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Journal Articles

Blasts Monocytic Myeloid-Derived Suppressor Cell Skewing Is a Potential Mechanism of AML Immune-Escape

Lauren E Martin, Francesco Mazziotta, Daniel Eagan, Miranda Lahman, Valentin Voillet, Filippo Milano, Sinéad Kinsella, Kelly Paulson, Philip D Greenberg, Aude G Chapuis

Blood (2024) 144 (Supplement 1): 5797.

https://doi.org/10.1182/blood-2024-208527

Published: 2024

Journal Articles

NK-like Skewing As the Key Driver of T Cell Dysfunction in AML: Implications for Enhancing TCR-T Cell Therapy Efficacy

Francesco Mazziotta, Lauren E Martin, Daniel Eagan, Filippo Milano, Valentin Voillet, Tzu-Hao Tang, Miranda Lahman, Sinéad Kinsella, Kelly Paulson, Philip D Greenberg, Aude G Chapuis

Blood (2024) 144 (Supplement 1): 3438.

https://doi.org/10.1182/blood-2024-208138

Published: 2024

Journal Articles

HA-1–targeted T-cell receptor T-cell therapy for recurrent leukemia after hematopoietic stem cell transplantation

Blood (2024) 144 (10): 1069–1082.

https://doi.org/10.1182/blood.2024024105

Published: 2024

Includes: Supplemental data

Journal Articles

A CD200R-CD28 fusion protein appropriates an inhibitory signal to enhance T-cell function and therapy of murine leukemia

Shannon K. Oda, Andrew W. Daman, Nicolas M. Garcia, Felecia Wagener, Thomas M. Schmitt, Xiaoxia Tan, Aude G. Chapuis, Philip D. Greenberg

Blood (2017) 130 (22): 2410–2419.

https://doi.org/10.1182/blood-2017-04-777052

Published: 2017

Includes: Supplemental data

Journal Articles

EBV-Specific Donor Cells Transduced to Express a High-Affinity WT1 TCR Can Prevent Recurrence in Post-HCT Patients with High-Risk AML

Blood (2016) 128 (22): 1001.

https://doi.org/10.1182/blood.V128.22.1001.1001

Published: 2016

Journal Articles

Transferred Donor-Derived Virus Specific CD8+ T Cells That Have Been Transduced to Express a WT1-Specific T Cell Receptor Can Persist and Provide Anti-Leukemic Activity in AML Patients Post-Transplant

Merav Bar, MD, Aude G. Chapuis, MD, Thomas M Schmitt, PhD, Hieu Nguyen, Natalie A Duerkopp, Mark F Tom, Felecia D Wagener, Colette N Chaney, RN, Kieu-Thu Bui, RN, Shelly Heimfeld, PhD, Philip D. Greenberg, MD

Blood (2014) 124 (21): 3939.

https://doi.org/10.1182/blood.V124.21.3939.3939

Published: 2014

Journal Articles

Enhanced-affinity murine T-cell receptors for tumor/self-antigens can be safe in gene therapy despite surpassing the threshold for thymic selection

Thomas M. Schmitt, David H. Aggen, Ingunn M. Stromnes, Michelle L. Dossett, Sarah A. Richman, David M. Kranz, Philip D. Greenberg

Blood (2013) 122 (3): 348–356.

https://doi.org/10.1182/blood-2013-01-478164

Published: 2013

Includes: Supplemental data

Journal Articles

Cyclin-A1 represents a new immunogenic targetable antigen expressed in acute myeloid leukemia stem cells with characteristics of a cancer-testis antigen

Sebastian Ochsenreither, Ravindra Majeti, Thomas Schmitt, Derek Stirewalt, Ulrich Keilholz, Keith R. Loeb, Brent Wood, Yongiae E. Choi, Marie Bleakley, Edus H. Warren, Michael Hudecek, Yoshiki Akatsuka, Irving L. Weissman, Philip D. Greenberg

Blood (2012) 119 (23): 5492–5501.

https://doi.org/10.1182/blood-2011-07-365890

Published: 2012

Includes: Supplemental data

Journal Articles

CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and 4-1BB domains: pilot clinical trial results

Brian G. Till, Michael C. Jensen, Jinjuan Wang, Xiaojun Qian, Ajay K. Gopal, David G. Maloney, Catherine G. Lindgren, Yukang Lin, John M. Pagel, Lihua E. Budde, Andrew Raubitschek, Stephen J. Forman, Philip D. Greenberg, Stanley R. Riddell, Oliver W. Press

Blood (2012) 119 (17): 3940–3950.

https://doi.org/10.1182/blood-2011-10-387969

Published: 2012

Includes: Supplemental data

Journal Articles

TCR Gene Editing Results in Effective Immunotherapy of Leukemia without the Development of GvHD

Blood (2011) 118 (21): 667.

https://doi.org/10.1182/blood.V118.21.667.667

Published: 2011

Journal Articles

Human microRNA-27a* targets Prf1 and GzmB expression to regulate NK-cell cytotoxicity

Tae-Don Kim, Su Ui Lee, Sohyun Yun, Hu-Nan Sun, Suk Hyung Lee, Jae Wha Kim, Hwan Mook Kim, Song-Kyu Park, Chang Woo Lee, Suk Ran Yoon, Philip D. Greenberg, Inpyo Choi

Blood (2011) 118 (20): 5476–5486.

https://doi.org/10.1182/blood-2011-04-347526

Published: 2011

Includes: Supplemental data

Journal Articles

Priming CD8 + T cells with dendritic cells matured using TLR4 and TLR7/8 ligands together enhances generation of CD8 + T cells retaining CD28

Jeffrey S. Pufnock, Melinda Cigal, Lisa S. Rolczynski, Erica Andersen-Nissen, Mathias Wolfl, M. Juliana McElrath, Philip D. Greenberg

Blood (2011) 117 (24): 6542–6551.

https://doi.org/10.1182/blood-2010-11-317966

Published: 2011

Journal Articles

HIV-specific CD8 + T cells from HIV + individuals receiving HAART can be expanded ex vivo to augment systemic and mucosal immunity in vivo

Aude G. Chapuis, Corey Casper, Steve Kuntz, Jia Zhu, Annelie Tjernlund, Kurt Diem, Cameron J. Turtle, Melinda L. Cigal, Roxanne Velez, Stanley Riddell, Lawrence Corey, Philip D. Greenberg

Blood (2011) 117 (20): 5391–5402.

https://doi.org/10.1182/blood-2010-11-320226

Published: 2011

Includes: Supplemental data

Journal Articles

Editing Human Lymphocyte Specificity for Safe and Effective Adoptive Immunotherapy of Leukemia.

Elena Provasi, PhD, Pietro Genovese, Angelo Lombardo, Zulma Magnani, Andreas Reik, Pei-Qi Liu, Victoria Chu, Jurgen Kuball, Attilio Bondanza, Giulia Casorati, Fabio Ciceri, Claudio Bordignon, MD, Philip D. Greenberg, Michael C. Holmes, Philip D. Gregory, Luigi Naldini, Chiara Bonini

Blood (2010) 116 (21): 3764.

https://doi.org/10.1182/blood.V116.21.3764.3764

Published: 2010

Journal Articles

Antibody-mediated B-cell depletion before adoptive immunotherapy with T cells expressing CD20-specific chimeric T-cell receptors facilitates eradication of leukemia in immunocompetent mice

Scott E. James, Nural N. Orgun, Thomas F. Tedder, Mark J. Shlomchik, Michael C. Jensen, Yukang Lin, Philip D. Greenberg, Oliver W. Press

Blood (2009) 114 (27): 5454–5463.

https://doi.org/10.1182/blood-2009-08-232967

Published: 2009

Includes: Supplemental data

Journal Articles

From TCR Gene Transfer to TCR Gene Editing of Central Memory T Lymphocytes for Immunotherapy of Leukemia.

Elena Provasi, Pietro Genovese, Zulma Magnani, Oscar Muniz Pello, Jurgen Kuball, Angelo Lombardo, Attilio Bondanza, Philip D. Gregory, Claudio Bordignon, Michael C. Holmes, Philip D. Greenberg, Luigi Naldini, Chiara Bonini

Blood (2009) 114 (22): 374.

https://doi.org/10.1182/blood.V114.22.374.374

Published: 2009

Journal Articles

Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells

Brian G. Till, Michael C. Jensen, Jinjuan Wang, Eric Y. Chen, Brent L. Wood, Harvey A. Greisman, Xiaojun Qian, Scott E. James, Andrew Raubitschek, Stephen J. Forman, Ajay K. Gopal, John M. Pagel, Catherine G. Lindgren, Philip D. Greenberg, Stanley R. Riddell, Oliver W. Press

Blood (2008) 112 (6): 2261–2271.

https://doi.org/10.1182/blood-2007-12-128843

Published: 2008

Includes: Supplemental data

Journal Articles

Adoptive Cellular Therapy for Follicular Lymphoma Using Genetically-Modified Autologous CD20-Specific T Cells.

Brian G. Till, MD, Michael C. Jensen, MD, Jinjuan Wang, MD, Eric Y. Chen, MD, PhD, Scott James, PhD, Andrew Raubitschek, MD, Stephen J. Forman, MD, Ajay K. Gopal, MD, John M. Pagel, MD, PhD, Catherine G. Lindgren, Philip D. Greenberg, MD, Stanley R. Riddell, MD, Oliver W. Press, MD, PhD

Blood (2007) 110 (11): 499.

https://doi.org/10.1182/blood.V110.11.499.499

Published: 2007

Journal Articles

Activation-induced expression of CD137 permits detection, isolation, and expansion of the full repertoire of CD8 + T cells responding to antigen without requiring knowledge of epitope specificities

Matthias Wolfl, Jürgen Kuball, William Y. Ho, Hieu Nguyen, Thomas J. Manley, Marie Bleakley, Philip D. Greenberg

Blood (2007) 110 (1): 201–210.

https://doi.org/10.1182/blood-2006-11-056168

Published: 2007

Journal Articles

CpG oligodeoxynucleotides allow for effective adoptive T-cell therapy in chronic retroviral infection

Anke R. M. Kraft, Frank Krux, Simone Schimmer, Claes Ohlen, Philip D. Greenberg, Ulf Dittmer

Blood (2006) 109 (7): 2982–2984.

https://doi.org/10.1182/blood-2006-06-022178

Published: 2006

Includes: Supplemental data

NARROW

Blasts Monocytic Myeloid-Derived Suppressor Cell Skewing Is a Potential Mechanism of AML Immune-Escape

NK-like Skewing As the Key Driver of T Cell Dysfunction in AML: Implications for Enhancing TCR-T Cell Therapy Efficacy

HA-1–targeted T-cell receptor T-cell therapy for recurrent leukemia after hematopoietic stem cell transplantation

A CD200R-CD28 fusion protein appropriates an inhibitory signal to enhance T-cell function and therapy of murine leukemia

EBV-Specific Donor Cells Transduced to Express a High-Affinity WT1 TCR Can Prevent Recurrence in Post-HCT Patients with High-Risk AML

Transferred Donor-Derived Virus Specific CD8+ T Cells That Have Been Transduced to Express a WT1-Specific T Cell Receptor Can Persist and Provide Anti-Leukemic Activity in AML Patients Post-Transplant

Enhanced-affinity murine T-cell receptors for tumor/self-antigens can be safe in gene therapy despite surpassing the threshold for thymic selection

Cyclin-A1 represents a new immunogenic targetable antigen expressed in acute myeloid leukemia stem cells with characteristics of a cancer-testis antigen

CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and 4-1BB domains: pilot clinical trial results

TCR Gene Editing Results in Effective Immunotherapy of Leukemia without the Development of GvHD

Human microRNA-27a* targets Prf1 and GzmB expression to regulate NK-cell cytotoxicity

Priming CD8 + T cells with dendritic cells matured using TLR4 and TLR7/8 ligands together enhances generation of CD8 + T cells retaining CD28

HIV-specific CD8 + T cells from HIV + individuals receiving HAART can be expanded ex vivo to augment systemic and mucosal immunity in vivo

Editing Human Lymphocyte Specificity for Safe and Effective Adoptive Immunotherapy of Leukemia.

Antibody-mediated B-cell depletion before adoptive immunotherapy with T cells expressing CD20-specific chimeric T-cell receptors facilitates eradication of leukemia in immunocompetent mice

From TCR Gene Transfer to TCR Gene Editing of Central Memory T Lymphocytes for Immunotherapy of Leukemia.

Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells

Adoptive Cellular Therapy for Follicular Lymphoma Using Genetically-Modified Autologous CD20-Specific T Cells.

Activation-induced expression of CD137 permits detection, isolation, and expansion of the full repertoire of CD8 + T cells responding to antigen without requiring knowledge of epitope specificities

CpG oligodeoxynucleotides allow for effective adoptive T-cell therapy in chronic retroviral infection

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American Society of Hematology

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ASH Publications

American Society of Hematology

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