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Thomas N. Williams
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Journal Articles

Hydroxyurea Treatment Reduces Infection Rates in African Children with Sickle Cell Anemia

Thomas N. Williams, Teresa S. Latham, George A. Tomlinson, Peter Olupot-Olupot, Brigida Santos, Leon Tshilolo, Adam C. Lane, Banu Aygun, Susan E. Stuber, Luke R. Smart, Russell E. Ware
Journal: Blood
Blood (2024) 144 (Supplement 1): 545.
https://doi.org/10.1182/blood-2024-210347
Published: 2024
Journal Articles

Growth and Puberty in African Children with Sickle Cell Anemia Treated with Hydroxyurea

Philippe Backeljauw, George A. Tomlinson, Luke R. Smart, Leon Tshilolo, Thomas N. Williams, Brigida Santos, Peter Olupot-Olupot, Susan E. Stuber, Adam C. Lane, Teresa S. Latham, Russell E. Ware
Journal: Blood
Blood (2024) 144 (Supplement 1): 544.
https://doi.org/10.1182/blood-2024-205848
Published: 2024
Journal Articles

RED Blood Cell Alloimmunization in Sickle Cell Anaemia Patients in Kilifi, Kenya

Sophie Uyoga, Michael Muteti, Johnstone Makale, George Mochamah, Russell E. Ware, Thomas N. Williams
Journal: Blood
Blood (2024) 144 (Supplement 1): 5602.
https://doi.org/10.1182/blood-2024-206754
Published: 2024
Journal Articles

Growth Curves for Children Living with Sickle Cell Anemia in Kilifi County, Kenya, Do Not Follow Who Curves for Normal Children

Thomas N. Williams, George Mochamah, Sophie Uyoga, Gideon Nyutu, Teresa S. Latham, Philippe Backeljauw, Russell E. Ware, George A. Tomlinson
Journal: Blood
Blood (2024) 144 (Supplement 1): 5315.
https://doi.org/10.1182/blood-2024-208843
Published: 2024
Journal Articles

Hydroxyurea Dose Optimization Is Safe and Improves Outcomes for Children with Sickle Cell Anemia Living in Sub-Saharan Africa: The Reach Experience

Banu Aygun, Adam C. Lane, Luke R. Smart, Leon Tshilolo, Thomas N. Williams, Peter Olupot-Olupot, Brigida Santos, Susan E. Stuber, George A. Tomlinson, Teresa S. Latham, Russell E. Ware
Journal: Blood
Blood (2023) 142 (Supplement 1): 6.
https://doi.org/10.1182/blood-2023-172919
Published: 2023
Journal Articles

Hydroxyurea treatment is associated with lower malaria incidence in children with sickle cell anemia in sub-Saharan Africa

Clinical Trials & Observations
Peter Olupot-Olupot, George Tomlinson, Thomas N. Williams, Léon Tshilolo, Brígida Santos, Luke R. Smart, Kathryn McElhinney, Thad A. Howard, Banu Aygun, Susan E. Stuber, Adam Lane, Teresa S. Latham, Russell E. Ware
Journal: Blood
Blood (2023) 141 (12): 1402–1410.
https://doi.org/10.1182/blood.2022017051
Published: 2023
Includes: Supplemental data
Journal Articles

Decreased Red Blood Cell Deformability Contributes to Loss of Splenic Filtration Function and Variations in Spleen Size in Children with Sickle Cell Anaemia

Amina Nardo-Marino, Andreas Glenthøj, John N. Brewin, Jesper Petersen, Thomas H. Braunstein, Jørgen A.L. Kurtzhals, Thomas N. Williams, David C. Rees
Journal: Blood
Blood (2022) 140 (Supplement 1): 1639–1640.
https://doi.org/10.1182/blood-2022-165460
Published: 2022
Journal Articles

Hydroxyurea Reduces the Transfusion Burden in Children with Sickle Cell Anemia: The Reach Experience

Alexandra Power-Hays, George A. Tomlinson, Leon Tshilolo, Brigida Santos, Thomas N. Williams, Peter Olupot-Olupot, Patrick T. McGann, Banu Aygun, Adam Lane, Susan E. Stuber, Teresa Latham, Russell E. Ware
Journal: Blood
Blood (2021) 138 (Supplement 1): 11.
https://doi.org/10.1182/blood-2021-146632
Published: 2021
Journal Articles

Novel Genetic Loci That Influence Fetal Hemoglobin Expression in Children with Sickle Cell Anemia

Anu Marahatta, PhD, Thad A. Howard, MS, Susan E. Stuber, MA, Kathryn L McElhinney, BS, Leon Tshilolo, MDPhD, Thomas N. Williams, MDPhD, Peter Olupot-Olupot, MDPhD, Brigida Santos, MD, Chandy C. John, MD MS, Robert Opoka, MMED, Rosa M. Nieves, MD, Rafael Mena, MD, Jasmine Baker, PhD, Teresa Latham, MA, Jonathan M. Flanagan, PhD, Russell E. Ware, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 33–34.
https://doi.org/10.1182/blood-2020-143025
Published: 2020
Journal Articles

Building Capacity and Assessing Stroke Risk with Transcranial Doppler Ultrasonography in Sub-Saharan Africa: The Reach Experience

Brigida Santos, MD, Maria Nakafeero, Adam Lane, PhD, Leon Tshilolo, MDPhD, Thomas N. Williams, MDPhD, Peter Olupot-Olupot, MDPhD, Janet Adams, Banu Aygun, MD, Susan E. Stuber, MA, George A. Tomlinson, PhD BSc, MSc, Teresa Latham, MA, Patrick T. McGann, MD MS, Russell E. Ware, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 17–18.
https://doi.org/10.1182/blood-2020-142318
Published: 2020
Journal Articles

Optimizing Hydroxyurea Therapy with Reduced Laboratory Monitoring for Children with Sickle Cell Anemia in Sub-Saharan Africa: The Reach Experience

Banu Aygun, MD, George A. Tomlinson, PhD BSc, MSc, Patrick T. McGann, MD MS, Leon Tshilolo, MDPhD, Thomas N. Williams, MDPhD, Peter Olupot-Olupot, MDPhD, Brigida Santos, MD, Susan E. Stuber, MA, Adam Lane, PhD, Teresa Latham, MA, Russell E. Ware, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 17.
https://doi.org/10.1182/blood-2020-134180
Published: 2020
Journal Articles

Genetic Variants That Influence Fetal Hemoglobin Expression from Hydroxyurea Treatment

Anu Marahatta, PhD, Jonathan M. Flanagan, PhD, Thad A. Howard, MS, Nicole Mortier, MHS, PA-C, William Schultz, MHS, PA, Kathryn L McElhinney, BS, Leon Tshilolo, MDPhD, Thomas N. Williams, MDPhD, Peter Olupot-Olupot, MDPhD, Brigida Santos, MD, Chandy C. John, MD MS, Robert Opoka, MMED, Rosa M. Nieves, MD, Rafael Mena, MD, Marvin E Reid, MB, BS, PhD, Angela Rankine-Mullings, MBBS, Jasmine Baker, PhD, Patrick T. McGann, MD MS, Banu Aygun, MD, Adam Lane, PhD, George A. Tomlinson, PhD BSc, MSc, Teresa Latham, MA, Susan E. Stuber, MA, Russell E. Ware, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 8–9.
https://doi.org/10.1182/blood-2020-143139
Published: 2020
Journal Articles

Effects of Hydroxyurea Treatment on Malaria Infections in Sub-Saharan Africa

Peter Olupot-Olupot, George A. Tomlinson, PhD BSc, MSc, Teresa S. Latham, MA, Patrick T. McGann, MD, Brigida Santos, Banu Aygun, MD, Susan Stuber, MA, Leon Tshilolo, MD PhD, Adam Lane, PhD, Thomas N. Williams, Russell E. Ware, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 522.
https://doi.org/10.1182/blood-2019-129251
Published: 2019
Journal Articles

Red Blood Cell Deformability Demonstrated with the Oxygenscan: Exploring the Association with Hydroxyurea Treatment, Co-Inherited α-Thalassemia, and Frequency of Pain in Children with Sickle Cell Anemia

Amina Nardo-Marino, Jesper Petersen, Andreas Glenthoej, MD PhD, John N. Brewin, Joergen Kurtzhals, Thomas N. Williams, David C. Rees, Henrik Birgens
Journal: Blood
Blood (2019) 134 (Supplement_1): 4834.
https://doi.org/10.1182/blood-2019-129836
Published: 2019
Journal Articles

Splenomegaly in Children with Sickle Cell Anemia Receiving Hydroxyurea in Sub-Saharan Africa

Leon Tshilolo, MD PhD, George A. Tomlinson, PhD BSc, MSc, Patrick T. McGann, MD, Teresa S. Latham, MA, Peter Olupot-Olupot, Brigida Santos, Banu Aygun, MD, Susan Stuber, MA, Adam Lane, PhD, Thomas N. Williams, Russell E. Ware, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 993.
https://doi.org/10.1182/blood-2019-129937
Published: 2019
Journal Articles

Realizing Effectiveness across Continents with Hydroxyurea (REACH): A Prospective Multi-National Trial of Hydroxyurea for Sickle Cell Anemia in Sub-Saharan Africa

Leon Tshilolo, MDPhD, George Tomlinson, Thomas N. Williams, Brigida Santos, Peter Olupot-Olupot, Adam Lane, PhD, Banu Aygun, MD, Susan Stuber, MA, Teresa Latham, MA, Patrick T. McGann, MD, Russell E. Ware, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3.
https://doi.org/10.1182/blood-2018-99-113818
Published: 2018
Journal Articles

Subphenotypes of sickle cell disease in Africa

Frédéric B. Piel, Thomas N. Williams
Journal: Blood
Blood (2017) 130 (20): 2157–2158.
https://doi.org/10.1182/blood-2017-10-808550
Published: 2017
Journal Articles

Combinatorial effects of malaria season, iron deficiency, and inflammation determine plasma hepcidin concentration in African children

Clinical Trials & Observations
Sarah H. Atkinson, Andrew E. Armitage, Shivani Khandwala, Tabitha W. Mwangi, Sophie Uyoga, Philip A. Bejon, Thomas N. Williams, Andrew M. Prentice, Hal Drakesmith
Journal: Blood
Blood (2014) 123 (21): 3221–3229.
https://doi.org/10.1182/blood-2013-10-533000
Published: 2014
Includes: Supplemental data
Journal Articles

Epistasis between the haptoglobin common variant and α + thalassemia influences risk of severe malaria in Kenyan children

Clinical Trials & Observations
Sarah H. Atkinson, Sophie M. Uyoga, Emily Nyatichi, Alex W. Macharia, Gideon Nyutu, Carolyne Ndila, Dominic P. Kwiatkowski, Kirk A. Rockett, Thomas N. Williams
Journal: Blood
Blood (2014) 123 (13): 2008–2016.
https://doi.org/10.1182/blood-2013-10-533489
Published: 2014
Journal Articles

High mortality from Plasmodium falciparum malaria in children living with sickle cell anemia on the coast of Kenya

Clinical Trials & Observations
Charlotte F. McAuley, Clare Webb, Julie Makani, Alexander Macharia, Sophie Uyoga, Daniel H. Opi, Carolyne Ndila, Antony Ngatia, John Anthony G. Scott, Kevin Marsh, Thomas N. Williams
Journal: Blood
Blood (2010) 116 (10): 1663–1668.
https://doi.org/10.1182/blood-2010-01-265249
Published: 2010