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Alex Sparreboom
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Journal Articles

Hydroxyurea Pharmacokinetics for Predicting Maximum Tolerated Dose in Children with Sickle Cell Anemia

Patrick T. McGann, MDMS, Alex Sparreboom, PhD, Nicole A Mortier, MHS, PA-C, Banu Aygun, MD, Thad A Howard, MS, Kerri Nottage, MD MPH, Russell E. Ware, MD PhD
Journal: Blood
Blood (2014) 124 (21): 2707.
https://doi.org/10.1182/blood.V124.21.2707.2707
Published: 2014
Journal Articles

Can “specific” OCT1 inhibitors be used to determine OCT1 transporter activity toward imatinib?

Herman Burger, Ron H. J. Mathijssen, Alex Sparreboom, Erik A. C. Wiemer
Journal: Blood
Blood (2013) 121 (24): 4965–4966.
https://doi.org/10.1182/blood-2013-03-493841
Published: 2013
Journal Articles

Organic Anion Transporting Polypeptide 1B (OATP1B) Transporters Modulate Hydroxyurea Pharmacokinetics

Aisha L. Walker, PhD, Cynthia S Lancaster, PhD, Russell E. Ware, MD, PhD, Alex Sparreboom, PhD
Journal: Blood
Blood (2012) 120 (21): 1008.
https://doi.org/10.1182/blood.V120.21.1008.1008
Published: 2012
Journal Articles

Predicting Hydroxyurea Responses in Children with Sickle Cell Anemia

Russell E. Ware, MD, PhD, Nicole A Mortier, MHS, PA-C, Matthew P Smeltzer, Thad A Howard, MS, Amy C Kimble, FNP, Jenny M Despotovic, DO, MS, Song Wu, PhD, Banu Aygun, MD, Jonathan Michael Flanagan, Ph.D, Alex Sparreboom, PhD
Journal: Blood
Blood (2011) 118 (21): 2131.
https://doi.org/10.1182/blood.V118.21.2131.2131
Published: 2011
Journal Articles

SLCO1B1 Variation and Methotrexate Disposition in Children with Acute Lymphoblastic Leukemia: The Importance of Rare Variants in Pharmacogenetics

Laura B. Ramsey, PhD, Gitte H Bruun, Wenjian Yang, PhD, Lisa R Trevino, PhD, Selina Vattathil, Paul Scheet, PhD, Cheng Cheng, PhD, Gary Rosner, Kathleen Giacomini, PhD, Yiping Fan, PhD, Alex Sparreboom, PhD, Torben Mikkelsen, MD PhD, Thomas J Corydon, PhD, Ching-Hon Pui, MD, William E. Evans, PharmD, Mary V. Relling, PharmD
Journal: Blood
Blood (2011) 118 (21): 571.
https://doi.org/10.1182/blood.V118.21.571.571
Published: 2011
Journal Articles

Pharmacokinetics, pharmacodynamics, and pharmacogenetics of hydroxyurea treatment for children with sickle cell anemia

Clinical Trials & Observations
Russell E. Ware, Jenny M. Despotovic, Nicole A. Mortier, Jonathan M. Flanagan, Jin He, Matthew P. Smeltzer, Amy C. Kimble, Banu Aygun, Song Wu, Thad Howard, Alex Sparreboom
Journal: Blood
Blood (2011) 118 (18): 4985–4991.
https://doi.org/10.1182/blood-2011-07-364190
Published: 2011
Includes: Supplemental data
Journal Articles

Movement of Hydroxyurea Across Cell Membranes Is Mediated by Specific Solute Carrier (SLC) Transporters.

Aisha L. Walker, PhD, Ryan M Franke, PhD, Alex Sparreboom, PhD, Russell E. Ware, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 2575.
https://doi.org/10.1182/blood.V114.22.2575.2575
Published: 2009
Journal Articles

A Whole Genome Analysis Identifies SLCO1B1 as a Determinant of Methotrexate Pharmacokinetics and Adverse Effects

Lisa R Trevino, Ph.D., Noriko Shimasaki, M.D., Wenjian Yang, Ph.D., John C. Panetta, Ph.D., Cheng Cheng, Ph.D., Deqing Pei, M.S., Diana Chan, M.S., Alex Sparreboom, Ph.D., Kathleen M Giacomini, Ph.D., Ching-Hon Pui, M.D., William E. Evans, Pharm.D., Mary V. Relling, Pharm.D.
Journal: Blood
Blood (2008) 112 (11): 214.
https://doi.org/10.1182/blood.V112.11.214.214
Published: 2008
Journal Articles

Distinct Phenotypes of Hydroxyurea Absorption among Children with Sickle Cell Anemia

Russell E. Ware, MD, PhD, Jin He, MD, Nicole A. Mortier, MHS, PA-C, Thad A. Howard, MS, Cheng Cheng, PhD, Jonathan M. Flanagan, PhD, Alex Sparreboom, PhD
Journal: Blood
Blood (2008) 112 (11): 709.
https://doi.org/10.1182/blood.V112.11.709.709
Published: 2008
Journal Articles

Phase 1 and pharmacologic study of MS-275, a histone deacetylase inhibitor, in adults with refractory and relapsed acute leukemias

Clinical Trials & Observations
Ivana Gojo, Anchalee Jiemjit, Jane B. Trepel, Alex Sparreboom, William D. Figg, Sandra Rollins, Michael L. Tidwell, Jacqueline Greer, Eun Joo Chung, Min-Jung Lee, Steven D. Gore, Edward A. Sausville, James Zwiebel, Judith E. Karp
Journal: Blood
Blood (2006) 109 (7): 2781–2790.
https://doi.org/10.1182/blood-2006-05-021873
Published: 2006