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Journal Articles

Splenomegaly patterns and clinical impact in African children with sickle cell anemia on hydroxyurea treatment

Free
Leon Tshilolo, George Tomlinson, Luke Smart, Teresa Latham, Peter Olupot-Olupot, Brigida Santos, Banu Aygun, Susan Stuber, Adam Lane, Thomas Williams, Russell Ware
Journal: Blood
Blood (2025) 146 (Supplement 1): 2971.
https://doi.org/10.1182/blood-2025-2971
Published: 2025
Journal Articles

Pharmacokinetic (PK)-guided vs weight-based dosing of hydroxyurea for tanzanian children with sickle cell anemia

Free
Luke Smart, Emmanuela Ambrose, Mwesige Charles, Kathryn McElhinney, Adam Lane, Susan Stuber, Teresa Latham, Russell Ware
Journal: Blood
Blood (2025) 146 (Supplement 1): 2959.
https://doi.org/10.1182/blood-2025-2959
Published: 2025
Journal Articles

Safety and efficacy of ten years of hydroxyurea treatment for young children with sickle cell anemia in Uganda

Free
Russell Ware, Robert Opoka, Teresa Latham, Phillip Kasirye, Priscilla Kasembo, Heather Ann Hume, Isaac Birungi, Norah Kadde, Bill Wambaka, Maria Nakafeero, Adam Lane, Chandy John
Journal: Blood
Blood (2025) 146 (Supplement 1): 412.
https://doi.org/10.1182/blood-2025-412
Published: 2025
Journal Articles

Benefits of hydroxyurea in hemoglobin SC: Results of the open-label phase of the prospective identification of variables as outcomes for treatment (PIVOT) trial

Free
Luke Smart, Yvonne Dei-Adomakoh, Adam Lane, Priscilla Ekpale, Lyudmyla Koni, Oksana Corquaye, Enoch Mensah, Susan Stuber, Teresa Latham, Catherine Segbefia, Russell Ware
Journal: Blood
Blood (2025) 146 (Supplement 1): 409.
https://doi.org/10.1182/blood-2025-409
Published: 2025
Journal Articles

Liver disease in shwachman-diamond syndrome: A report from the shwachman-diamond syndrome registry

Free
Jane Koo, Meghan Haney, Diana Schwarz, Jaeson Kim, Lois Schwarz, Sarah Steltz, Elizabeth Korn, Leah Cheng, Sara Loveless, Richard Cooper, Claire Dusa, Adam Lane, Juan Putra, Akiko Shimamura, Kasiani Myers, Amit Grover, Andrew Wehrman
Journal: Blood
Blood (2025) 146 (Supplement 1): 1436.
https://doi.org/10.1182/blood-2025-1436
Published: 2025
Journal Articles

A randomized phase 2 trial of oral vitamin A for graft-versus-host disease in children and young adults

Free
Clinical Trials & Observations
Pooja Khandelwal, Lucille Langenberg, Nathan Luebbering, Kelly E. Lake, Abigail Butcher, Kylie Bota, Kristie N. Ramos, Cynthia Taggart, Hannah Choe, Sumithira Vasu, Ashley Teusink-Cross, Jane Koo, Gregory Wallace, Lindsey Romick-Rosendale, Miki Watanabe-Chailland, David B. Haslam, Adam Lane, Stella M. Davies
Journal: Blood
Blood (2024) 143 (12): 1181–1192.
https://doi.org/10.1182/blood.2023022865
Published: 2024
Includes: Supplemental data
Journal Articles

A prospective multi-institutional study of eculizumab to treat high-risk stem cell transplantation–associated TMA

Free
Clinical Trials & Observations
Sonata Jodele, Christopher E. Dandoy, Paibel Aguayo-Hiraldo, Adam Lane, Ashley Teusink-Cross, Anthony Sabulski, Kana Mizuno, Benjamin L. Laskin, Jason Freedman, Stella M. Davies
Journal: Blood
Blood (2024) 143 (12): 1112–1123.
https://doi.org/10.1182/blood.2023022526
Published: 2024
Includes: Supplemental data
Journal Articles

Hydroxyurea treatment is associated with lower malaria incidence in children with sickle cell anemia in sub-Saharan Africa

Free
Clinical Trials & Observations
Peter Olupot-Olupot, George Tomlinson, Thomas N. Williams, Léon Tshilolo, Brígida Santos, Luke R. Smart, Kathryn McElhinney, Thad A. Howard, Banu Aygun, Susan E. Stuber, Adam Lane, Teresa S. Latham, Russell E. Ware
Journal: Blood
Blood (2023) 141 (12): 1402–1410.
https://doi.org/10.1182/blood.2022017051
Published: 2023
Includes: Supplemental data
Journal Articles

Hydroxyurea Pharmacokinetics and Fetal Hemoglobin Response in Ugandan Children with Sickle Cell Anemia

Free
Alexandra Power-Hays, Min Dong, Kathryn McElhinney, Andrea L. Conroy, Teresa Latham, Adam Lane, Robert O. Opoka, Alexander A. Vinks, Russell E. Ware
Journal: Blood
Blood (2022) 140 (Supplement 1): 5461–5462.
https://doi.org/10.1182/blood-2022-170839
Published: 2022
Journal Articles

Hydroxyurea with Dose Escalation to Reduce Primary Stroke Risk in Children with Sickle Cell Anemia in Dominican Republic: The Sacred Trial

Free
Rosa M. Nieves, Teresa Latham, Nicolle Marte, Luisanna Sanchez, Melissa E. Berges, Gabriela S. Urcuyo, Carla Florencio, Carla Gonzalez, Paola Del Villar, Sheena Chen, Paula Reyes, Daniel Ramirez, Euladys Matos, Manuel Marinez, Susan E. Stuber, William Schultz, Adam Lane, Rafael Mena, Russell E. Ware
Journal: Blood
Blood (2022) 140 (Supplement 1): 451–452.
https://doi.org/10.1182/blood-2022-168324
Published: 2022
Journal Articles

Hydroxyurea with Dose-Escalation to Reduce Primary Stroke Risk in Children with Sickle Cell Anemia in Tanzania: Primary Results of the Sphere Trial

Free
Emmanuela E. Ambrose, Teresa Latham, Primrose Songoro, Mwesige Charles, Adam Lane, Susan E. Stuber, Abel Nkono Makubi, Russell E. Ware, Luke R. Smart
Journal: Blood
Blood (2022) 140 (Supplement 1): 447–448.
https://doi.org/10.1182/blood-2022-164787
Published: 2022
Journal Articles

Outcomes of Hematologic Complications in Shwachman Diamond Syndrome: High Risk Features and Implications for Surveillance

Free
Ashley Galvin, Chris R. Reilly, Maggie Malsch, Sara Loveless, Joseph H. Antin, Stella M Davies, Courtney D. DiNardo, Adam Lane, Coleman Lindsley, Taizo A. Nakano, Richard Cooper, Katherine Coyne, Claire Dusa, Margret Joos, Mark D. Fleming, Kasiani C. Myers, Akiko Shimamura
Journal: Blood
Blood (2022) 140 (Supplement 1): 2949–2950.
https://doi.org/10.1182/blood-2022-164969
Published: 2022
Journal Articles

An improved index for diagnosis and mortality prediction in malignancy-associated hemophagocytic lymphohistiocytosis

Free
CME Clinical Trials & Observations
Adi Zoref-Lorenz, Jun Murakami, Liron Hofstetter, Swaminathan Iyer, Ahmad S. Alotaibi, Shehab Fareed Mohamed, Peter G. Miller, Elad Guber, Shiri Weinstein, Joanne Yacobovich, Sarah Nikiforow, Benjamin L. Ebert, Adam Lane, Oren Pasvolsky, Pia Raanani, Arnon Nagler, Nancy Berliner, Naval Daver, Martin Ellis, Michael B. Jordan
Journal: Blood
Blood (2022) 139 (7): 1098–1110.
https://doi.org/10.1182/blood.2021012764
Published: 2022
Includes: Supplemental data
Journal Articles

Hydroxyurea Reduces the Transfusion Burden in Children with Sickle Cell Anemia: The Reach Experience

Free
Alexandra Power-Hays, George A. Tomlinson, Leon Tshilolo, Brigida Santos, Thomas N. Williams, Peter Olupot-Olupot, Patrick T. McGann, Banu Aygun, Adam Lane, Susan E. Stuber, Teresa Latham, Russell E. Ware
Journal: Blood
Blood (2021) 138 (Supplement 1): 11.
https://doi.org/10.1182/blood-2021-146632
Published: 2021
Journal Articles

Building Capacity and Assessing Stroke Risk with Transcranial Doppler Ultrasonography in Sub-Saharan Africa: The Reach Experience

Free
Brigida Santos, MD, Maria Nakafeero, Adam Lane, PhD, Leon Tshilolo, MDPhD, Thomas N. Williams, MDPhD, Peter Olupot-Olupot, MDPhD, Janet Adams, Banu Aygun, MD, Susan E. Stuber, MA, George A. Tomlinson, PhD BSc, MSc, Teresa Latham, MA, Patrick T. McGann, MD MS, Russell E. Ware, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 17–18.
https://doi.org/10.1182/blood-2020-142318
Published: 2020
Journal Articles

Hydroxyurea to Reduce Stroke Risk in Tanzanian Children with Sickle Cell Anemia

Free
Emmanuela E. Ambrose, MD, Luke R. Smart, MD, Primrose Songoro, RN, Idd Shabani, MD, Protas Komba, MD, Mwesige Charles, BScHLS, Thad A. Howard, MS, Susan E. Stuber, MA, Adam Lane, PhD, Teresa Latham, MA, Abel Nkono Makubi, PhD MD MSc, Russell E. Ware, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 20–21.
https://doi.org/10.1182/blood-2020-135944
Published: 2020
Journal Articles

Optimizing Hydroxyurea Therapy with Reduced Laboratory Monitoring for Children with Sickle Cell Anemia in Sub-Saharan Africa: The Reach Experience

Free
Banu Aygun, MD, George A. Tomlinson, PhD BSc, MSc, Patrick T. McGann, MD MS, Leon Tshilolo, MDPhD, Thomas N. Williams, MDPhD, Peter Olupot-Olupot, MDPhD, Brigida Santos, MD, Susan E. Stuber, MA, Adam Lane, PhD, Teresa Latham, MA, Russell E. Ware, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 17.
https://doi.org/10.1182/blood-2020-134180
Published: 2020
Journal Articles

Genetic Variants That Influence Fetal Hemoglobin Expression from Hydroxyurea Treatment

Free
Anu Marahatta, PhD, Jonathan M. Flanagan, PhD, Thad A. Howard, MS, Nicole Mortier, MHS, PA-C, William Schultz, MHS, PA, Kathryn L McElhinney, BS, Leon Tshilolo, MDPhD, Thomas N. Williams, MDPhD, Peter Olupot-Olupot, MDPhD, Brigida Santos, MD, Chandy C. John, MD MS, Robert Opoka, MMED, Rosa M. Nieves, MD, Rafael Mena, MD, Marvin E Reid, MB, BS, PhD, Angela Rankine-Mullings, MBBS, Jasmine Baker, PhD, Patrick T. McGann, MD MS, Banu Aygun, MD, Adam Lane, PhD, George A. Tomlinson, PhD BSc, MSc, Teresa Latham, MA, Susan E. Stuber, MA, Russell E. Ware, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 8–9.
https://doi.org/10.1182/blood-2020-143139
Published: 2020
Journal Articles

Thrombosis Risk in Transgender Adolescents Receiving Gender-Affirming Hormone Therapy

Free
Eric S. Mullins, MD, Rebecca Geer, Megan Metcalf, Jeanne Piccola, Adam Lane, PhD, Lee Ann E Conard, RPh, DO, MPH, Tanya Lilliane Kowalczyk Mullins, MD MS
Journal: Blood
Blood (2020) 136 (Supplement 1): 5.
https://doi.org/10.1182/blood-2020-143231
Published: 2020
Journal Articles

Complement blockade for TA-TMA: lessons learned from a large pediatric cohort treated with eculizumab

Free
Clinical Trials & Observations
Sonata Jodele, Christopher E. Dandoy, Adam Lane, Benjamin L. Laskin, Ashley Teusink-Cross, Kasiani C. Myers, Gregory Wallace, Adam Nelson, Jack Bleesing, Ranjit S. Chima, Russel Hirsch, Thomas D. Ryan, Stefanie Benoit, Kana Mizuno, Mikako Warren, Stella M. Davies
Journal: Blood
Blood (2020) 135 (13): 1049–1057.
https://doi.org/10.1182/blood.2019004218
Published: 2020
Includes: Supplemental data