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Amanda F. Gilkes
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Journal Articles

Overlapping features of therapy-related and de novo NPM1 -mutated AML

Clinical Trials & Observations
Jad Othman, Manja Meggendorfer, Enrico Tiacci, Christian Thiede, Richard Schlenk, Richard Dillon, Sebastian Stasik, Alessandra Venanzi, Sarah Bertoli, Eric Delabesse, Pierre-Yves Dumas, Arnaud Pigneux, Audrey Bidet, Amanda F. Gilkes, Ian Thomas, Maria Teresa Voso, Alessandro Rambaldi, Lorenzo Brunetti, Vincenzo M. Perriello, Vibeke Andresen, Bjorn T. Gjertsen, Maria Paola Martelli, Christian Récher, Christoph Röllig, Martin Bornhäuser, Hubert Serve, Carsten Müller-Tidow, Claudia D. Baldus, Tortsten Haferlach, Nigel Russell, Brunangelo Falini
Journal: Blood
Blood (2023) 141 (15): 1846–1857.
https://doi.org/10.1182/blood.2022018108
Published: 2023
Includes: Supplemental data
Journal Articles

Molecular Detection of Minimal Residual Disease Provides the Most Powerful Independent Prognostic Factor Irrespective of Clonal Architecture in Nucleophosmin (NPM1) Mutant Acute Myeloid Leukemia

Adam Ivey, Robert K Hills, Michael A Simpson, Jelena V Jovanovic, Amanda F Gilkes, MSc, Yashma Patel, Neesa Bhudia, Hassan Farah, Joanne Mason, Kerry Wall, Susanna Akiki, Ellen Solomon, Frank McCaughan, David C Linch, FMedSci, Rosemary E Gale, PhD, Paresh Vyas, Sylvie D Freeman, Nigel Russell, Alan K. Burnett, MDFRCP, David Grimwade
Journal: Blood
Blood (2014) 124 (21): 70.
https://doi.org/10.1182/blood.V124.21.70.70
Published: 2014
Journal Articles

The ATRA Question In AML: Lack Of Benefit Overall Or In Any Molecular Subgroup In The NCRI AML16 Trial

Alan K. Burnett, MD, Robert K. Hills, MA, MSc, DPhil, Lone S. Friis, MD, PhD, Lars Kjeldsen, MD, PhD, Donald Milligan, MD, FRCP, FRCPath, Ann E. Hunter, MBBS, FRCP, FRCPath, Michelle Lazenby, Amanda F Gilkes, MSc, David Bowen, MD, PhD, Nigel Russell, MD
Journal: Blood
Blood (2013) 122 (21): 493.
https://doi.org/10.1182/blood.V122.21.493.493
Published: 2013
Journal Articles

Downregulation Of The Wnt Inhibitor CXXC5 Predicts a Better Prognosis In Acute Myeloid Leukemia

Andrea Kühnl, Peter J. M. Valk, Mathijs A. Sanders, Robert K. Hills, MA, MSc, DPhil, Ken I. Mills, PhD, Rosemary E Gale, PhD, Martin Kaiser, MD, Richard Dillon, Melanie Joannides, Adam Ivey, Amanda F Gilkes, MSc, Torsten Haferlach, MD, Susanne Schnittger, PhD, Estelle Duprez, David Linch, FMedSci, Ruud Delwel, Bob Löwenberg, MD, PhD, Claudia D. Baldus, MD, PhD, Ellen Solomon, Alan K Burnett, MD, David Grimwade, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 52.
https://doi.org/10.1182/blood.V122.21.52.52
Published: 2013
Journal Articles

Identification of the Wnt Signalling Protein, TCF7L2 As a Significantly Overexpressed Transcription Factor in AML

Siti Sarah Daud, MMedSc, Sara L Pumford, MPhil, Marie N Gilmour, PhD, Amanda F Gilkes, MSc, Alan K Burnett, MD, Robert Hills, MA, MSc, DPhil, Alex Tonks, PhD, Richard L Darley, PhD
Journal: Blood
Blood (2012) 120 (21): 1281.
https://doi.org/10.1182/blood.V120.21.1281.1281
Published: 2012
Journal Articles

Combination of Gene Expression Data from Myeloid Cell Lines with In Vitro Response to Molecularly Targeted Therapies.

Ken I. Mills, PhD, Amanda F. Gilkes, Beth J. Walsby, PhD, Eleanor L. Woodward, Steve J. Austin, Chris Jenkins, MD, Steven Knapper, MD, Alan K. Burnett, MD
Journal: Blood
Blood (2006) 108 (11): 1361.
https://doi.org/10.1182/blood.V108.11.1361.1361
Published: 2006
Journal Articles

The effects of lestaurtinib (CEP701) and PKC412 on primary AML blasts: the induction of cytotoxicity varies with dependence on FLT3 signaling in both FLT3-mutated and wild-type cases

Steven Knapper, Kenneth I. Mills, Amanda F. Gilkes, Steve J. Austin, Val Walsh, Alan K. Burnett
Journal: Blood
Blood (2006) 108 (10): 3494–3503.
https://doi.org/10.1182/blood-2006-04-015487
Published: 2006
Journal Articles

Relationship between FLT3 mutation status, biologic characteristics, and response to targeted therapy in acute promyelocytic leukemia

Clinical Trials & Observations
Rosemary E. Gale, Robert Hills, Arnold R. Pizzey, Panagiotis D. Kottaridis, David Swirsky, Amanda F. Gilkes, Elizabeth Nugent, Kenneth I. Mills, Keith Wheatley, Ellen Solomon, Alan K. Burnett, David C. Linch, David Grimwade, for the NCRI Adult Leukaemia Working Party
Journal: Blood
Blood (2005) 106 (12): 3768–3776.
https://doi.org/10.1182/blood-2005-04-1746
Published: 2005
Includes: Supplemental data
Journal Articles

Gene Expression Profiling Can Identify Novel MRD Markers for AML.

Eleanor L. Woodward, Amanda F. Gilkes, Val Walsh, Steve J. Austin, Sarah B. Daly, J. A. Lin, David Grimwade, MD, PhD, Alan K. Burnett, MD, Kenneth I. Mills, PhD
Journal: Blood
Blood (2005) 106 (11): 2354.
https://doi.org/10.1182/blood.V106.11.2354.2354
Published: 2005
Journal Articles

Heat Shock Protein 90 (Hsp90) Inhibition Results in Apoptotic Killing of Primary AML Cells with FLT3/ITD Mutation.

Laila M. Al-Shaer, Amanda F. Gilkes, Kenneth I. Mills, Alan K. Burnett, Clare J. Rowntree
Journal: Blood
Blood (2004) 104 (11): 2525.
https://doi.org/10.1182/blood.V104.11.2525.2525
Published: 2004
Journal Articles

Rapid and Quantitative Detection of Mutations of the FLT3 Gene in AML.

Amanda F. Gilkes, Valerie Walsh, Marion C. Sweeney, Steven J. Austin, Rosemary E. Gale, Kenneth I. Mills
Journal: Blood
Blood (2004) 104 (11): 1066.
https://doi.org/10.1182/blood.V104.11.1066.1066
Published: 2004
Journal Articles

Hsp90 Expression in Acute Myeloid Leukaemia.

Elisabeth J. Walsby, Amanda F. Gilkes, Valerie Walsh, Kenneth I. Mills, Alan K. Burnett
Journal: Blood
Blood (2004) 104 (11): 4471.
https://doi.org/10.1182/blood.V104.11.4471.4471
Published: 2004
Journal Articles

CEP701 and PKC412 Predictably and Reliably Inhibit FLT3 Phosphorylation in Primary AML Blasts but Their Induction of a Cytotoxic Response Appears to Be Much More Variable.

Steven Knapper, Alan K. Burnett, Amanda F. Gilkes, Kenneth I. Mills, Val Walsh
Journal: Blood
Blood (2004) 104 (11): 95.
https://doi.org/10.1182/blood.V104.11.95.95
Published: 2004