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Journal Articles

Community Health Worker and Mobile Health Programs to Help Young Adults with Sickle Cell Disease Transition to Using Adult Healthcare Services – the Comets Study; Results from Patient-Reported Outcomes at 6 Months

Sophia Jan, Caren Steinway, Tanisha Belton, Justine Shults, Laura Bennett, Heather Griffis, Banu Aygun, Abena Appiah-Kubi, Nataly Apollonsky, Donna Boruchov, Omar Niss, Lisa A. Schwartz, Lori E. Crosby, Lamia Barakat, Biree Andemariam, David Rubin, Kim Smith-Whitley
Journal: Blood
Blood (2024) 144 (Supplement 1): 1066.
https://doi.org/10.1182/blood-2024-205273
Published: 2024
Journal Articles

Hydroxyurea Treatment Reduces Infection Rates in African Children with Sickle Cell Anemia

Thomas N. Williams, Teresa S. Latham, George A. Tomlinson, Peter Olupot-Olupot, Brigida Santos, Leon Tshilolo, Adam C. Lane, Banu Aygun, Susan E. Stuber, Luke R. Smart, Russell E. Ware
Journal: Blood
Blood (2024) 144 (Supplement 1): 545.
https://doi.org/10.1182/blood-2024-210347
Published: 2024
Journal Articles

Community Health Worker Engagement with Adolescents and Young Adults with Sickle Cell Disease: Findings from the Comets Study

Jayanne Forrest, Caren Steinway, Eelia Shaw, Sophia Jan, Banu Aygun, Abena Appiah-Kubi, Nataly Apollonsky, Donna Boruchov, Omar Niss, Biree Andemariam, Kim Smith-Whitley, Symme Trachtenberg, Tanisha Belton
Journal: Blood
Blood (2024) 144 (Supplement 1): 617.
https://doi.org/10.1182/blood-2024-206036
Published: 2024
Journal Articles

Habit Efficacy Trial: A Multi-Site Randomized Controlled Trial of Community Health Worker Support to Increase Hydroxyurea Adherence of Youth with Sickle Cell Disease

Nancy S. Green, Deepa Manwani, Banu Aygun, Abena Appiah-Kubi, Kim Smith-Whitley, Haomiao Jia, Arlene Smaldone
Journal: Blood
Blood (2023) 142 (Supplement 1): 3901.
https://doi.org/10.1182/blood-2023-190031
Published: 2023
Journal Articles

Efficacy, Safety, and Health-Related Quality of Life (HRQOL) in Patients with Sickle Cell Disease (SCD) Who Have Received Lovotibeglogene Autotemcel (Lovo-cel) Gene Therapy: Up to 60 Months of Follow-up

Julie Kanter, Alexis A. Thompson, Janet L. Kwiatkowski, Suhag Parikh, Markus Mapara, Stacey Rifkin-Zenenberg, Banu Aygun, Kimberly A. Kasow, Ashish O. Gupta, Lixin Zhang, Emily Sheldon-Waniga, Meghan Gallagher, Katiana Gruppioni, Anjulika Chawla, Heidi Elliot, Francis J. Pierciey, Mark C. Walters, John F. Tisdale
Journal: Blood
Blood (2023) 142 (Supplement 1): 1051.
https://doi.org/10.1182/blood-2023-174229
Published: 2023
Journal Articles

Hydroxyurea Dose Optimization Is Safe and Improves Outcomes for Children with Sickle Cell Anemia Living in Sub-Saharan Africa: The Reach Experience

Banu Aygun, Adam C. Lane, Luke R. Smart, Leon Tshilolo, Thomas N. Williams, Peter Olupot-Olupot, Brigida Santos, Susan E. Stuber, George A. Tomlinson, Teresa S. Latham, Russell E. Ware
Journal: Blood
Blood (2023) 142 (Supplement 1): 6.
https://doi.org/10.1182/blood-2023-172919
Published: 2023
Journal Articles

Hydroxyurea treatment is associated with lower malaria incidence in children with sickle cell anemia in sub-Saharan Africa

Clinical Trials & Observations
Peter Olupot-Olupot, George Tomlinson, Thomas N. Williams, Léon Tshilolo, Brígida Santos, Luke R. Smart, Kathryn McElhinney, Thad A. Howard, Banu Aygun, Susan E. Stuber, Adam Lane, Teresa S. Latham, Russell E. Ware
Journal: Blood
Blood (2023) 141 (12): 1402–1410.
https://doi.org/10.1182/blood.2022017051
Published: 2023
Includes: Supplemental data
Journal Articles

Lovo-cel (bb1111) Gene Therapy for Sickle Cell Disease: Updated Clinical Results and Investigations into Two Cases of Anemia from Group C of the Phase 1/2 HGB-206 Study

Mark C. Walters, Alexis A. Thompson, Janet L. Kwiatkowski, Suhag Parikh, Markus Y. Mapara, Stacey Rifkin-Zenenberg, Banu Aygun, Kimberly A. Kasow, Alex Miller, Lixin Zhang, Anjulika Chawla, Elizabeth R. Macari, Francis J. Pierciey, Jr., John F. Tisdale, Julie Kanter
Journal: Blood
Blood (2022) 140 (Supplement 1): 26–28.
https://doi.org/10.1182/blood-2022-162288
Published: 2022
Journal Articles

Assessing Multi-Level Barriers to Medication Adherence in Youth with Sickle Cell Disease Using Pharmacy-Based Prescription Refill Data

Arlene Smaldone, Deepa Manwani, Banu Aygun, Abena Appiah-Kubi, Kim Smith-Whitley, Nancy S. Green
Journal: Blood
Blood (2022) 140 (Supplement 1): 2149–2150.
https://doi.org/10.1182/blood-2022-157527
Published: 2022
Journal Articles

Polyclonality Strongly Correlates with Biological Outcomes and Is Significantly Increased Following Improvements to the Phase 1/2 HGB-206 Protocol and Manufacturing of LentiGlobin for Sickle Cell Disease (SCD; bb1111) Gene Therapy (GT)

John F. Tisdale, Alexis A. Thompson, Markus Y. Mapara, Janet L. Kwiatkowski, Lakshmanan Krishnamurti, Banu Aygun, Kimberly A. Kasow, Stacey Rifkin-Zenenberg, Manfred Schmidt, Francis J. Pierciey, Jr., Dustin Whitney, Cynthia Rogers, Mauris Nnamani, Marianna Foos, Alex Miller, Xinyan Zhang, Jessie Lynch, Mark C. Walters, Julie Kanter, Melissa Bonner
Journal: Blood
Blood (2021) 138 (Supplement 1): 561.
https://doi.org/10.1182/blood-2021-147760
Published: 2021
Journal Articles

Hydroxyurea Reduces the Transfusion Burden in Children with Sickle Cell Anemia: The Reach Experience

Alexandra Power-Hays, George A. Tomlinson, Leon Tshilolo, Brigida Santos, Thomas N. Williams, Peter Olupot-Olupot, Patrick T. McGann, Banu Aygun, Adam Lane, Susan E. Stuber, Teresa Latham, Russell E. Ware
Journal: Blood
Blood (2021) 138 (Supplement 1): 11.
https://doi.org/10.1182/blood-2021-146632
Published: 2021
Journal Articles

Sustained Improvements in Patient-Reported Quality of Life up to 24 Months Post-Treatment with LentiGlobin for Sickle Cell Disease (bb1111) Gene Therapy

Mark C. Walters, John F. Tisdale, Markus Y. Mapara, Lakshmanan Krishnamurti, Janet L. Kwiatkowski, Banu Aygun, Kimberly A. Kasow, Stacey Rifkin-Zenenberg, Jennifer Jaroscak, Diana Garbinsky, Costel Chirila, Meghan E. Gallagher, Xinyan Zhang, Pei-Ran Ho, Alexis A. Thompson, Julie Kanter
Journal: Blood
Blood (2021) 138 (Supplement 1): 7.
https://doi.org/10.1182/blood-2021-146905
Published: 2021
Journal Articles

Resolution of Serious Vaso-Occlusive Pain Crises and Reduction in Patient-Reported Pain Intensity: Results from the Ongoing Phase 1/2 HGB-206 Group C Study of LentiGlobin for Sickle Cell Disease (bb1111) Gene Therapy

Alexis A. Thompson, MD, Mark C. Walters, MD, Markus Y Mapara, MD PhD, Janet L. Kwiatkowski, MD MSCE, Lakshmanan Krishnamurti, MD, Banu Aygun, MD, Kimberly A. Kasow, DO, Stacey Rifkin-Zenenberg, DO, Manfred Schmidt, PhD, Jay DelCarpini, Francis J. Pierciey, Jr., Alexandra L. Miller, Meghan E. Gallagher, MSc, Ren Chen, Sunita Goyal, MD, Julie Kanter, MD, John F. Tisdale, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 16–17.
https://doi.org/10.1182/blood-2020-134940
Published: 2020
Journal Articles

Building Capacity and Assessing Stroke Risk with Transcranial Doppler Ultrasonography in Sub-Saharan Africa: The Reach Experience

Brigida Santos, MD, Maria Nakafeero, Adam Lane, PhD, Leon Tshilolo, MDPhD, Thomas N. Williams, MDPhD, Peter Olupot-Olupot, MDPhD, Janet Adams, Banu Aygun, MD, Susan E. Stuber, MA, George A. Tomlinson, PhD BSc, MSc, Teresa Latham, MA, Patrick T. McGann, MD MS, Russell E. Ware, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 17–18.
https://doi.org/10.1182/blood-2020-142318
Published: 2020
Journal Articles

Optimizing Hydroxyurea Therapy with Reduced Laboratory Monitoring for Children with Sickle Cell Anemia in Sub-Saharan Africa: The Reach Experience

Banu Aygun, MD, George A. Tomlinson, PhD BSc, MSc, Patrick T. McGann, MD MS, Leon Tshilolo, MDPhD, Thomas N. Williams, MDPhD, Peter Olupot-Olupot, MDPhD, Brigida Santos, MD, Susan E. Stuber, MA, Adam Lane, PhD, Teresa Latham, MA, Russell E. Ware, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 17.
https://doi.org/10.1182/blood-2020-134180
Published: 2020
Journal Articles

Genetic Variants That Influence Fetal Hemoglobin Expression from Hydroxyurea Treatment

Anu Marahatta, PhD, Jonathan M. Flanagan, PhD, Thad A. Howard, MS, Nicole Mortier, MHS, PA-C, William Schultz, MHS, PA, Kathryn L McElhinney, BS, Leon Tshilolo, MDPhD, Thomas N. Williams, MDPhD, Peter Olupot-Olupot, MDPhD, Brigida Santos, MD, Chandy C. John, MD MS, Robert Opoka, MMED, Rosa M. Nieves, MD, Rafael Mena, MD, Marvin E Reid, MB, BS, PhD, Angela Rankine-Mullings, MBBS, Jasmine Baker, PhD, Patrick T. McGann, MD MS, Banu Aygun, MD, Adam Lane, PhD, George A. Tomlinson, PhD BSc, MSc, Teresa Latham, MA, Susan E. Stuber, MA, Russell E. Ware, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 8–9.
https://doi.org/10.1182/blood-2020-143139
Published: 2020
Journal Articles

Mental Health Assessment of Youth with Sickle Cell Disease and Their Primary Caretakers: Baseline Depression and COVID-19 Pandemic-Associated Psychosocial Stress in a Multi-Site Study

Nancy S. Green, MD, Deepa Manwani, MD, Kim Smith-Whitley, MD, Banu Aygun, MD, Abena Appiah-Kubi, MD MPH, Arlene Smaldone, PhD CPNP
Journal: Blood
Blood (2020) 136 (Supplement 1): 41–42.
https://doi.org/10.1182/blood-2020-140866
Published: 2020
Journal Articles

Effects of Hydroxyurea Treatment on Malaria Infections in Sub-Saharan Africa

Peter Olupot-Olupot, George A. Tomlinson, PhD BSc, MSc, Teresa S. Latham, MA, Patrick T. McGann, MD, Brigida Santos, Banu Aygun, MD, Susan Stuber, MA, Leon Tshilolo, MD PhD, Adam Lane, PhD, Thomas N. Williams, Russell E. Ware, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 522.
https://doi.org/10.1182/blood-2019-129251
Published: 2019
Journal Articles

Benefit and Safety of Isovolemic Hemodilution Prior to Red Cell Exchange in Chronically Transfused Sickle Cell Patients

Katayoun Fomani, MD, Cindy Xu, Swathi Ratkal, MD, Vijay Nandi, PhD, Abena Appiah-Kubi, MD MPH, Banu Aygun, MD, James Louie, MD, Patricia Shi, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2291.
https://doi.org/10.1182/blood-2019-122259
Published: 2019
Journal Articles

Splenomegaly in Children with Sickle Cell Anemia Receiving Hydroxyurea in Sub-Saharan Africa

Leon Tshilolo, MD PhD, George A. Tomlinson, PhD BSc, MSc, Patrick T. McGann, MD, Teresa S. Latham, MA, Peter Olupot-Olupot, Brigida Santos, Banu Aygun, MD, Susan Stuber, MA, Adam Lane, PhD, Thomas N. Williams, Russell E. Ware, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 993.
https://doi.org/10.1182/blood-2019-129937
Published: 2019