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Journal Articles

Randomized Trial of Prophylactic Donor Lymphocyte Infusion with Positively Selected CD4+ T Cells after HLA-Identical Allogeneic Stem Cell Transplantation

Joost Van Der Hem, Peter Van Balen, Sabrina Veld, Peter A. Von Dem Borne, Danielle Van Lammeren, Tjeerd Snijders, Jaap Jan Zwaginga, Hendrik Veelken, Rosa De Groot, Inge Jedema, Liesbeth C. de Wreede, Constantijn Halkes, J.H. Frederik Falkenburg

Blood (2023) 142 (Supplement 1): 6887.

https://doi.org/10.1182/blood-2023-188843

Published: 2023

Journal Articles

A minority of T cells recognizing tumor-associated antigens presented in self-HLA can provoke antitumor reactivity

Marthe C. J. Roex, Lois Hageman, Sabrina A. J. Veld, Esther van Egmond, Conny Hoogstraten, Christian Stemberger, Lothar Germeroth, Hermann Einsele, J. H. Frederik Falkenburg, Inge Jedema

Blood (2020) 136 (4): 455–467.

https://doi.org/10.1182/blood.2019004443

Published: 2020

Includes: Supplemental data

Journal Articles

Off-Target HLA Cross-Reactivity By (Third Party) Virus-Specific T Cells Is Surprisingly Affected By HLA Restriction and HLA Background but Not By Virus Specificity

Wesley Huisman, MSc, Didier A.T. Leboux, Lieve E. van der Maarel, Lois Hageman, Derk Amsen, PhD, Fred Falkenburg, MD PhD, Inge Jedema, PhD

Blood (2019) 134 (Supplement_1): 4440.

https://doi.org/10.1182/blood-2019-124785

Published: 2019

Journal Articles

The First Functional HLA-a*01:01-Restricted EBV-LMP2-Specific T-Cell Receptors for TCR Gene Therapy of Patients with EBV-Associated Type II/III Malignancies

Wesley Huisman, MSc, Ilse Gille, Lieve E. van der Maarel, Lois Hageman, Rob C.M. de Jong, PhD, Derk Amsen, PhD, Fred Falkenburg, MD PhD, Inge Jedema, PhD

Blood (2019) 134 (Supplement_1): 4448.

https://doi.org/10.1182/blood-2019-123736

Published: 2019

Journal Articles

Isolation and Validation of the First Functional HLA-a*01:01 Restricted EBV-LMP2 Specific T Cells for Treatment of EBV Associated Type II/III Lymphomas

Wesley Huisman, MSc, Lieve E. van der Maarel, Lois Hageman, Rob C.M. de Jong, Derk Amsen, PhD, J.H. Frederik Falkenburg, MD PhD, Inge Jedema, PhD

Blood (2018) 132 (Supplement 1): 1578.

https://doi.org/10.1182/blood-2018-99-116127

Published: 2018

Journal Articles

Whole Transcriptome RNA Sequencing As a Comprehensive Diagnostic Tool for Acute Myeloid Leukemia

Blood (2018) 132 (Supplement 1): 2762.

https://doi.org/10.1182/blood-2018-99-111115

Published: 2018

Journal Articles

Prophylactic Infusion of Multi-Antigen Specific T-Cell Products to Prevent Complications after T Cell Depleted Allogeneic Stem Cell Transplantation — a Phase I/II Study

Marthe C.J. Roex, MD, Peter van Balen, MD, Lothar Germeroth, PhD, Lois Hageman, Esther van Egmond, Sabrina A.J. Veld, Conny Hoogstraten, Ellis van Liempt, PhD, Jaap J. Zwaginga, MD PhD, Liesbeth C. de Wreede, PhD, Hermann Einsele, MD PhD, Hendrik Veelken, MD PhD, Constantijn J.M. Halkes, MD, Inge Jedema, PhD, J.H. Frederik Falkenburg, MD PhD

Blood (2018) 132 (Supplement 1): 119.

https://doi.org/10.1182/blood-2018-99-111749

Published: 2018

Journal Articles

Patient Bone Marrow Chimerism at Time of Donor Lymphocyte Infusion Predicts Development of Graft Versus Host Disease

Eva AS Koster, MD, Liesbeth C. de Wreede, PhD, Sylwia Wallet-Malicka, Lisette Bogers, Peter van Balen, MD, Waf Marijt, MD, Inge Jedema, PhD, Peter von dem Borne, MD PhD, Hendrik Veelken, MD PhD, J.H. Frederik Falkenburg, MD PhD, Constantijn J.M. Halkes, MD

Blood (2018) 132 (Supplement 1): 2132.

https://doi.org/10.1182/blood-2018-99-113839

Published: 2018

Journal Articles

The Scope of Allo-HLA Cross-Reactivity By (Third Party) Virus Specific T Cells Is Surprisingly Affected By HLA Restriction Rather Than Virus Specificity

Wesley Huisman, MSc, Didier A.T. Leboux, Lieve E. van der Maarel, Lois Hageman, Derk Amsen, PhD, J.H. Frederik Falkenburg, MD PhD, Inge Jedema, PhD

Blood (2018) 132 (Supplement 1): 2048.

https://doi.org/10.1182/blood-2018-99-116028

Published: 2018

Journal Articles

Mutated NPM1 As Target for Immunotherapy of Acute Myeloid Leukemia

Dyantha I. Van Der Lee, BSc., Helena M. Bijen, MSc, Renate S. Hagedoorn, ing., Willy M. Honders, ing., Michel G.D. Kester, ing., Dirk M. van der Steen, ing., Arnoud H. de Ru, ing., Inge Jedema, PhD, Hendrik Veelken, MD PhD, Mirjam H.M. Heemskerk, PhD, Peter A. van Veelen, PhD, J.H. Frederik Falkenburg, MD PhD, Marieke Griffioen, PhD

Blood (2017) 130 (Supplement 1): 168.

https://doi.org/10.1182/blood.V130.Suppl_1.168.168

Published: 2017

Journal Articles

Prevention of Viral Infections after T Cell Depleted Allogeneic Stem Cell Transplantation By Infusion of Multi-Antigen Specific T Cell Products

Marthe C.J. Roex, MD, Peter Van Balen, MD, Lois Hageman, Esther Van Egmond, Sabrina A.J. Veld, Conny Hoogstraten, Ellis van Liempt, PhD, Lothar Germeroth, PhD, Hermann Einsele, MD, Constantijn J.M. Halkes, MD PhD, Inge Jedema, PhD, J.H. Frederik Falkenburg, MD PhD

Blood (2016) 128 (22): 1228.

https://doi.org/10.1182/blood.V128.22.1228.1228

Published: 2016

Journal Articles

Whole Transcriptome Sequencing (RNAseq) As a Comprehensive, Cost-Efficient Diagnostic Tool for Acute Myeloid Leukemia

Marieke Griffioen, PhD, Wibowo Arindrarto, MSc, Daniel Borràs, MSc, Saskia A.M.E. van Diessen, BSc, Edith D. van der Meijden, M. Willy Honders, Mariam Alloul, PhD, Inge Jedema, PhD, Wilma G.M. Kroes, PhD, Peter J.M. Valk, PhD, Bart Janssen, PhD, Cornelis A.M. van Bergen, PhD, Szymon M. Kiełbasa, PhD, Jeroen F.J. Laros, PhD, Peter A.C. 't Hoen, PhD, Hendrik Veelken, MD PhD

Blood (2016) 128 (22): 1701.

https://doi.org/10.1182/blood.V128.22.1701.1701

Published: 2016

Journal Articles

The Allo-HLA-DP Restricted T Cell Repertoire Contains a Variety of Tissue-Restricted Specificities with Therapeutic Value

Aicha Laghmouchi, Conny Hoogstraten, Peter Van Balen, MD, Rick van de Water, Marian van de Meent, J.H. Frederik Falkenburg, Prof, MD PhD, Inge Jedema, PhD

Blood (2016) 128 (22): 3356.

https://doi.org/10.1182/blood.V128.22.3356.3356

Published: 2016

Journal Articles

A Polyclonal Population of Piga Mutant CD52 and GPI Anchor Negative T Cells Can Give Early Immune Protection after Alemtuzumab-Based T Cell Depleted Allogeneic Stem Cell Transplantation

Floris C. Loeff, J.H. Frederik Falkenburg, MD PhD, Lois Hageman, Sabrina A.J. Veld, Marian van de Meent, Constantijn J.M. Halkes, MD PhD, Inge Jedema, PhD

Blood (2015) 126 (23): 3134.

https://doi.org/10.1182/blood.V126.23.3134.3134

Published: 2015

Journal Articles

Loss of Pigh Expression Frequently Results in a GPI-Negative Subclone Lacking CD52 Membrane Expression, Conferring Alemtuzumab Resistance to B Cell Acute Lymphoblastic Leukemia

Floris C. Loeff, Kevin Rijs, Willem H. Zoutman, Esther H.M. Egmond, Maarten H. Vermeer, MD PhD, J.H. Frederik Falkenburg, MD PhD, Constantijn J.M. Halkes, MD PhD, Inge Jedema, PhD

Blood (2015) 126 (23): 1435.

https://doi.org/10.1182/blood.V126.23.1435.1435

Published: 2015

Journal Articles

Tumor Associated Antigen Reactive Donor T Cells As Elementary Components of Streptamer Isolated Multi-Antigen Specific T Cells

Marthe C.J. Roex, MD, Ellis van Liempt, PhD, Lois Hageman, Lothar Germeroth, PhD, Constantijn J.M. Halkes, MD PhD, J.H. Frederik Falkenburg, MD PhD, Inge Jedema, PhD

Blood (2014) 124 (21): 313.

https://doi.org/10.1182/blood.V124.21.313.313

Published: 2014

Journal Articles

Effectivity Of Complement-Dependent Cytotoxicity Induced By Therapeutic Antibodies In Acute Lymphoblastic Leukemia Is Dictated By Antigen Expression Levels and Curtailed By Membrane-Bound Complement Regulatory Proteins

Floris C Loeff, MSc, Esther H.M. van Egmond, Judith Olde Wolbers, J.H. Frederik Falkenburg, MD, PhD, Constantijn J.M. Halkes, MD, PhD, Inge Jedema, PhD

Blood (2013) 122 (21): 3909.

https://doi.org/10.1182/blood.V122.21.3909.3909

Published: 2013

Journal Articles

Graft Versus Leukemia Separates From Graft Versus Host Disease By Magnitude and Avidity Of The Allo-Reactive T Cell Response After Allogeneic Stem Cell Transplantation and Donor Lymphocyte Infusion

Cornelis A.M. van Bergen, Simone A.P. Van Luxemburg-Heijs, Matthijs Eefting, MD, Maria W. Honders, Inge Jedema, PhD, Constantijn J.M. Halkes, MD, PhD, Marieke Griffioen, PhD, J.H. Frederik Falkenburg, MD, PhD

Blood (2013) 122 (21): 2014.

https://doi.org/10.1182/blood.V122.21.2014.2014

Published: 2013

Journal Articles

Immune Surveillance By Autoreactive Helper But Not Cytolytic T Cells Is a Common Phenomenon In Patients With Acute Myeloid Leukemia

Tin Sing Lam, Marian van de Meent, J.H. Frederik Falkenburg, MD, PhD, Inge Jedema, PhD

Blood (2013) 122 (21): 1044.

https://doi.org/10.1182/blood.V122.21.1044.1044

Published: 2013

Journal Articles

HLA class II upregulation during viral infection leads to HLA-DP–directed graft-versus-host disease after CD4+ donor lymphocyte infusion

Sanja Stevanović, Cornelis A. M. van Bergen, Simone A. P. van Luxemburg-Heijs, Boris van der Zouwen, Ekaterina S. Jordanova, Alwine B. Kruisselbrink, Marian van de Meent, Jessica C. Harskamp, Frans H. J. Claas, Erik W. A. Marijt, Jaap Jan Zwaginga, Constantijn J. M. Halkes, Inge Jedema, Marieke Griffioen, J. H. Frederik Falkenburg

Blood (2013) 122 (11): 1963–1973.

https://doi.org/10.1182/blood-2012-12-470872

Published: 2013

Includes: Supplemental data

NARROW

Randomized Trial of Prophylactic Donor Lymphocyte Infusion with Positively Selected CD4+ T Cells after HLA-Identical Allogeneic Stem Cell Transplantation

A minority of T cells recognizing tumor-associated antigens presented in self-HLA can provoke antitumor reactivity

Off-Target HLA Cross-Reactivity By (Third Party) Virus-Specific T Cells Is Surprisingly Affected By HLA Restriction and HLA Background but Not By Virus Specificity

The First Functional HLA-a*01:01-Restricted EBV-LMP2-Specific T-Cell Receptors for TCR Gene Therapy of Patients with EBV-Associated Type II/III Malignancies

Isolation and Validation of the First Functional HLA-a*01:01 Restricted EBV-LMP2 Specific T Cells for Treatment of EBV Associated Type II/III Lymphomas

Whole Transcriptome RNA Sequencing As a Comprehensive Diagnostic Tool for Acute Myeloid Leukemia

Prophylactic Infusion of Multi-Antigen Specific T-Cell Products to Prevent Complications after T Cell Depleted Allogeneic Stem Cell Transplantation — a Phase I/II Study

Patient Bone Marrow Chimerism at Time of Donor Lymphocyte Infusion Predicts Development of Graft Versus Host Disease

The Scope of Allo-HLA Cross-Reactivity By (Third Party) Virus Specific T Cells Is Surprisingly Affected By HLA Restriction Rather Than Virus Specificity

Mutated NPM1 As Target for Immunotherapy of Acute Myeloid Leukemia

Prevention of Viral Infections after T Cell Depleted Allogeneic Stem Cell Transplantation By Infusion of Multi-Antigen Specific T Cell Products

Whole Transcriptome Sequencing (RNAseq) As a Comprehensive, Cost-Efficient Diagnostic Tool for Acute Myeloid Leukemia

The Allo-HLA-DP Restricted T Cell Repertoire Contains a Variety of Tissue-Restricted Specificities with Therapeutic Value

A Polyclonal Population of Piga Mutant CD52 and GPI Anchor Negative T Cells Can Give Early Immune Protection after Alemtuzumab-Based T Cell Depleted Allogeneic Stem Cell Transplantation

Loss of Pigh Expression Frequently Results in a GPI-Negative Subclone Lacking CD52 Membrane Expression, Conferring Alemtuzumab Resistance to B Cell Acute Lymphoblastic Leukemia

Tumor Associated Antigen Reactive Donor T Cells As Elementary Components of Streptamer Isolated Multi-Antigen Specific T Cells

Effectivity Of Complement-Dependent Cytotoxicity Induced By Therapeutic Antibodies In Acute Lymphoblastic Leukemia Is Dictated By Antigen Expression Levels and Curtailed By Membrane-Bound Complement Regulatory Proteins

Graft Versus Leukemia Separates From Graft Versus Host Disease By Magnitude and Avidity Of The Allo-Reactive T Cell Response After Allogeneic Stem Cell Transplantation and Donor Lymphocyte Infusion

Immune Surveillance By Autoreactive Helper But Not Cytolytic T Cells Is a Common Phenomenon In Patients With Acute Myeloid Leukemia

HLA class II upregulation during viral infection leads to HLA-DP–directed graft-versus-host disease after CD4+ donor lymphocyte infusion

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American Society of Hematology

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American Society of Hematology

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