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Journal Articles

Cytokinetically quiescent (G 0 /G 1 ) human multiple myeloma cells are susceptible to simultaneous inhibition of Chk1 and MEK1/2

Xin-Yan Pei, Yun Dai, Leena E. Youssefian, Shuang Chen, Wesley W. Bodie, Yukie Takabatake, Jessica Felthousen, Jorge A. Almenara, Lora B. Kramer, Paul Dent, Steven Grant

Blood (2011) 118 (19): 5189–5200.

https://doi.org/10.1182/blood-2011-02-339432

Published: 2011

Includes: Supplemental data

Journal Articles

Disruption of Src function potentiates Chk1-inhibitor–induced apoptosis in human multiple myeloma cells in vitro and in vivo

Yun Dai, Shuang Chen, Rena Shah, Xin-Yan Pei, Li Wang, Jorge A. Almenara, Lora B. Kramer, Paul Dent, Steven Grant

Blood (2011) 117 (6): 1947–1957.

https://doi.org/10.1182/blood-2010-06-291146

Published: 2011

Includes: Supplemental data

Journal Articles

Bortezomib Interacts Synergistically with Belinostat to Induce Apoptosis In Human Acute Myeloid and Lymphoid Leukemia Cells

Yun Dai, Shuang Chen, Li Wang, Xin-Yan Pei, Lora Kramer, Paul Dent, Steven Grant, MD

Blood (2010) 116 (21): 3266.

https://doi.org/10.1182/blood.V116.21.3266.3266

Published: 2010

Journal Articles

Histone Deacetylase Inhibitors Potentiate the Lethality of the Irreversible Proteasome Inhibitor Carfilzomib In Mantle Cell Lymphoma Cells In Vitro and In Vivo

Girija Dasmahapatra, Dmitry Lembersky, Jonathan W. Friedberg, MD, Richard I Fisher, MD, Paul Dent, Steven Grant, MD

Blood (2010) 116 (21): 3938.

https://doi.org/10.1182/blood.V116.21.3938.3938

Published: 2010

Journal Articles

The pan-HDAC inhibitor vorinostat potentiates the activity of the proteasome inhibitor carfilzomib in human DLBCL cells in vitro and in vivo

Girija Dasmahapatra, Dmitry Lembersky, Lora Kramer, Richard I. Fisher, Jonathan Friedberg, Paul Dent, Steven Grant

Blood (2010) 115 (22): 4478–4487.

https://doi.org/10.1182/blood-2009-12-257261

Published: 2010

Includes: Supplemental data

Journal Articles

The Novel Proteasome Inhibitor Carfilzomib Interacts Synergistically with HDAC Inhibitors in ABC- and GC-DLBCL Cells Both in Vitro and In Vivo through Mechanisms Involving JNK Activation, NF-κB Inactivation, and DNA Damage..

Girija Dasmahapatra, Dmitry Lembersky, Lora Kramer, Jonathan W. Friedberg, MD, Richard I Fisher, MD, Paul Dent, Steven Grant, MD

Blood (2009) 114 (22): 1688.

https://doi.org/10.1182/blood.V114.22.1688.1688

Published: 2009

Journal Articles

Targeting CDK9 Dramatically Potentiates ABT-737-Induced Apoptosis in Human Multiple Myeloma Cells through a Bim-Dependent Mechanism.

Yun Dai, MD, PhD., Shuang Chen, MD, PhD, Xin-Yan Pei, MD, Viswanathan Ramakrishnan, Ph.D, Michael Wang, MD, MS., Robert Orlowski, PhD, Paul Dent, PhD, Steven Grant, MD

Blood (2009) 114 (22): 297.

https://doi.org/10.1182/blood.V114.22.297.297

Published: 2009

Journal Articles

The BH3-only protein Bim plays a critical role in leukemia cell death triggered by concomitant inhibition of the PI3K/Akt and MEK/ERK1/2 pathways

Mohamed Rahmani, Anh Anderson, Joseph Reza Habibi, Timothy Ryan Crabtree, Mandy Mayo, Hisashi Harada, Andrea Ferreira-Gonzalez, Paul Dent, Steven Grant

Blood (2009) 114 (20): 4507–4516.

https://doi.org/10.1182/blood-2008-09-177881

Published: 2009

Includes: Supplemental data

Journal Articles

Interruption of the Ras/MEK/ERK signaling cascade enhances Chk1 inhibitor–induced DNA damage in vitro and in vivo in human multiple myeloma cells

Yun Dai, Shuang Chen, Xin-Yan Pei, Jorge A. Almenara, Lora B. Kramer, Charis A. Venditti, Paul Dent, Steven Grant

Blood (2008) 112 (6): 2439–2449.

https://doi.org/10.1182/blood-2008-05-159392

Published: 2008

Includes: Supplemental data

Journal Articles

Vorinostat synergistically potentiates MK-0457 lethality in chronic myelogenous leukemia cells sensitive and resistant to imatinib mesylate

Yun Dai, Shuang Chen, Charis A. Venditti, Xin-Yan Pei, Tri K. Nguyen, Paul Dent, Steven Grant

Blood (2008) 112 (3): 793–804.

https://doi.org/10.1182/blood-2007-10-116376

Published: 2008

Includes: Supplemental data

Journal Articles

Vorinostat Synergistically Potentiates MK-0457 Lethality in Chronic Myelogenous Leukemia (CML) Cells Sensitive and Resistant to Imatinib Mesylate.

Yun Dai, PhD, Shuang Chen, PhD/MD, Charis A. Venditti, MD, Tri K. Nguyen, PhD, Paul Dent, PhD, Steven Grant, MD

Blood (2007) 110 (11): 1041.

https://doi.org/10.1182/blood.V110.11.1041.1041

Published: 2007

Journal Articles

MEK1/2 inhibitors potentiate UCN-01 lethality in human multiple myeloma cells through a Bim-dependent mechanism

Xin-Yan Pei, Yun Dai, Sarah Tenorio, Jianghua Lu, Hisashi Harada, Paul Dent, Steven Grant

Blood (2007) 110 (6): 2092–2101.

https://doi.org/10.1182/blood-2007-04-083204

Published: 2007

Journal Articles

Statins synergistically potentiate 7-hydroxystaurosporine (UCN-01) lethality in human leukemia and myeloma cells by disrupting Ras farnesylation and activation

Yun Dai, Payal Khanna, Shuang Chen, Xin-Yan Pei, Paul Dent, Steven Grant

Blood (2007) 109 (10): 4415–4423.

https://doi.org/10.1182/blood-2006-09-047076

Published: 2007

Journal Articles

MEK1/2 inhibitors sensitize Bcr/Abl + human leukemia cells to the dual Abl/Src inhibitor BMS-354/825

Tri K. Nguyen, Mohamed Rahmani, Hisashi Harada, Paul Dent, Steven Grant

Blood (2007) 109 (9): 4006–4015.

https://doi.org/10.1182/blood-2006-09-045039

Published: 2007

Journal Articles

The tyrphostin adaphostin interacts synergistically with proteasome inhibitors to induce apoptosis in human leukemia cells through a reactive oxygen species (ROS)-dependent mechanism

Girija Dasmahapatra, Mohamed Rahmani, Paul Dent, Steven Grant

Blood (2006) 107 (1): 232–240.

https://doi.org/10.1182/blood-2005-06-2302

Published: 2006

Journal Articles

Synergistic antileukemic interactions between 2-medroxyestradiol (2-ME) and histone deacetylase inhibitors involve Akt down-regulation and oxidative stress

Ning Gao, Mohamed Rahmani, Xianglin Shi, Paul Dent, Steven Grant

Blood (2006) 107 (1): 241–249.

https://doi.org/10.1182/blood-2005-06-2409

Published: 2006

Journal Articles

Farnesyltransferase inhibitors interact synergistically with the Chk1 inhibitor UCN-01 to induce apoptosis in human leukemia cells through interruption of both Akt and MEK/ERK pathways and activation of SEK1/JNK

Yun Dai, Mohamed Rahmani, Xin-Yan Pei, Payal Khanna, Song Iy Han, Clint Mitchell, Paul Dent, Steven Grant

Blood (2005) 105 (4): 1706–1716.

https://doi.org/10.1182/blood-2004-07-2767

Published: 2005

Journal Articles

Co-Administration of SAHA and 17-AAG Synergistically Induces Apoptosis in Bcr-Abl + Cells Sensitive and Resistant to STI-571 in Association with Down-Regulation of Bcr-Abl, Abrogation of STAT5 Activity, and Bax Conformational Change.

Mohamed Rahmani, Erin Reese, Yun Dai, Cheryl Bauer, Lora Kramer, Mei Huang, Richard Jove, Paul Dent, Steven Grant

Blood (2004) 104 (11): 1995.

https://doi.org/10.1182/blood.V104.11.1995.1995

Published: 2004

Journal Articles

Highly Synergistic Interaction between Farnesyltransferase Inhibitors and the Chk1 Inhibitor UCN-01 to Induce Apoptosis in Human Leukemia Cells through Interruption of Both Akt and MEK/ERK Pathways and Activation of SEK1/JNK.

Yun Dai, Ph.D., Mohamed Rahmani, Ph.D., Xin-Yan Pei, M.D., Payal Khanna, Paul Dent, Ph.D., Steven Grant, M.D.

Blood (2004) 104 (11): 3403.

https://doi.org/10.1182/blood.V104.11.3403.3403

Published: 2004

Journal Articles

Bortezomib and flavopiridol interact synergistically to induce apoptosis in chronic myeloid leukemia cells resistant to imatinib mesylate through both Bcr/Abl-dependent and -independent mechanisms

Yun Dai, Mohamed Rahmani, Xin-Yan Pei, Paul Dent, Steven Grant

Blood (2004) 104 (2): 509–518.

https://doi.org/10.1182/blood-2003-12-4121

Published: 2004

NARROW

Cytokinetically quiescent (G 0 /G 1 ) human multiple myeloma cells are susceptible to simultaneous inhibition of Chk1 and MEK1/2

Disruption of Src function potentiates Chk1-inhibitor–induced apoptosis in human multiple myeloma cells in vitro and in vivo

Bortezomib Interacts Synergistically with Belinostat to Induce Apoptosis In Human Acute Myeloid and Lymphoid Leukemia Cells

Histone Deacetylase Inhibitors Potentiate the Lethality of the Irreversible Proteasome Inhibitor Carfilzomib In Mantle Cell Lymphoma Cells In Vitro and In Vivo

The pan-HDAC inhibitor vorinostat potentiates the activity of the proteasome inhibitor carfilzomib in human DLBCL cells in vitro and in vivo

The Novel Proteasome Inhibitor Carfilzomib Interacts Synergistically with HDAC Inhibitors in ABC- and GC-DLBCL Cells Both in Vitro and In Vivo through Mechanisms Involving JNK Activation, NF-κB Inactivation, and DNA Damage..

Targeting CDK9 Dramatically Potentiates ABT-737-Induced Apoptosis in Human Multiple Myeloma Cells through a Bim-Dependent Mechanism.

The BH3-only protein Bim plays a critical role in leukemia cell death triggered by concomitant inhibition of the PI3K/Akt and MEK/ERK1/2 pathways

Interruption of the Ras/MEK/ERK signaling cascade enhances Chk1 inhibitor–induced DNA damage in vitro and in vivo in human multiple myeloma cells

Vorinostat synergistically potentiates MK-0457 lethality in chronic myelogenous leukemia cells sensitive and resistant to imatinib mesylate

Vorinostat Synergistically Potentiates MK-0457 Lethality in Chronic Myelogenous Leukemia (CML) Cells Sensitive and Resistant to Imatinib Mesylate.

MEK1/2 inhibitors potentiate UCN-01 lethality in human multiple myeloma cells through a Bim-dependent mechanism

Statins synergistically potentiate 7-hydroxystaurosporine (UCN-01) lethality in human leukemia and myeloma cells by disrupting Ras farnesylation and activation

MEK1/2 inhibitors sensitize Bcr/Abl + human leukemia cells to the dual Abl/Src inhibitor BMS-354/825

The tyrphostin adaphostin interacts synergistically with proteasome inhibitors to induce apoptosis in human leukemia cells through a reactive oxygen species (ROS)-dependent mechanism

Synergistic antileukemic interactions between 2-medroxyestradiol (2-ME) and histone deacetylase inhibitors involve Akt down-regulation and oxidative stress

Farnesyltransferase inhibitors interact synergistically with the Chk1 inhibitor UCN-01 to induce apoptosis in human leukemia cells through interruption of both Akt and MEK/ERK pathways and activation of SEK1/JNK

Co-Administration of SAHA and 17-AAG Synergistically Induces Apoptosis in Bcr-Abl + Cells Sensitive and Resistant to STI-571 in Association with Down-Regulation of Bcr-Abl, Abrogation of STAT5 Activity, and Bax Conformational Change.

Highly Synergistic Interaction between Farnesyltransferase Inhibitors and the Chk1 Inhibitor UCN-01 to Induce Apoptosis in Human Leukemia Cells through Interruption of Both Akt and MEK/ERK Pathways and Activation of SEK1/JNK.

Bortezomib and flavopiridol interact synergistically to induce apoptosis in chronic myeloid leukemia cells resistant to imatinib mesylate through both Bcr/Abl-dependent and -independent mechanisms

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American Society of Hematology

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American Society of Hematology

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