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Journal Articles

Quantifying the Size and Diversity of the Human Alloresponse Via High-Throughput T Cell Receptor Sequencing

Susan Dewolf, MD, Boris Grinshpun, Thomas Savage, Sai ping Lau, Aleksandar Obradovic, Brittany Shonts, Suxiao Yang, Heather Morris, MD, Julien Zuber, MDPhD, Robert Winchester, MD, Megan Sykes, MD, Yufeng Shen, PhD

Blood (2017) 130 (Supplement 1): 1898.

https://doi.org/10.1182/blood.V130.Suppl_1.1898.1898

Published: 2017

Journal Articles

Enforced Co-Stimulation and Co-Inhibitory Blockade Synergize to Enhance the Functions of Exhausted CTL

Barry Flutter, PhD, Noha Edwards, Lei Zhang, Shivajanani Sivakumaran, Michael Croft, PhD, Megan Sykes, MD, Ronjon Chakraverty, MD, PhD

Blood (2011) 118 (21): 1911.

https://doi.org/10.1182/blood.V118.21.1911.1911

Published: 2011

Journal Articles

LAG-3, TGF-β, and cell-intrinsic PD-1 inhibitory pathways contribute to CD8 but not CD4 T-cell tolerance induced by allogeneic BMT with anti-CD40L

Carrie L. Lucas, Creg J. Workman, Semir Beyaz, Samuel LoCascio, Guiling Zhao, Dario A. A. Vignali, Megan Sykes

Blood (2011) 117 (20): 5532–5540.

https://doi.org/10.1182/blood-2010-11-318675

Published: 2011

Journal Articles

A CD8 T cell–intrinsic role for the calcineurin-NFAT pathway for tolerance induction in vivo

Thomas Fehr, Carrie L. Lucas, Josef Kurtz, Takashi Onoe, Guiling Zhao, Timothy Hogan, Casey Vallot, Anjana Rao, Megan Sykes

Blood (2010) 115 (6): 1280–1287.

https://doi.org/10.1182/blood-2009-07-230680

Published: 2010

Journal Articles

Long Term Follow-up of Recipients of Combined HLA-Matched Nonmyeloablative Bone Marrow and Kidney Transplantation for Multiple Myeloma with End-Stage Renal Disease.

Thomas R Spitzer, MD, Megan Sykes, MD, Nina Tolkoff Rubin, MD, Tatsuo Kawai, MD, Steven L McAfee, MD, Bimalangshu Dey, MD, PhD, Karen Ballen, MD, Francis Delmonico, MD, Susan Saidman, PhD, David H Sachs, M.D., Benedict Cosimi, MD

Blood (2009) 114 (22): 3368.

https://doi.org/10.1182/blood.V114.22.3368.3368

Published: 2009

Journal Articles

Persistence of Donor-Derived Protein in Host Myeloid Cells After Induced Rejection of Engrafted Allogeneic Bone Marrow Cells.

Toshiki Saito, MD, PhD, Joji Fujisaki, MD, Alicia Carlson, PhD, Charles P. Lin, PhD, Megan Sykes, MD, PhD

Blood (2009) 114 (22): 63.

https://doi.org/10.1182/blood.V114.22.63.63

Published: 2009

Journal Articles

CTLA-4 on alloreactive CD4 T cells interacts with recipient CD80/86 to promote tolerance

Josef Kurtz, Forum Raval, Casey Vallot, Jayden Der, Megan Sykes

Blood (2009) 113 (15): 3475–3484.

https://doi.org/10.1182/blood-2008-01-133736

Published: 2009

Journal Articles

Paradoxical effects of IFN-γ in graft-versus-host disease reflect promotion of lymphohematopoietic graft-versus-host reactions and inhibition of epithelial tissue injury

Hui Wang, Wannee Asavaroengchai, Beow Yong Yeap, Min-Guang Wang, Shumei Wang, Megan Sykes, Yong-Guang Yang

Blood (2009) 113 (15): 3612–3619.

https://doi.org/10.1182/blood-2008-07-168419

Published: 2009

Includes: Supplemental data

Journal Articles

Lack of “Bystander” Activation and Evidence for Competition for Resources among Gvh-Reactive CD4 T Cells

Giovanna Andreola, MD, Meredith Chittenden, Megan Sykes, MD

Blood (2008) 112 (11): 3507.

https://doi.org/10.1182/blood.V112.11.3507.3507

Published: 2008

Journal Articles

Host Environment Determines the Development of Gvhd but Not the Extent of Activation and Expansion of Gvh-Reactive CD4 T Cells

Giovanna Andreola, MD, Meredith Chittenden, Megan Sykes, MD

Blood (2008) 112 (11): 3508.

https://doi.org/10.1182/blood.V112.11.3508.3508

Published: 2008

Journal Articles

Characterization of NK1.1 + CD8 T Cells in Allogeneic Hematopoietic Cell Transplantation Recipients

Yi Wang, Hui Wang, MD, PhD, Shumei Wang, Megan Sykes, MD, Yong-Guang Yang, MD, PhD

Blood (2008) 112 (11): 4616.

https://doi.org/10.1182/blood.V112.11.4616.4616

Published: 2008

Journal Articles

Peripheral Alloantigen Drives Early Dysfunction and Eventual Exhaustion of CTL Following Delayed Donor Leukocyte Infusions.

Barry R Flutter, PhD, Farnaz Fallah-Arani, PhD, Clare Bennett, PhD, Janani Sivakumaran, Gordon J Freeman, PhD, Megan Sykes, MD, PhD, Ronjon Chakraverty, MD, PhD

Blood (2008) 112 (11): 2346.

https://doi.org/10.1182/blood.V112.11.2346.2346

Published: 2008

Journal Articles

Peripheral deletional tolerance of alloreactive CD8 but not CD4 T cells is dependent on the PD-1/PD-L1 pathway

Fabienne Haspot, Thomas Fehr, Carrie Gibbons, Guiling Zhao, Timothy Hogan, Tasuku Honjo, Gordon J. Freeman, Megan Sykes

Blood (2008) 112 (5): 2149–2155.

https://doi.org/10.1182/blood-2007-12-127449

Published: 2008

Includes: Supplemental data

Journal Articles

Antigen-specific human T-cell responses and T cell–dependent production of human antibodies in a humanized mouse model

Noriko Tonomura, Katsuyoshi Habiro, Akira Shimizu, Megan Sykes, Yong-Guang Yang

Blood (2008) 111 (8): 4293–4296.

https://doi.org/10.1182/blood-2007-11-121319

Published: 2008

Includes: Supplemental data

Journal Articles

Non-Myeloablative T-Cell Depleted (TCD) Haploidentical Hematopoietic Cell Transplantation (HCT) Followed by Donor Leukocyte Infusion(s) for Hematologic Malignancies: The MGH Experience.

Bimalangshu R. Dey, MD, PhD, Andrew J. Yee, MD, Steven McAfee, MD, Christine Dube, Karen Ballen, MD, Eyal Attar, MD, Christine Colby, Susan Saidman, PhD, Karen Malikowski, Frederic Preffer, PhD, Megan Sykes, MD, Thomas R. Spitzer, MD

Blood (2007) 110 (11): 5088.

https://doi.org/10.1182/blood.V110.11.5088.5088

Published: 2007

Journal Articles

A Role for Regulatory Cells in Tolerance Induction in Recipients of Haploidentical Combined Non-Myeloablative Bone Marrow and Kidney Transplantation?.

Giovanna Andreola, Meredith Chittenden, Juanita Shaffer, A. Benedict Cosimi, Tatsuo Kawai, Pete Cotter, Bimalangshu R. Dey, Nina Tolkoff-Rubin, Frederic Preffer, Susan Saidman, Kristin Kattleman, Thomas R. Spitzer, David H. Sachs, Megan Sykes

Blood (2007) 110 (11): 3255.

https://doi.org/10.1182/blood.V110.11.3255.3255

Published: 2007

Journal Articles

Clonal Expansion of Graft-Versus-Host Reactive CD8+ T Cells Is Dissociated from Full Effector Differentiation Following Delayed DLI.

Ronjon Chakraverty, MD, Barry Flutter, PhD, Hyeon-Seok Eom, MD, Farnaz Fallah-Arani, PhD, Guiling Zhao, Megan Sykes, MD

Blood (2007) 110 (11): 2170.

https://doi.org/10.1182/blood.V110.11.2170.2170

Published: 2007

Journal Articles

Targeting CD134 Results in Selective Depletion of Alloreactive Human T Cells without Loss of Virus-Specific and Leukemia-Specific Effectors.

Xupeng Ge, MD, PhD, Megan Sykes, MD, Julia Brown, PhD, Vassiliki A. Boussiotis, MD, PhD

Blood (2007) 110 (11): 2174.

https://doi.org/10.1182/blood.V110.11.2174.2174

Published: 2007

Journal Articles

Lymphopenia Promotes the Development of Graft-Versus-Host Disease upon Donor Leukocyte Infusion.

Jessica Sachs, MD, Megan Sykes, MD

Blood (2007) 110 (11): 2185.

https://doi.org/10.1182/blood.V110.11.2185.2185

Published: 2007

Journal Articles

The role of antigen-presenting cells in triggering graft-versus-host disease and graft-versus-leukemia

Ronjon Chakraverty, Megan Sykes

Blood (2007) 110 (1): 9–17.

https://doi.org/10.1182/blood-2006-12-022038

Published: 2007

NARROW

Quantifying the Size and Diversity of the Human Alloresponse Via High-Throughput T Cell Receptor Sequencing

Enforced Co-Stimulation and Co-Inhibitory Blockade Synergize to Enhance the Functions of Exhausted CTL

LAG-3, TGF-β, and cell-intrinsic PD-1 inhibitory pathways contribute to CD8 but not CD4 T-cell tolerance induced by allogeneic BMT with anti-CD40L

A CD8 T cell–intrinsic role for the calcineurin-NFAT pathway for tolerance induction in vivo

Long Term Follow-up of Recipients of Combined HLA-Matched Nonmyeloablative Bone Marrow and Kidney Transplantation for Multiple Myeloma with End-Stage Renal Disease.

Persistence of Donor-Derived Protein in Host Myeloid Cells After Induced Rejection of Engrafted Allogeneic Bone Marrow Cells.

CTLA-4 on alloreactive CD4 T cells interacts with recipient CD80/86 to promote tolerance

Paradoxical effects of IFN-γ in graft-versus-host disease reflect promotion of lymphohematopoietic graft-versus-host reactions and inhibition of epithelial tissue injury

Lack of “Bystander” Activation and Evidence for Competition for Resources among Gvh-Reactive CD4 T Cells

Host Environment Determines the Development of Gvhd but Not the Extent of Activation and Expansion of Gvh-Reactive CD4 T Cells

Characterization of NK1.1 + CD8 T Cells in Allogeneic Hematopoietic Cell Transplantation Recipients

Peripheral Alloantigen Drives Early Dysfunction and Eventual Exhaustion of CTL Following Delayed Donor Leukocyte Infusions.

Peripheral deletional tolerance of alloreactive CD8 but not CD4 T cells is dependent on the PD-1/PD-L1 pathway

Antigen-specific human T-cell responses and T cell–dependent production of human antibodies in a humanized mouse model

Non-Myeloablative T-Cell Depleted (TCD) Haploidentical Hematopoietic Cell Transplantation (HCT) Followed by Donor Leukocyte Infusion(s) for Hematologic Malignancies: The MGH Experience.

A Role for Regulatory Cells in Tolerance Induction in Recipients of Haploidentical Combined Non-Myeloablative Bone Marrow and Kidney Transplantation?.

Clonal Expansion of Graft-Versus-Host Reactive CD8+ T Cells Is Dissociated from Full Effector Differentiation Following Delayed DLI.

Targeting CD134 Results in Selective Depletion of Alloreactive Human T Cells without Loss of Virus-Specific and Leukemia-Specific Effectors.

Lymphopenia Promotes the Development of Graft-Versus-Host Disease upon Donor Leukocyte Infusion.

The role of antigen-presenting cells in triggering graft-versus-host disease and graft-versus-leukemia

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American Society of Hematology

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ASH Publications

American Society of Hematology

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