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Carole Le Pogam
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Efficacy of ABT-737, a BCL-2 Inhibitor, in an NRAS/BCL2 Mouse Model of High Risk Myelodysplasia (HR-MDS) By Targeting Pathways Identified By Gene Expression Profiling

Rose Ann Padua, PhD, Petra Gorombei, MSc, Stéphanie Beurlet, DMV, PhD, Nader Omidvar, PhD, Satyananda Patel, PhD, Laura Guerenne, MSc, Carole Le Pogam, PhD, Niclas Setterblad, PhD, Pierre de la Grange, PhD, Fabien Guidez, PhD, Christophe Le Boeuf, PhD, Anne Janin, MD PhD, Maria-Elena Noguera, MD, Laure Sarda-Mantel, MD PhD, Pascal Merlet, MD, Robert West, PhD, Marika Pla, PhD, Pierre Fenaux, MD PhD, Patricia Krief, PhD, Christine Chomienne, MD PhD
Journal: Blood
Blood (2014) 124 (21): 3249.
https://doi.org/10.1182/blood.V124.21.3249.3249
Published: 2014
Journal Articles

pVAX14 DNA, a Non-Specific DNA Vaccine, Improves Survival In An Acute Promyelocytic Leukemia (APL) Mouse Model Treated With All-Trans Retinoic Acid (ATRA) and Arsenic Trioxide (ATO) and Targets Leukemia Initiating Cells (LICs)

Satyananda Patel, PhD, Laura Guerenne, Carole Le Pogam, Petra Gorombei, Patricia Krief, PhD, Marie-Helene Schlageter, Robert West, Vikram Mathews, MD, Marika Pla, PhD, Pierre Fenaux, MD, PhD, Christine Chomienne, MD, PhD, Rose Ann Padua, PhD
Journal: Blood
Blood (2013) 122 (21): 235.
https://doi.org/10.1182/blood.V122.21.235.235
Published: 2013
Journal Articles

BCL-2 inhibition with ABT-737 prolongs survival in an NRAS/BCL-2 mouse model of AML by targeting primitive LSK and progenitor cells

Stephanie Beurlet, Nader Omidvar, Petra Gorombei, Patricia Krief, Carole Le Pogam, Niclas Setterblad, Pierre de la Grange, Christophe Leboeuf, Anne Janin, Maria-Elena Noguera, Florence Hervatin, Laure Sarda-Mantel, Marina Konopleva, Michael Andreeff, Andrea W. Tu, Alice C. Fan, Dean W. Felsher, Anthony Whetton, Marika Pla, Robert West, Pierre Fenaux, Christine Chomienne, Rose Ann Padua
Journal: Blood
Blood (2013) 122 (16): 2864–2876.
https://doi.org/10.1182/blood-2012-07-445635
Published: 2013
Includes: Supplemental data
Journal Articles

NRAS:BCL-2 Complex Localization Determines Anti-Apoptotic Features Associated with Progressive Disease in Myelodysplastic Syndromes (MDS)

Rose Ann Padua, PhD, Carole Le Pogam, MSc, Patricia Krief, PhD, Stephanie Beurlet, DMV, PhD, Bruno Cassinat, PharmD, PhD, Hélène Cavé, PhD, Olivier Kosmider, MD, PhD, Niclas Setterblad, PhD, Christophe Leboeuf, PhD, Laure Sarda-Mantel, MD, PhD, Florence Hervatin, PhD, Pascal Merlet, MD, Maria-Elena Noguera, MD, Anne Janin, MD, PhD, Marika Pla, PhD, Michaela Fontenay, MD, PhD, Lionel Ades, MD, PhD, Pierre Fenaux, MD, PhD, Christine Chomienne, MD, PhD, Nader Omidvar, PhD
Journal: Blood
Blood (2012) 120 (21): 3835.
https://doi.org/10.1182/blood.V120.21.3835.3835
Published: 2012
Journal Articles

Tracking the Extramedullary PML-RARα-Positive Cell Reservoirs in a Preclinical Model of APL: Biomarker of Long-Term Drug Efficacy

Katerina Pokorna, PhD, Carole Le Pogam, BSc, Martine Chopin, Bruno Cassinat, PharmD, PhD, Pierre Fenaux, MD, PhD, Christine Chomienne, MD, PhD, Rose Ann Padua, PhD, Marika Pla, PhD
Journal: Blood
Blood (2012) 120 (21): 1510.
https://doi.org/10.1182/blood.V120.21.1510.1510
Published: 2012
Journal Articles

ABT-737 Targets Leukemic Stem Cells In Mouse Models of Mutant NRASD12/hBCL-2- Mediated Acute Myeloid Leukemia Progression with Increased Survival

Rose Ann Padua, PhD, Stephanie Beurlet, DMV, Patricia Krief, PhD, Nader Omidvar, PhD, Carole Le Pogam, BSc, Didier Auboeuf, PhD, Pierre de la Grange, PhD, Annie Soulie, Anne Janin, MD, PhD, Maria-Elena Noguera, MD, Pascal Merlet, MD, Laure Sarda-Mantel, MD, PhD, Pierre Fenaux, MD, PhD, Marina Konopleva, MD, PhD, Michael Andreeff, MD, PhD, Andrea Tu, PhD, Phoebe Yang, PhD, Alice C. Fan, MD, Scott C. Kogan, MD, Irving L. Weissman, MD, Dean W. Felsher, MD, PhD, Marika Pla, PhD, Robert West, PhD, Christine Chomienne, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 3308.
https://doi.org/10.1182/blood.V116.21.3308.3308
Published: 2010
Journal Articles

Mutant BCL2 Co-Operates with CBFβ/PEBP2β-MYH11 to Promote Expansion of Leukemia Initiating Cells with a Predominantly Pro-Apoptotic Mechanism Via Recruitment of Ras-GTP In a Mouse Model of Progressive Acute Myeloid Leukemia.

Nader Omidvar, PhD, Carole Le Pogam, BSc, Stephanie Beurlet, DMV, Maria-Elena Noguera, MD, Ann Janin, MD, PhD, Scott C. Kogan, MD, Irving L. Weissman, MD, Marika Pla, PhD, Christine Chomienne, MD, PhD, Rose Ann Padua, PhD
Journal: Blood
Blood (2010) 116 (21): 1050.
https://doi.org/10.1182/blood.V116.21.1050.1050
Published: 2010
Journal Articles

DNA and All-Trans Retinoic Acid as Immunotherapy or Add-on Adjuvants to 5-Azacytidine In Myelodysplastic Syndromes

Carole Le Pogam, BSc, Patricia Krief, PhD, Stéphanie Beurlet, DMV, Murielle Reboul, Robert West, PhD, Marika Pla, PhD, Dominique Charron, MD, PhD, Pierre Fenaux, MD, PhD, Christine Chomienne, MD, PhD, Rose Ann Padua, PhD
Journal: Blood
Blood (2010) 116 (21): 2938.
https://doi.org/10.1182/blood.V116.21.2938.2938
Published: 2010
Journal Articles

DNA vaccination with all- trans retinoic acid treatment induces long-term survival and elicits specific immune responses requiring CD4 + and CD8 + T-cell activation in an acute promyelocytic leukemia mouse model

Brief Report
Kouichi Furugaki, Katerina Pokorna, Carole Le Pogam, Masayuki Aoki, Murielle Reboul, Véronique Bajzik, Patricia Krief, Anne Janin, Marie-Elena Noguera, Robert West, Dominique Charron, Christine Chomienne, Marika Pla, Hélène Moins-Teisserenc, Rose Ann Padua
Journal: Blood
Blood (2010) 115 (3): 653–656.
https://doi.org/10.1182/blood-2007-08-109009
Published: 2010
Includes: Supplemental data
Journal Articles

ABT-737 Targets Intrinsic Apoptosis during Cooperation of BCL-2 and Oncogenic NRAS in An in Vivo Progression Model of Myelodysplasia/Acute Myeloid Leukaemia

Nader Omidvar, Stephanie Beurlet, Carole Le Pogam, Anne Janin, Christophe Leboeuf, Annie Soulie, Niclas Setterblad, Maria-Elena Noguera, Laure Sarda-Mantel, Pascal Merlet, Marika Pla, Scott C. Kogan, MD, Irving L Weissman, Marina Konopleva, William Bormann, Michael Andreeff, Christine Chomienne, Rose Ann Padua
Journal: Blood
Blood (2008) 112 (11): 848.
https://doi.org/10.1182/blood.V112.11.848.848
Published: 2008
Journal Articles

DNA Vaccination and All-Trans Retinoic Acid Treatment-Induced Long Term Survival Requires CD4+ and CD8+ T-Cell Activation in An APL Mouse Model.

Rose Ann Padua, PhD, Kouichi Furugaki, MD, PhD, Helene Moins-Teisserenc, MD, PhD, Katerina Pokorna, Carole Le Pogam, Murielle Reboul, Masayuki Aoki, PhD, Veronique Bajzik, Patricia Krief, PhD, Anne Janin, MD, PhD, Maria-Elena Noguera, MD, Robert West, PhD, Marie-Helene Schlageter, PhD, Dominique Charron, MD, PhD, Marika Pla, PhD, Christine Chomienne, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 962.
https://doi.org/10.1182/blood.V112.11.962.962
Published: 2008