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Journal Articles

A CCR2 macrophage endocytic pathway mediates extravascular fibrin clearance in vivo

Michael P. Motley, Daniel H. Madsen, Henrik J. Jürgensen, David E. Spencer, Roman Szabo, Kenn Holmbeck, Matthew J. Flick, Daniel A. Lawrence, Francis J. Castellino, Roberto Weigert, Thomas H. Bugge

Blood (2016) 127 (9): 1085–1096.

https://doi.org/10.1182/blood-2015-05-644260

Published: 2016

Includes: Supplemental data

Journal Articles

AAV-mediated gene transfer in the perinatal period results in expression of FVII at levels that protect against fatal spontaneous hemorrhage

Christopher Binny, Jenny McIntosh, Marco Della Peruta, Hanna Kymalainen, Edward G. D. Tuddenham, Suzanne M. K. Buckley, Simon N. Waddington, John H. McVey, Yunyu Spence, Christopher L. Morton, Adrian J. Thrasher, John T. Gray, Francis J. Castellino, Alice F. Tarantal, Andrew M. Davidoff, Amit C. Nathwani

Blood (2012) 119 (4): 957–966.

https://doi.org/10.1182/blood-2011-09-377630

Published: 2012

Includes: Supplemental data

Journal Articles

Monoclonal antibodies detect receptor-induced binding sites in Glu-plasminogen

Jaena Han, Nagyung Baik, Kee-Hwan Kim, Jian-Ming Yang, Gye Won Han, Yun Gong, Mercè Jardí, Francis J. Castellino, Jordi Felez, Robert J. Parmer, Lindsey A. Miles

Blood (2011) 118 (6): 1653–1662.

https://doi.org/10.1182/blood-2010-11-316943

Published: 2011

Includes: Supplemental data

Journal Articles

An accompanying genetic severe deficiency of tissue factor protects mice with a protein C deficiency from lethal endotoxemia

Francis J. Castellino, Deborah L. Donahue, Rudolph M. Navari, Victoria A. Ploplis, Mark Walsh

Blood (2011) 117 (1): 283–289.

https://doi.org/10.1182/blood-2010-07-299057

Published: 2011

Journal Articles

Plasminogen activator inhibitor-1 (PAI-1) is cardioprotective in mice by maintaining microvascular integrity and cardiac architecture

Zhi Xu, Francis J. Castellino, Victoria A. Ploplis

Blood (2010) 115 (10): 2038–2047.

https://doi.org/10.1182/blood-2009-09-244962

Published: 2010

Journal Articles

The protein C pathway in tissue inflammation and injury: pathogenic role and therapeutic implications

Silvio Danese, Stefania Vetrano, Li Zhang, Victoria A. Poplis, Francis J. Castellino

Blood (2010) 115 (6): 1121–1130.

https://doi.org/10.1182/blood-2009-09-201616

Published: 2010

Journal Articles

Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality

Frank Niessen, Christian Furlan-Freguia, José A. Fernández, Laurent O. Mosnier, Francis J. Castellino, Hartmut Weiler, Hugh Rosen, John H. Griffin, Wolfram Ruf

Blood (2009) 113 (12): 2859–2866.

https://doi.org/10.1182/blood-2008-12-192385

Published: 2009

Journal Articles

Deletion of murine kininogen gene 1 ( mKng1 ) causes loss of plasma kininogen and delays thrombosis

Sergei Merkulov, Wan-Ming Zhang, Anton A. Komar, Alvin H. Schmaier, Ellen Barnes, Yihua Zhou, Xincheng Lu, Takayuki Iwaki, Francis J. Castellino, Guangbin Luo, Keith R. McCrae

Blood (2008) 111 (3): 1274–1281.

https://doi.org/10.1182/blood-2007-06-092338

Published: 2008

Journal Articles

A FVII Deficiency Induces Cardiac Fibrosis in Mice Resulting in Systolic and Diastolic Dysfunction.

Haifeng Xu, MD, PhD, Mayra Sandoval-Cooper, B.S., Deborah L. Donahue, B.S., Victoria A. Ploplis, Ph.D, Francis J. Castellino, Ph.D.

Blood (2007) 110 (11): 1747.

https://doi.org/10.1182/blood.V110.11.1747.1747

Published: 2007

Journal Articles

The Protective Role of Protein C in Endotoxin-Induced Shock.

Angelina J. Lay, PhD, Deborah Donahue, BS, Meng-Ju Tsai, BS, Francis J. Castellino, PhD

Blood (2007) 110 (11): 1748.

https://doi.org/10.1182/blood.V110.11.1748.1748

Published: 2007

Journal Articles

Exosomes released from macrophages infected with intracellular pathogens stimulate a proinflammatory response in vitro and in vivo

Sanchita Bhatnagar, Kazuhiko Shinagawa, Francis J. Castellino, Jeffrey S. Schorey

Blood (2007) 110 (9): 3234–3244.

https://doi.org/10.1182/blood-2007-03-079152

Published: 2007

Journal Articles

Plasminogen Activator Inhibitor 1 Deficiency Reduces the Progression of Atherosclerosis in a Murine Model of Human Familial Hypercholesterolemia.

Takayuki Iwaki, MD, PhD, Ploplis A. Victoria, Ph.D., Francis J. Castellino, Ph.D.

Blood (2006) 108 (11): 1804.

https://doi.org/10.1182/blood.V108.11.1804.1804

Published: 2006

Journal Articles

Mechanisms for Mortality Reduction by Activated Protein C in Severe Sepsis.

Edward J. Kerschen, PhD, Brian C. Cooley, PhD, Francis J. Castellino, PhD, Shaun R. Coughlin, MD, PhD, Jose A. Fernandez, MD, PhD, John H. Griffin, PhD, Hartmut Weiler, PhD

Blood (2006) 108 (11): 1.

https://doi.org/10.1182/blood.V108.11.1.1

Published: 2006

Journal Articles

Performance of Murine Soluble Thrombomodulin (rmsTM) in a Murine Model of Endotoxin-Induced Sepsis.

David E. Joyce, MD, Haifeng Xu, MD, Sumeet Mathur, Francis J. Castellino, PhD

Blood (2006) 108 (11): 3933.

https://doi.org/10.1182/blood.V108.11.3933.3933

Published: 2006

Journal Articles

Acute inflammation is exacerbated in mice genetically predisposed to a severe protein C deficiency

Angelina J. Lay, Deborah Donahue, Meng-Ju Tsai, Francis J. Castellino

Blood (2006) 109 (5): 1984–1991.

https://doi.org/10.1182/blood-2006-07-037945

Published: 2006

Journal Articles

Plasminogen inhibits TNFα-induced apoptosis in monocytes

Jennifer W. Mitchell, Nagyung Baik, Francis J. Castellino, Lindsey A. Miles

Blood (2006) 107 (11): 4383–4390.

https://doi.org/10.1182/blood-2005-07-2872

Published: 2006

Journal Articles

A fibrinogen deficiency accelerates the initiation of LDL cholesterol–driven atherosclerosis via thrombin generation and platelet activation in genetically predisposed mice

Takayuki Iwaki, Mayra J. Sandoval-Cooper, Markus Brechmann, Victoria A. Ploplis, Francis J. Castellino

Blood (2006) 107 (10): 3883–3891.

https://doi.org/10.1182/blood-2005-09-3780

Published: 2006

Journal Articles

Recombinant Human Activated Protein C Suppresses Endotoxin Induced Hypotension in Mice Deficient of the Endothelial Protein C Receptor (EPCR).

David E. Joyce, MD, Deborah L. Donahue, BS, Patricia C. Liaw, PhD, Francis J. Castellino, PhD

Blood (2005) 106 (11): 3696.

https://doi.org/10.1182/blood.V106.11.3696.3696

Published: 2005

Journal Articles

Protective Effect of Activated Protein C in Murine Endotoxemia: Mechanism of Action.

Edward J. Kerschen, PhD, Brian C. Cooley, MD, Francis J. Castellino, PhD, John H. Griffin, PhD, Hartmut Weiler, PhD

Blood (2005) 106 (11): 26.

https://doi.org/10.1182/blood.V106.11.26.26

Published: 2005

Journal Articles

A cardioprotective role for the endothelial protein C receptor in lipopolysaccharide-induced endotoxemia in the mouse

Takayuki Iwaki, Diana T. Cruz, J. Andrew Martin, Francis J. Castellino

Blood (2005) 105 (6): 2364–2371.

https://doi.org/10.1182/blood-2004-06-2456

Published: 2005

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A CCR2 macrophage endocytic pathway mediates extravascular fibrin clearance in vivo

AAV-mediated gene transfer in the perinatal period results in expression of FVII at levels that protect against fatal spontaneous hemorrhage

Monoclonal antibodies detect receptor-induced binding sites in Glu-plasminogen

An accompanying genetic severe deficiency of tissue factor protects mice with a protein C deficiency from lethal endotoxemia

Plasminogen activator inhibitor-1 (PAI-1) is cardioprotective in mice by maintaining microvascular integrity and cardiac architecture

The protein C pathway in tissue inflammation and injury: pathogenic role and therapeutic implications

Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality

Deletion of murine kininogen gene 1 ( mKng1 ) causes loss of plasma kininogen and delays thrombosis

A FVII Deficiency Induces Cardiac Fibrosis in Mice Resulting in Systolic and Diastolic Dysfunction.

The Protective Role of Protein C in Endotoxin-Induced Shock.

Exosomes released from macrophages infected with intracellular pathogens stimulate a proinflammatory response in vitro and in vivo

Plasminogen Activator Inhibitor 1 Deficiency Reduces the Progression of Atherosclerosis in a Murine Model of Human Familial Hypercholesterolemia.

Mechanisms for Mortality Reduction by Activated Protein C in Severe Sepsis.

Performance of Murine Soluble Thrombomodulin (rmsTM) in a Murine Model of Endotoxin-Induced Sepsis.

Acute inflammation is exacerbated in mice genetically predisposed to a severe protein C deficiency

Plasminogen inhibits TNFα-induced apoptosis in monocytes

A fibrinogen deficiency accelerates the initiation of LDL cholesterol–driven atherosclerosis via thrombin generation and platelet activation in genetically predisposed mice

Recombinant Human Activated Protein C Suppresses Endotoxin Induced Hypotension in Mice Deficient of the Endothelial Protein C Receptor (EPCR).

Protective Effect of Activated Protein C in Murine Endotoxemia: Mechanism of Action.

A cardioprotective role for the endothelial protein C receptor in lipopolysaccharide-induced endotoxemia in the mouse

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