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Journal Articles

Pharmacokinetics/Pharmacodynamics, Safety, and Efficacy of Crizanlizumab in Patients with Sickle Cell Disease Aged 6 to <12 Years: 2-Year Data from the Phase 2 Solace-Kids Study

Matthew M. Heeney, David C Rees, Slimane Allali, Isaac Odame, Rodolfo D Cançado, Adlette Inati, Elena Cela, Deborah Keefe, Evgeniya Reshetnyak, Velusamy Shanmuganathan Muthusamy, Lidiya Bebrevska, Michele L Nassin, Julie Kanter

Blood (2024) 144 (Supplement 1): 180.

https://doi.org/10.1182/blood-2024-207207

Published: 2024

Journal Articles

The Darc Side of Vivax Malaria in Africa: Unveiling Invasion Pathways into Duffy-Negative Erythroblasts

Isabelle Bouyssou, Sara El Hoss, Cécile Doderer-Lang, Matthieu Schoenhals, Lova Tsikiniaina Rasoloharimanana, Inès Vigan-Womas, Arsène Ratsimbasoa, David C Rees, Andargie Abate, Lemu Golassa, Solenne Mabilotte, Micheline Guillotte, Francisco J. Martinez Blazquez, Chetan E. Chitnis, John Strouboulis, Didier Ménard

Blood (2023) 142 (Supplement 1): 1074.

https://doi.org/10.1182/blood-2023-184938

Published: 2023

Journal Articles

Unravelling the Mechanism behind Ineffective Erythropoiesis in Sickle Cell Disease: The Role of GATA-1

Sara El Hoss, Panicos Shangaris, John Brewin, Maria Eleni Psychogyiou, Cecilia Ng, Kypros Herodotos Nicolaides, Nicola Conran, David C Rees, John Strouboulis

Blood (2023) 142 (Supplement 1): 2458.

https://doi.org/10.1182/blood-2023-178851

Published: 2023

Journal Articles

Decreased Red Blood Cell Deformability Contributes to Loss of Splenic Filtration Function and Variations in Spleen Size in Children with Sickle Cell Anaemia

Amina Nardo-Marino, Andreas Glenthøj, John N. Brewin, Jesper Petersen, Thomas H. Braunstein, Jørgen A.L. Kurtzhals, Thomas N. Williams, David C. Rees

Blood (2022) 140 (Supplement 1): 1639–1640.

https://doi.org/10.1182/blood-2022-165460

Published: 2022

Journal Articles

A randomized, placebo-controlled, double-blind trial of canakinumab in children and young adults with sickle cell anemia

Blood (2022) 139 (17): 2642–2652.

https://doi.org/10.1182/blood.2021013674

Published: 2022

Includes: Supplemental data

Journal Articles

Initial Safety and Efficacy Results from the Phase II, Multicenter, Open-Label Solace-Kids Trial of Crizanlizumab in Adolescents with Sickle Cell Disease (SCD)

Matthew M. Heeney, David C. Rees, Mariane De Montalembert, Isaac Odame, R. Clark Clark Brown, Yasser Wali, Thu Thuy Nguyen, Du Lam, Nadege Pfender, Julie Kanter

Blood (2021) 138 (Supplement 1): 12.

https://doi.org/10.1182/blood-2021-144730

Published: 2021

Journal Articles

Two brothers with a novel KLF1 mutation

Robin M. Ireland, David C. Rees

Blood (2021) 138 (12): 1087.

https://doi.org/10.1182/blood.2021011704

Published: 2021

Journal Articles

Hydroxyurea: coming to conclusions on safety

David C. Rees

Blood (2021) 137 (6): 728–729.

https://doi.org/10.1182/blood.2020008803

Published: 2021

Journal Articles

Study Design and Initial Baseline Characteristics in Solace-Kids: Crizanlizumab in Pediatric Patients with Sickle Cell Disease

Matthew M. Heeney, MD, David C. Rees, MD, Mariane de Montalembert, MD PhD, Isaac Odame, MD, R. Clark Brown, MD PhD, Yasser Wali, MD, Thu Thuy Nguyen, Du Lam, MD, Raquel Merino Herranz, Julie Kanter, MD

Blood (2020) 136 (Supplement 1): 22–24.

https://doi.org/10.1182/blood-2020-137081

Published: 2020

Journal Articles

Eighteen-Month Interim Analysis of Efficacy and Safety of Givosiran, an RNAi Therapeutic for Acute Hepatic Porphyria, in the Envision Open Label Extension

David J. Kuter, MD, Sioban Keel, MD, Charles J. Parker, MD, David C. Rees, MD, Ulrich Stölzel, MD, Paolo Ventura, MD, Manisha Balwani, Laurent Gouya, MD, PhD, Amy Simon, MD, Shangbin Liu, PhD, John J Ko, PharmD,MSc, Sean Rhyee, MD, M.P.H, Samuel M. Silver, MD PhD

Blood (2020) 136 (Supplement 1): 13.

https://doi.org/10.1182/blood-2020-134564

Published: 2020

Journal Articles

Whole Exome Sequencing in Children with Sickle Cell Anemia Who Developed Ischemic Stroke Prior to 4 Years of Age Reveals a Strong Association with Inherited Dyslipidemias

John N. Brewin, Riley Cook, MD, Alexander E Smith, PhD, Valentine Brousse, MD PhD, Julie Brent, MD, Sanjay Tewari, FRCPath, MBBS, Baba PD Inusa, MD, Stephan Menzel, MD PhD, David C Rees

Blood (2019) 134 (Supplement_1): 3571.

https://doi.org/10.1182/blood-2019-123764

Published: 2019

Journal Articles

Double-Blind, Randomized Study of Canakinumab Treatment in Pediatric and Young Adult Patients with Sickle Cell Anemia

Blood (2019) 134 (Supplement_1): 615.

https://doi.org/10.1182/blood-2019-123355

Published: 2019

Journal Articles

Red Blood Cell Deformability Demonstrated with the Oxygenscan: Exploring the Association with Hydroxyurea Treatment, Co-Inherited α-Thalassemia, and Frequency of Pain in Children with Sickle Cell Anemia

Amina Nardo-Marino, Jesper Petersen, Andreas Glenthoej, MD PhD, John N. Brewin, Joergen Kurtzhals, Thomas N. Williams, David C. Rees, Henrik Birgens

Blood (2019) 134 (Supplement_1): 4834.

https://doi.org/10.1182/blood-2019-129836

Published: 2019

Journal Articles

A Review of 1000 Molecular Investigations of Rare Inherited Anaemia and Related Conditions with the Red Cell Gene Panel

Rachel Mayhew, Frances Smith, Laura Steedman, Nicholas Parkin, Eva Moldes Beiro, Peter Rushton, Alison Bybee, David Brawand, Judith Marsh, Austin G. Kulasekararaj, MBBS, MD MRCP, FRCPath, Shreyans Ghandi, Sahar Mansour, Ghulam Mufti, Antonio Pagliuca, Subarna Chakravorty, David C Rees, Barnaby Clark

Blood (2018) 132 (Supplement 1): 3609.

https://doi.org/10.1182/blood-2018-99-118799

Published: 2018

Journal Articles

Hemoglobin S Induces Exposure of Red Blood Cell Membrane Skeleton Microdomains Bearing Mannose That Stimulate Phagocytosis By Macrophages: A Molecular Basis for Hemolysis in Sickle Cell Disease but Protection Against Plasmodium Falciparum malaria

Blood (2018) 132 (Supplement 1): 3642.

https://doi.org/10.1182/blood-2018-99-117290

Published: 2018

Journal Articles

Lipid metabolism in terminal erythropoiesis

John S. Gibson, David C. Rees

Blood (2018) 131 (26): 2872–2874.

https://doi.org/10.1182/blood-2018-05-850255

Published: 2018

Journal Articles

Prevalence of High Body Mass Index in Children with Sickle Cell Disease and Its Correlation of Disease Severity

Rachael Hall, Kate Gardner, MA, MRCP, MBBS, David C Rees, MA, MBBS, FRCP, Subarna Chakravorty, MBBS, PhD FRCPath, MRCP

Blood (2017) 130 (Supplement 1): 3553.

https://doi.org/10.1182/blood.V130.Suppl_1.3553.3553

Published: 2017

Journal Articles

Prevention of Morbidity in Sickle Cell Disease Phase II (Improvement of Cognition in children with Sickle Cell Disease with Auto-adjusting Continuous Positive Airways Pressure: Phase II) (POMS 2b paediatric cohort)

April E Slee, Jamie M Kawadler, PhD, Melanie Koelbel, MSc, Hanne Stotesbury, MSc, David C Rees, MD, Maria Pelidis, MD, Jo Howard, MBBCh, Swee Lay Thein, DSc,FRCP,FRCPath,MBBS,MRCPath,MRCP, Simon Skene, PhD, Sahota Sati, BSc, Carol Nwosu, BSc, Maureen Gwam, BSc, Dawn Saunders, MD, Johanna C Gavlak, PhD, Gupta Atul, MD, Simrat Sarkaria, Christina Liossi, PhD, Fenella J Kirkham, MD, Baba Inusa, MD MRCP

Blood (2017) 130 (Supplement 1): 3556.

https://doi.org/10.1182/blood.V130.Suppl_1.3556.3556

Published: 2017

Journal Articles

Explore: A Prospective, Multinational Natural History Study of Patients with Acute Hepatic Porphyrias (AHP) with Recurrent Attacks

Blood (2017) 130 (Supplement 1): 2211.

https://doi.org/10.1182/blood.V130.Suppl_1.2211.2211

Published: 2017

Journal Articles

Exteriorisation of Mannoses on Human Erythrocyte Membrane Skeleton Provides 'Eat Me' Signals for Oxidatively Damaged Cells to be Cleared By Macrophages: A Pathway Mediating Hemolysis in Sickle Cell Disease

Mark A Vickers, MD MA, MBBChir, Robert N Barker, Bsc BVSc PhD, Huan Cao, MA PhD, Heather J Wassall, BSc PhD, Megan A Forrester, MA PhD, Lindsay S Hall, BSc PhD, Michael Moss, Bsc PhD, Sadie Henderson, BSc, Gabriela Konieczny, BSc, Minter Beverly, BSc PhD, Jenna Shepherd, B MDSci, Stuart M Haslam, BSc PhD, David C Rees, MA, MBBS, FRCP, Heather M Wilson, BSc PhD, Dimitrios Tampakis, BSc, Maria-Louise Williams, BSc

Blood (2017) 130 (Supplement 1): 919.

https://doi.org/10.1182/blood.V130.Suppl_1.919.919

Published: 2017

NARROW

Pharmacokinetics/Pharmacodynamics, Safety, and Efficacy of Crizanlizumab in Patients with Sickle Cell Disease Aged 6 to <12 Years: 2-Year Data from the Phase 2 Solace-Kids Study

The Darc Side of Vivax Malaria in Africa: Unveiling Invasion Pathways into Duffy-Negative Erythroblasts

Unravelling the Mechanism behind Ineffective Erythropoiesis in Sickle Cell Disease: The Role of GATA-1

Decreased Red Blood Cell Deformability Contributes to Loss of Splenic Filtration Function and Variations in Spleen Size in Children with Sickle Cell Anaemia

A randomized, placebo-controlled, double-blind trial of canakinumab in children and young adults with sickle cell anemia

Initial Safety and Efficacy Results from the Phase II, Multicenter, Open-Label Solace-Kids Trial of Crizanlizumab in Adolescents with Sickle Cell Disease (SCD)

Two brothers with a novel KLF1 mutation

Hydroxyurea: coming to conclusions on safety

Study Design and Initial Baseline Characteristics in Solace-Kids: Crizanlizumab in Pediatric Patients with Sickle Cell Disease

Eighteen-Month Interim Analysis of Efficacy and Safety of Givosiran, an RNAi Therapeutic for Acute Hepatic Porphyria, in the Envision Open Label Extension

Whole Exome Sequencing in Children with Sickle Cell Anemia Who Developed Ischemic Stroke Prior to 4 Years of Age Reveals a Strong Association with Inherited Dyslipidemias

Double-Blind, Randomized Study of Canakinumab Treatment in Pediatric and Young Adult Patients with Sickle Cell Anemia

Red Blood Cell Deformability Demonstrated with the Oxygenscan: Exploring the Association with Hydroxyurea Treatment, Co-Inherited α-Thalassemia, and Frequency of Pain in Children with Sickle Cell Anemia

A Review of 1000 Molecular Investigations of Rare Inherited Anaemia and Related Conditions with the Red Cell Gene Panel

Hemoglobin S Induces Exposure of Red Blood Cell Membrane Skeleton Microdomains Bearing Mannose That Stimulate Phagocytosis By Macrophages: A Molecular Basis for Hemolysis in Sickle Cell Disease but Protection Against Plasmodium Falciparum malaria

Lipid metabolism in terminal erythropoiesis

Prevalence of High Body Mass Index in Children with Sickle Cell Disease and Its Correlation of Disease Severity

Prevention of Morbidity in Sickle Cell Disease Phase II (Improvement of Cognition in children with Sickle Cell Disease with Auto-adjusting Continuous Positive Airways Pressure: Phase II) (POMS 2b paediatric cohort)

Explore: A Prospective, Multinational Natural History Study of Patients with Acute Hepatic Porphyrias (AHP) with Recurrent Attacks

Exteriorisation of Mannoses on Human Erythrocyte Membrane Skeleton Provides 'Eat Me' Signals for Oxidatively Damaged Cells to be Cleared By Macrophages: A Pathway Mediating Hemolysis in Sickle Cell Disease

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American Society of Hematology

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American Society of Hematology

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