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Journal Articles

LAG-3, TGF-β, and cell-intrinsic PD-1 inhibitory pathways contribute to CD8 but not CD4 T-cell tolerance induced by allogeneic BMT with anti-CD40L

Carrie L. Lucas, Creg J. Workman, Semir Beyaz, Samuel LoCascio, Guiling Zhao, Dario A. A. Vignali, Megan Sykes

Blood (2011) 117 (20): 5532–5540.

https://doi.org/10.1182/blood-2010-11-318675

Published: 2011

Journal Articles

A CD8 T cell–intrinsic role for the calcineurin-NFAT pathway for tolerance induction in vivo

Thomas Fehr, Carrie L. Lucas, Josef Kurtz, Takashi Onoe, Guiling Zhao, Timothy Hogan, Casey Vallot, Anjana Rao, Megan Sykes

Blood (2010) 115 (6): 1280–1287.

https://doi.org/10.1182/blood-2009-07-230680

Published: 2010

Journal Articles

Peripheral deletional tolerance of alloreactive CD8 but not CD4 T cells is dependent on the PD-1/PD-L1 pathway

Fabienne Haspot, Thomas Fehr, Carrie Gibbons, Guiling Zhao, Timothy Hogan, Tasuku Honjo, Gordon J. Freeman, Megan Sykes

Blood (2008) 112 (5): 2149–2155.

https://doi.org/10.1182/blood-2007-12-127449

Published: 2008

Includes: Supplemental data

Journal Articles

Clonal Expansion of Graft-Versus-Host Reactive CD8+ T Cells Is Dissociated from Full Effector Differentiation Following Delayed DLI.

Ronjon Chakraverty, MD, Barry Flutter, PhD, Hyeon-Seok Eom, MD, Farnaz Fallah-Arani, PhD, Guiling Zhao, Megan Sykes, MD

Blood (2007) 110 (11): 2170.

https://doi.org/10.1182/blood.V110.11.2170.2170

Published: 2007

Journal Articles

Host MHC class II + antigen-presenting cells and CD4 cells are required for CD8-mediated graft-versus-leukemia responses following delayed donor leukocyte infusions

Ronjon Chakraverty, Hyeon-Seok Eom, Jessica Sachs, Jennifer Buchli, Pete Cotter, Richard Hsu, Guiling Zhao, Megan Sykes

Blood (2006) 108 (6): 2106–2113.

https://doi.org/10.1182/blood-2006-03-007427

Published: 2006

Includes: Supplemental data

Journal Articles

Proliferation, Expansion, Effector Differentiation and Survival of GVH-Reactive T Cells Following Delayed DLI to Mixed Chimeras.

Ronjon Chakraverty, MD PhD, Jennifer Buchli, BA, Guiling Zhao, Megan Sykes, MD

Blood (2004) 104 (11): 594.

https://doi.org/10.1182/blood.V104.11.594.594

Published: 2004

Journal Articles

Requirement for CD4 Help for Optimal GVL Effects of Alloreactive T Cells Given to Established Mixed Chimeras but Not Freshly Irradiated Mice.

Hyeon-Seok Eom, MD, PhD, Ronjon Chakraverty, MD, PhD, Jessica Sachs, MD, Guiling Zhao, Megan Sykes, MD

Blood (2004) 104 (11): 3044.

https://doi.org/10.1182/blood.V104.11.3044.3044

Published: 2004

Journal Articles

Host Environment Dictates the Outcome Following Transfer of Graft-Versus-Host Reactive Effector/Memory T Cells.

Ronjon Chakraverty, MD, PhD, Jennifer Buchli, BA, Guiling Zhao, Richard Hsu, Megan Sykes, MD

Blood (2004) 104 (11): 3046.

https://doi.org/10.1182/blood.V104.11.3046.3046

Published: 2004

Journal Articles

Sequential Blockade and Engagement of Co-Stimulatory Pathways: A Potential Strategy for Amplifying Graft-Versus-Leukemia Responses without GVHD.

Ronjon Chakraverty, MD PhD, Jennifer Buchli, BA, Guiling Zhao, Richard Hsu, Michael Croft, PhD, Megan Sykes, MD

Blood (2004) 104 (11): 3075.

https://doi.org/10.1182/blood.V104.11.3075.3075

Published: 2004

Journal Articles

Graft-versus-host-reactive donor CD4 cells can induce T cell-mediated rejection of the donor marrow in mixed allogeneic chimeras prepared with nonmyeloablative conditioning

Yong-Mi Kim, Markus Y. Mapara, Julian D. Down, Kevin W. Johnson, Florence Boisgerault, Yoshinobu Akiyama, Gilles Benichou, Michele Pelot, Guiling Zhao, Megan Sykes

Blood (2004) 103 (2): 732–739.

https://doi.org/10.1182/blood-2003-02-0643

Published: 2004

Journal Articles

Antitumor effect of donor marrow graft rejection induced by recipient leukocyte infusions in mixed chimeras prepared with nonmyeloablative conditioning: critical role for recipient-derived IFN-γ

Marie-Therese Rubio, Yong-Mi Kim, Teviah Sachs, Markus Mapara, Guiling Zhao, Megan Sykes

Blood (2003) 102 (6): 2300–2307.

https://doi.org/10.1182/blood-2002-12-3949

Published: 2003

Journal Articles

A novel application of cyclosporine A in nonmyeloablative pretransplant host conditioning for allogeneic BMT

Boris Nikolic, Guiling Zhao, Kirsten Swenson, Megan Sykes

Blood (2000) 96 (3): 1166–1172.

https://doi.org/10.1182/blood.V96.3.1166

Published: 2000

NARROW

LAG-3, TGF-β, and cell-intrinsic PD-1 inhibitory pathways contribute to CD8 but not CD4 T-cell tolerance induced by allogeneic BMT with anti-CD40L

A CD8 T cell–intrinsic role for the calcineurin-NFAT pathway for tolerance induction in vivo

Peripheral deletional tolerance of alloreactive CD8 but not CD4 T cells is dependent on the PD-1/PD-L1 pathway

Clonal Expansion of Graft-Versus-Host Reactive CD8+ T Cells Is Dissociated from Full Effector Differentiation Following Delayed DLI.

Host MHC class II + antigen-presenting cells and CD4 cells are required for CD8-mediated graft-versus-leukemia responses following delayed donor leukocyte infusions

Proliferation, Expansion, Effector Differentiation and Survival of GVH-Reactive T Cells Following Delayed DLI to Mixed Chimeras.

Requirement for CD4 Help for Optimal GVL Effects of Alloreactive T Cells Given to Established Mixed Chimeras but Not Freshly Irradiated Mice.

Host Environment Dictates the Outcome Following Transfer of Graft-Versus-Host Reactive Effector/Memory T Cells.

Sequential Blockade and Engagement of Co-Stimulatory Pathways: A Potential Strategy for Amplifying Graft-Versus-Leukemia Responses without GVHD.

Graft-versus-host-reactive donor CD4 cells can induce T cell-mediated rejection of the donor marrow in mixed allogeneic chimeras prepared with nonmyeloablative conditioning

Antitumor effect of donor marrow graft rejection induced by recipient leukocyte infusions in mixed chimeras prepared with nonmyeloablative conditioning: critical role for recipient-derived IFN-γ

A novel application of cyclosporine A in nonmyeloablative pretransplant host conditioning for allogeneic BMT

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American Society of Hematology

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American Society of Hematology

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