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Journal Articles

A Novel Oral Prodrug AN233 Induces Fetal Hemoglobin Expression in Sickle Cell Disease Mice and Baboons

Chithra D. Palani, Abraham Nudelman, Ada W. Rephaeli, Donald E. Lavelle, Manickam Alagar, Nikhil Patel, Zhi Wenbo, Betty S. Pace

Blood (2024) 144 (Supplement 1): 1115.

https://doi.org/10.1182/blood-2024-212046

Published: 2024

Journal Articles

Collaborative Innovation: Tackling Health Disparities in Youth Living with Sickle Cell Disease through Co-Design

Keesha Roach, Betty S. Pace, Dora L Clayton-Jones, Janet Lucas, Joshua Field, Abir Bekhet, Ed Jenkins, Anne Costello, Joan Totka, Lee Za Ong, Kristin Haglund, Sylvia Pena

Blood (2024) 144 (Supplement 1): 7535.

https://doi.org/10.1182/blood-2024-210939

Published: 2024

Journal Articles

Nrf2 sensitizes ferroptosis through l-2-hydroxyglutarate–mediated chromatin modifications in sickle cell disease

Caixia Xi, Junfeng Pang, Wenbo Zhi, Chang-Sheng S. Chang, Umapathy Siddaramappa, Huidong Shi, Anatoli Horuzsko, Betty S. Pace, Xingguo Zhu

Blood (2023) 142 (4): 382–396.

https://doi.org/10.1182/blood.2022018159

Published: 2023

Includes: Supplemental data

Journal Articles

BACH1 Inhibitor Hpp-D Mediates γ-Globin Gene Activation in Sickle Erythroid Progenitors

Chithra D Palani, Xingguo Zhu, Manickam Alagar, Otis C Attucks, Betty S. Pace

Blood (2022) 140 (Supplement 1): 2521–2522.

https://doi.org/10.1182/blood-2022-169980

Published: 2022

Journal Articles

MiRNA29B Induces Fetal Hemoglobin through Targeting DNMT3 and MYB in Vitro and In Vivo in Preclinical Townes Sickle Cell Mice

Ernestine Amos-Abanyie, Chithra Palani, Alana Smith, Qingqing Gu, Ugochi Ogu, Daniel Johnson, Umapathy N Siddaramappa, Betty S. Pace, Athena Starlard-Davenport

Blood (2022) 140 (Supplement 1): 2496–2497.

https://doi.org/10.1182/blood-2022-165597

Published: 2022

Journal Articles

Development of the Novel Cytosine Analog Aza-T-Dcyd (AB1) As a Fetal Hemoglobin Inducer to Treat Sickle Cell Disease.

Manickam Alagar, Biaoru Li, Santhosh Vadivelu, Robert Schaub, Chithra D. Palani, Betty S. Pace

Blood (2022) 140 (Supplement 1): 4957–4958.

https://doi.org/10.1182/blood-2022-169657

Published: 2022

Journal Articles

Early Effects of a Repurposed Therapeutic PB-04 in Beta Thalassemia Intermedia and in Transgenic Sickle Mice

Betty S. Pace, Seyed Mehdi Nouraie, Kevin H.M. Kuo, Sylvia Singer, Mayuko Takezaki, Biaoru Li, Aidan D Faller, Abdullah Kutlar, Susan P Perrine

Blood (2022) 140 (Supplement 1): 5360–5361.

https://doi.org/10.1182/blood-2022-169310

Published: 2022

Journal Articles

A randomized, placebo-controlled, double-blind trial of canakinumab in children and young adults with sickle cell anemia

Blood (2022) 139 (17): 2642–2652.

https://doi.org/10.1182/blood.2021013674

Published: 2022

Includes: Supplemental data

Journal Articles

IMR-261, a Novel Oral Nrf2 Activator, Induces Fetal Hemoglobin in Human Erythroblasts, Reduces VOCs, and Ameliorates Ineffective Erythropoiesis in Experimental Mouse Models of Sickle Cell Disease and Beta-Thalassemia

Thiago Trovati Maciel, Caroline Carvalho, Rachel Rignault, Biree Andemariam, Betty S. Pace, Jennifer Isler OCain, Rahul Ballal

Blood (2021) 138 (Supplement 1): 853.

https://doi.org/10.1182/blood-2021-149528

Published: 2021

Journal Articles

The Benefits Trial of PB-04 to Evaluate Safety, PK, and Preliminary Efficacy in Inducing Fetal Globin Expression in Beta Thalassemia Intermedia and Sickle Cell Disease

Kevin H.M. Kuo, Sylvia Singer, Sujit Sheth, Hanny Al-Samkari, Gershwin Blyden, Lanetta Bronte-Hall, Betty S. Pace, Abdullah Kutlar, Franciscus A. Kuypers, Aidan D Faller, Seyed Mehdi Nouraie, Pramod Terse, Haksong Jin, Xin Xu, Asaf Alimardanov, Arthur J. Sytkowski, Sharie Haugabook, Susan P Perrine

Blood (2021) 138 (Supplement 1): 4159.

https://doi.org/10.1182/blood-2021-148909

Published: 2021

Journal Articles

Investigation of miRNA-29b As a Fetal Hemoglobin Inducer in Sickle Cell Disease

Athena Starlard-Davenport, Alana Smith, Qingqing Gu, Umapathy N Siddaramappa, Chithra Palani, Betty S. Pace

Blood (2021) 138 (Supplement 1): 2023.

https://doi.org/10.1182/blood-2021-153290

Published: 2021

Journal Articles

Salubrinal Mediated Fetal Hemoglobin Induction through the eIF2α-ATF4 Signaling Pathway

Nicole Hope Lopez, BS, Biaoru Li, MDPhD, Xingguo Zhu, PhD, Betty S. Pace, MD

Blood (2020) 136 (Supplement 1): 32.

https://doi.org/10.1182/blood-2020-139969

Published: 2020

Journal Articles

Double-Blind, Randomized Study of Canakinumab Treatment in Pediatric and Young Adult Patients with Sickle Cell Anemia

Blood (2019) 134 (Supplement_1): 615.

https://doi.org/10.1182/blood-2019-123355

Published: 2019

Journal Articles

Downregulation of Cytoskeletal Protein Kazrin in Lung Endothelial Cells of Preclinical Sickle Cell Disease Mouse Model - Essential Role of Endothelial Barrier Function

Umapathy N Siddaramappa, PhD, Niren Patel, MBBS, Betty S. Pace, MD, Abdullah Kutlar, MD

Blood (2019) 134 (Supplement_1): 2258.

https://doi.org/10.1182/blood-2019-130924

Published: 2019

Journal Articles

NRF2 Mediates Epigenetic Changes in DNA and Chromatin Structure to Regulate γ-Globin Gene Expression in a Human βYAC Transgenic Mouse Model

Xingguo Zhu, PhD, Alexander H. Ward, PhD, Caixia Xi, PhD, Betty S. Pace, MD

Blood (2018) 132 (Supplement 1): 1053.

https://doi.org/10.1182/blood-2018-99-116438

Published: 2018

Journal Articles

Loss of NRF2 function exacerbates the pathophysiology of sickle cell disease in a transgenic mouse model

Xingguo Zhu, Caixia Xi, Bobby Thomas, Betty S. Pace

Blood (2018) 131 (5): 558–562.

https://doi.org/10.1182/blood-2017-10-810531

Published: 2018

Includes: Supplemental data

Journal Articles

Loss of NRF2 Function Worsens the Pathophysiology of Sickle Cell Disease in a Transgenic Mouse Model

Xingguo Zhu, PhD, Betty S. Pace, MD

Blood (2017) 130 (Supplement 1): 960.

https://doi.org/10.1182/blood.V130.Suppl_1.960.960

Published: 2017

Journal Articles

Characterization of a HBB -Locus Fetal Chromatin Domain Region during Adult Erythropoiesis

Li Liu, PhD, Xingguo Zhu, PhD, Alexander Yu, PhD, Betty S. Pace, MD

Blood (2017) 130 (Supplement 1): 2223.

https://doi.org/10.1182/blood.V130.Suppl_1.2223.2223

Published: 2017

Journal Articles

Salubrinal Mediated Fetal Hemoglobin Induction through the eIF2α-ATF4 Signaling Pathway

Nicole Hope Lopez, BS, Biaoru Li, MD PhD, Levi Makala, DVM, MBA, PhD, Betty S. Pace, MD

Blood (2017) 130 (Supplement 1): 2235.

https://doi.org/10.1182/blood.V130.Suppl_1.2235.2235

Published: 2017

Journal Articles

Novel Conjugates of Butyrate and δ-Aminolevulinate Increase γ-Globin Gene Expression and Fetal Hemoglobin Synthesis in Erythroid Progenitors

Aluya R. Oseghale, BSc, Marjorie M. Johnson, BS, Xingguo Zhu, PhD, Abraham Nudelman, PhD, Ada Rephaeli, PhD, Betty S. Pace, MD

Blood (2017) 130 (Supplement 1): 3511.

https://doi.org/10.1182/blood.V130.Suppl_1.3511.3511

Published: 2017

NARROW

A Novel Oral Prodrug AN233 Induces Fetal Hemoglobin Expression in Sickle Cell Disease Mice and Baboons

Collaborative Innovation: Tackling Health Disparities in Youth Living with Sickle Cell Disease through Co-Design

Nrf2 sensitizes ferroptosis through l-2-hydroxyglutarate–mediated chromatin modifications in sickle cell disease

BACH1 Inhibitor Hpp-D Mediates γ-Globin Gene Activation in Sickle Erythroid Progenitors

MiRNA29B Induces Fetal Hemoglobin through Targeting DNMT3 and MYB in Vitro and In Vivo in Preclinical Townes Sickle Cell Mice

Development of the Novel Cytosine Analog Aza-T-Dcyd (AB1) As a Fetal Hemoglobin Inducer to Treat Sickle Cell Disease.

Early Effects of a Repurposed Therapeutic PB-04 in Beta Thalassemia Intermedia and in Transgenic Sickle Mice

A randomized, placebo-controlled, double-blind trial of canakinumab in children and young adults with sickle cell anemia

IMR-261, a Novel Oral Nrf2 Activator, Induces Fetal Hemoglobin in Human Erythroblasts, Reduces VOCs, and Ameliorates Ineffective Erythropoiesis in Experimental Mouse Models of Sickle Cell Disease and Beta-Thalassemia

The Benefits Trial of PB-04 to Evaluate Safety, PK, and Preliminary Efficacy in Inducing Fetal Globin Expression in Beta Thalassemia Intermedia and Sickle Cell Disease

Investigation of miRNA-29b As a Fetal Hemoglobin Inducer in Sickle Cell Disease

Salubrinal Mediated Fetal Hemoglobin Induction through the eIF2α-ATF4 Signaling Pathway

Double-Blind, Randomized Study of Canakinumab Treatment in Pediatric and Young Adult Patients with Sickle Cell Anemia

Downregulation of Cytoskeletal Protein Kazrin in Lung Endothelial Cells of Preclinical Sickle Cell Disease Mouse Model - Essential Role of Endothelial Barrier Function

NRF2 Mediates Epigenetic Changes in DNA and Chromatin Structure to Regulate γ-Globin Gene Expression in a Human βYAC Transgenic Mouse Model

Loss of NRF2 function exacerbates the pathophysiology of sickle cell disease in a transgenic mouse model

Loss of NRF2 Function Worsens the Pathophysiology of Sickle Cell Disease in a Transgenic Mouse Model

Characterization of a HBB -Locus Fetal Chromatin Domain Region during Adult Erythropoiesis

Salubrinal Mediated Fetal Hemoglobin Induction through the eIF2α-ATF4 Signaling Pathway

Novel Conjugates of Butyrate and δ-Aminolevulinate Increase γ-Globin Gene Expression and Fetal Hemoglobin Synthesis in Erythroid Progenitors

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American Society of Hematology

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American Society of Hematology

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