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Jan Krönke
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Journal Articles

Failure to Execute Caspase Activation Drives Therapy Resistance in TP53 Mutated AML

Ahmed M Mamdouh, Fang Qi Lim, Yang Mi, Elyse A Olesinski, Yichen Wang, Shaista Shabbir Jasdanwala, Karanpreet Singh Bhatia, Xiao Xian Lin, Valeriia Sapozhnikova, Philipp Mertins, Brandon D. Brown, Yihua Qiu, Anthony G. Letai, Alexandre Puissant, Steven M. Kornblau, Jan Krönke, Edward Ayoub, Koji Itahana, Michael Andreeff, Shruti Bhatt
Journal: Blood
Blood (2024) 144 (Supplement 1): 53.
https://doi.org/10.1182/blood-2024-211997
Published: 2024
Journal Articles

Phase 2 Study of Teclistamab-Based Induction Regimens in Patients with Transplant-Eligible (TE) Newly Diagnosed Multiple Myeloma (NDMM): Results from the GMMG-HD10/DSMM-XX (MajesTEC-5) Trial

Marc S. Raab, Niels Weinhold, K. Martin Kortüm, Jan Krönke, Lilli Podola, Uta Bertsch, Jan H. Frenking, Julia Mersi, Stefanie Huhn, Michael Hundemer, Gunhild Mechtersheimer, Roland Fenk, Katja C. Weisel, Natalie Schub, Florian Bassermann, Monika Engelhardt, Raphael Teipel, Mathias Hänel, Hans Salwender, Bas D Koster, Elena Ershova, Caline Sakabedoyan, Isobel Barrott, Agnes Balogh, Sanjay Vara, Tobias Kampfenkel, Hartmut Goldschmidt, Hermann Einsele, Leo Rasche
Journal: Blood
Blood (2024) 144 (Supplement 1): 493.
https://doi.org/10.1182/blood-2024-206003
Published: 2024
Journal Articles

Phase 1b Study of Menin-KMT2A Inhibitor Bleximenib in Combination with Intensive Chemotherapy in Newly Diagnosed Acute Myeloid Leukemia with KMT2Ar or NPM1 Alterations

Christian Recher, Jenny O'Nions, Ibrahim Aldoss, Ana Alfonso Pierola, Alicia Allred, Juan Manuel Alonso-Dominguez, Laura Barreyro, Pierre Bories, Martin Curtis, Nikki Daskalakis, Matteo Giovanni Della Porta, Hartmut Döhner, Amber D'Souza, James P. Dugan, Jordi Esteve Reyner, Matthew Exum, Amir T. Fathi, Pasquale L. Fedele, Lucille Ferrante, Stan Gaj, Sylvain Garciaz, Ana Garrido, Sara Garrido Paniagua, Christina Guttke, Emmanuel Gyan, Brett Hiebert, Elias Jabbour, Madlen Jentzsch, Hagop M. Kantarjian, Marina Konopleva, Jan Krönke, Min Chul Kwon, Christina Loefgren, Oliver Lomas, Valentina Mancini, Ioannis Mantzaris, Giovanni Martinelli, Daniel Morillo Giles, Joseph Murphy, Kathryn Packman, Cristina Papayannidis, Ulrike Philippar, Uwe Platzbecker, Sravanti Rangaraju, Christoph Röllig, Olga Salamero, Madhu Sanga, Tim Sauer, Emma Searle, Natalia Tovar, Trevor Tucker, Nicolas Vallet, Lachlin Vaughan, Gala Vega, Paresh Vyas, Andrew Wei
Journal: Blood
Blood (2024) 144 (Supplement 1): 215.
https://doi.org/10.1182/blood-2024-207072
Published: 2024
Journal Articles

Efficacy of Anti-BCMA CAR-T Cell Therapies in Multiple Myeloma Patients with Prior Exposure to Bispecific Antibodies- Results from a Retrospective Multi-Center Registry Analysis

Johannes Waldschmidt, David Fandrei, Vladan Vucinic, Ralph Wäsch, Axel Nogai, Winfried Alsdorf, Annamaria Brioli, Evgenii Shumilov, Fabian Mueller, Raphael Teipel, Nico Gagelmann, Monika Engelhardt, Jan Krönke, Julia Mersi, Michael Hudecek, Martin K. Kortüm, Uwe Platzbecker, Hermann Einsele, Max S. Topp, Leo Rasche, Maximilian Merz
Journal: Blood
Blood (2024) 144 (Supplement 1): 2007.
https://doi.org/10.1182/blood-2024-210451
Published: 2024
Journal Articles

Functional and Molecular Analyses Reveal Impaired HSPCs in Multiple Myeloma Patients Post-Induction

Thanh Mai Baumhardt, Vadim Sakk, Karin Soller, Miriam Kull, Jan Kronke, Hartmut Geiger, Medhanie Assmelash Mulaw
Journal: Blood
Blood (2024) 144 (Supplement 1): 1901.
https://doi.org/10.1182/blood-2024-202903
Published: 2024
Journal Articles

Making AML fly too close to the sun

Lars Bullinger, Jan Krönke
Journal: Blood
Blood (2024) 143 (15): 1438–1439.
https://doi.org/10.1182/blood.2023023531
Published: 2024
Journal Articles

Genomic Characterization of Acute Myeloid Leukemia with Aberrations of Chromosome 7: A Multinational Cohort of 523 Patients

Adriane Halik, Marlon Tilgner, Patricia Silva, Natalia Estrada-Barreras, Robert Altwasser, Ekaterina Jahn, Michael Heuser, Hsin-An Hou, Marta Pratcorona, Robert Kerrin Hills, Klaus H Metzeler, Laurène Fenwarth, Anna Dolnik, Christine Terré, Klara Kopp, Martin Szyska, Jan Krönke, Loïc Vasseur, Bob Lowenberg, Jordi Esteve, Peter J. M. Valk, Matthieu Duchmann, Wen-Chien Chou, David C. Linch, Hartmut Döhner, Rosemary E. Gale, Konstanze Döhner, Lars Bullinger, Kenichi Yoshida, Frederik Damm
Journal: Blood
Blood (2023) 142 (Supplement 1): 63.
https://doi.org/10.1182/blood-2023-185627
Published: 2023
Journal Articles

Real-World Analysis of Teclistamab in 115 RRMM Patients from Germany

Christine Riedhammer, Florian Bassermann, Britta Besemer, Moritz Bewarder, Franziska Brunner, Alexander Carpinteiro, Hermann Einsele, Josefine Faltin, Jan Frenking, Deniz Gezer, Sarah Goldman-Mazur, Mathias Hanel, Marion Hoegner, K. Martin Kortüm, Jan Krönke, Miriam Kull, Theo Leitner, Christoph Mann, Rabea Mecklenbrauck, Maximilian Merz, Anke Morgner, Axel Nogai, Marc S. Raab, Raphael Teipel, Ralph Wäsch, Leo Rasche
Journal: Blood
Blood (2023) 142 (Supplement 1): 3329.
https://doi.org/10.1182/blood-2023-180032
Published: 2023
Journal Articles

Therapy-Related AML: Clinical/Biological Features and Long-Term Outcome in a Cohort of 1133 Adult AML Patients

Sophia Gross, Jana Ihlow, Leonie Busack, Kacper Adamiak, Jens F. Schrezenmeier, Julia Jesse, Michaela Schwarz, Anne Floercken, Kathrin Rieger, Jan Krönke, Philipp le Coutre, Vivien Boldt, Ann-Christin von Bruenneck, David Horst, Thomas Burmeister, Igor Wolfgang Blau, Ulrich Keller, Lars Bullinger, Joerg Westermann
Journal: Blood
Blood (2022) 140 (Supplement 1): 1291–1292.
https://doi.org/10.1182/blood-2022-164798
Published: 2022
Journal Articles

Long-Term Outcome of a Prospective Randomized Trial Comparing Continuous Lenalidomide/Dexamethasone with Lenalidomide/Dexamethasone Induction, MEL140 with Autologous Blood Stem Cell Transplantation and Single Agent Lenalidomide Maintenance in Patients of Age 60-75 Years with Newly Diagnosed Multiple Myeloma

Christian Straka, Kerstin Schaefer-Eckart, Bernd Hertenstein, Florian Bassermann, Hans Salwender, Christian Langer, Jan Krönke, Miriam Kull, Georgia Schilling, Aneta Schieferdecker, Monika Engelhardt, Stefan Knop, Julia Reusch, Wolf Roesler, Bernd Metzner, Holger Hebart, Albrecht Reichle, Matthias Grube, Norbert Frickhofen, Christian Gerecke, Stephan Fuhrmann, Wolfram Jung, Martin Gramatzki, Thomas Decker, Tobias Dechow, Jochen Greiner, Tim H. Brümmendorf, Juliana Ababei, Ivana von Metzler, Ralph Naumann, Elisabeth Fritz, Marcus Hentrich, Peter Bojko, Thomas Kubin, Christian Schmidt, Martin Kaufmann, Burkhard Schmidt, Axel Hinke, Hermann Einsele
Journal: Blood
Blood (2022) 140 (Supplement 1): 287–288.
https://doi.org/10.1182/blood-2022-159357
Published: 2022
Journal Articles

Impact of ABCB1 Promoter Methylation on PI-Resistance in Multiple Myeloma

Seungbin Han, Larissa Haertle, Lenka Besse, Chien-Yun Lee, Xiang Zhou, Umair Munawar, Andrej Besse, Miriam Kull, Max Bittrich, Max Johannes Steinhardt, Julia Mersi, Eva Teufel, Silvia Nerreter, Cornelia Vogt, Sophia Danhof, Jan Krönke, Niels Weinhold, Marc S Raab, Thomas Haaf, Christoph Driessen, Hermann Einsele, Leo Rasche, Bernhard Küster, Martin Kortuem
Journal: Blood
Blood (2022) 140 (Supplement 1): 12462–12463.
https://doi.org/10.1182/blood-2022-168694
Published: 2022
Journal Articles

Combination Treatment of Venetoclax and Hypomethylating Agents (HMA) or Low-Dose Cytarabine (LDAC) for Patients with Acute Myeloid Leukemia (AML) - Real-World Data from Two German Academic Centers

Laura K. Schmalbrock, Krischan Braitsch, Paul Jung, Irmgard Bumeder, Philipp Kiewe, Jörg Westermann, Lars Bullinger, Ulrich Keller, Florian Bassermann, Jan Krönke, Kathrin Rieger, Katharina S. Goetze
Journal: Blood
Blood (2021) 138 (Supplement 1): 1257.
https://doi.org/10.1182/blood-2021-150943
Published: 2021
Journal Articles

Cereblon enhancer methylation and IMiD resistance in multiple myeloma

Clinical Trials & Observations Brief Report
Larissa Haertle, Santiago Barrio, Umair Munawar, Seungbin Han, Xiang Zhou, Cornelia Vogt, Rafael Alonso Fernández, Max Bittrich, Yanira Ruiz-Heredia, Matteo Da Viá, Josip Zovko, Andoni Garitano-Trojaola, Niccolò Bolli, Anna Ruckdeschel, Thorsten Stühmer, Manik Chatterjee, Miriam Kull, Jan Krönke, Xabier Agirre, Jose I. Martin-Subero, Peter Raab, Hermann Einsele, Leo Rasche, Joaquin Martinez-Lopez, Thomas Haaf, K. Martin Kortüm
Journal: Blood
Blood (2021) 138 (18): 1721–1726.
https://doi.org/10.1182/blood.2020010452
Published: 2021
Includes: Supplemental data
Journal Articles

Triggering T-cell activity in CLL

Daniel Mertens, Jan Krönke
Journal: Blood
Blood (2021) 137 (2): 150–151.
https://doi.org/10.1182/blood.2020009360
Published: 2021
Journal Articles

Impact of gemtuzumab ozogamicin on MRD and relapse risk in patients with NPM1 -mutated AML: results from the AMLSG 09-09 trial

Clinical Trials & Observations
Silke Kapp-Schwoerer, Daniela Weber, Andrea Corbacioglu, Verena I. Gaidzik, Peter Paschka, Jan Krönke, Frauke Theis, Frank G. Rücker, Maria-Veronica Teleanu, Ekaterina Panina, Nikolaus Jahn, Julia Herzig, Lena Kubanek, Anika Schrade, Gudrun Göhring, Walter Fiedler, Thomas Kindler, Thomas Schroeder, Karin T. Mayer, Michael Lübbert, Mohammed Wattad, Katharina S. Götze, Heinz A. Horst, Elisabeth Koller, Gerald Wulf, Jan Schleicher, Martin Bentz, Jürgen Krauter, Lars Bullinger, Julia Krzykalla, Axel Benner, Richard F. Schlenk, Felicitas Thol, Michael Heuser, Arnold Ganser, Hartmut Döhner, Konstanze Döhner
Journal: Blood
Blood (2020) 136 (26): 3041–3050.
https://doi.org/10.1182/blood.2020005998
Published: 2020
Includes: Supplemental data
Journal Articles

Exome Sequencing of Relapsed Multiple Myeloma Combined with Pooled CRISPR/Cas9 Screens Identifies Gene Mutations Associated with Drug-Specific Resistance

Stephan Bohl, Laura K. Schmalbrock, MD, Imke Bauhuf, Anna Dolnik, Tamara J. Blätte, MSc, Stefanie Lindner, Dr., Tatjana Meyer, MSc, BSc, Sarah Knödler, Denise Miller, Miriam Kull, Christian Langer, MD, Hartmut Döhner, MD, Dirk Heckl, PhD, Lars Bullinger, Jan Krönke, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 809.
https://doi.org/10.1182/blood-2019-131245
Published: 2019
Journal Articles

Lenalidomide, Adriamycin and Dexamethasone (RAD) Versus Bortezomib, Lenalidomide and Dexamethasone (VRD) in Newly Diagnosed Multiple Myeloma (MM) - Post-Induction Response and MRD Results By Flow Cytometry and NGS from a Phase 3 Randomized Controlled Clinical Trial (RCT)

Thomas Stübig, MD, Christian Langer, MD, Monika Engelhardt, MD, Lars-Olof Mügge, MD, Florian Bassermann, MD PhD, Martin Schreder, MD, Kerstin Schäfer-Eckart, MD, Igor Wolfgang Blau, Denise Wolleschak, Albrecht Reichle, MD, Ivana Metzler, MD, Bernd Metzner, MDPhD, Christoph Rollig, MD MSC, Bernd Hertenstein, MD, Heinz Dürk, Harald Biersack, MD, Helge Menzel, MD, Tobias Dechow, Jan Schleicher, Martin Gramatzki, MD, Tim H. Brümmendorf, MD, Stephan Fuhrmann, Max Bittrich, MD, Franziska Appelt, Martina Müller, Jan Krönke, MD, Julia Reusch, Christian Schmidt, MD, Monika Brüggemann, MD, Swantje Held, Stefan Knop, Hermann Einsele, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1979.
https://doi.org/10.1182/blood-2018-99-116067
Published: 2018
Journal Articles

The Role of PPM1D Mutations in Lenalidomide Resistance and Progression in Patients with MDS and Deletion of Chromosome 5q

Victoria Panagiota, MD, Manja Meggendorfer, PhD, Anne Sophie Kubasch, MD, Razif Gabdoulline, Jan Krönke, MD, Rabia Shahswar, Anna Mies, Christian Kandziora, MD, Piroska Klement, Johannes Schiller, Gudrun Göhring, MD, Claudia Haferlach, MD, Christina Ganster, Katayoon Shirneshan, Annika Gutermuth, Christian Thiede, MD, Ulrich Germing, MD, Thomas Schroeder, Guido Kobbe, Sabrina Klesse, Christian Koenecke, Brigitte Schlegelberger, MD PhD, Nicolaus Kroeger, MD, Detlef Haase, MD PhD, Konstanze Döhner, MD, Wolfgang R. Sperr, Peter Valent, Arnold Ganser, MD, Felicitas Thol, MD, Torsten Haferlach, MD, Uwe Platzbecker, Michael Heuser, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4360.
https://doi.org/10.1182/blood-2018-99-114026
Published: 2018
Journal Articles

Pomalidomide-Based Homo-Protacs for the Chemical Knockdown of Cereblon

Stefanie Lindner, Dr., Christian Steinebach, Namrata Udeshi, Deepak Mani, Hannes Kehm, Simon Köpff, Steven A. Carr, PhD, Michael Gütschow, Prof. Dr., Jan Krönke, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 260.
https://doi.org/10.1182/blood-2018-99-116376
Published: 2018
Journal Articles

Role of N6-Methyladenosine (m6A) RNA Modification in Multiple Myeloma

Christian Bach, Magdalena Leffler, Cindy Flamann, Jan Kronke, Dimitrios Mougiakakos, Andreas Mackensen, MD, Heiko Bruns, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5601.
https://doi.org/10.1182/blood-2018-99-115820
Published: 2018