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A Subpopulation of Blasts with Attenuated p38 MAPK Response Is Seen in Virtually All AML Patients and AML Cell Lines and Is Defined By Cells with Augmented Lipid-Associated Anti-Oxidant Defense

Paul S. Hole, PhD, Sara Davies, MSc, Chinmay R Munje, BSc PhD, Sandra Kreuser, BSc, Robert K. Hills, MA MSc DPhil, Nader Omidvar, PhD, Steven Knapper, DM BMBCh, Alan K. Burnett, MDFRCP, Alex Tonks, BSc PhD, Richard L. Darley, BSc PhD
Journal: Blood
Blood (2014) 124 (21): 785.
https://doi.org/10.1182/blood.V124.21.785.785
Published: 2014
Journal Articles

Efficacy of ABT-737, a BCL-2 Inhibitor, in an NRAS/BCL2 Mouse Model of High Risk Myelodysplasia (HR-MDS) By Targeting Pathways Identified By Gene Expression Profiling

Rose Ann Padua, PhD, Petra Gorombei, MSc, Stéphanie Beurlet, DMV, PhD, Nader Omidvar, PhD, Satyananda Patel, PhD, Laura Guerenne, MSc, Carole Le Pogam, PhD, Niclas Setterblad, PhD, Pierre de la Grange, PhD, Fabien Guidez, PhD, Christophe Le Boeuf, PhD, Anne Janin, MD PhD, Maria-Elena Noguera, MD, Laure Sarda-Mantel, MD PhD, Pascal Merlet, MD, Robert West, PhD, Marika Pla, PhD, Pierre Fenaux, MD PhD, Patricia Krief, PhD, Christine Chomienne, MD PhD
Journal: Blood
Blood (2014) 124 (21): 3249.
https://doi.org/10.1182/blood.V124.21.3249.3249
Published: 2014
Journal Articles

BCL-2 inhibition with ABT-737 prolongs survival in an NRAS/BCL-2 mouse model of AML by targeting primitive LSK and progenitor cells

Stephanie Beurlet, Nader Omidvar, Petra Gorombei, Patricia Krief, Carole Le Pogam, Niclas Setterblad, Pierre de la Grange, Christophe Leboeuf, Anne Janin, Maria-Elena Noguera, Florence Hervatin, Laure Sarda-Mantel, Marina Konopleva, Michael Andreeff, Andrea W. Tu, Alice C. Fan, Dean W. Felsher, Anthony Whetton, Marika Pla, Robert West, Pierre Fenaux, Christine Chomienne, Rose Ann Padua
Journal: Blood
Blood (2013) 122 (16): 2864–2876.
https://doi.org/10.1182/blood-2012-07-445635
Published: 2013
Includes: Supplemental data
Journal Articles

BCL-2 Inhibition with ABT-737 Prolongs Survival in an NRAS/BCL2-Mediated MOUSE MODEL of Myelodyspastic Syndrome (MDS) Progressing to ACUTE Myelogenous Leukemia (AML) by Targeting Leukemia Initiating CELLS

Petra Gorombei, MSc, Beurlet Stephanie, DMV, PhD, Nader Omidvar, PhD, Krief Patricia, PhD, Le Pogam Carole, MSc, Pierre de la Grange, PhD, Leboeuf Christophe, MD, PhD, Anne Janin, MD, PhD, Noguera Maria-Elena, MD, Marina Konopleva, MD, PhD, Michael Andreeff, MD, PhD, Pla Marika, PhD, West Robert, PhD, Pierre Fenaux, MD, PhD, Christine Chomienne, MD, PhD, Rose Ann Padua, PhD
Journal: Blood
Blood (2012) 120 (21): 678.
https://doi.org/10.1182/blood.V120.21.678.678
Published: 2012
Journal Articles

NRAS:BCL-2 Complex Localization Determines Anti-Apoptotic Features Associated with Progressive Disease in Myelodysplastic Syndromes (MDS)

Rose Ann Padua, PhD, Carole Le Pogam, MSc, Patricia Krief, PhD, Stephanie Beurlet, DMV, PhD, Bruno Cassinat, PharmD, PhD, Hélène Cavé, PhD, Olivier Kosmider, MD, PhD, Niclas Setterblad, PhD, Christophe Leboeuf, PhD, Laure Sarda-Mantel, MD, PhD, Florence Hervatin, PhD, Pascal Merlet, MD, Maria-Elena Noguera, MD, Anne Janin, MD, PhD, Marika Pla, PhD, Michaela Fontenay, MD, PhD, Lionel Ades, MD, PhD, Pierre Fenaux, MD, PhD, Christine Chomienne, MD, PhD, Nader Omidvar, PhD
Journal: Blood
Blood (2012) 120 (21): 3835.
https://doi.org/10.1182/blood.V120.21.3835.3835
Published: 2012
Journal Articles

ABT-737 Targets Leukemic Stem Cells In Mouse Models of Mutant NRASD12/hBCL-2- Mediated Acute Myeloid Leukemia Progression with Increased Survival

Rose Ann Padua, PhD, Stephanie Beurlet, DMV, Patricia Krief, PhD, Nader Omidvar, PhD, Carole Le Pogam, BSc, Didier Auboeuf, PhD, Pierre de la Grange, PhD, Annie Soulie, Anne Janin, MD, PhD, Maria-Elena Noguera, MD, Pascal Merlet, MD, Laure Sarda-Mantel, MD, PhD, Pierre Fenaux, MD, PhD, Marina Konopleva, MD, PhD, Michael Andreeff, MD, PhD, Andrea Tu, PhD, Phoebe Yang, PhD, Alice C. Fan, MD, Scott C. Kogan, MD, Irving L. Weissman, MD, Dean W. Felsher, MD, PhD, Marika Pla, PhD, Robert West, PhD, Christine Chomienne, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 3308.
https://doi.org/10.1182/blood.V116.21.3308.3308
Published: 2010
Journal Articles

Mutant BCL2 Co-Operates with CBFβ/PEBP2β-MYH11 to Promote Expansion of Leukemia Initiating Cells with a Predominantly Pro-Apoptotic Mechanism Via Recruitment of Ras-GTP In a Mouse Model of Progressive Acute Myeloid Leukemia.

Nader Omidvar, PhD, Carole Le Pogam, BSc, Stephanie Beurlet, DMV, Maria-Elena Noguera, MD, Ann Janin, MD, PhD, Scott C. Kogan, MD, Irving L. Weissman, MD, Marika Pla, PhD, Christine Chomienne, MD, PhD, Rose Ann Padua, PhD
Journal: Blood
Blood (2010) 116 (21): 1050.
https://doi.org/10.1182/blood.V116.21.1050.1050
Published: 2010
Journal Articles

ABT-737 Targets Intrinsic Apoptosis during Cooperation of BCL-2 and Oncogenic NRAS in An in Vivo Progression Model of Myelodysplasia/Acute Myeloid Leukaemia

Nader Omidvar, Stephanie Beurlet, Carole Le Pogam, Anne Janin, Christophe Leboeuf, Annie Soulie, Niclas Setterblad, Maria-Elena Noguera, Laure Sarda-Mantel, Pascal Merlet, Marika Pla, Scott C. Kogan, MD, Irving L Weissman, Marina Konopleva, William Bormann, Michael Andreeff, Christine Chomienne, Rose Ann Padua
Journal: Blood
Blood (2008) 112 (11): 848.
https://doi.org/10.1182/blood.V112.11.848.848
Published: 2008
Journal Articles

Protein kinase C mediates mutant N-Ras–induced developmental abnormalities in normal human erythroid cells

Richard L. Darley, Lorna Pearn, Nader Omidvar, Marion Sweeney, Janet Fisher, Sarah Phillips, Terry Hoy, Alan K. Burnett
Journal: Blood
Blood (2002) 100 (12): 4185–4192.
https://doi.org/10.1182/blood-2002-05-1358
Published: 2002