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Issue Archive

Volume 115, Issue 6
February 11 2010
Issue Cover

Table of Contents

INSIDE BLOOD

CLINICAL TRIALS
A TAD better for myeloma therapy?
Sergio Giralt
View Articletitled, A TAD better for myeloma therapy?
IMMUNOBIOLOGY
NK-cell education: KIR-S come into play
Thierry Walzer
View Articletitled, NK-cell education: KIR-S come into play
PLATELETS & THROMBOPOIESIS
A means to an end: ubiquitination of Mpl
Wei Tong
View Articletitled, A means to an end: ubiquitination of Mpl
TRANSPLANTATION
Breaking barriers
Ann Woolfrey
View Articletitled, Breaking barriers

PLENARY PAPERS

A randomized phase 3 study on the effect of thalidomide combined with adriamycin, dexamethasone, and high-dose melphalan, followed by thalidomide maintenance in patients with multiple myeloma
Henk M. Lokhorst,Bronno van der Holt,Sonja Zweegman,Edo Vellenga,Sandra Croockewit,Marinus H. van Oers,Peter von dem Borne,Pierre Wijermans,Ron Schaafsma,Okke de Weerdt,Shulamiet Wittebol,Michel Delforge,Henriëtte Berenschot,Gerard M. Bos,Kon-Siong G. Jie,Harm Sinnige,Marinus van Marwijk-Kooy,Peter Joosten,Monique C. Minnema,Rianne van Ammerlaan,Pieter Sonneveld,for Dutch-Belgian Hemato-Oncology Group (HOVON)
View Articletitled, A randomized phase 3 study on the effect of thalidomide combined with adriamycin, dexamethasone, and high-dose melphalan, followed by thalidomide maintenance in patients with multiple myeloma

REVIEW ARTICLES

The protein C pathway in tissue inflammation and injury: pathogenic role and therapeutic implications
Silvio Danese,Stefania Vetrano,Li Zhang,Victoria A. Poplis,Francis J. Castellino
View Articletitled, The protein C pathway in tissue inflammation and injury: pathogenic role and therapeutic implications

CLINICAL TRIALS AND OBSERVATIONS

Phase 2 study of CEP-701, an orally available JAK2 inhibitor, in patients with primary or post-polycythemia vera/essential thrombocythemia myelofibrosis
Clinical Trials & Observations
Fabio P. S. Santos,Hagop M. Kantarjian,Nitin Jain,Taghi Manshouri,Deborah A. Thomas,Guillermo Garcia-Manero,Debra Kennedy,Zeev Estrov,Jorge Cortes,Srdan Verstovsek
View Articletitled, Phase 2 study of CEP-701, an orally available JAK2 inhibitor, in patients with primary or post-polycythemia vera/essential thrombocythemia myelofibrosis

HEMATOPOIESIS AND STEM CELLS

Multiple extrathymic precursors contribute to T-cell development with different kinetics
Namita Saran,Marcin Łyszkiewicz,Jens Pommerencke,Katrin Witzlau,Ramin Vakilzadeh,Matthias Ballmaier,Harald von Boehmer,Andreas Krueger
View Articletitled, Multiple extrathymic precursors contribute to T-cell development with different kinetics

IMMUNOBIOLOGY

Transient Epstein-Barr virus reactivation in CD3 monoclonal antibody-treated patients
Bart Keymeulen,Sophie Candon,Samira Fafi-Kremer,Anette Ziegler,Marianne Leruez-Ville,Chantal Mathieu,Evy Vandemeulebroucke,Markus Walter,Laurent Crenier,Eric Thervet,Christophe Legendre,Denis Pierard,Geoff Hale,Herman Waldmann,Jean-François Bach,Jean Marie Seigneurin,Daniel Pipeleers,Lucienne Chatenoud
View Articletitled, Transient Epstein-Barr virus reactivation in CD3 monoclonal antibody-treated patients
Supplemental data
Granzyme B produced by human plasmacytoid dendritic cells suppresses T-cell expansion
Bernd Jahrsdörfer,Angelika Vollmer,Sue E. Blackwell,Julia Maier,Kai Sontheimer,Thamara Beyer,Birgit Mandel,Oleg Lunov,Kyrylo Tron,G. Ulrich Nienhaus,Thomas Simmet,Klaus-Michael Debatin,George J. Weiner,Dorit Fabricius
View Articletitled, Granzyme B produced by human plasmacytoid dendritic cells suppresses T-cell expansion
Supplemental data
Education of human natural killer cells by activating killer cell immunoglobulin-like receptors
Cyril Fauriat,Martin A. Ivarsson,Hans-Gustaf Ljunggren,Karl-Johan Malmberg,Jakob Michaëlsson
View Articletitled, Education of human natural killer cells by activating killer cell immunoglobulin-like receptors
Supplemental data

LYMPHOID NEOPLASIA

Acute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss
Hind Medyouf,Xiuhua Gao,Florence Armstrong,Samuel Gusscott,Qing Liu,Amanda Larson Gedman,Larry H. Matherly,Kirk R. Schultz,Francoise Pflumio,Mingjian James You,Andrew P. Weng
View Articletitled, Acute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss
Supplemental data
Alterations in the antigen processing-presenting machinery of transformed plasma cells are associated with reduced recognition by CD8+ T cells and characterize the progression of MGUS to multiple myeloma
Vito Racanelli,Patrizia Leone,Maria Antonia Frassanito,Claudia Brunetti,Federico Perosa,Soldano Ferrone,Franco Dammacco
View Articletitled, Alterations in the antigen processing-presenting machinery of transformed plasma cells are associated with reduced recognition by CD8<sup>+</sup> T cells and characterize the progression of MGUS to multiple myeloma
Supplemental data
Retroviral insertional mutagenesis identifies Zeb2 activation as a novel leukemogenic collaborating event in CALM-AF10 transgenic mice
David Caudell,David P. Harper,Rachel L. Novak,Rachel M. Pierce,Christopher Slape,Linda Wolff,Peter D. Aplan
View Articletitled, Retroviral insertional mutagenesis identifies <em>Zeb2</em> activation as a novel leukemogenic collaborating event in <em>CALM-AF10</em> transgenic mice
Supplemental data
CD19 targeting of chronic lymphocytic leukemia with a novel Fc-domain–engineered monoclonal antibody
Farrukh T. Awan,Rosa Lapalombella,Rossana Trotta,Jonathan P. Butchar,Bo Yu,Don M. Benson, Jr,Julie M. Roda,Carolyn Cheney,Xiaokui Mo,Amy Lehman,Jeffrey Jones,Joseph Flynn,David Jarjoura,John R. Desjarlais,Susheela Tridandapani,Michael A. Caligiuri,Natarajan Muthusamy,John C. Byrd
View Articletitled, CD19 targeting of chronic lymphocytic leukemia with a novel Fc-domain–engineered monoclonal antibody
DNA methylation for subtype classification and prediction of treatment outcome in patients with childhood acute lymphoblastic leukemia
Lili Milani,Anders Lundmark,Anna Kiialainen,Jessica Nordlund,Trond Flaegstad,Erik Forestier,Mats Heyman,Gudmundur Jonmundsson,Jukka Kanerva,Kjeld Schmiegelow,Stefan Söderhäll,Mats G. Gustafsson,Gudmar Lönnerholm,Ann-Christine Syvänen
View Articletitled, DNA methylation for subtype classification and prediction of treatment outcome in patients with childhood acute lymphoblastic leukemia
Supplemental data
Gene expression profiling identifies emerging oncogenic pathways operating in extranodal NK/T-cell lymphoma, nasal type
Yenlin Huang,Aurélien de Reyniès,Laurence de Leval,Bouchra Ghazi,Nadine Martin-Garcia,Marion Travert,Jacques Bosq,Josette Brière,Barbara Petit,Emilie Thomas,Paul Coppo,Teresa Marafioti,Jean-François Emile,Marie-Hélène Delfau-Larue,Christian Schmitt,Philippe Gaulard
View Articletitled, Gene expression profiling identifies emerging oncogenic pathways operating in extranodal NK/T-cell lymphoma, nasal type
Supplemental data

MYELOID NEOPLASIA

Ras-induced reactive oxygen species promote growth factor–independent proliferation in human CD34+ hematopoietic progenitor cells
Paul S. Hole,Lorna Pearn,Amanda J. Tonks,Philip E. James,Alan K. Burnett,Richard L. Darley,Alex Tonks
View Articletitled, Ras-induced reactive oxygen species promote growth factor–independent proliferation in human CD34<sup>+</sup> hematopoietic progenitor cells
Supplemental data

PLATELETS AND THROMBOPOIESIS

A murine model of severe immune thrombocytopenia is induced by antibody- and CD8+ T cell–mediated responses that are differentially sensitive to therapy
Leola Chow,Rukhsana Aslam,Edwin R. Speck,Michael Kim,Norman Cridland,Michelle Lee Webster,Pingguo Chen,Kim Sahib,Heyu Ni,Alan H. Lazarus,M. Bernadette Garvey,John Freedman,John W. Semple
View Articletitled, A murine model of severe immune thrombocytopenia is induced by antibody- and CD8<sup>+</sup> T cell–mediated responses that are differentially sensitive to therapy
Supplemental data
Ubiquitination and degradation of the thrombopoietin receptor c-Mpl
Sebastian J. Saur,Veena Sangkhae,Amy E. Geddis,Kenneth Kaushansky,Ian S. Hitchcock
View Articletitled, Ubiquitination and degradation of the thrombopoietin receptor c-Mpl
Persons with Quebec platelet disorder have a tandem duplication of PLAU, the urokinase plasminogen activator gene
Brief Report
Andrew D. Paterson,Johanna M. Rommens,Bhupinder Bharaj,Jessica Blavignac,Isidro Wong,Maria Diamandis,John S. Waye,Georges E. Rivard,Catherine P. M. Hayward
View Articletitled, Persons with Quebec platelet disorder have a tandem duplication of <em>PLAU</em>, the urokinase plasminogen activator gene
Supplemental data

THROMBOSIS AND HEMOSTASIS

The mouse mutation “thrombocytopenia and cardiomyopathy” (trac) disrupts Abcg5: a spontaneous single gene model for human hereditary phytosterolemia/sitosterolemia
Thomas H. Chase,Bonnie L. Lyons,Roderick T. Bronson,Oded Foreman,Leah Rae Donahue,Lisa M. Burzenski,Bruce Gott,Priscilla Lane,Belinda Harris,Uta Ceglarek,Joachim Thiery,Henning Wittenburg,Jonathan N. Thon,Joseph E. Italiano, Jr,Kenneth R. Johnson,Leonard D. Shultz
View Articletitled, The mouse mutation “thrombocytopenia and cardiomyopathy” <em>(trac)</em> disrupts <em>Abcg5</em>: a spontaneous single gene model for human hereditary phytosterolemia/sitosterolemia
Impaired clot retraction in factor XIII A subunit–deficient mice
Brief Report
Kohji Kasahara,Masayoshi Souri,Mizuho Kaneda,Toshiaki Miki,Naomasa Yamamoto,Akitada Ichinose
View Articletitled, Impaired clot retraction in factor XIII A subunit–deficient mice
Supplemental data

TRANSPLANTATION

A CD8 T cell–intrinsic role for the calcineurin-NFAT pathway for tolerance induction in vivo
Thomas Fehr,Carrie L. Lucas,Josef Kurtz,Takashi Onoe,Guiling Zhao,Timothy Hogan,Casey Vallot,Anjana Rao,Megan Sykes
View Articletitled, A CD8 T cell–intrinsic role for the calcineurin-NFAT pathway for tolerance induction in vivo
Donor statin treatment protects against severe acute graft-versus-host disease after related allogeneic hematopoietic cell transplantation
Marcello Rotta,Barry E. Storer,Rainer F. Storb,Paul J. Martin,Shelly Heimfeld,Amanda Peffer,David G. Maloney,H. Joachim Deeg,Brenda M. Sandmaier,Frederick R. Appelbaum,Marco Mielcarek
View Articletitled, Donor statin treatment protects against severe acute graft-versus-host disease after related allogeneic hematopoietic cell transplantation
Purified T-depleted, CD34+ peripheral blood and bone marrow cell transplantation from haploidentical mother to child with thalassemia
Pietro Sodani,Antonella Isgrò,Javid Gaziev,Paola Polchi,Katia Paciaroni,Marco Marziali,Maria Domenica Simone,Andrea Roveda,Aldo Montuoro,Cecilia Alfieri,Gioia De Angelis,Cristiano Gallucci,Buket Erer,Giancarlo Isacchi,Francesco Zinno,Gaspare Adorno,Alessandro Lanti,Lawrence Faulkner,Manuela Testi,Marco Andreani,Guido Lucarelli
View Articletitled, Purified T-depleted, CD34<sup>+</sup> peripheral blood and bone marrow cell transplantation from haploidentical mother to child with thalassemia

VASCULAR BIOLOGY

Fluorinated per-acetylated GalNAc metabolically alters glycan structures on leukocyte PSGL-1 and reduces cell binding to selectins
Dhananjay D. Marathe,Alexander Buffone, Jr,E. V. Chandrasekaran,Jun Xue,Robert D. Locke,Mehrab Nasirikenari,Joseph T. Y. Lau,Khushi L. Matta,Sriram Neelamegham
View Articletitled, Fluorinated per-acetylated GalNAc metabolically alters glycan structures on leukocyte PSGL-1 and reduces cell binding to selectins
Supplemental data

ERRATA

Graves et al. Stable trichimerism after marrow grafting from 2 DLA-identical canine donors and nonmyeloablative conditioning. Blood. 2007;110(1):418–423.
View Articletitled, Graves et al. Stable trichimerism after marrow grafting from 2 DLA-identical canine donors and nonmyeloablative conditioning. <em>Blood</em>. 2007;110(1):<span class="related-article">418–423</span>.
Brodin et al. The strength of inhibitory input during education quantitatively tunes the functional responsiveness of individual natural killer cells. Blood. 2009;113(11):2434–2441.
View Articletitled, Brodin et al. The strength of inhibitory input during education quantitatively tunes the functional responsiveness of individual natural killer cells. <em>Blood</em>. 2009;113(11):<span class="related-article">2434–2441</span>.
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