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Journal Articles

Preclinical and Clinical Use of AB1, a DNMT1 Protein Depleter, to Upregulate Fetal Hemoglobin in Townes Sickle Cell Disease (SCD) Mice and Patients with SCD

Nirmish Shah, Girindra Raval, Abdullah Kutlar, Niren Patel, Mayuko Takezaki, Biaoru Li, Manickam Alagar, Hongyan Xu, Kelly Blackburn, Santhosh Vadivelu, Robert Schaub, David Santos, Betty Pace

Blood (2023) 142 (Supplement 1): 276.

https://doi.org/10.1182/blood-2023-188165

Published: 2023

Journal Articles

Development of the Novel Cytosine Analog Aza-T-Dcyd (AB1) As a Fetal Hemoglobin Inducer to Treat Sickle Cell Disease.

Manickam Alagar, Biaoru Li, Santhosh Vadivelu, Robert Schaub, Chithra D. Palani, Betty S. Pace

Blood (2022) 140 (Supplement 1): 4957–4958.

https://doi.org/10.1182/blood-2022-169657

Published: 2022

Journal Articles

Pharmacokinetics and Pharmacodynamics after Subcutaneous Dosing of the iNKT Cell Depleting Antibody NKTT120

Robert Schaub, PhD, Abraham Thariath, PhD, Felix Scheuplein, PhD, Robert Mashal, MD

Blood (2015) 126 (23): 4575.

https://doi.org/10.1182/blood.V126.23.4575.4575

Published: 2015

Journal Articles

Antibody Mediated Depletion of iNKT Cells Protects Against Hypoxia-Induced Pulmonary Injury in a Murine Model of Sickle Cell Disease

Hong Pei, PhD, Robert Schaub, PhD, Felix Scheuplein, PhD, Robert Mashal, MD, Joel Linden, PhD

Blood (2014) 124 (21): 2697.

https://doi.org/10.1182/blood.V124.21.2697.2697

Published: 2014

Journal Articles

Adult Patients with Stable Sickle Cell Disease Prior to Treatment with the iNKT Cell Depleting Antibody NKTT120 Have Consistent and Elevated Numbers of Activated (CD69 + ) iNKT Cells Relative to Healthy Adult Volunteers

Rosemary Mazanet, MD PhD, Robert Schaub, PhD, Felix Scheuplein, PhD, Cheryl A. Eaton, BA, Robert Mashal, MD, Joshua J. Field, MD MS

Blood (2014) 124 (21): 4097.

https://doi.org/10.1182/blood.V124.21.4097.4097

Published: 2014

Journal Articles

Mouse Invariant TCR Specific Monoclonal Antibody NKT14: A Novel Tool To Manipulate Invariant NKT Cell Function In Vivo

Felix Scheuplein, Ph.D., Abraham Thariath, Ph.D., Robert Mashal, MD, Robert Schaub, Ph.D.

Blood (2013) 122 (21): 3478.

https://doi.org/10.1182/blood.V122.21.3478.3478

Published: 2013

Journal Articles

Cynomolgus Monkey Invariant NKT (iNKT) Cells Recover Following Depletion by Treatment with the Anti-Invariant T Cell Receptor Antibody NKTT120

Felix Scheuplein, Ph.D., Susan Macdonald, Ph.D., Brandon Zeigler, Ph.D., Elen LeBel, M.Sc., Abraham Thariath, Ph.D., Alem Truneh, Robert Mashal, M.D., David G. Nathan, MD, Robert Schaub, Ph.D.

Blood (2012) 120 (21): 4836.

https://doi.org/10.1182/blood.V120.21.4836.4836

Published: 2012

Journal Articles

The Safety Evaluation of NKTT120, an Invariant NKT (iNKT) Cell Depleting Antibody in the Cynomolgus Monkey.

Susan Macdonald, Ph.D., Felix Scheuplein, Ph.D., Abraham Thariath, Ph.D., Elen LeBel, M.Sc., Brandon Zeigler, Ph.D., Alem Truneh, Robert Mashal, M.D., Robert Schaub, Ph.D.

Blood (2012) 120 (21): 2150.

https://doi.org/10.1182/blood.V120.21.2150.2150

Published: 2012

Journal Articles

Discovery and Characterization of An Anti-APC Aptamer for Use In Hemophilia

Patricia G.M. Wagner, Michael C. Schwartz, Kathleen E. McGinness, Ryan M. Genga, Jeffrey C. Kurz, PhD, Emily K. Waters, PhD, Robert Schaub, PhD

Blood (2010) 116 (21): 2222.

https://doi.org/10.1182/blood.V116.21.2222.2222

Published: 2010

Journal Articles

The Generation of An Aptamer Inhibitor of Murine Von Willebrand Factor (VWF) Mediated Platelet Aggregation

Melissa Woelfel, Simon De Meyer, PhD, Patricia Wagner, Kathleen E McGinness, PhD, Denisa D. Wagner, PhD, Robert Schaub, PhD

Blood (2010) 116 (21): 4312.

https://doi.org/10.1182/blood.V116.21.4312.4312

Published: 2010

Journal Articles

The Aptamer ARC1779 Potently and Specifically Inhibits the Excessive von Willebrand Factor (vWF) Activity and vWF-Mediated Ex Vivo Platelet Function of Patients with Thrombotic Thrombocytopenic Purpura (TTP).

Bernd Jilma, MD, Florian B. Mayr, MD, Paul Knoebl, MD, Alexander O. Spiel, MD, Patricia G. Merlino, Robert Schaub, PhD, James C. Gilbert, MD

Blood (2007) 110 (11): 279.

https://doi.org/10.1182/blood.V110.11.279.279

Published: 2007

NARROW

Preclinical and Clinical Use of AB1, a DNMT1 Protein Depleter, to Upregulate Fetal Hemoglobin in Townes Sickle Cell Disease (SCD) Mice and Patients with SCD

Development of the Novel Cytosine Analog Aza-T-Dcyd (AB1) As a Fetal Hemoglobin Inducer to Treat Sickle Cell Disease.

Pharmacokinetics and Pharmacodynamics after Subcutaneous Dosing of the iNKT Cell Depleting Antibody NKTT120

Antibody Mediated Depletion of iNKT Cells Protects Against Hypoxia-Induced Pulmonary Injury in a Murine Model of Sickle Cell Disease

Adult Patients with Stable Sickle Cell Disease Prior to Treatment with the iNKT Cell Depleting Antibody NKTT120 Have Consistent and Elevated Numbers of Activated (CD69 + ) iNKT Cells Relative to Healthy Adult Volunteers

Mouse Invariant TCR Specific Monoclonal Antibody NKT14: A Novel Tool To Manipulate Invariant NKT Cell Function In Vivo

Cynomolgus Monkey Invariant NKT (iNKT) Cells Recover Following Depletion by Treatment with the Anti-Invariant T Cell Receptor Antibody NKTT120

The Safety Evaluation of NKTT120, an Invariant NKT (iNKT) Cell Depleting Antibody in the Cynomolgus Monkey.

Discovery and Characterization of An Anti-APC Aptamer for Use In Hemophilia

The Generation of An Aptamer Inhibitor of Murine Von Willebrand Factor (VWF) Mediated Platelet Aggregation

The Aptamer ARC1779 Potently and Specifically Inhibits the Excessive von Willebrand Factor (vWF) Activity and vWF-Mediated Ex Vivo Platelet Function of Patients with Thrombotic Thrombocytopenic Purpura (TTP).

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American Society of Hematology

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ASH Publications

American Society of Hematology

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