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Journal Articles

Childhood Treatment with Adeno-Associated Viral Gene Therapy Results in Stable FVIII Expression and Improved Bleeding Phenotype in Adult Severe Hemophilia A Dogs

Paul Batty, Alex Menard, Aomei Mo, Christine Brown, Ashrafali M Ismail, Bridget Yates, Laura Swystun, Lori Harpell, Abbey Pender, Andrew Winterborn, Sylvia Fong, David Lillicrap

Blood (2023) 142 (Supplement 1): 2248.

https://doi.org/10.1182/blood-2023-174468

Published: 2023

Journal Articles

A Real-World Population Pharmacokinetic (PK) Study of Two Recombinant Factor VIII (rFVIII) Concentrates in Boys with Severe Hemophilia a without Inhibitors

Viviane Grassmann, Dagmar M Hajducek, Andrea N Edginton, Vanessa Bouskill, Christine Brown, Manuel Carcao, David Lillicrap, Roxy H O'Rourke, Roona Sinha, Jayson Stoffman, Cindy Wakefield, Margaret L. Rand, Victor Blanchette

Blood (2022) 140 (Supplement 1): 8453–8455.

https://doi.org/10.1182/blood-2022-160289

Published: 2022

Journal Articles

Genetic determinants of VWF clearance and FVIII binding modify FVIII pharmacokinetics in pediatric hemophilia A patients

Laura L. Swystun, Kenichi Ogiwara, Orla Rawley, Christine Brown, Ilinca Georgescu, Wilma Hopman, Veerle Labarque, Christoph Male, Katharina Thom, Victor S. Blanchette, Manuel D. Carcao, David Lillicrap

Blood (2019) 134 (11): 880–891.

https://doi.org/10.1182/blood.2019000190

Published: 2019

Includes: Supplemental data

Journal Articles

Adult Patients with ALL Treated with CD62L+ T Naïve/Memory-Enriched T Cells Expressing a CD19-CAR Mediate Potent Antitumor Activity with a Low Toxicity Profile

Samer K. Khaled, MD, Suzette Blanchard, PhD, Xiuli Wang, PhD, Jamie Wagner, BS, Araceli Naranjo, BS, Jennifer Simpson, Sandra Thomas, PhD, Julie Ostberg, PhD, Christine Brown, PhD, Stephen J Forman

Blood (2018) 132 (Supplement 1): 4016.

https://doi.org/10.1182/blood-2018-99-119883

Published: 2018

Journal Articles

CD19-CAR Therapy Using Naive/Memory or Central Memory T Cells Integrated into the Autologous Stem Cell Transplant Regimen for Patients with B-NHL

Leslie Popplewell, MD, Xiuli Wang, PhD, Suzette Blanchard, PhD, Jamie Wagner, BS, Araceli Naranjo, BS, Arencibia Adria, BS, Jinny Paul, PhD, Laura Lim, Wen-Chung Chang, PhD, Elizabeth E Budde, MD PhD, Sandra Thomas, PhD, Christine Brown, PhD, Stephen J Forman

Blood (2018) 132 (Supplement 1): 610.

https://doi.org/10.1182/blood-2018-99-119650

Published: 2018

Journal Articles

The Cerebroventricular Environment Reprograms Locally Infused CAR T Cells for Superior Activity Against Both CNS and Systemic B Cell Lymphoma

Xiuli Wang, PhD, Christian Huynh, Ryan Urak, Miriam Walter, Lihong Weng, MD, Laura Lim, Vibhuti Vyas, Brenda Aguilar, Alfonso Brito, Aniee Sarkissian, Achini Bandara, PhD, Elizabeth E Budde, MD PhD, Leslie Popplewell, MD, Tanya Siddiqi, MD, Christine Brown, PhD, Stephen J Forman

Blood (2018) 132 (Supplement 1): 965.

https://doi.org/10.1182/blood-2018-99-119335

Published: 2018

Journal Articles

Ancestral Sequence Reconstruction of Von Willebrand Factor Reveals Highly Conserved Structure/Function

Philip M Zakas, PhD, Caelan Radford, Christine Brown, Courtney Dwyer, RLAT, Christopher B Doering, PhD, Eric A Gaucher, PhD, David Lillicrap, MD FRCPC

Blood (2017) 130 (Supplement 1): 240.

https://doi.org/10.1182/blood.V130.Suppl_1.240.240

Published: 2017

Journal Articles

New Therapeutic Approach for Central Nervous System Lymphoma By Intracerebroventricular Delivery of CD19CAR T Cells

Xiuli Wang, MD PhD, Ryan Urak, MS, Walter Miriam, MS, Laura Lim, BS, Brenda Aguilar, BS, Alfonso Brito, BS, Aniee Sarkissian, BS, Christine Brown, PhD, Sandra H. Thomas, PhD, Leslie Popplewell, MD, Lihua E. Budde, MD PhD, Stephen J. Forman, MD

Blood (2016) 128 (22): 2161.

https://doi.org/10.1182/blood.V128.22.2161.2161

Published: 2016

Journal Articles

Phase I Studies of Cellular Immunotherapy Using Central Memory Derived-CD19-Specific T Cells Following Autologous Stem Cell Transplantation for Patients with High-Risk Intermediate Grade B-Lineage Non-Hodgkin Lymphoma

Leslie Popplewell, MD, Xiuli Wang, PhD, Araceli Naranjo, BS, Suzette Blanchard, PhD, Jamie Wagner, BS, ChingLam Wong, BS, Ryan Urak, MS, Wen-Chung Chang, MS, Samer K Khaled, MD, Tanya Siddiqi, MD, Elizabeth E. Budde, MD PhD, Jingying Xu, PhD, Brenda Chang, BS, Sandra H. Thomas, PhD, Stanley R. Riddell, MD, Christine Brown, PhD, Michael C Jensen, MD, Stephen J. Forman, MD

Blood (2015) 126 (23): 930.

https://doi.org/10.1182/blood.V126.23.930.930

Published: 2015

Journal Articles

Ex Vivo AKT Inhibition Promotes the Generation of Potent CD19CAR T Cells for Adoptive Immunotherapy

Ryan Urak, MS, ChingLam Wong, BS, Wen-Chung Chang, MS, Elizabeth E. Budde, MD PhD, Christine Brown, PhD, Sandra H. Thomas, PhD, Stephen J. Forman, MD, Xiuli Wang, PhD

Blood (2015) 126 (23): 3086.

https://doi.org/10.1182/blood.V126.23.3086.3086

Published: 2015

Journal Articles

Characterization of Type 2N Von Willebrand Disease Mutations Using Ιn Vitro and Ιn Vivo Mouse Models

Laura L Swystun, PhD, Ilinca Georgescu, Meghan Deforest, Mia Golder, PhD, Kate Sponagle, Christine Brown, Colleen Notley, David Lillicrap, MD

Blood (2014) 124 (21): 471.

https://doi.org/10.1182/blood.V124.21.471.471

Published: 2014

Journal Articles

Clearance and Genetic Variability of Von Willebrand Factor Are Major Determinants of the Pharmacokinetic Behavior of Factor VIII Concentrates in the Treatment of Pediatric Hemophilia A

Kenichi Ogiwara, MD PhD, Laura L Swystun, PhD, Ilinca Georgescu, Christine Brown, Angie Tuttle, Shawn Tinlin, Jayne Leggo, Silvia Albánez, MSc, Manuel Carcao, MD MSc, Victor S. Blanchette, MD FRCPC, Christoph Male, MD MSC, Katharina Thom, David Lillicrap, MD

Blood (2014) 124 (21): 473.

https://doi.org/10.1182/blood.V124.21.473.473

Published: 2014

Journal Articles

CS-1 Re-Directed Central Memory T Cell Therapy for Multiple Myeloma

Xiuli Wang, PhD, ChingLam W Wong, BS, Ryan Urak, MS, Wen-Chung Chang, MS, Elizabeth E. Budde, MD PhD, Christine Brown, PhD, Stephen J. Forman, MD

Blood (2014) 124 (21): 1114.

https://doi.org/10.1182/blood.V124.21.1114.1114

Published: 2014

Journal Articles

Analysis of the role of von Willebrand factor, platelet glycoprotein VI-, and α2β1-mediated collagen binding in thrombus formation

Yasuaki Shida, Natalia Rydz, David Stegner, Christine Brown, Jeffrey Mewburn, Kate Sponagle, Ozge Danisment, Bredon Crawford, Barbara Vidal, Carol A. Hegadorn, Cynthia M. Pruss, Bernhard Nieswandt, David Lillicrap

Blood (2014) 124 (11): 1799–1807.

https://doi.org/10.1182/blood-2013-09-521484

Published: 2014

Journal Articles

Omental implantation of BOECs in hemophilia dogs results in circulating FVIII antigen and a complex immune response

Margareth C. Ozelo, Barbara Vidal, Christine Brown, Colleen Notley, Carol Hegadorn, Sandra Webster, Lori Harpell, James Ahlin, Andrew Winterborn, Janine Handforth, Valder R. Arruda, Christine Hough, David Lillicrap

Blood (2014) 123 (26): 4045–4053.

https://doi.org/10.1182/blood-2013-12-545780

Published: 2014

Includes: Supplemental data

Journal Articles

Targeting Of Leukemia Stem Cells By Interfering With Niches Using CD44 Variant 6 Chimeric Antigen Receptor Redirected Central Memory T Cells

Xiuli Wang, PhD, ChingLam W Wong, BS, Ryan Urak, MS, Armen Mardiros, MS, Wen-Chung Chang, MS, Ellie Taus, BS, Lihua E Budde, MD, PhD, Julie R Ostberg, Ph.D, Christine Brown, PhD, Stephen J. Forman, MD

Blood (2013) 122 (21): 4497.

https://doi.org/10.1182/blood.V122.21.4497.4497

Published: 2013

Journal Articles

Truncated Cell-Surface CD19 As a Conditional Suicide Switch For Adoptive T Cell Immunotherapy

Lihua Elizabeth Budde, MD, PhD, Armen Mardiros, MS, Wen-Chung Chang, MS, Xiuli Wang, MD, PhD, Carolina Berger, MD, Christine Brown, PhD, Stanley R Riddell, MD, Oliver W. Press, MD, PhD, Stephen J. Forman, MD

Blood (2013) 122 (21): 1660.

https://doi.org/10.1182/blood.V122.21.1660.1660

Published: 2013

Journal Articles

Platelet-Mediated Mechanical Tensile Force Influences ADAMTS13 Localization and Regulation Of Thrombus Development At The Site Of Platelet Accumulation

Yasuaki Shida, MD, PhD, Laura L. Swystun, PhD, Christine Brown, Jeff Mewburn, Kate Sponagle, Ozge Danisment, Jacob Riches, Christine Hough, PhD, David Lillicrap

Blood (2013) 122 (21): 454.

https://doi.org/10.1182/blood.V122.21.454.454

Published: 2013

Journal Articles

Enhanced Antitumor Efficacy of Adoptively Transferred CD19-Redirected CMV Specific Central Memory T Cells by CMV Vaccine.

Xiuli Wang, MD, PhD, Winnie Wong, B.S, Wen-Chung Chang, MS, Don Diamond, PhD, Michael C. Jensen, MD, Christine Brown, PhD, John Zaia, MD, Stephen J. Forman, MD

Blood (2012) 120 (21): 3014.

https://doi.org/10.1182/blood.V120.21.3014.3014

Published: 2012

Journal Articles

Functional Characterization of the Type 1 VWD Candidate VWF Gene Variants: P.M771I, p.L881R, p.P1413L, and p.Q1475X

Ergul Berber, PhD, Christine Brown, Kutluhan Incekara, Zafer Baslar, Hande Caglayan, David Lillicrap, MD

Blood (2012) 120 (21): 97.

https://doi.org/10.1182/blood.V120.21.97.97

Published: 2012

NARROW

Childhood Treatment with Adeno-Associated Viral Gene Therapy Results in Stable FVIII Expression and Improved Bleeding Phenotype in Adult Severe Hemophilia A Dogs

A Real-World Population Pharmacokinetic (PK) Study of Two Recombinant Factor VIII (rFVIII) Concentrates in Boys with Severe Hemophilia a without Inhibitors

Genetic determinants of VWF clearance and FVIII binding modify FVIII pharmacokinetics in pediatric hemophilia A patients

Adult Patients with ALL Treated with CD62L+ T Naïve/Memory-Enriched T Cells Expressing a CD19-CAR Mediate Potent Antitumor Activity with a Low Toxicity Profile

CD19-CAR Therapy Using Naive/Memory or Central Memory T Cells Integrated into the Autologous Stem Cell Transplant Regimen for Patients with B-NHL

The Cerebroventricular Environment Reprograms Locally Infused CAR T Cells for Superior Activity Against Both CNS and Systemic B Cell Lymphoma

Ancestral Sequence Reconstruction of Von Willebrand Factor Reveals Highly Conserved Structure/Function

New Therapeutic Approach for Central Nervous System Lymphoma By Intracerebroventricular Delivery of CD19CAR T Cells

Phase I Studies of Cellular Immunotherapy Using Central Memory Derived-CD19-Specific T Cells Following Autologous Stem Cell Transplantation for Patients with High-Risk Intermediate Grade B-Lineage Non-Hodgkin Lymphoma

Ex Vivo AKT Inhibition Promotes the Generation of Potent CD19CAR T Cells for Adoptive Immunotherapy

Characterization of Type 2N Von Willebrand Disease Mutations Using Ιn Vitro and Ιn Vivo Mouse Models

Clearance and Genetic Variability of Von Willebrand Factor Are Major Determinants of the Pharmacokinetic Behavior of Factor VIII Concentrates in the Treatment of Pediatric Hemophilia A

CS-1 Re-Directed Central Memory T Cell Therapy for Multiple Myeloma

Analysis of the role of von Willebrand factor, platelet glycoprotein VI-, and α2β1-mediated collagen binding in thrombus formation

Omental implantation of BOECs in hemophilia dogs results in circulating FVIII antigen and a complex immune response

Targeting Of Leukemia Stem Cells By Interfering With Niches Using CD44 Variant 6 Chimeric Antigen Receptor Redirected Central Memory T Cells

Truncated Cell-Surface CD19 As a Conditional Suicide Switch For Adoptive T Cell Immunotherapy

Platelet-Mediated Mechanical Tensile Force Influences ADAMTS13 Localization and Regulation Of Thrombus Development At The Site Of Platelet Accumulation

Enhanced Antitumor Efficacy of Adoptively Transferred CD19-Redirected CMV Specific Central Memory T Cells by CMV Vaccine.

Functional Characterization of the Type 1 VWD Candidate VWF Gene Variants: P.M771I, p.L881R, p.P1413L, and p.Q1475X

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American Society of Hematology

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ASH Publications

American Society of Hematology

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