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Phase 2 study of CEP-701, an orally available JAK2 inhibitor, in patients with primary or post-polycythemia vera/essential thrombocythemia myelofibrosis
Issue Archive
February 11 2010
Table of Contents
INSIDE BLOOD
PLENARY PAPERS
A randomized phase 3 study on the effect of thalidomide combined with adriamycin, dexamethasone, and high-dose melphalan, followed by thalidomide maintenance in patients with multiple myeloma
Henk M. Lokhorst,Bronno van der Holt,Sonja Zweegman,Edo Vellenga,Sandra Croockewit,Marinus H. van Oers,Peter von dem Borne,Pierre Wijermans,Ron Schaafsma,Okke de Weerdt,Shulamiet Wittebol,Michel Delforge,Henriëtte Berenschot,Gerard M. Bos,Kon-Siong G. Jie,Harm Sinnige,Marinus van Marwijk-Kooy,Peter Joosten,Monique C. Minnema,Rianne van Ammerlaan,Pieter Sonneveld,for Dutch-Belgian Hemato-Oncology Group (HOVON)
REVIEW ARTICLES
CLINICAL TRIALS AND OBSERVATIONS
Phase 2 study of CEP-701, an orally available JAK2 inhibitor, in patients with primary or post-polycythemia vera/essential thrombocythemia myelofibrosis
Clinical Trials & Observations
Fabio P. S. Santos,Hagop M. Kantarjian,Nitin Jain,Taghi Manshouri,Deborah A. Thomas,Guillermo Garcia-Manero,Debra Kennedy,Zeev Estrov,Jorge Cortes,Srdan Verstovsek
HEMATOPOIESIS AND STEM CELLS
IMMUNOBIOLOGY
Transient Epstein-Barr virus reactivation in CD3 monoclonal antibody-treated patients
Bart Keymeulen,Sophie Candon,Samira Fafi-Kremer,Anette Ziegler,Marianne Leruez-Ville,Chantal Mathieu,Evy Vandemeulebroucke,Markus Walter,Laurent Crenier,Eric Thervet,Christophe Legendre,Denis Pierard,Geoff Hale,Herman Waldmann,Jean-François Bach,Jean Marie Seigneurin,Daniel Pipeleers,Lucienne Chatenoud
Granzyme B produced by human plasmacytoid dendritic cells suppresses T-cell expansion
Bernd Jahrsdörfer,Angelika Vollmer,Sue E. Blackwell,Julia Maier,Kai Sontheimer,Thamara Beyer,Birgit Mandel,Oleg Lunov,Kyrylo Tron,G. Ulrich Nienhaus,Thomas Simmet,Klaus-Michael Debatin,George J. Weiner,Dorit Fabricius
LYMPHOID NEOPLASIA
Alterations in the antigen processing-presenting machinery of transformed plasma cells are associated with reduced recognition by CD8+ T cells and characterize the progression of MGUS to multiple myeloma
Vito Racanelli,Patrizia Leone,Maria Antonia Frassanito,Claudia Brunetti,Federico Perosa,Soldano Ferrone,Franco Dammacco
CD19 targeting of chronic lymphocytic leukemia with a novel Fc-domain–engineered monoclonal antibody
Farrukh T. Awan,Rosa Lapalombella,Rossana Trotta,Jonathan P. Butchar,Bo Yu,Don M. Benson, Jr,Julie M. Roda,Carolyn Cheney,Xiaokui Mo,Amy Lehman,Jeffrey Jones,Joseph Flynn,David Jarjoura,John R. Desjarlais,Susheela Tridandapani,Michael A. Caligiuri,Natarajan Muthusamy,John C. Byrd
DNA methylation for subtype classification and prediction of treatment outcome in patients with childhood acute lymphoblastic leukemia
Lili Milani,Anders Lundmark,Anna Kiialainen,Jessica Nordlund,Trond Flaegstad,Erik Forestier,Mats Heyman,Gudmundur Jonmundsson,Jukka Kanerva,Kjeld Schmiegelow,Stefan Söderhäll,Mats G. Gustafsson,Gudmar Lönnerholm,Ann-Christine Syvänen
Gene expression profiling identifies emerging oncogenic pathways operating in extranodal NK/T-cell lymphoma, nasal type
Yenlin Huang,Aurélien de Reyniès,Laurence de Leval,Bouchra Ghazi,Nadine Martin-Garcia,Marion Travert,Jacques Bosq,Josette Brière,Barbara Petit,Emilie Thomas,Paul Coppo,Teresa Marafioti,Jean-François Emile,Marie-Hélène Delfau-Larue,Christian Schmitt,Philippe Gaulard
MYELOID NEOPLASIA
PLATELETS AND THROMBOPOIESIS
A murine model of severe immune thrombocytopenia is induced by antibody- and CD8+ T cell–mediated responses that are differentially sensitive to therapy
Leola Chow,Rukhsana Aslam,Edwin R. Speck,Michael Kim,Norman Cridland,Michelle Lee Webster,Pingguo Chen,Kim Sahib,Heyu Ni,Alan H. Lazarus,M. Bernadette Garvey,John Freedman,John W. Semple
THROMBOSIS AND HEMOSTASIS
The mouse mutation “thrombocytopenia and cardiomyopathy” (trac) disrupts Abcg5: a spontaneous single gene model for human hereditary phytosterolemia/sitosterolemia
Thomas H. Chase,Bonnie L. Lyons,Roderick T. Bronson,Oded Foreman,Leah Rae Donahue,Lisa M. Burzenski,Bruce Gott,Priscilla Lane,Belinda Harris,Uta Ceglarek,Joachim Thiery,Henning Wittenburg,Jonathan N. Thon,Joseph E. Italiano, Jr,Kenneth R. Johnson,Leonard D. Shultz
TRANSPLANTATION
Donor statin treatment protects against severe acute graft-versus-host disease after related allogeneic hematopoietic cell transplantation
Marcello Rotta,Barry E. Storer,Rainer F. Storb,Paul J. Martin,Shelly Heimfeld,Amanda Peffer,David G. Maloney,H. Joachim Deeg,Brenda M. Sandmaier,Frederick R. Appelbaum,Marco Mielcarek
Purified T-depleted, CD34+ peripheral blood and bone marrow cell transplantation from haploidentical mother to child with thalassemia
Pietro Sodani,Antonella Isgrò,Javid Gaziev,Paola Polchi,Katia Paciaroni,Marco Marziali,Maria Domenica Simone,Andrea Roveda,Aldo Montuoro,Cecilia Alfieri,Gioia De Angelis,Cristiano Gallucci,Buket Erer,Giancarlo Isacchi,Francesco Zinno,Gaspare Adorno,Alessandro Lanti,Lawrence Faulkner,Manuela Testi,Marco Andreani,Guido Lucarelli
VASCULAR BIOLOGY
ERRATA
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Cover Image
Cover Image
![issue cover]()
A genetic defect in sterol regulatory mechanisms leads to high levels of plant sterols in a mutant mouse, resulting in cardiac and hematologic abnormalities. This image of a Masson trichrome--stained section of an entire mouse heart shows the severe patchy collagen deposition (blue) that replaces dying cardiomyocytes (red). See the article by Chase et al on page 1267.
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