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Journal Articles

Indoximod Combined with Standard Induction Chemotherapy Is Well Tolerated and Induces a High Rate of Complete Remission with MRD-Negativity in Patients with Newly Diagnosed AML: Results from a Phase 1 Trial

Ashkan Emadi, MD PhD, Vu H. Duong, MD, Jeremy Pantin, MD, Mohammad Imran, MD, Rima Koka, MD PhD, Zeba Singh, MBBS, Edward A. Sausville, MD PhD, Jennie Y. Law, MD, Seung Tae Lee, MD PhD, Huidong Shi, PhD, Ravindra Kolhe, MD PhD, Maria R. Baer, MD, Michael R. Loken, PhD, Eugene P. Kennedy, MD, Charles Link, MD, David H. Munn, MD

Blood (2018) 132 (Supplement 1): 332.

https://doi.org/10.1182/blood-2018-99-117433

Published: 2018

Journal Articles

Peripheral Blood Blast Clearance As an Independent Predictor of Clinical Response and Outcomes in Acute Myeloid Leukemia

Noa G. Holtzman, MD, Firas El Chaer, MD, Omer Ali, MD, Ameet Patel, MD, Maria R. Baer, MD, Vu H. Duong, MD, Edward A. Sausville, MD PhD, Arash Etemadi, MD PhD, Ashkan Emadi, MD PhD

Blood (2018) 132 (Supplement 1): 2684.

https://doi.org/10.1182/blood-2018-99-115512

Published: 2018

Journal Articles

Clinical Benefit Of Anticoagulation In Treatment Of Catheter-Related Deep Vein Thrombosis In Patients With Acute Leukemia

Briana Short, MD, Nora Oliver, MD, Mya S Thein, MD, Vu H. Duong, MD, Michael L. Tidwell, C.R.N.P., Edward A. Sausville, MD, PhD, Farin Kamangar, MD, PhD, Maria R. Baer, MD, Ashkan Emadi, M.D., Ph.D.

Blood (2013) 122 (21): 2389.

https://doi.org/10.1182/blood.V122.21.2389.2389

Published: 2013

Journal Articles

Synergistic Antileukemic Effect Of Sequential Administration Of Dichloroacetate (DCA) Combined With Arsenic Trioxide (ATO) In Primary Blasts From Patients With Acute Myeloid Leukemia (AML) and FLT3-ITD AML Cell Lines

Ashkan Emadi, M.D., Ph.D., Brandon Carter-Cooper, BS, Mariola Sadowska, PhD, Omasiri Wonodi, BS, Rena G. Lapidus, PhD, Mark Levis, MD, PhD, Edward A. Sausville, MD, PhD

Blood (2013) 122 (21): 3955.

https://doi.org/10.1182/blood.V122.21.3955.3955

Published: 2013

Journal Articles

Dimeric Naphthoquinones: Novel Anti-Leukemic Agents Modulating Cellular Redox Status

Ashkan Emadi, M.D., Ph.D., Mariola Sadowska, PhD, Brandon Carter-Cooper, BS, Omasiri Wonodi, BS, Nidal Muvarak, BS, Feyruz Rassool, PhD, Anil Jaiswal, PhD, Maria R. Baer, MD, Rena G. Lapidus, PhD, Edward A. Sausville, MD, PhD

Blood (2013) 122 (21): 1290.

https://doi.org/10.1182/blood.V122.21.1290.1290

Published: 2013

Journal Articles

Phase 1 Study of UCN-01 in Combination with Perifosine in Patients with Relapsed and Refractory Acute Leukemias and High Risk Myelodysplastic Syndromes (MDS)

Kelly J. Norsworthy, MD, Alexander E Perl, MD, Martin Carroll, MD, Selina M. Luger, MD, Kenneth S. Bauer, PharmD, PhD, Michael L. Tidwell, CRNP, Dina Ioffe, BA, Maria R. Baer, MD, Edward A. Sausville, MD, PhD, Ivana Gojo, MD

Blood (2011) 118 (21): 1557.

https://doi.org/10.1182/blood.V118.21.1557.1557

Published: 2011

Journal Articles

Phase 1b Evaluation of the Safety and Efficacy of a 30-Minute IV Infusion of Carfilzomib In Patients with Relapsed and/or Refractory Multiple Myeloma

Kyriakos Papadopoulos, MD, David Samuel diCapua Siegel, MD, PhD, Seema B. Singhal, MD, Jeffrey R. Infante, MD, Edward A. Sausville, MD, PhD, Michael S. Gordon, MD, Michael Kauffman, MD, PhD, Tina Woo, Susan Lee, Lynne Bui, MD, Alison L. Hannah, MD, Peter Lee, MD, PhD

Blood (2010) 116 (21): 3024.

https://doi.org/10.1182/blood.V116.21.3024.3024

Published: 2010

Journal Articles

Single Agent Activity of the Cyclin-Dependent Kinase (CDK) Inhibitor Dinaciclib (SCH 727965) In Acute Myeloid and Lymphoid Leukemia Cells

Mariola Sadowska, PhD, Nidal Muvarak, BS, Rena G. Lapidus, PhD, Edward A. Sausville, MD, PhD, Rajat Bannerji, MD, PhD, Ivana Gojo, MD

Blood (2010) 116 (21): 3981.

https://doi.org/10.1182/blood.V116.21.3981.3981

Published: 2010

Journal Articles

Phase 1 and pharmacologic study of MS-275, a histone deacetylase inhibitor, in adults with refractory and relapsed acute leukemias

Ivana Gojo, Anchalee Jiemjit, Jane B. Trepel, Alex Sparreboom, William D. Figg, Sandra Rollins, Michael L. Tidwell, Jacqueline Greer, Eun Joo Chung, Min-Jung Lee, Steven D. Gore, Edward A. Sausville, James Zwiebel, Judith E. Karp

Blood (2006) 109 (7): 2781–2790.

https://doi.org/10.1182/blood-2006-05-021873

Published: 2006

Journal Articles

Adaphostin-induced apoptosis in CLL B cells is associated with induction of oxidative stress and exhibits synergy with fludarabine

Tait D. Shanafelt, Yean K. Lee, Nancy D. Bone, Ann K. Strege, Ven L. Narayanan, Edward A. Sausville, Susan M. Geyer, Scott H. Kaufmann, Neil E. Kay

Blood (2005) 105 (5): 2099–2106.

https://doi.org/10.1182/blood-2004-06-2205

Published: 2005

Journal Articles

Involvement of reactive oxygen species in adaphostin-induced cytotoxicity in human leukemia cells

Joya Chandra, Jennifer Hackbarth, Son Le, David Loegering, Nancy Bone, Laura M. Bruzek, Ven L. Narayanan, Alex A. Adjei, Neil E. Kay, Ayalew Tefferi, Judith E. Karp, Edward A. Sausville, Scott H. Kaufmann

Blood (2003) 102 (13): 4512–4519.

https://doi.org/10.1182/blood-2003-02-0562

Published: 2003

Journal Articles

Synergistic antileukemic interactions between 17-AAG and UCN-01 involve interruption of RAF/MEK- and AKT-related pathways

Wentao Jia, Chunrong Yu, Mohamed Rahmani, Geoffrey Krystal, Edward A. Sausville, Paul Dent, Steven Grant

Blood (2003) 102 (5): 1824–1832.

https://doi.org/10.1182/blood-2002-12-3785

Published: 2003

Journal Articles

Effects of the Bcr/abl kinase inhibitors STI571 and adaphostin (NSC 680410) on chronic myelogenous leukemia cells in vitro

Benjamin M. F. Mow, Joya Chandra, Phyllis A. Svingen, Christopher G. Hallgren, Ellen Weisberg, Timothy J. Kottke, Ven L. Narayanan, Mark R. Litzow, James D. Griffin, Edward A. Sausville, Ayalew Tefferi, Scott H. Kaufmann

Blood (2002) 99 (2): 664–671.

https://doi.org/10.1182/blood.V99.2.664

Published: 2002

Journal Articles

Flavopiridol Induces Apoptosis of Normal Lymphoid Cells, Causes Immunosuppression, and Has Potent Antitumor Activity In Vivo Against Human Leukemia and Lymphoma Xenografts

Francisco Arguello, Mark Alexander, Judith A. Sterry, Gabriela Tudor, Erik M. Smith, Naina T. Kalavar, John F. Greene, Jr, William Koss, C. David Morgan, Sherman F. Stinson, Timothy J. Siford, W. Gregory Alvord, Richard L. Klabansky, Edward A. Sausville

Blood (1998) 91 (7): 2482–2490.

https://doi.org/10.1182/blood.V91.7.2482

Published: 1998

Journal Articles

Early Induction of Apoptosis in Hematopoietic Cell Lines After Exposure to Flavopiridol

Bernard W. Parker, Gurmeet Kaur, Wilberto Nieves-Neira, Mohammed Taimi, Glenda Kohlhagen, Tsunehiro Shimizu, Michael D. Losiewicz, Yves Pommier, Edward A. Sausville, Adrian M. Senderowicz

Blood (1998) 91 (2): 458–465.

https://doi.org/10.1182/blood.V91.2.458

Published: 1998

NARROW

Indoximod Combined with Standard Induction Chemotherapy Is Well Tolerated and Induces a High Rate of Complete Remission with MRD-Negativity in Patients with Newly Diagnosed AML: Results from a Phase 1 Trial

Peripheral Blood Blast Clearance As an Independent Predictor of Clinical Response and Outcomes in Acute Myeloid Leukemia

Clinical Benefit Of Anticoagulation In Treatment Of Catheter-Related Deep Vein Thrombosis In Patients With Acute Leukemia

Synergistic Antileukemic Effect Of Sequential Administration Of Dichloroacetate (DCA) Combined With Arsenic Trioxide (ATO) In Primary Blasts From Patients With Acute Myeloid Leukemia (AML) and FLT3-ITD AML Cell Lines

Dimeric Naphthoquinones: Novel Anti-Leukemic Agents Modulating Cellular Redox Status

Phase 1 Study of UCN-01 in Combination with Perifosine in Patients with Relapsed and Refractory Acute Leukemias and High Risk Myelodysplastic Syndromes (MDS)

Phase 1b Evaluation of the Safety and Efficacy of a 30-Minute IV Infusion of Carfilzomib In Patients with Relapsed and/or Refractory Multiple Myeloma

Single Agent Activity of the Cyclin-Dependent Kinase (CDK) Inhibitor Dinaciclib (SCH 727965) In Acute Myeloid and Lymphoid Leukemia Cells

Phase 1 and pharmacologic study of MS-275, a histone deacetylase inhibitor, in adults with refractory and relapsed acute leukemias

Adaphostin-induced apoptosis in CLL B cells is associated with induction of oxidative stress and exhibits synergy with fludarabine

Involvement of reactive oxygen species in adaphostin-induced cytotoxicity in human leukemia cells

Synergistic antileukemic interactions between 17-AAG and UCN-01 involve interruption of RAF/MEK- and AKT-related pathways

Effects of the Bcr/abl kinase inhibitors STI571 and adaphostin (NSC 680410) on chronic myelogenous leukemia cells in vitro

Flavopiridol Induces Apoptosis of Normal Lymphoid Cells, Causes Immunosuppression, and Has Potent Antitumor Activity In Vivo Against Human Leukemia and Lymphoma Xenografts

Early Induction of Apoptosis in Hematopoietic Cell Lines After Exposure to Flavopiridol

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American Society of Hematology

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American Society of Hematology

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