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Journal Articles

Overproduction of NOX-derived ROS in AML promotes proliferation and is associated with defective oxidative stress signaling

Paul S. Hole, Joanna Zabkiewicz, Chinmay Munje, Zarabeth Newton, Lorna Pearn, Paul White, Nuria Marquez, Robert K. Hills, Alan K. Burnett, Alex Tonks, Richard L. Darley
Journal: Blood
Blood (2013) 122 (19): 3322–3330.
https://doi.org/10.1182/blood-2013-04-491944
Published: 2013
Includes: Supplemental data
Journal Articles

PDK1 Overexpression In Acute Myeloid Leukemia; Clinical Significance and Potential as a Therapeutic Target

Joanna Zabkiewicz, PhD, Lorna Pearn, Robert Hills, MA, MSc, DPhil, Rhys, Gareth Morgan, BSc, Alan Burnett, MD, Alex Tonks, PhD, Richard L Darley, PhD
Journal: Blood
Blood (2010) 116 (21): 2162.
https://doi.org/10.1182/blood.V116.21.2162.2162
Published: 2010
Journal Articles

Distinct Regulation of β- and γ-Catenin throughout Hematopoietic Development Contrasts with Their Cooperative Roles In Acute Myeloid Leukemia.

Rhys Gareth Morgan, BSc, Lorna Pearn, Kate Liddiard, PhD, Robert Hills, MA, MSc, DPhil, Alan Burnett, MD, Alex Tonks, PhD, Richard L Darley, PhD
Journal: Blood
Blood (2010) 116 (21): 1573.
https://doi.org/10.1182/blood.V116.21.1573.1573
Published: 2010
Journal Articles

Ras-induced reactive oxygen species promote growth factor–independent proliferation in human CD34 + hematopoietic progenitor cells

Paul S. Hole, Lorna Pearn, Amanda J. Tonks, Philip E. James, Alan K. Burnett, Richard L. Darley, Alex Tonks
Journal: Blood
Blood (2010) 115 (6): 1238–1246.
https://doi.org/10.1182/blood-2009-06-222869
Published: 2010
Includes: Supplemental data
Journal Articles

Ras Promotes Production of Reactive Oxygen Species in Normal Human CD34 + Cells: Role in Promoting Cell Survival and Protein Phosphorylation

Paul S Hole, BA, Lorna Pearn, Philip E James, PhD, Alan Burnett, MD, Richard L Darley, PhD, Alex Tonks, PhD
Journal: Blood
Blood (2008) 112 (11): 3797.
https://doi.org/10.1182/blood.V112.11.3797.3797
Published: 2008
Journal Articles

The role of PKC and PDK1 in monocyte lineage specification by Ras

Lorna Pearn, Janet Fisher, Alan K. Burnett, Richard L. Darley
Journal: Blood
Blood (2007) 109 (10): 4461–4469.
https://doi.org/10.1182/blood-2006-09-047217
Published: 2007
Journal Articles

Aberrant Megakaryocyte Antigen Expression on Myelodysplastic Erythroid Cells: Role of Protein Kinase C?.

Rachel Elliott, Lorna Pearn, Ala Al-Sabah, Steven Knapper, Alan K. Burnett, Richard Darley
Journal: Blood
Blood (2006) 108 (11): 2625.
https://doi.org/10.1182/blood.V108.11.2625.2625
Published: 2006
Journal Articles

Expression of RUNX1-RUNX1T1 Alone Has No Effect on the Intrinsic Susceptibility to Cytotoxic Chemicals.

Alex Tonks, PhD, Lorna Pearn, Amanda Tonks, PhD, Ken I. Mills, PhD, Alan K. Burnett, MD, Richard L. Darley, PhD
Journal: Blood
Blood (2006) 108 (11): 2602.
https://doi.org/10.1182/blood.V108.11.2602.2602
Published: 2006
Journal Articles

RUNX1-RUNX1T1 Induces Over-Expression of γ-Catenin in Human CD34 + Cells, Increasing Self Renewal and Impairing Granulocytic Differentiation.

Alex Tonks, PhD, Lorna Pearn, Megan Musson, Amanda Gilkes, Ken Mills, PhD, Alan Burnett, MD, Richard Darley, PhD
Journal: Blood
Blood (2005) 106 (11): 3003.
https://doi.org/10.1182/blood.V106.11.3003.3003
Published: 2005
Journal Articles

The AML1-ETO fusion gene promotes extensive self-renewal of human primary erythroid cells

Alex Tonks, Lorna Pearn, Amanda J. Tonks, Laurence Pearce, Terry Hoy, Sarah Phillips, Janet Fisher, James R. Downing, Alan K. Burnett, Richard L. Darley
Journal: Blood
Blood (2003) 101 (2): 624–632.
https://doi.org/10.1182/blood-2002-06-1732
Published: 2003
Journal Articles

Protein kinase C mediates mutant N-Ras–induced developmental abnormalities in normal human erythroid cells

Richard L. Darley, Lorna Pearn, Nader Omidvar, Marion Sweeney, Janet Fisher, Sarah Phillips, Terry Hoy, Alan K. Burnett
Journal: Blood
Blood (2002) 100 (12): 4185–4192.
https://doi.org/10.1182/blood-2002-05-1358
Published: 2002