphoblastic leukemia
Brief Report

Elise Chapiro,Lisa Russell,Isabelle Radford-Weiss,Christian Bastard,Michel Lessard,Stephanie Struski,Helene Cave,Sandra Fert-Ferrer,Carole Barin,Odile Maarek,Veronique Della-Valle,Jonathan C. Strefford,Roland Berger,Christine J. Harrison,Olivier A. Bernard,Florence Nguyen-Khac,the Groupe Francophone de Cytogénétique Hématologique

View Articletitled, Overexpression of CEBPA resulting from the translocation t(14;19)(q32;q13) of human precursor B acute lymphoblastic leukemia

Supplemental data

PHAGOCYTES

Phagocyte cell migration is mediated by phospholipases PLD1 and PLD2

Nicholas Lehman,Mauricio Di Fulvio,Nicholas McCray,Isabel Campos,Farnaz Tabatabaian,Julian Gomez-Cambronero

View Articletitled, Phagocyte cell migration is mediated by phospholipases PLD1 and PLD2

FcRn: an IgG receptor on phagocytes with a novel role in phagocytosis

Gestur Vidarsson,Annette M. Stemerding,Nigel M. Stapleton,Suzanne E. Spliethoff,Hans Janssen,Frank E. Rebers,Masja de Haas,Jan G. van de Winkel

View Articletitled, FcRn: an IgG receptor on phagocytes with a novel role in phagocytosis

Apoptotic cell thrombospondin-1 and heparin-binding domain lead to dendritic-cell phagocytic and tolerizing states

Alon Krispin,Yaniv Bledi,Mizhir Atallah,Uriel Trahtemberg,Inna Verbovetski,Efrat Nahari,Orly Zelig,Michal Linial,Dror Mevorach

View Articletitled, Apoptotic cell thrombospondin-1 and heparin-binding domain lead to dendritic-cell phagocytic and tolerizing states

Supplemental data

RED CELLS

Mechanism for fetal hemoglobin induction by histone deacetylase inhibitors involves γ-globin activation by CREB1 and ATF-2

Jose Sangerman,Moo Seung Lee,Xiao Yao,Eugene Oteng,Cheng-Hui Hsiao,Wei Li,Sima Zein,Solomon F. Ofori-Acquah,Betty S. Pace

View Articletitled, Mechanism for fetal hemoglobin induction by histone deacetylase inhibitors involves γ-globin activation by CREB1 and ATF-2

Pediatric patients with essential thrombocythemia are mostly polyclonal and V617FJAK2 negative
Brief Report

Maria Luigia Randi,Maria Caterina Putti,Margherita Scapin,Enrica Pacquola,Fabio Tucci,Concetta Micalizzi,Luigi Zanesco,Fabrizio Fabris

View Articletitled, Pediatric patients with essential thrombocythemia are mostly polyclonal and V617FJAK2 negative

TRANSFUSION MEDICINE

Dissociation of local nitric oxide concentration and vasoconstriction in the presence of cell-free hemoglobin oxygen carriers

Amy G. Tsai,Pedro Cabrales,Belur N. Manjula,Seetharama A. Acharya,Robert M. Winslow,Marcos Intaglietta

View Articletitled, Dissociation of local nitric oxide concentration and vasoconstriction in the presence of cell-free hemoglobin oxygen carriers

TRANSPLANTATION

Humoral immunity is the dominant barrier for allogeneic bone marrow engraftment in sensitized recipients

Hong Xu,Paula M. Chilton,Michael K. Tanner,Yiming Huang,Carrie L. Schanie,Mariano Dy-Liacco,Jun Yan,Suzanne T. Ildstad

View Articletitled, Humoral immunity is the dominant barrier for allogeneic bone marrow engraftment in sensitized recipients

CORRESPONDENCE

Units of analysis in accelerated telomere shortening in glycosylphosphatidylinositol (GPI)-negative compared with GPI-positive granulocytes from patients with paroxysmal nocturnal hemoglobinuria (PNH) detected by proaerolysin flow-FISH

Azadeh Stark,Daniel Schultz

View Articletitled, Units of analysis in accelerated telomere shortening in glycosylphosphatidylinositol (GPI)-negative compared with GPI-positive granulocytes from patients with paroxysmal nocturnal hemoglobinuria (PNH) detected by proaerolysin flow-FISH

HAART- and AIDS-related lymphomas

Jaswinder Singh,Ashok K. Malani,Siddhartha Ganguly,Suman Kambhampati

View Articletitled, HAART- and AIDS-related lymphomas

Analysis of the CD95 ligand gene in 20 children with autoimmune lymphoproliferative syndrome (ALPS)

Eva Pauly,Benedikt Fritzsching,Markus Dechant,Joerg Fellenberg,Christian Gerold Scheuerpflug,Klaus-Michael Debatin

View Articletitled, Analysis of the CD95 ligand gene in 20 children with autoimmune lymphoproliferative syndrome (ALPS)

Subtype preference of the BCL6_397G/C polymorphism in germinal-center and non-germinal-center subtypes of diffuse large B-cell lymphoma

Mattias Berglund,Rose-Marie Amini,Majlis Book,Richard Rosenquist,Göran Roos,Ulf Thunberg

View Articletitled, Subtype preference of the BCL6397G/C polymorphism in germinal-center and non-germinal-center subtypes of diffuse large B-cell lymphoma

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Issue Archive

Table of Contents

INSIDE BLOOD

CHEMOKINES, CYTOKINES, AND INTERLEUKINS

CLINICAL TRIALS AND OBSERVATIONS

A phase 2 trial of the FLT3 inhibitor lestaurtinib (CEP701) as first-line treatment for older patients with acute myeloid leukemia not considered fit for intensive chemotherapy Clinical Trials & Observations

Phase 1/2 study of the combination of 5-aza-2′-deoxycytidine with valproic acid in patients with leukemia Clinical Trials & Observations

Cytogenetics and age are major determinants of outcome in intensively treated acute myeloid leukemia patients older than 60 years: results from AMLSG trial AML HD98-B Clinical Trials & Observations

Maintenance therapy with thalidomide improves survival in patients with multiple myeloma Clinical Trials & Observations

Rituximab maintenance improves clinical outcome of relapsed/resistant follicular non-Hodgkin lymphoma in patients both with and without rituximab during induction: results of a prospective randomized phase 3 intergroup trial Clinical Trials & Observations

Prognostic significance of CD20 expression in childhood B-cell precursor acute lymphoblastic leukemia Clinical Trials & Observations Brief Report

GENE THERAPY

HEMATOPOIESIS

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Assay of the von Willebrand factor (VWF) propeptide to identify patients with type 1 von Willebrand disease with decreased VWF survival Clinical Trials & Observations

Differential effects of recombinant thrombopoietin and bone marrow stromal-conditioned media on neonatal versus adult megakaryocytes Brief Report

IMMUNOBIOLOGY

NEOPLASIA

A randomized phase 2 study of lenalidomide therapy for patients with relapsed or relapsed and refractory multiple myeloma Clinical Trials & Observations

MPL515 mutations in myeloproliferative and other myeloid disorders: a study of 1182 patients Clinical Trials & Observations

Prognostic significance of metallothionein in B-cell lymphomas Clinical Trials & Observations

Mutation of JAK2 in the myeloproliferative disorders: timing, clonality studies, cytogenetic associations, and role in leukemic transformation Clinical Trials & Observations

NUP214-ABL1 in adult T-ALL: the GMALL study group experience Clinical Trials & Observations

Overexpression of CEBPA resulting from the translocation t(14;19)(q32;q13) of human precursor B acute lymphoblastic leukemia Brief Report

PHAGOCYTES

RED CELLS

Pediatric patients with essential thrombocythemia are mostly polyclonal and V617FJAK2 negative Brief Report

TRANSFUSION MEDICINE

TRANSPLANTATION

CORRESPONDENCE

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American Society of Hematology

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A phase 2 trial of the FLT3 inhibitor lestaurtinib (CEP701) as first-line treatment for older patients with acute myeloid leukemia not considered fit for intensive chemotherapy
Clinical Trials & Observations

Phase 1/2 study of the combination of 5-aza-2′-deoxycytidine with valproic acid in patients with leukemia
Clinical Trials & Observations

Cytogenetics and age are major determinants of outcome in intensively treated acute myeloid leukemia patients older than 60 years: results from AMLSG trial AML HD98-B
Clinical Trials & Observations

Maintenance therapy with thalidomide improves survival in patients with multiple myeloma
Clinical Trials & Observations

Rituximab maintenance improves clinical outcome of relapsed/resistant follicular non-Hodgkin lymphoma in patients both with and without rituximab during induction: results of a prospective randomized phase 3 intergroup trial
Clinical Trials & Observations

Prognostic significance of CD20 expression in childhood B-cell precursor acute lymphoblastic leukemia
Clinical Trials & Observations Brief Report

Assay of the von Willebrand factor (VWF) propeptide to identify patients with type 1 von Willebrand disease with decreased VWF survival
Clinical Trials & Observations

Differential effects of recombinant thrombopoietin and bone marrow stromal-conditioned media on neonatal versus adult megakaryocytes
Brief Report

A randomized phase 2 study of lenalidomide therapy for patients with relapsed or relapsed and refractory multiple myeloma
Clinical Trials & Observations

MPL515 mutations in myeloproliferative and other myeloid disorders: a study of 1182 patients
Clinical Trials & Observations

Prognostic significance of metallothionein in B-cell lymphomas
Clinical Trials & Observations

Mutation of JAK2 in the myeloproliferative disorders: timing, clonality studies, cytogenetic associations, and role in leukemic transformation
Clinical Trials & Observations

NUP214-ABL1 in adult T-ALL: the GMALL study group experience
Clinical Trials & Observations

Overexpression of CEBPA resulting from the translocation t(14;19)(q32;q13) of human precursor B acute lymphoblastic leukemia
Brief Report

Pediatric patients with essential thrombocythemia are mostly polyclonal and V617FJAK2 negative
Brief Report