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Issue Archive

Volume 113, Issue 10
March 5 2009
Issue Cover

Table of Contents

INSIDE BLOOD

INSIDE BLOOD
There will be blood: targeting tumor vasculature
Nathan Fowler,Anas Younes
View Articletitled, There will be blood: targeting tumor vasculature
CLINICAL TRIALS
Romiplostim: chronic therapy for a chronic disease?
Adam Cuker,Charles S. Abrams
View Articletitled, Romiplostim: chronic therapy for a chronic disease?
VASCULAR BIOLOGY
The ins and outs of VEGF signaling
Stephen C. Ekker,Victoria M. Bedell
View Articletitled, The ins and outs of VEGF signaling

BLOOD WORK

Howell-Jolly bodies in patients with chronic GVHD
View Articletitled, Howell-Jolly bodies in patients with chronic GVHD

PLENARY PAPERS

Developmental regulation of MHC II expression and transport in human plasmacytoid-derived dendritic cells
Charlotte Sadaka,Marie-Annick Marloie-Provost,Vassili Soumelis,Philippe Benaroch
View Articletitled, Developmental regulation of MHC II expression and transport in human plasmacytoid-derived dendritic cells
Supplemental data

REVIEW ARTICLES

Chaperoning erythropoiesis
Mitchell J. Weiss,Camila O. dos Santos
View Articletitled, Chaperoning erythropoiesis

CLINICAL TRIALS AND OBSERVATIONS

Population-specific genetic variants important in susceptibility to cytarabine arabinoside cytotoxicity
Clinical Trials & Observations
Christine M. Hartford,Shiwei Duan,Shannon M. Delaney,Shuangli Mi,Emily O. Kistner,Jatinder K. Lamba,R. Stephanie Huang,M. Eileen Dolan
View Articletitled, Population-specific genetic variants important in susceptibility to cytarabine arabinoside cytotoxicity
Supplemental data
Imatinib mesylate dose escalation is associated with durable responses in patients with chronic myeloid leukemia after cytogenetic failure on standard-dose imatinib therapy
Clinical Trials & Observations
Elias Jabbour,Hagop M. Kantarjian,Dan Jones,Jenny Shan,Susan O'Brien,Neeli Reddy,William G. Wierda,Stefan Faderl,Guillermo Garcia-Manero,Srdan Verstovsek,Mary Beth Rios,Jorge Cortes
View Articletitled, Imatinib mesylate dose escalation is associated with durable responses in patients with chronic myeloid leukemia after cytogenetic failure on standard-dose imatinib therapy
Safety and efficacy of long-term treatment with romiplostim in thrombocytopenic patients with chronic ITP
Clinical Trials & Observations
James B. Bussel,David J. Kuter,Vinod Pullarkat,Roger M. Lyons,Matthew Guo,Janet L. Nichol
View Articletitled, Safety and efficacy of long-term treatment with romiplostim in thrombocytopenic patients with chronic ITP
Supplemental data

GENE THERAPY

Correction of murine ADAMTS13 deficiency by hematopoietic progenitor cell–mediated gene therapy
Pablo Laje,Dezhi Shang,Wenjing Cao,Masami Niiya,Masayuki Endo,Antoneta Radu,Nicole DeRogatis,Friedrich Scheiflinger,Philip W. Zoltick,Alan W. Flake,X. Long Zheng
View Articletitled, Correction of murine <em>ADAMTS13</em> deficiency by hematopoietic progenitor cell–mediated gene therapy
Supplemental data

HEMATOPOIESIS AND STEM CELLS

ATR-dependent phosphorylation of FANCA on serine 1449 after DNA damage is important for FA pathway function
Natalie B. Collins,James B. Wilson,Thomas Bush,Andrei Thomashevski,Kate J. Roberts,Nigel J. Jones,Gary M. Kupfer
View Articletitled, ATR-dependent phosphorylation of FANCA on serine 1449 after DNA damage is important for FA pathway function
Supplemental data
SCL and associated proteins distinguish active from repressive GATA transcription factor complexes
Tamara Tripic,Wulan Deng,Yong Cheng,Ying Zhang,Christopher R. Vakoc,Gregory D. Gregory,Ross C. Hardison,Gerd A. Blobel
View Articletitled, SCL and associated proteins distinguish active from repressive GATA transcription factor complexes
Supplemental data
PIAS3 negatively regulates RANKL-mediated osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblasts
Tomohiro Hikata,Hironari Takaishi,Jiro Takito,Akihiro Hakozaki,Mitsuru Furukawa,Shinichi Uchikawa,Tokuhiro Kimura,Yasunori Okada,Masahito Matsumoto,Akihiko Yoshimura,Riko Nishimura,Sakamuri V. Reddy,Hiroshi Asahara,Yoshiaki Toyama
View Articletitled, PIAS3 negatively regulates RANKL-mediated osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblasts
Supplemental data
In vivo efficacy of anti-MPL agonist antibody in promoting primary human hematopoietic cells
Brief Report
Masayuki Kai,Tetsuya Hagiwara,Chie Emuta,Yukiko Chisaka,Kumi Tsuruhata,Chisato Endo,Yoshimasa Inagaki,Hiroshi Miyazaki,Shiro Kataoka
View Articletitled, In vivo efficacy of anti-MPL agonist antibody in promoting primary human hematopoietic cells

IMMUNOBIOLOGY

Indian hedgehog (Ihh) both promotes and restricts thymocyte differentiation
Susan V. Outram,Ariadne L. Hager-Theodorides,Divya K. Shah,Nicola J. Rowbotham,Ekati Drakopoulou,Susan E. Ross,Beate Lanske,Johannes T. Dessens,Tessa Crompton
View Articletitled, Indian hedgehog (Ihh) both promotes and restricts thymocyte differentiation
Genetic disruption of p38α Tyr323 phosphorylation prevents T-cell receptor–mediated p38α activation and impairs interferon-γ production
Ludmila Jirmanova,Dandapantula N. Sarma,Dragana Jankovic,Paul R. Mittelstadt,Jonathan D. Ashwell
View Articletitled, Genetic disruption of p38α Tyr323 phosphorylation prevents T-cell receptor–mediated p38α activation and impairs interferon-γ production
High avidity myeloid leukemia-associated antigen-specific CD8+ T cells preferentially reside in the bone marrow
J. Joseph Melenhorst,Phillip Scheinberg,Pratip K. Chattopadhyay,Emma Gostick,Kristin Ladell,Mario Roederer,Nancy F. Hensel,Daniel C. Douek,A. John Barrett,David A. Price
View Articletitled, High avidity myeloid leukemia-associated antigen-specific CD8<sup>+</sup> T cells preferentially reside in the bone marrow
Ex vivo characterization of polyclonal memory CD8+ T-cell responses to PRAME-specific peptides in patients with acute lymphoblastic leukemia and acute and chronic myeloid leukemia
Katayoun Rezvani,Agnes S. M. Yong,Abdul Tawab,Behnam Jafarpour,Rhoda Eniafe,Stephan Mielke,Bipin N. Savani,Keyvan Keyvanfar,Yixin Li,Roger Kurlander,A. John Barrett
View Articletitled, Ex vivo characterization of polyclonal memory CD8<sup>+</sup> T-cell responses to PRAME-specific peptides in patients with acute lymphoblastic leukemia and acute and chronic myeloid leukemia
Supplemental data
A critical role for direct TLR2-MyD88 signaling in CD8 T-cell clonal expansion and memory formation following vaccinia viral infection
Michael Quigley,Jennifer Martinez,Xiaopei Huang,Yiping Yang
View Articletitled, A critical role for direct TLR2-MyD88 signaling in CD8 T-cell clonal expansion and memory formation following vaccinia viral infection
Supplemental data

LYMPHOID NEOPLASIA

Expression of the oncofetal ED-B–containing fibronectin isoform in hematologic tumors enables ED-B–targeted 131I-L19SIP radioimmunotherapy in Hodgkin lymphoma patients
Stefanie Sauer,Paola A. Erba,Mario Petrini,Andreas Menrad,Leonardo Giovannoni,Chiara Grana,Burkhard Hirsch,Luciano Zardi,Giovanni Paganelli,Giuliano Mariani,Dario Neri,Horst Dürkop,Hans D. Menssen
View Articletitled, Expression of the oncofetal ED-B–containing fibronectin isoform in hematologic tumors enables ED-B–targeted <sup>131</sup>I-L19SIP radioimmunotherapy in Hodgkin lymphoma patients
Complete eradication of human B-cell lymphoma xenografts using rituximab in combination with the immunocytokine L19-IL2
Christoph Schliemann,Alessandro Palumbo,Kathrin Zuberbühler,Alessandra Villa,Manuela Kaspar,Eveline Trachsel,Wolfram Klapper,Hans Dietrich Menssen,Dario Neri
View Articletitled, Complete eradication of human B-cell lymphoma xenografts using rituximab in combination with the immunocytokine L19-IL2
Supplemental data
Polymorphisms in folate-related genes and risk of pediatric acute lymphoblastic leukemia
Robert de Jonge,Wim J. E. Tissing,Jan Hendrik Hooijberg,Gerrit Jansen,Gertjan J. L. Kaspers,Jan Lindemans,Godefridus J. Peters,Rob Pieters
View Articletitled, Polymorphisms in folate-related genes and risk of pediatric acute lymphoblastic leukemia
Dysfunctional homologous recombination mediates genomic instability and progression in myeloma
Masood A. Shammas,Robert J. Shmookler Reis,Hemanta Koley,Ramesh B. Batchu,Cheng Li,Nikhil C. Munshi
View Articletitled, Dysfunctional homologous recombination mediates genomic instability and progression in myeloma
Regions of acquired uniparental disomy at diagnosis of follicular lymphoma are associated with both overall survival and risk of transformation
Brief Report
Derville O'Shea,Ciarán O'Riain,Manu Gupta,Rachel Waters,Youwen Yang,David Wrench,John Gribben,Andreas Rosenwald,German Ott,Lisa M. Rimsza,Harald Holte,Jean-Baptiste Cazier,Nathalie A. Johnson,Elias Campo,Wing C. Chan,Randy D. Gascoyne,Bryan D. Young,Louis M. Staudt,T. Andrew Lister,Jude Fitzgibbon
View Articletitled, Regions of acquired uniparental disomy at diagnosis of follicular lymphoma are associated with both overall survival and risk of transformation
Supplemental data

MYELOID NEOPLASIA

BH3-only protein Bim more critical than Puma in tyrosine kinase inhibitor–induced apoptosis of human leukemic cells and transduced hematopoietic progenitors carrying oncogenic FLT3
Amanda Nordigården,Maria Kraft,Pernilla Eliasson,Verena Labi,Eric W.-F. Lam,Andreas Villunger,Jan-Ingvar Jönsson
View Articletitled, BH3-only protein Bim more critical than Puma in tyrosine kinase inhibitor–induced apoptosis of human leukemic cells and transduced hematopoietic progenitors carrying oncogenic FLT3
Myeloid leukemic progenitor cells can be specifically targeted by minor histocompatibility antigen LRH-1–reactive cytotoxic T cells
Wieger J. Norde,Ingrid M. Overes,Frans Maas,Hanny Fredrix,Johanna C. M. Vos,Michel G. D. Kester,Robbert van der Voort,Inge Jedema,J. H. Frederik Falkenburg,Anton V. Schattenberg,Theo M. de Witte,Harry Dolstra
View Articletitled, Myeloid leukemic progenitor cells can be specifically targeted by minor histocompatibility antigen LRH-1–reactive cytotoxic T cells
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Differential requirement for the activation of the inflammasome for processing and release of IL-1β in monocytes and macrophages
Mihai G. Netea,Claudia A. Nold-Petry,Marcel F. Nold,Leo A. B. Joosten,Bastian Opitz,Jonathan H. M. van der Meer,Frank L. van de Veerdonk,Gerben Ferwerda,Bas Heinhuis,Isabel Devesa,C. Joel Funk,Robert J. Mason,Bart Jan Kullberg,Anna Rubartelli,Jos W. M. van der Meer,Charles A. Dinarello
View Articletitled, Differential requirement for the activation of the inflammasome for processing and release of IL-1β in monocytes and macrophages

THROMBOSIS AND HEMOSTASIS

Association of the protein Z ATG haplotype with symptomatic nonvascular stroke or thromboembolism in white children: a family-based cohort study
Ulrike Nowak-Göttl,Birgit Fröhlich,Sabine Thedieck,Andreas Huge,Monika Stoll
View Articletitled, Association of the protein Z ATG haplotype with symptomatic nonvascular stroke or thromboembolism in white children: a family-based cohort study
Supplemental data

TRANSPLANTATION

Mesenchymal stem/progenitor cells promote the reconstitution of exogenous hematopoietic stem cells in Fancg−/− mice in vivo
Yan Li,Shi Chen,Jin Yuan,Yanzhu Yang,Jingling Li,Jin Ma,Xiaohua Wu,Marcel Freund,Karen Pollok,Helmut Hanenberg,W. Scott Goebel,Feng-Chun Yang
View Articletitled, Mesenchymal stem/progenitor cells promote the reconstitution of exogenous hematopoietic stem cells in <em>Fancg</em><sup>−/−</sup> mice in vivo
Supplemental data
Interleukin-23 secretion by donor antigen-presenting cells is critical for organ-specific pathology in graft-versus-host disease
Rupali Das,Xiao Chen,Richard Komorowski,Martin J. Hessner,William R. Drobyski
View Articletitled, Interleukin-23 secretion by donor antigen-presenting cells is critical for organ-specific pathology in graft-versus-host disease
Supplemental data

VASCULAR BIOLOGY

Degradation of soluble VEGF receptor-1 by MMP-7 allows VEGF access to endothelial cells
Ta-Kashi Ito,Genichiro Ishii,Seiji Saito,Keiichi Yano,Ayuko Hoshino,Tasuku Suzuki,Atsushi Ochiai
View Articletitled, Degradation of soluble VEGF receptor-1 by MMP-7 allows VEGF access to endothelial cells

RETRACTIONS

Reyes M, Lund T, Lenvik T, Aguiar D, Koodie L, Verfaillie CM. Purification and ex vivo expansion of postnatal human marrow mesodermal progenitor cells. Blood. 2001;98:2615-2625.
View Articletitled, Reyes M, Lund T, Lenvik T, Aguiar D, Koodie L, Verfaillie CM. Purification and ex vivo expansion of postnatal human marrow mesodermal progenitor cells. Blood. 2001;98:2615-2625.
Roman-Gomez J, Jiminez-Velasco A, Castillejo JA, Agirre X, Barrios M, Navarro G, Molina FJ, Calasanz MJ, Prosper F, Heiniger A, Torres A. Promoter hypermethylation of cancer-related genes: a strong independent prognostic factor in acute lymphoblastic leukemia. Blood. 2004;104:2492-2498.
View Articletitled, Roman-Gomez J, Jiminez-Velasco A, Castillejo JA, Agirre X, Barrios M, Navarro G, Molina FJ, Calasanz MJ, Prosper F, Heiniger A, Torres A. Promoter hypermethylation of cancer-related genes: a strong independent prognostic factor in acute lymphoblastic leukemia. Blood. 2004;104:2492-2498.
  • Cover Image

    Cover Image

    issue cover

    Transaxial 18F-FDG PET scans captured before (top), and 1 month (middle) and 2 months (bottom) after treatment with 131I-L19SIP, targeting the ED-B fibronectin domain expressed in newly formed tumor blood vessels, show a significant shrinkage in size and a complete disappearance of metabolic activity in the initially large pulmonary lymphoma lesion, indicative of lymphoma response to 131I-L19SIP radioimmunotherapy. See the article by Sauer et al on page 2265.

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