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Journal Articles

Incomplete inhibition by eculizumab: mechanistic evidence for residual C5 activity during strong complement activation

Markus J. Harder, Nadine Kuhn, Hubert Schrezenmeier, Britta Höchsmann, Inge von Zabern, Christof Weinstock, Thomas Simmet, Daniel Ricklin, John D. Lambris, Arne Skerra, Markus Anliker, Christoph Q. Schmidt

Blood (2017) 129 (8): 970–980.

https://doi.org/10.1182/blood-2016-08-732800

Published: 2017

Includes: Supplemental data

Journal Articles

Interleukin-21-Induced Granzyme B-Expressing B Lymphocytes Infiltrate Tumors and Regulate T Cells

Stefanie Lindner, Karen Dahlke, Kai Sontheimer, Magdalena Hagn, MD, Christof Kaltenmeier, Thomas F.E. Barth, Thamara Beyer, Frank Reister, MD, Dorit Fabricius, MD, Ramin Lotfi, MD, Oleg Lunov, PhD, Ulrich Nienhaus, PhD, Thomas Simmet, MD, Rolf Kreienberg, MD, Peter Moeller, MD, PhD, Hubert Schrezenmeier, MD, Bernd Jahrsdörfer, MD

Blood (2012) 120 (21): 3278.

https://doi.org/10.1182/blood.V120.21.3278.3278

Published: 2012

Journal Articles

Incompletely Activated CD4+ T Cells Induce Granzyme B+ Regulatory B Cells In An Interleukin 21-Dependent Manner

Bernd Jahrsdoerfer, MD, Karen Dahlke, Magdalena Hagn, MD, Kai Sontheimer, Thamara Beyer, Oleg Lunov, Dorit Fabricius, MD, Kyrylo Tron, G. Ulrich Nienhaus, PhD, Thomas Simmet, MD

Blood (2010) 116 (21): 3905.

https://doi.org/10.1182/blood.V116.21.3905.3905

Published: 2010

Journal Articles

Induction of a CTL-Like Phenotype In B-CLL Cells Stimulated with Interleukin 21 and CpG Oligodeoxynucleotides

Bernd Jahrsdoerfer, MD, Sue E Blackwell, Magdalena Hagn, MD, Verena Ebel, Thamara Beyer, Kai Sontheimer, Karen Dahlke, George Weiner, MD, Thomas Simmet, MD

Blood (2010) 116 (21): 3906.

https://doi.org/10.1182/blood.V116.21.3906.3906

Published: 2010

Journal Articles

Granzyme B produced by human plasmacytoid dendritic cells suppresses T-cell expansion

Bernd Jahrsdörfer, Angelika Vollmer, Sue E. Blackwell, Julia Maier, Kai Sontheimer, Thamara Beyer, Birgit Mandel, Oleg Lunov, Kyrylo Tron, G. Ulrich Nienhaus, Thomas Simmet, Klaus-Michael Debatin, George J. Weiner, Dorit Fabricius

Blood (2010) 115 (6): 1156–1165.

https://doi.org/10.1182/blood-2009-07-235382

Published: 2010

Includes: Multimedia, Supplemental data

Journal Articles

Granzyme B Produced by Human Plasmacytoid Dendritic Cells Suppresses T Cell Expansion.

Dorit Fabricius, MD, Angelika Vollmer, Sue Blackwell, Julia Maier, Kai Sontheimer, Thamara Beyer, Birgit Mandel, Oleg Lunov, Kyrylo Tron, G. Ulrich Nienhaus, PhD, Thomas Simmet, MD, Klaus-Michael Debatin, MD, George J Weiner, MD, Bernd Jahrsdoerfer, MD

Blood (2009) 114 (22): 2674.

https://doi.org/10.1182/blood.V114.22.2674.2674

Published: 2009

Journal Articles

CD40 Ligand Determines Whether Interleukin 21 Induces Differentiation of Human B Cells Into Plasma Cells or Into Granzyme B-Secreting Cytotoxic Cells.

Bernd Jahrsdoerfer, MD, Magdalena Hagn, MD, Kai Sontheimer, Elisabeth Schwesinger, Verena Ebel, Julia Maier, Thamara Beyer, Dorit Fabricius, MD, Oleg Lunov, Kyrylo Tron, Tatjana Syrovets, PhD, Thomas FE Barth, MD, G. Ulrich Nienhaus, PhD, Thomas Simmet, MD

Blood (2009) 114 (22): 2675.

https://doi.org/10.1182/blood.V114.22.2675.2675

Published: 2009

Journal Articles

Stimulation of B-CLL Cells with Interleukin 21 and Toll Like Receptor Agonists Induces a CTL-Like Transcriptional Profile.

Magdalena Hagn, MD, Verena Ebel, Kai Sontheimer, Thamara Beyer, Sue E. Blackwell, Thomas Simmet, MD, George J. Weiner, MD, Bernd Jahrsdoerfer, MD

Blood (2009) 114 (22): 3685.

https://doi.org/10.1182/blood.V114.22.3685.3685

Published: 2009

Journal Articles

Viral Antigens Trigger Granzyme B Secretion by Human CD5+ B1 Cells in the Presence of Interleukin 21.

Kai Sontheimer, Sue Blackwell, Magdalena Hagn, MD, Verena Ebel, Thamara Beyer, Thomas Simmet, MD, Bernd Jahrsdoerfer, MD

Blood (2009) 114 (22): 4729.

https://doi.org/10.1182/blood.V114.22.4729.4729

Published: 2009

Journal Articles

Specific Induction of Granzyme B in Human B Cells by Viral Antigens.

Magdalena Hagn, MD, Julia Maier, Tatjana Syrovets, PhD, Thomas Simmet, MD, Bernd Jahrsdoerfer, MD

Blood (2008) 112 (11): 1556.

https://doi.org/10.1182/blood.V112.11.1556.1556

Published: 2008

Journal Articles

Naïve B Cells Differentiate into Highly Activated Granzyme B-Secreting B Cells in Response to Interleukin 21 and B Cell Receptor Stimulation

Elisabeth Schwesinger, Magdalena Hagn, MD, Thomas Simmet, MD, Bernd Jahrsdoerfer, MD

Blood (2008) 112 (11): 2555.

https://doi.org/10.1182/blood.V112.11.2555.2555

Published: 2008

Journal Articles

Human B Cell Lines and Primary B Cells Actively Secrete Granzyme B in Response to IL-2 Family Cytokines.

Bernd Jahrsdoerfer, MD, Sue E. Blackwell, Thomas Simmet, MD, George J. Weiner, MD

Blood (2007) 110 (11): 1340.

https://doi.org/10.1182/blood.V110.11.1340.1340

Published: 2007

Journal Articles

Identification of the annexin A2 heterotetramer as a receptor for the plasmin-induced signaling in human peripheral monocytes

Yves Laumonnier, Tatiana Syrovets, Ladislav Burysek, Thomas Simmet

Blood (2006) 107 (8): 3342–3349.

https://doi.org/10.1182/blood-2005-07-2840

Published: 2006

Journal Articles

Differential expression and regulation of protease-activated receptors in human peripheral monocytes and monocyte-derived antigen-presenting cells

Renato Colognato, Joseph R. Slupsky, Marina Jendrach, Ladislav Burysek, Tatiana Syrovets, Thomas Simmet

Blood (2003) 102 (7): 2645–2652.

https://doi.org/10.1182/blood-2002-08-2497

Published: 2003

Journal Articles

Plasmin-induced expression of cytokines and tissue factor in human monocytes involves AP-1 and IKKβ-mediated NF-κB activation

Tatiana Syrovets, Marina Jendrach, Angela Rohwedder, Almut Schüle, Thomas Simmet

Blood (2001) 97 (12): 3941–3950.

https://doi.org/10.1182/blood.V97.12.3941

Published: 2001

Journal Articles

Lipoprotein(a) Is a Potent Chemoattractant for Human Peripheral Monocytes

Tatjana Syrovets, Joëlle Thillet, M. John Chapman, Thomas Simmet

Blood (1997) 90 (5): 2027–2036.

https://doi.org/10.1182/blood.V90.5.2027

Published: 1997

Journal Articles

Plasmin Is a Potent and Specific Chemoattractant for Human Peripheral Monocytes Acting Via a Cyclic Guanosine Monophosphate–Dependent Pathway

Tatjana Syrovets, Bettina Tippler, Maike Rieks, Thomas Simmet

Blood (1997) 89 (12): 4574–4583.

https://doi.org/10.1182/blood.V89.12.4574

Published: 1997

NARROW

Incomplete inhibition by eculizumab: mechanistic evidence for residual C5 activity during strong complement activation

Interleukin-21-Induced Granzyme B-Expressing B Lymphocytes Infiltrate Tumors and Regulate T Cells

Incompletely Activated CD4+ T Cells Induce Granzyme B+ Regulatory B Cells In An Interleukin 21-Dependent Manner

Induction of a CTL-Like Phenotype In B-CLL Cells Stimulated with Interleukin 21 and CpG Oligodeoxynucleotides

Granzyme B produced by human plasmacytoid dendritic cells suppresses T-cell expansion

Granzyme B Produced by Human Plasmacytoid Dendritic Cells Suppresses T Cell Expansion.

CD40 Ligand Determines Whether Interleukin 21 Induces Differentiation of Human B Cells Into Plasma Cells or Into Granzyme B-Secreting Cytotoxic Cells.

Stimulation of B-CLL Cells with Interleukin 21 and Toll Like Receptor Agonists Induces a CTL-Like Transcriptional Profile.

Viral Antigens Trigger Granzyme B Secretion by Human CD5+ B1 Cells in the Presence of Interleukin 21.

Specific Induction of Granzyme B in Human B Cells by Viral Antigens.

Naïve B Cells Differentiate into Highly Activated Granzyme B-Secreting B Cells in Response to Interleukin 21 and B Cell Receptor Stimulation

Human B Cell Lines and Primary B Cells Actively Secrete Granzyme B in Response to IL-2 Family Cytokines.

Identification of the annexin A2 heterotetramer as a receptor for the plasmin-induced signaling in human peripheral monocytes

Differential expression and regulation of protease-activated receptors in human peripheral monocytes and monocyte-derived antigen-presenting cells

Plasmin-induced expression of cytokines and tissue factor in human monocytes involves AP-1 and IKKβ-mediated NF-κB activation

Lipoprotein(a) Is a Potent Chemoattractant for Human Peripheral Monocytes

Plasmin Is a Potent and Specific Chemoattractant for Human Peripheral Monocytes Acting Via a Cyclic Guanosine Monophosphate–Dependent Pathway

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American Society of Hematology

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ASH Publications

American Society of Hematology

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