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Journal Articles

A Therapeutic siRNA Targeting Plasminogen Acts As a Long-Lasting Antifibrinolytic in Nonhuman Primates

Amy W Strilchuk, Lih Jiin Juang, Andrew Winterborn, Lori Harpell, Abbey Pender, Aomei Mo, Fateme Babaha, Christian J. Kastrup, David Lillicrap

Blood (2024) 144 (Supplement 1): 3959.

https://doi.org/10.1182/blood-2024-211420

Published: 2024

Journal Articles

Vector integration and fate in the hemophilia dog liver multiple years after AAV-FVIII gene transfer

Paul Batty, Sylvia Fong, Matteo Franco, Choong-Ryoul Sihn, Laura L. Swystun, Saira Afzal, Lorianne Harpell, David Hurlbut, Abbey Pender, Cheng Su, Hauke Thomsen, Christopher Wilson, Loubna Youssar, Andrew Winterborn, Irene Gil-Farina, David Lillicrap

Blood (2024) 143 (23): 2373–2385.

https://doi.org/10.1182/blood.2023022589

Published: 2024

Includes: Supplemental data

Journal Articles

Childhood Treatment with Adeno-Associated Viral Gene Therapy Results in Stable FVIII Expression and Improved Bleeding Phenotype in Adult Severe Hemophilia A Dogs

Paul Batty, Alex Menard, Aomei Mo, Christine Brown, Ashrafali M Ismail, Bridget Yates, Laura Swystun, Lori Harpell, Abbey Pender, Andrew Winterborn, Sylvia Fong, David Lillicrap

Blood (2023) 142 (Supplement 1): 2248.

https://doi.org/10.1182/blood-2023-174468

Published: 2023

Journal Articles

A Real-World Population Pharmacokinetic (PK) Study of Two Recombinant Factor VIII (rFVIII) Concentrates in Boys with Severe Hemophilia a without Inhibitors

Viviane Grassmann, Dagmar M Hajducek, Andrea N Edginton, Vanessa Bouskill, Christine Brown, Manuel Carcao, David Lillicrap, Roxy H O'Rourke, Roona Sinha, Jayson Stoffman, Cindy Wakefield, Margaret L. Rand, Victor Blanchette

Blood (2022) 140 (Supplement 1): 8453–8455.

https://doi.org/10.1182/blood-2022-160289

Published: 2022

Journal Articles

Investigating the Role of Von Willebrand Factor (VWF) in Modulating In Vivo angiogenesis in VWF-Deficient Mice

Edwin K. Ocran, Erin Burnett, Mackenzie L. Bowman, Orla Rawley, Matthew Cormier, Donald Maurice, David Lillicrap, Paula D. James

Blood (2022) 140 (Supplement 1): 11222–11223.

https://doi.org/10.1182/blood-2022-159053

Published: 2022

Journal Articles

Immune complications and their management in inherited and acquired bleeding disorders

Valder R. Arruda, David Lillicrap, Roland W. Herzog

Blood (2022) 140 (10): 1075–1085.

https://doi.org/10.1182/blood.2022016530

Published: 2022

Journal Articles

Moderate-intensity aerobic exercise vs desmopressin in adolescent males with mild hemophilia A: a randomized trial

Riten Kumar, Amy L. Dunn, Jane E. Schneiderman, Anne Gonzales, Vanessa Bouskill, Pamela Widener, Joseph Stanek, Fred G. Pluthero, Amanda Waller, Cristina Tarango, Sanjay Ahuja, Bryce A. Kerlin, Walter H. A. Kahr, Margaret L. Rand, David Lillicrap, Manuel Carcao

Blood (2022) 140 (10): 1156–1166.

https://doi.org/10.1182/blood.2022016146

Published: 2022

Includes: Supplemental data

Journal Articles

Low von Willebrand factor phenotype: the enigma continues

David Lillicrap

Blood (2022) 139 (14): 2102–2103.

https://doi.org/10.1182/blood.2021013541

Published: 2022

Journal Articles

Assembly of alternative prothrombinase by extracellular histones initiates and disseminates intravascular coagulation

Simon T. Abrams, Dunhao Su, Yasmina Sahraoui, Ziqi Lin, Zhenxing Cheng, Kate Nesbitt, Yasir Alhamdi, Micaela Harrasser, Min Du, Jonathan H. Foley, David Lillicrap, Guozheng Wang, Cheng-Hock Toh

Blood (2021) 137 (1): 103–114.

https://doi.org/10.1182/blood.2019002973

Published: 2021

Includes: Supplemental data

Journal Articles

Genetic determinants of VWF clearance and FVIII binding modify FVIII pharmacokinetics in pediatric hemophilia A patients

Laura L. Swystun, Kenichi Ogiwara, Orla Rawley, Christine Brown, Ilinca Georgescu, Wilma Hopman, Veerle Labarque, Christoph Male, Katharina Thom, Victor S. Blanchette, Manuel D. Carcao, David Lillicrap

Blood (2019) 134 (11): 880–891.

https://doi.org/10.1182/blood.2019000190

Published: 2019

Includes: Supplemental data

Journal Articles

A Practical, One Clinic Visit, Population Pharmacokinetic (PK) Protocol for Generation of PK Profiles in Subjects with Severe Hemophilia a

Victor S. Blanchette, FRCP, Laura Tiseo, BSc, CCRP, David Lillicrap, MD, Shannon Jackson, MD FRCPC, Massimo Morfini, MD, Vanessa Bouskill, MN, Manuel Carcao, Margaret L. Rand, PhD, Derek Stephens, MSc, Liane Khoo, MD, Ester Zapotocka, MD, Vladimir Komrska, MD, Jan Blatny, MD PhD

Blood (2018) 132 (Supplement 1): 2480.

https://doi.org/10.1182/blood-2018-99-111024

Published: 2018

Journal Articles

The Highly Prevalent Deletions in F8 Intron 13 Found in French Mild Haemophilia a Patients Result of Both Founder Effect and Recurrent De Novo Events

Yohann Jourdy, PhD PharmD, Mathilde Fretigny, PharmD, Fanny Lassalle, PharmD, David Lillicrap, MD, Claude Negrier, Patrice Bouvagnet, MD, Christine Vinciguerra, PharmD

Blood (2018) 132 (Supplement 1): 2489.

https://doi.org/10.1182/blood-2018-99-111791

Published: 2018

Journal Articles

Tolerogenic properties of the Fc portion of IgG and its relevance to the treatment and management of hemophilia

Richard S. Blumberg, David Lillicrap, the IgG Fc Immune Tolerance Group

Blood (2018) 131 (20): 2205–2214.

https://doi.org/10.1182/blood-2017-12-822908

Published: 2018

Journal Articles

Ancestral Sequence Reconstruction of Von Willebrand Factor Reveals Highly Conserved Structure/Function

Philip M Zakas, PhD, Caelan Radford, Christine Brown, Courtney Dwyer, RLAT, Christopher B Doering, PhD, Eric A Gaucher, PhD, David Lillicrap, MD FRCPC

Blood (2017) 130 (Supplement 1): 240.

https://doi.org/10.1182/blood.V130.Suppl_1.240.240

Published: 2017

Journal Articles

A Factor VIII Fusion with an Inactivated FIX Generates a Biologically Active Molecule with Delayed Clearance in a FVIII/VWF Knockout Mouse Model

Oladipo Jude Akinwale, MSc,BSc, Ian Wilkinson, PhD, Christine Hough, PhD, David Lillicrap, MD FRCPC, Michael Makris, MD, Richard Ross, MD FRCP

Blood (2017) 130 (Supplement 1): 2344.

https://doi.org/10.1182/blood.V130.Suppl_1.2344.2344

Published: 2017

Journal Articles

A Novel Von Willebrand Factor Fragment Acts As a Chaperone to Prolong the Half-Life of Recombinant Human FVIII (Simoctocog Alfa) in Hemophilia a Dogs and FVIII/VWF Double Knockout Mice

Barbara A Solecka-Witulska, PhD, David Lillicrap, MD FRCPC, Christine Hough, PhD, Christoph Kannicht, PhD

Blood (2017) 130 (Supplement 1): 178.

https://doi.org/10.1182/blood.V130.Suppl_1.178.178

Published: 2017

Journal Articles

Immune Tolerance Induction in Hemophilia A Patients Using Wilate® —a Canadian 10 Year Study (PREVAIL)

Paul Moorehead, MD, Mark J. Belletrutti, MD MSc, David Lillicrap, MD FRCPC, Robert J Klaassen, MD FRCPC, Manuel Carcao, MDMSc, Georges E. Rivard, MD FRCPC

Blood (2017) 130 (Supplement 1): 3679.

https://doi.org/10.1182/blood.V130.Suppl_1.3679.3679

Published: 2017

Journal Articles

Does Age Affect Desmopressin Responsiveness in Patients with Von Willebrand Disease?

Nicola Goldberg, MD, Rosane Nisenbaum, PhD, Hong Song, David Lillicrap, MD FRCPC, Jerome M. Teitel, MD FRCPC, Paula D. James, MD, Michelle Sholzberg, MDM, MSc, FRCPC

Blood (2017) 130 (Supplement 1): 3681.

https://doi.org/10.1182/blood.V130.Suppl_1.3681.3681

Published: 2017

Journal Articles

Exome Sequencing Studies Identify Mutations in STAB2 As a Genetic Risk for Venous Thromboembolic Disease

Karl Desch, MD, Ayse Bilge Ozel, PhD, Matthew Halvorsen, PhD, Alison L. Michels, Laura L Swystun, BSc, PhD, Lauren Mokry, PhD, Brent Richards, Marine Germain, David A. Tregouet, PhD, Pieter H. Reitsma, PhD, Clive Kearon, MB, Jun Z Li, PhD, David B. Goldstein, PhD, David Lillicrap, MD FRCPC, David Ginsburg, MD

Blood (2017) 130 (Supplement 1): 457.

https://doi.org/10.1182/blood.V130.Suppl_1.457.457

Published: 2017

Journal Articles

Biological considerations of plasma-derived and recombinant factor VIII immunogenicity

Jesse Lai, Christine Hough, Julie Tarrant, David Lillicrap

Blood (2017) 129 (24): 3147–3154.

https://doi.org/10.1182/blood-2016-11-750885

Published: 2017

NARROW

A Therapeutic siRNA Targeting Plasminogen Acts As a Long-Lasting Antifibrinolytic in Nonhuman Primates

Vector integration and fate in the hemophilia dog liver multiple years after AAV-FVIII gene transfer

Childhood Treatment with Adeno-Associated Viral Gene Therapy Results in Stable FVIII Expression and Improved Bleeding Phenotype in Adult Severe Hemophilia A Dogs

A Real-World Population Pharmacokinetic (PK) Study of Two Recombinant Factor VIII (rFVIII) Concentrates in Boys with Severe Hemophilia a without Inhibitors

Investigating the Role of Von Willebrand Factor (VWF) in Modulating In Vivo angiogenesis in VWF-Deficient Mice

Immune complications and their management in inherited and acquired bleeding disorders

Moderate-intensity aerobic exercise vs desmopressin in adolescent males with mild hemophilia A: a randomized trial

Low von Willebrand factor phenotype: the enigma continues

Assembly of alternative prothrombinase by extracellular histones initiates and disseminates intravascular coagulation

Genetic determinants of VWF clearance and FVIII binding modify FVIII pharmacokinetics in pediatric hemophilia A patients

A Practical, One Clinic Visit, Population Pharmacokinetic (PK) Protocol for Generation of PK Profiles in Subjects with Severe Hemophilia a

The Highly Prevalent Deletions in F8 Intron 13 Found in French Mild Haemophilia a Patients Result of Both Founder Effect and Recurrent De Novo Events

Tolerogenic properties of the Fc portion of IgG and its relevance to the treatment and management of hemophilia

Ancestral Sequence Reconstruction of Von Willebrand Factor Reveals Highly Conserved Structure/Function

A Factor VIII Fusion with an Inactivated FIX Generates a Biologically Active Molecule with Delayed Clearance in a FVIII/VWF Knockout Mouse Model

A Novel Von Willebrand Factor Fragment Acts As a Chaperone to Prolong the Half-Life of Recombinant Human FVIII (Simoctocog Alfa) in Hemophilia a Dogs and FVIII/VWF Double Knockout Mice

Immune Tolerance Induction in Hemophilia A Patients Using Wilate® —a Canadian 10 Year Study (PREVAIL)

Does Age Affect Desmopressin Responsiveness in Patients with Von Willebrand Disease?

Exome Sequencing Studies Identify Mutations in STAB2 As a Genetic Risk for Venous Thromboembolic Disease

Biological considerations of plasma-derived and recombinant factor VIII immunogenicity

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American Society of Hematology

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American Society of Hematology

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