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Journal Articles

A Mutation in Complement Factor H (W1183R) Enhances VWF Proteolysis By ADAMTS13 Under Shear

Wenjing Cao, Yi Liu, X. Frank Zhang, X. Long Zheng

Blood (2023) 142 (Supplement 1): 24.

https://doi.org/10.1182/blood-2023-190083

Published: 2023

Journal Articles

Coagulation Factor VIII Enhances the Cleavage of Von Willebrand Factor By ADAMTS13 In Vivo

Wenjing Cao, Aria Bales, Antonia Bignotti, Noritaka Yada, Liang Zheng, Lindsey George, Denise E. Sabatino, Marie Scully, Rodney M. Camire, X. Long Zheng

Blood (2022) 140 (Supplement 1): 5572–5573.

https://doi.org/10.1182/blood-2022-167539

Published: 2022

Journal Articles

Binding of Gpibα to VWF A2 Domain Alters Mechanical Unraveling of the A2 Domain

Yi Liu, MS, Wenpeng Cao, PhD, Wenjing Cao, MDPhD, X. Long Zheng, MDPhD, Xiaohui Zhang, PhD

Blood (2020) 136 (Supplement 1): 24–25.

https://doi.org/10.1182/blood-2020-143275

Published: 2020

Journal Articles

Plasma Levels of Histone-DNA Complex and Cell-Free DNA Predict Mortality in Patients with Immune Thrombotic Thrombocytopenic Purpura

Jingrui (Jean) Sui, MD, Konstantine Halkidis, MD PhD, Nicole K. Kocher, Lance A. Williams, III, MD, Radhika Gangaraju, MD, Bryan K. Guillory, MD, Marisa B. Marques, MD, Wenjing Cao, MD,PhD, X. Long Zheng, MD, PhD

Blood (2019) 134 (Supplement_1): 1070.

https://doi.org/10.1182/blood-2019-131585

Published: 2019

Journal Articles

Exome Sequencing Identifies Glycosylation Defects As a Probable Cause of Immune Thrombotic Thrombocytopenic Purpura

Felipe Massicano, PhD, Elizabeth M. Staley, MD, PhD, Konstantine Halkidis, MD PhD, Nicole K. Kocher, Lance A. Williams, III, MD, Marisa B. Marques, MD, Bryan K. Guillory, MD, Wenjing Cao, MD,PhD, Malay K. Basu, PhD, X. Long Zheng, MD, PhD

Blood (2019) 134 (Supplement_1): 217.

https://doi.org/10.1182/blood-2019-131511

Published: 2019

Journal Articles

Binding of Factor VIII to D'D3 and A2 Domains of Von Willebrand Factor Facilitates Mechanical Unraveling of the A2 Domain

Wenjing Cao, MD,PhD, Wenpeng Cao, Wei Zhang, X. Long Zheng, MD, PhD, Xiaohui (Frank) Zhang, PhD

Blood (2019) 134 (Supplement_1): 95.

https://doi.org/10.1182/blood-2019-125115

Published: 2019

Journal Articles

The Factor VIII Variant X5 Enhances Hemophilia a Gene Therapy Efficiency By Its Improved Secretion

Franziska Horling, PhD, Johannes Lengler, PhD, Wenjing Cao, PhD, Biao Dong, PhD, Bagirath Gangadharan, Maurus De La Rosa, PhD, Werner Hoellriegl, PhD, Birgit M Reipert, PhD, Friedrich Scheiflinger, Weidong Xiao, PhD, Hanspeter Rottensteiner

Blood (2019) 134 (Supplement_1): 3356.

https://doi.org/10.1182/blood-2019-126489

Published: 2019

Journal Articles

Longitudinal Assessment of Plasma ADAMTS13 Biomarkers Helps Predict Recurrence of Immune Thrombotic Thrombocytopenic Purpura

Jingrui (Jean) Sui, MD, Wenjing Cao, MD,PhD, Mohammad S. Abdelgawwad, MD, Konstantine Halkidis, MD PhD, Nicole K. Kocher, Bryan K. Guillory, MD, Lance A. Williams, III, MD, Marisa B. Marques, MD, Radhika Gangaraju, MD, X. Long Zheng, MD, PhD

Blood (2019) 134 (Supplement_1): 2456.

https://doi.org/10.1182/blood-2019-126093

Published: 2019

Journal Articles

Synergistic effects of ADAMTS13 deficiency and complement activation in pathogenesis of thrombotic microangiopathy

Liang Zheng, Di Zhang, Wenjing Cao, Wen-Chao Song, X. Long Zheng

Blood (2019) 134 (13): 1095–1105.

https://doi.org/10.1182/blood.2019001040

Published: 2019

Journal Articles

Active and Ultra-Large Von Willebrand Factor Is Significantly Elevated in Patients with Immune Thrombotic Thrombocytopenic Purpura

Wenjing Cao, PhD, Alicia Veninga, M.Sc., Elizabeth M. Staley, MD, PhD, Adam Miszta, PhD, Nicole Kocher, B.Sc., Lance Williams, III, MD, Marisa B. Marques, MD, Bas de Laat, MD, PhD, X. Long Zheng, MD PhD

Blood (2018) 132 (Supplement 1): 523.

https://doi.org/10.1182/blood-2018-99-117647

Published: 2018

Journal Articles

Apolipoprotein B-100 Binds Von Willebrand Factor and Accelerates Its Proteolysis By ADAMTS13 Under Fluidic Shear

Wenjing Cao, PhD, Jingzhi Li, PhD, X. Long Zheng, MD, PhD

Blood (2017) 130 (Supplement 1): 3653.

https://doi.org/10.1182/blood.V130.Suppl_1.3653.3653

Published: 2017

Journal Articles

Platelet-Delivered Recombinant ADAMTS13 Inhibits Platelet Adhesion and Aggregation on Collagen Surface Under Flow in the Presence of Autoantibodies from Acquired Thrombotic Thrombocytopenic Purpura

Mohammad S. Abdelgawwad, MD, M.Sc., Jenny K. McDaniel, MD, Wenjing Cao, MD, PhD, Huy P. Pham, MD, M.P.H., Lance A. Williams, MD, X. Long Zheng, MD, PhD

Blood (2016) 128 (22): 1374.

https://doi.org/10.1182/blood.V128.22.1374.1374

Published: 2016

Journal Articles

Distal Carboxyl-Terminal Domains of ADAMTS13 Determine Its Substrate Specificity

Wenjing Cao, MD, PhD, Catherine B. Zander, PhD, X. Long Zheng, MD, PhD

Blood (2016) 128 (22): 1383.

https://doi.org/10.1182/blood.V128.22.1383.1383

Published: 2016

Journal Articles

Predictors for in-Hospital Mortality in Patients with Autoimmune Thrombotic Thrombocytopenia Purpura (TTP): A Single Center Experience

Huy P. Pham, MD, M.P.H., Wenjing Cao, MD, PhD, Lance A. Williams, MD, Alexander Z. Feldman, MD, Rance C. Siniard, MD, Robin G. Lorenz, MD, PhD, Dheeraj Raju, PhD, Marisa B. Marques, MD, PhD, X. Long Zheng, MD, PhD

Blood (2016) 128 (22): 3853.

https://doi.org/10.1182/blood.V128.22.3853.3853

Published: 2016

Journal Articles

Human Neutrophil Peptides (HNPs) Enhance Thrombus Formation Under Flow By Inhibiting Proteolytic Activity of Plasma ADAMTS13 Metalloprotease

Vikram G. Pillai, PhD, Jialing Bao, PhD, Jenny McDaniel, MD, Catherine B. Zander1, PhD, Wenjing Cao, MD, PhD, Khalil Bdeir, PhD, Douglas B. Cines, MD, X. Long Zheng, MD PhD

Blood (2015) 126 (23): 105.

https://doi.org/10.1182/blood.V126.23.105.105

Published: 2015

Journal Articles

Plasma Levels of Human Neutrophil Peptides and Complement Activation Markers in Patients with Acquired Autoimmune Thrombotic Thrombocytopenic Purpura

Wenjing Cao, MD, PhD, Huy Phu Pham, MD, M.P.H., Lawrence A. Williams, MD, Zheng Ping, MD, PhD, Robin G. Lorenz, MD, PhD, Marisa B. Marques, MD, PhD, X. Long Zheng, MD PhD

Blood (2015) 126 (23): 1147.

https://doi.org/10.1182/blood.V126.23.1147.1147

Published: 2015

Journal Articles

The Light Chain of Rat Factor VIII Confers Its Superior Cofactor Activity

Qizhao Wang, PhD, Jenni Firrman, PhD, Katie A Pokiniewski, Wenjing Cao, MD, PhD, Hongying Wei, PhD, Roland Herzog, PhD, Weidong Xiao, PhD

Blood (2015) 126 (23): 2038.

https://doi.org/10.1182/blood.V126.23.2038.2038

Published: 2015

Journal Articles

Reconstitution of Recombinant Factor VIII In fVIII -/- mice Restores Von Willebrand Factor Homeostasis

Wenjing Cao, M.D., Ph.D., Denise E Sabatino, Ph.D., Ekaterina Altynova, B.S., X. Long Zheng, M.D., Ph.D.

Blood (2010) 116 (21): 2213.

https://doi.org/10.1182/blood.V116.21.2213.2213

Published: 2010

Journal Articles

Compromised Proteolytic Cleavage of Von Willebrand Factor Type 2N Variants by ADAMTS13 in the Presence of Factor VIII (and Platelets) Under Fluid Shear Stress.

Christopher G. Skipwith, Sandra L. Haberichter, Ph.D., Wenjing Cao, M.D., Ph.D., Ashley L. Gehrand, X. Long Zheng, M.D., Ph.D.

Blood (2009) 114 (22): 28.

https://doi.org/10.1182/blood.V114.22.28.28

Published: 2009

Journal Articles

Structural Elements of FVIII Required for Accelerating Proteolytic Cleavage of Von Willebrand Factor by ADAMTS13.

Wenjing Cao, Ph.D., M.D., Denise E Sabatino, Ph.D., Ekaterina Altynova, B.S., Rodney M. Camire, Ph.D., X. Long Zheng, Ph.D., M.D.

Blood (2009) 114 (22): 849.

https://doi.org/10.1182/blood.V114.22.849.849

Published: 2009

NARROW

A Mutation in Complement Factor H (W1183R) Enhances VWF Proteolysis By ADAMTS13 Under Shear

Coagulation Factor VIII Enhances the Cleavage of Von Willebrand Factor By ADAMTS13 In Vivo

Binding of Gpibα to VWF A2 Domain Alters Mechanical Unraveling of the A2 Domain

Plasma Levels of Histone-DNA Complex and Cell-Free DNA Predict Mortality in Patients with Immune Thrombotic Thrombocytopenic Purpura

Exome Sequencing Identifies Glycosylation Defects As a Probable Cause of Immune Thrombotic Thrombocytopenic Purpura

Binding of Factor VIII to D'D3 and A2 Domains of Von Willebrand Factor Facilitates Mechanical Unraveling of the A2 Domain

The Factor VIII Variant X5 Enhances Hemophilia a Gene Therapy Efficiency By Its Improved Secretion

Longitudinal Assessment of Plasma ADAMTS13 Biomarkers Helps Predict Recurrence of Immune Thrombotic Thrombocytopenic Purpura

Synergistic effects of ADAMTS13 deficiency and complement activation in pathogenesis of thrombotic microangiopathy

Active and Ultra-Large Von Willebrand Factor Is Significantly Elevated in Patients with Immune Thrombotic Thrombocytopenic Purpura

Apolipoprotein B-100 Binds Von Willebrand Factor and Accelerates Its Proteolysis By ADAMTS13 Under Fluidic Shear

Platelet-Delivered Recombinant ADAMTS13 Inhibits Platelet Adhesion and Aggregation on Collagen Surface Under Flow in the Presence of Autoantibodies from Acquired Thrombotic Thrombocytopenic Purpura

Distal Carboxyl-Terminal Domains of ADAMTS13 Determine Its Substrate Specificity

Predictors for in-Hospital Mortality in Patients with Autoimmune Thrombotic Thrombocytopenia Purpura (TTP): A Single Center Experience

Human Neutrophil Peptides (HNPs) Enhance Thrombus Formation Under Flow By Inhibiting Proteolytic Activity of Plasma ADAMTS13 Metalloprotease

Plasma Levels of Human Neutrophil Peptides and Complement Activation Markers in Patients with Acquired Autoimmune Thrombotic Thrombocytopenic Purpura

The Light Chain of Rat Factor VIII Confers Its Superior Cofactor Activity

Reconstitution of Recombinant Factor VIII In fVIII -/- mice Restores Von Willebrand Factor Homeostasis

Compromised Proteolytic Cleavage of Von Willebrand Factor Type 2N Variants by ADAMTS13 in the Presence of Factor VIII (and Platelets) Under Fluid Shear Stress.

Structural Elements of FVIII Required for Accelerating Proteolytic Cleavage of Von Willebrand Factor by ADAMTS13.

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American Society of Hematology

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American Society of Hematology

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