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Results of a randomized international study of high-risk central nervous system B non-Hodgkin lymphoma and B acute lymphoblastic leukemia in children and adolescents
Pharmacodynamics and safety of intravenous pegaspargase during remission induction in adults aged 55 years or younger with newly diagnosed acute lymphoblastic leukemia
Hyperacute GVHD: risk factors, outcomes, and clinical implications
Intensified 12-week CHOP (I-CHOP) plus G-CSF compared with standard 24-week CHOP (CHOP-21) for patients with intermediate-risk aggressive non-Hodgkin lymphoma: a phase 3 trial of the Dutch-Belgian Hemato-Oncology Cooperative Group (HOVON)
Bortezomib, melphalan, prednisone, and thalidomide for relapsed multiple myeloma
Results of the randomized international FAB/LMB96 trial for intermediate risk B-cell non-Hodgkin lymphoma in children and adolescents: it is possible to reduce treatment for the early responding patients
Phase 1 and pharmacologic study of MS-275, a histone deacetylase inhibitor, in adults with refractory and relapsed acute leukemias
Prophylactic administration of imatinib after hematopoietic cell transplantation for high-risk Philadelphia chromosome–positive leukemia
Granulocyte-stimulating factor and severe aplastic anemia: a survey by the European Group for Blood and Marrow Transplantation (EBMT)
Prognostic value of anti-ADAMTS13 antibody features (Ig isotype, titer, and inhibitory effect) in a cohort of 35 adult French patients undergoing a first episode of thrombotic microangiopathy with undetectable ADAMTS13 activity
Slow disease progression and robust therapy-mediated CD4+ T-cell recovery are associated with efficient thymopoiesis during HIV-1 infection
Comprehensive characterization of IGHV3-21–expressing B-cell chronic lymphocytic leukemia: an Italian multicenter study
Blockade of adaptive defensive changes in cholesterol uptake and synthesis in AML by the addition of pravastatin to idarubicin + high-dose Ara-C: a phase 1 study
Gene-nutrient interactions among determinants of folate and one-carbon metabolism on the risk of non-Hodgkin lymphoma: NCI-SEER Case-Control Study
CD10−MUM1+ follicular lymphoma lacks BCL2 gene translocation and shows characteristic biologic and clinical features
Connective tissue growth factor (CTGF) expression and outcome in adult patients with acute lymphoblastic leukemia
Issue Archive
April 1 2007
In this Issue
Table of Contents
INSIDE BLOOD
BLOOD WORK
PLENARY PAPERS
PERSPECTIVE
REVIEW ARTICLES
REVIEW IN TRANSLATIONAL HEMATOLOGY
CHEMOKINES, CYTOKINES, AND INTERLEUKINS
Mechanisms of regulation of CXCR4/SDF-1 (CXCL12)–dependent migration and homing in multiple myeloma
Yazan Alsayed,Hai Ngo,Judith Runnels,Xavier Leleu,Ujjal K. Singha,Costas M. Pitsillides,Joel A. Spencer,Teresa Kimlinger,Joanna M. Ghobrial,Xiaoying Jia,Ganwei Lu,Michael Timm,Ashok Kumar,Daniel Côté,Israel Veilleux,Karen E. Hedin,G. David Roodman,Thomas E. Witzig,Andrew L. Kung,Teru Hideshima,Kenneth C. Anderson,Charles P. Lin,Irene M. Ghobrial
ERRATUM
CLINICAL TRIALS AND OBSERVATIONS
Results of a randomized international study of high-risk central nervous system B non-Hodgkin lymphoma and B acute lymphoblastic leukemia in children and adolescents
Clinical Trials & Observations
Mitchell S. Cairo,Mary Gerrard,Richard Sposto,Anne Auperin,C. Ross Pinkerton,Jean Michon,Claire Weston,Sherrie L. Perkins,Martine Raphael,Keith McCarthy,Catherine Patte,on behalf of the FAB LMB96 International Study Committee
Pharmacodynamics and safety of intravenous pegaspargase during remission induction in adults aged 55 years or younger with newly diagnosed acute lymphoblastic leukemia
Clinical Trials & Observations
Dan Douer,Henry Yampolsky,Lewis J. Cohen,Kristy Watkins,Alexandra M. Levine,Antonia P. Periclou,Vassilios I. Avramis
Hyperacute GVHD: risk factors, outcomes, and clinical implications
Clinical Trials & Observations
Rima M. Saliba,Marcos de Lima,Sergio Giralt,Borje Andersson,Issa F. Khouri,Chitra Hosing,Shubhra Ghosh,Joyce Neumann,Yvonne Hsu,Jorge De Jesus,Muzaffar H. Qazilbash,Richard E. Champlin,Daniel R. Couriel
Intensified 12-week CHOP (I-CHOP) plus G-CSF compared with standard 24-week CHOP (CHOP-21) for patients with intermediate-risk aggressive non-Hodgkin lymphoma: a phase 3 trial of the Dutch-Belgian Hemato-Oncology Cooperative Group (HOVON)
Clinical Trials & Observations
Leo F. Verdonck,Annelise Notenboom,Daphne D. de Jong,Marius A. MacKenzie,Gregor E. G. Verhoef,Mark H. H. Kramer,Gert J. Ossenkoppele,Jeanette K. Doorduijn,Pieter Sonneveld,Gustaaf W. van Imhoff
Bortezomib, melphalan, prednisone, and thalidomide for relapsed multiple myeloma
Clinical Trials & Observations
Antonio Palumbo,Maria Teresa Ambrosini,Giulia Benevolo,Patrizia Pregno,Norbert Pescosta,Vincenzo Callea,Clotilde Cangialosi,Tommaso Caravita,Fortunato Morabito,Pellegrino Musto,Sara Bringhen,Patrizia Falco,Ilaria Avonto,Federica Cavallo,Mario Boccadoro,for the Italian Multiple Myeloma Network, Gruppo Italiano Malattie Ematologiche dell'Adulto (GIMEMA)
Results of the randomized international FAB/LMB96 trial for intermediate risk B-cell non-Hodgkin lymphoma in children and adolescents: it is possible to reduce treatment for the early responding patients
Clinical Trials & Observations
Catherine Patte,Anne Auperin,Mary Gerrard,Jean Michon,Ross Pinkerton,Richard Sposto,Claire Weston,Martine Raphael,Sherrie L. Perkins,Keith McCarthy,Mitchell S. Cairo,for the FAB/LMB96 International Study Committee
Phase 1 and pharmacologic study of MS-275, a histone deacetylase inhibitor, in adults with refractory and relapsed acute leukemias
Clinical Trials & Observations
Ivana Gojo,Anchalee Jiemjit,Jane B. Trepel,Alex Sparreboom,William D. Figg,Sandra Rollins,Michael L. Tidwell,Jacqueline Greer,Eun Joo Chung,Min-Jung Lee,Steven D. Gore,Edward A. Sausville,James Zwiebel,Judith E. Karp
Prophylactic administration of imatinib after hematopoietic cell transplantation for high-risk Philadelphia chromosome–positive leukemia
Clinical Trials & Observations
Brief Report
Paul A. Carpenter,David S. Snyder,Mary E. D. Flowers,Jean E. Sanders,Theodore A. Gooley,Paul J. Martin,Frederick R. Appelbaum,Jerald P. Radich
Granulocyte-stimulating factor and severe aplastic anemia: a survey by the European Group for Blood and Marrow Transplantation (EBMT)
Clinical Trials & Observations
Brief Report
Gerard Socie,Jean-Yves Mary,Hubert Schrezenmeier,Judith Marsh,Andrea Bacigalupo,Anna Locasciulli,Monica Fuehrer,Albert Bekassy,Andre Tichelli,Jakob Passweg
GENE THERAPY
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
Prognostic value of anti-ADAMTS13 antibody features (Ig isotype, titer, and inhibitory effect) in a cohort of 35 adult French patients undergoing a first episode of thrombotic microangiopathy with undetectable ADAMTS13 activity
Clinical Trials & Observations
Silvia Ferrari,Friedrich Scheiflinger,Manfred Rieger,Geert Mudde,Martine Wolf,Paul Coppo,Jean-Pierre Girma,Elie Azoulay,Christian Brun-Buisson,Fadi Fakhouri,Jean-Paul Mira,Eric Oksenhendler,Pascale Poullin,Eric Rondeau,Nicolas Schleinitz,Benoit Schlemmer,Jean-Louis Teboul,Philippe Vanhille,Jean-Paul Vernant,Dominique Meyer,Agnès Veyradier,for the French and Clinical Biological Network on Adult Thrombotic Microangiopathies
IMMUNOBIOLOGY
Modulation of tryptophan catabolism by human leukemic cells results in the conversion of CD25− into CD25+ T regulatory cells
Antonio Curti,Simona Pandolfi,Barbara Valzasina,Michela Aluigi,Alessandro Isidori,Elisa Ferri,Valentina Salvestrini,Giuseppina Bonanno,Sergio Rutella,Ilaria Durelli,Alberto L. Horenstein,Francesca Fiore,Massimo Massaia,Mario P. Colombo,Michele Baccarani,Roberto M. Lemoli
Slow disease progression and robust therapy-mediated CD4+ T-cell recovery are associated with efficient thymopoiesis during HIV-1 infection
Clinical Trials & Observations
Marie-Lise Dion,Rebeka Bordi,Joumana Zeidan,Robert Asaad,Mohammed-Rachid Boulassel,Jean-Pierre Routy,Micheal M. Lederman,Rafick-Pierre Sekaly,Remi Cheynier
NEOPLASIA
Comprehensive characterization of IGHV3-21–expressing B-cell chronic lymphocytic leukemia: an Italian multicenter study
Clinical Trials & Observations
Riccardo Bomben,Michele Dal Bo,Daniela Capello,Dania Benedetti,Daniela Marconi,Antonella Zucchetto,Francesco Forconi,Rossana Maffei,Emanuela M. Ghia,Luca Laurenti,Pietro Bulian,Maria Ilaria Del Principe,Giuseppe Palermo,Mia Thorsélius,Massimo Degan,Renato Campanini,Anna Guarini,Giovanni Del Poeta,Richard Rosenquist,Dimitar G. Efremov,Roberto Marasca,Robin Foà,Gianluca Gaidano,Valter Gattei
Blockade of adaptive defensive changes in cholesterol uptake and synthesis in AML by the addition of pravastatin to idarubicin + high-dose Ara-C: a phase 1 study
Clinical Trials & Observations
Steven M. Kornblau,Deborah E. Banker,Derek Stirewalt,Danny Shen,Elizabeth Lemker,Srdan Verstovsek,Zeev Estrov,Stefan Faderl,Jorge Cortes,Miloslav Beran,C. Ellen Jackson,Wenjing Chen,Elihu Estey,Frederick R. Appelbaum
Comprehensive analysis of homeobox genes in Hodgkin lymphoma cell lines identifies dysregulated expression of HOXB9 mediated via ERK5 signaling and BMI1
Stefan Nagel,Christof Burek,Letizia Venturini,Michaela Scherr,Hilmar Quentmeier,Corinna Meyer,Andreas Rosenwald,Hans G. Drexler,Roderick A. F. MacLeod
Identification of MCL1 as a novel target in neoplastic mast cells in systemic mastocytosis: inhibition of mast cell survival by MCL1 antisense oligonucleotides and synergism with PKC412
Karl J. Aichberger,Matthias Mayerhofer,Karoline V. Gleixner,Maria-Theresa Krauth,Alexander Gruze,Winfried F. Pickl,Volker Wacheck,Edgar Selzer,Leonhard Müllauer,Hermine Agis,Christian Sillaber,Peter Valent
Gene-nutrient interactions among determinants of folate and one-carbon metabolism on the risk of non-Hodgkin lymphoma: NCI-SEER Case-Control Study
Clinical Trials & Observations
Unhee Lim,Sophia S. Wang,Patricia Hartge,Wendy Cozen,Linda E. Kelemen,Stephen Chanock,Scott Davis,Aaron Blair,Maryjean Schenk,Nathaniel Rothman,Qing Lan
CD10−MUM1+ follicular lymphoma lacks BCL2 gene translocation and shows characteristic biologic and clinical features
Clinical Trials & Observations
Brief Report
Kennosuke Karube,Ying Guo,Junji Suzumiya,Yasuo Sugita,Yuko Nomura,Kohei Yamamoto,Kei Shimizu,Shirou Yoshida,Hideki Komatani,Morishige Takeshita,Masahiro Kikuchi,Naoya Nakamura,Osamu Takasu,Fumiko Arakawa,Hiroyuki Tagawa,Masao Seto,Koichi Ohshima
Connective tissue growth factor (CTGF) expression and outcome in adult patients with acute lymphoblastic leukemia
Clinical Trials & Observations
Brief Report
Olga Sala-Torra,Holly M. Gundacker,Derek L. Stirewalt,Paula A. Ladne,Era L. Pogosova-Agadjanyan,Marilyn L. Slovak,Cheryl L. Willman,Shelly Heimfeld,David H. Boldt,Jerald P. Radich
PHAGOCYTES
RED CELLS
Hemolysis in sickle cell mice causes pulmonary hypertension due to global impairment in nitric oxide bioavailability
Lewis L. Hsu,Hunter C. Champion,Sally A. Campbell-Lee,Trinity J. Bivalacqua,Elizabeth A. Manci,Bhalchandra A. Diwan,Daniel M. Schimel,Audrey E. Cochard,Xunde Wang,Alan N. Schechter,Constance T. Noguchi,Mark T. Gladwin
TRANSFUSION MEDICINE
TRANSPLANTATION
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