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INSIDE BLOOD

HEMOSTASIS

Full clot retraction: running on mTOR

Michael C. Berndt,Robert K. Andrews

View Articletitled, Full clot retraction: running on mTOR

CHEMOKINES

HTLV-IIb reduces HIV infection

Davide Zella

View Articletitled, HTLV-IIb reduces HIV infection

HEMOSTASIS

Thrombospondin says no to NO

Themis R. Kyriakides

View Articletitled, Thrombospondin says no to NO

CLINICAL TRIALS AND OBSERVATIONS

Acquired hemophilia A: is more better?
Clinical Trials & Observations

Joan Cox Gill

View Articletitled, Acquired hemophilia A: is more better?

HEMOSTASIS

Bone morphogenetic proteins go endothelial

Danny Huylebroeck

View Articletitled, Bone morphogenetic proteins go endothelial

HEMOSTASIS

Will the real EPC please stand up?

Aernout Luttun,Catherine M. Verfaillie

View Articletitled, Will the real EPC please stand up?

IMMUNOBIOLOGY

Fast track to becoming a regulatory T cell: “trogocytosis” of immune-tolerogenic HLA-G

Heinz Wiendl

View Articletitled, Fast track to becoming a regulatory T cell: “trogocytosis” of immune-tolerogenic HLA-G

NEOPLASIA

Advances in myeloma therapy: breaking the cycle

Carl Gregory

View Articletitled, Advances in myeloma therapy: breaking the cycle

BLOOD WORK

Beyond the wide blue sea

View Articletitled, Beyond the wide blue sea

PLENARY PAPERS

Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals

Mervin C. Yoder,Laura E. Mead,Daniel Prater,Theresa R. Krier,Karim N. Mroueh,Fang Li,Rachel Krasich,Constance J. Temm,Josef T. Prchal,David A. Ingram

View Articletitled, Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals

PERSPECTIVE

End points to establish the efficacy of new agents in the treatment of acute leukemia
Clinical Trials & Observations

Frederick R. Appelbaum,Daniel Rosenblum,Robert J. Arceci,William L. Carroll,Philip P. Breitfeld,Stephen J. Forman,Richard A. Larson,Stephanie J. Lee,Sharon B. Murphy,Susan O'Brien,Jerald Radich,Nancy S. Scher,Franklin O. Smith,Richard M. Stone,Martin S. Tallman

View Articletitled, End points to establish the efficacy of new agents in the treatment of acute leukemia

ERRATUM

Correction for Dou et al., Development of a macrophage-based nanoparticle platform for antiretroviral drug delivery

View Articletitled, Correction for Dou et al., Development of a macrophage-based nanoparticle platform for antiretroviral drug delivery

Correction for Kelly et al., CRM197-conjugated serogroup C meningococcal capsular polysaccharide, but not the native polysaccharide, induces persistent antigen-specific memory B cells

View Articletitled, Correction for Kelly et al., CRM197-conjugated serogroup C meningococcal capsular polysaccharide, but not the native polysaccharide, induces persistent antigen-specific memory B cells

REVIEW ARTICLES

Neutrophil elastase in cyclic and severe congenital neutropenia
Clinical Trials & Observations

Marshall S. Horwitz,Zhijun Duan,Brice Korkmaz,Hu-Hui Lee,Matthew E. Mealiffe,Stephen J. Salipante

View Articletitled, Neutrophil elastase in cyclic and severe congenital neutropenia

CHEMOKINES, CYTOKINES, AND INTERLEUKINS

Endolyn (CD164) modulates the CXCL12-mediated migration of umbilical cord blood CD133⁺ cells

Sinead Forde,Britt Jorgensen Tye,Sarah E. Newey,Maria Roubelakis,Jon Smythe,Colin P. McGuckin,Ruth Pettengell,Suzanne M. Watt

View Articletitled, Endolyn (CD164) modulates the CXCL12-mediated migration of umbilical cord blood CD133+ cells

Supplemental data

Bone morphogenic protein antagonist Drm/gremlin is a novel proangiogenic factor

Helena Stabile,Stefania Mitola,Emanuela Moroni,Mirella Belleri,Stefania Nicoli,Daniela Coltrini,Francesco Peri,Antonello Pessi,Laura Orsatti,Fabio Talamo,Vincent Castronovo,David Waltregny,Franco Cotelli,Domenico Ribatti,Marco Presta

View Articletitled, Bone morphogenic protein antagonist Drm/gremlin is a novel proangiogenic factor

Supplemental data

Noninfectious papilloma virus–like particles inhibit HIV-1 replication: implications for immune control of HIV-1 infection by IL-27

J. Mohamad Fakruddin,Richard A. Lempicki,Robert J. Gorelick,Jun Yang,Joseph W. Adelsberger,Alfonso J. Garcia-Pineres,Ligia A. Pinto,H. Clifford Lane,Tomozumi Imamichi

View Articletitled, Noninfectious papilloma virus–like particles inhibit HIV-1 replication: implications for immune control of HIV-1 infection by IL-27

Postgenomic up-regulation of CCL3L1 expression in HTLV-2–infected persons curtails HIV-1 replication
Clinical Trials & Observations

Elisabetta Pilotti,Lisa Elviri,Elisa Vicenzi,Umberto Bertazzoni,Maria Carla Re,Sonia Allibardi,Guido Poli,Claudio Casoli

View Articletitled, Postgenomic up-regulation of CCL3L1 expression in HTLV-2–infected persons curtails HIV-1 replication

Supplemental data

CLINICAL TRIALS AND OBSERVATIONS

The revised International Prognostic Index (R-IPI) is a better predictor of outcome than the standard IPI for patients with diffuse large B-cell lymphoma treated with R-CHOP
Clinical Trials & Observations

Laurie H. Sehn,Brian Berry,Mukesh Chhanabhai,Catherine Fitzgerald,Karamjit Gill,Paul Hoskins,Richard Klasa,Kerry J. Savage,Tamara Shenkier,Judy Sutherland,Randy D. Gascoyne,Joseph M. Connors

View Articletitled, The revised International Prognostic Index (R-IPI) is a better predictor of outcome than the standard IPI for patients with diffuse large B-cell lymphoma treated with R-CHOP

Effect of genetic variations in platelet glycoproteins Ibα and VI on the risk for coronary heart disease events in postmenopausal women taking hormone therapy
Clinical Trials & Observations

Paul F. Bray,Timothy D. Howard,Eric Vittinghoff,David C. Sane,David M. Herrington

View Articletitled, Effect of genetic variations in platelet glycoproteins Ibα and VI on the risk for coronary heart disease events in postmenopausal women taking hormone therapy

Supplemental data

Acquired hemophilia A in the United Kingdom: a 2-year national surveillance study by the United Kingdom Haemophilia Centre Doctors' Organisation
Clinical Trials & Observations

Peter W. Collins,Sybil Hirsch,Trevor P. Baglin,Gerard Dolan,John Hanley,Michael Makris,David M. Keeling,Ri Liesner,Simon A. Brown,Charles R. M. Hay,UK Haemophilia Centre Doctors' Organisation

View Articletitled, Acquired hemophilia A in the United Kingdom: a 2-year national surveillance study by the United Kingdom Haemophilia Centre Doctors' Organisation

Late cardiotoxicity after treatment for Hodgkin lymphoma
Clinical Trials & Observations

Berthe M. P. Aleman,Alexandra W. van den Belt-Dusebout,Marie L. De Bruin,Mars B. van 't Veer,Margreet H. A. Baaijens,Jan Paul de Boer,Augustinus A. M. Hart,Willem J. Klokman,Marianne A. Kuenen,Gabey M. Ouwens,Harry Bartelink,Flora E. van Leeuwen

View Articletitled, Late cardiotoxicity after treatment for Hodgkin lymphoma

HEMATOPOIESIS

ATM deficiency disrupts Tcra locus integrity and the maturation of CD4⁺CD8⁺ thymocytes

Irina R. Matei,Rebecca A. Gladdy,Lauryl M. J. Nutter,Angelo Canty,Cynthia J. Guidos,Jayne S. Danska

View Articletitled, ATM deficiency disrupts Tcra locus integrity and the maturation of CD4+CD8+ thymocytes

Supplemental data

Retroviral vector insertion sites associated with dominant hematopoietic clones mark “stemness” pathways

Olga S. Kustikova,Hartmut Geiger,Zhixiong Li,Martijn H. Brugman,Stuart M. Chambers,Chad A. Shaw,Karin Pike-Overzet,Dick de Ridder,Frank J. T. Staal,Gottfried von Keudell,Kerstin Cornils,Kalpana Jekumar Nattamai,Ute Modlich,Gerard Wagemaker,Margaret A. Goodell,Boris Fehse,Christopher Baum

View Articletitled, Retroviral vector insertion sites associated with dominant hematopoietic clones mark “stemness” pathways

Supplemental data

The paralogous hematopoietic regulators Lyl1 and Scl are coregulated by Ets and GATA factors, but Lyl1 cannot rescue the early Scl^–/– phenotype

Wan Y. I. Chan,George A. Follows,Georges Lacaud,John E. Pimanda,Josette-Renee Landry,Sarah Kinston,Kathy Knezevic,Sandie Piltz,Ian J. Donaldson,Laure Gambardella,Fred Sablitzky,Anthony R. Green,Valerie Kouskoff,Berthold Göttgens

View Articletitled, The paralogous hematopoietic regulators Lyl1 and Scl are coregulated by Ets and GATA factors, but Lyl1 cannot rescue the early Scl–/– phenotype

Supplemental data

Ape1 regulates hematopoietic differentiation of embryonic stem cells through its redox functional domain

Gang-Ming Zou,Mei-Hua Luo,April Reed,Mark R. Kelley,Mervin C. Yoder

View Articletitled, Ape1 regulates hematopoietic differentiation of embryonic stem cells through its redox functional domain

Mad2 is required for optimal hematopoiesis: Mad2 associates with c-Kit in MO7e cells

Shigeki Ito,Charlie R. Mantel,Myung-Kwan Han,Sunanda Basu,Seiji Fukuda,Scott Cooper,Hal E. Broxmeyer

View Articletitled, Mad2 is required for optimal hematopoiesis: Mad2 associates with c-Kit in MO7e cells

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Active tissue factor pathway inhibitor is expressed on the surface of coated platelets

Susan A. Maroney,Sandra L. Haberichter,Paul Friese,Maureen L. Collins,Josephine P. Ferrel,George L. Dale,Alan E. Mast

View Articletitled, Active tissue factor pathway inhibitor is expressed on the surface of coated platelets

Tumor necrosis factor α (TNF-α) receptor-II is required for TNF-α–induced leukocyte-endothelial interaction in vivo

Unni M. Chandrasekharan,Maria Siemionow,Murat Unsal,Lin Yang,Earl Poptic,Justin Bohn,Kagan Ozer,Zhongmin Zhou,Philip H. Howe,Marc Penn,Paul E. DiCorleto

View Articletitled, Tumor necrosis factor α (TNF-α) receptor-II is required for TNF-α–induced leukocyte-endothelial interaction in vivo

Thrombospondin-1 limits ischemic tissue survival by inhibiting nitric oxide–mediated vascular smooth muscle relaxation

Jeff S. Isenberg,Fuminori Hyodo,Ken-Ichiro Matsumoto,Martin J. Romeo,Mones Abu-Asab,Maria Tsokos,Periannan Kuppusamy,David A. Wink,Murali C. Krishna,David D. Roberts

View Articletitled, Thrombospondin-1 limits ischemic tissue survival by inhibiting nitric oxide–mediated vascular smooth muscle relaxation

Supplemental data

Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells

Laurent David,Christine Mallet,Sabine Mazerbourg,Jean-Jacques Feige,Sabine Bailly

View Articletitled, Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells

Cooperation between VEGF and β3 integrin during cardiac vascular development

Sara M. Weis,Jeffrey N. Lindquist,Leo A. Barnes,Kimberly M. Lutu-Fuga,Jianhua Cui,Malcolm R. Wood,David A. Cheresh

View Articletitled, Cooperation between VEGF and β3 integrin during cardiac vascular development

Human plasma fibrinogen is synthesized in the liver

Glenys A. Tennent,Stephen O. Brennan,Arie J. Stangou,John O'Grady,Philip N. Hawkins,Mark B. Pepys

View Articletitled, Human plasma fibrinogen is synthesized in the liver

mTOR-dependent synthesis of Bcl-3 controls the retraction of fibrin clots by activated human platelets

Andrew S. Weyrich,Melvin M. Denis,Hansjorg Schwertz,Neal D. Tolley,Jason Foulks,Eliott Spencer,Larry W. Kraiss,Kurt H. Albertine,Thomas M. McIntyre,Guy A. Zimmerman

View Articletitled, mTOR-dependent synthesis of Bcl-3 controls the retraction of fibrin clots by activated human platelets

Supplemental data

Acute inflammation is exacerbated in mice genetically predisposed to a severe protein C deficiency

Angelina J. Lay,Deborah Donahue,Meng-Ju Tsai,Francis J. Castellino

View Articletitled, Acute inflammation is exacerbated in mice genetically predisposed to a severe protein C deficiency

Thrombin-activatable procarboxypeptidase B regulates activated complement C5a in vivo

Toshihiko Nishimura,Timothy Myles,Adrian M. Piliposky,Peter N. Kao,Gerald J. Berry,Lawrence L. K. Leung

View Articletitled, Thrombin-activatable procarboxypeptidase B regulates activated complement C5a in vivo

ADAMTS13 and von Willebrand factor and the risk of myocardial infarction in men
Clinical Trials & Observations Brief Report

Chan K. N. K. Chion,Carine J. M. Doggen,James T. B. Crawley,David A. Lane,Frits R. Rosendaal

View Articletitled, ADAMTS13 and von Willebrand factor and the risk of myocardial infarction in men

IMMUNOBIOLOGY

Differential epitope mapping of antibodies to PDC-E2 in patients with hematologic malignancies after allogeneic hematopoietic stem cell transplantation and primary biliary cirrhosis

Roberto Bellucci,Sabine Oertelt,Meagan Gallagher,Sigui Li,Emmanuel Zorn,Edie Weller,Fabrice Porcheray,Edwin P. Alyea,Robert J. Soiffer,Nikhil C. Munshi,M. Eric Gershwin,Jerome Ritz

View Articletitled, Differential epitope mapping of antibodies to PDC-E2 in patients with hematologic malignancies after allogeneic hematopoietic stem cell transplantation and primary biliary cirrhosis

In vivo control of acute lymphoblastic leukemia by immunostimulatory CpG oligonucleotides

Hisaki Fujii,Jacqueline D. Trudeau,David T. Teachey,Jonathan D. Fish,Stephan A. Grupp,Kirk R. Schultz,Gregor S. D. Reid

View Articletitled, In vivo control of acute lymphoblastic leukemia by immunostimulatory CpG oligonucleotides

Altered activation of AKT is required for the suppressive function of human CD4⁺CD25⁺ T regulatory cells

Natasha K. Crellin,Rosa V. Garcia,Megan K. Levings

View Articletitled, Altered activation of AKT is required for the suppressive function of human CD4+CD25+ T regulatory cells

Supplemental data

IL-21 receptor signaling is integral to the development of Th2 effector responses in vivo

Anja Fröhlich,Benjamin J. Marsland,Ivo Sonderegger,Michael Kurrer,Martin R. Hodge,Nicola L. Harris,Manfred Kopf

View Articletitled, IL-21 receptor signaling is integral to the development of Th2 effector responses in vivo

ZAP-70 enhances B-cell–receptor signaling despite absent or inefficient tyrosine kinase activation in chronic lymphocytic leukemia and lymphoma B cells

Stefania Gobessi,Luca Laurenti,Pablo G. Longo,Simona Sica,Giuseppe Leone,Dimitar G. Efremov

View Articletitled, ZAP-70 enhances B-cell–receptor signaling despite absent or inefficient tyrosine kinase activation in chronic lymphocytic leukemia and lymphoma B cells

Supplemental data

Immune regulation by pretenders: cell-to-cell transfers of HLA-G make effector T cells act as regulatory cells

Joel LeMaoult,Julien Caumartin,Marina Daouya,Benoit Favier,Solene Le Rond,Alvaro Gonzalez,Edgardo D. Carosella

View Articletitled, Immune regulation by pretenders: cell-to-cell transfers of HLA-G make effector T cells act as regulatory cells

Supplemental data

Cytotoxic CD4⁺ T cells use granulysin to kill Cryptococcus neoformans, and activation of this pathway is defective in HIV patients
Clinical Trials & Observations

Chun Fu Zheng,Ling Ling Ma,Gareth J. Jones,M. John Gill,Alan M. Krensky,Paul Kubes,Christopher H. Mody

View Articletitled, Cytotoxic CD4+ T cells use granulysin to kill Cryptococcus neoformans, and activation of this pathway is defective in HIV patients

Galectin-1: a key effector of regulation mediated by CD4⁺CD25⁺ T cells

Marina I. Garín,Chung-Ching Chu,Dela Golshayan,Eva Cernuda-Morollón,Robin Wait,Robert I. Lechler

View Articletitled, Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells

Supplemental data

Gene expression patterns in blood leukocytes discriminate patients with acute infections
Clinical Trials & Observations

Octavio Ramilo,Windy Allman,Wendy Chung,Asuncion Mejias,Monica Ardura,Casey Glaser,Knut M. Wittkowski,Bernard Piqueras,Jacques Banchereau,A. Karolina Palucka,Damien Chaussabel

View Articletitled, Gene expression patterns in blood leukocytes discriminate patients with acute infections

Supplemental data

Expansion of Vδ1 T lymphocytes producing IL-4 in low-grade non-Hodgkin lymphomas expressing UL-16–binding proteins

Silvia Catellani,Alessandro Poggi,Andrea Bruzzone,Patrizia Dadati,Jean Louis Ravetti,Marco Gobbi,Maria Raffaella Zocchi

View Articletitled, Expansion of Vδ1 T lymphocytes producing IL-4 in low-grade non-Hodgkin lymphomas expressing UL-16–binding proteins

Idiopathic CD4⁺ T lymphocytopenia is associated with increases in immature/transitional B cells and serum levels of IL-7
Brief Report

Angela Malaspina,Susan Moir,Doreen G. Chaitt,Catherine A. Rehm,Shyam Kottilil,Judith Falloon,Anthony S. Fauci

View Articletitled, Idiopathic CD4+ T lymphocytopenia is associated with increases in immature/transitional B cells and serum levels of IL-7

Supplemental data

NEOPLASIA

4q loss is potentially an important genetic event in MM tumorigenesis: identification of a tumor suppressor gene regulated by promoter methylation at 4q13.3, platelet factor 4

Suk Hang Cheng,Margaret H. L. Ng,Kin Mang Lau,Herman S. Y. Liu,Joyce C. W. Chan,Angela B. Y. Hui,Kwok Wai Lo,Hua Jiang,Jian Hou,Raymond W. Chu,Wai Shan Wong,Natalie P. H. Chan,,Ho Keung Ng

View Articletitled, 4q loss is potentially an important genetic event in MM tumorigenesis: identification of a tumor suppressor gene regulated by promoter methylation at 4q13.3, platelet factor 4

Circulating proteasome levels are an independent prognostic factor for survival in multiple myeloma
Clinical Trials & Observations

Christian Jakob,Karl Egerer,Peter Liebisch,Seval Türkmen,Ivana Zavrski,Ulrike Kuckelkorn,Ulrike Heider,Martin Kaiser,Claudia Fleissner,Jan Sterz,Lorenz Kleeberg,Eugen Feist,Gerd-R. Burmester,Peter-M. Kloetzel,Orhan Sezer

View Articletitled, Circulating proteasome levels are an independent prognostic factor for survival in multiple myeloma

Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo

Shmuel Yaccoby,Wen Ling,Fenghuang Zhan,Ronald Walker,Bart Barlogie,John D. Shaughnessy, Jr

View Articletitled, Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo

Beneficial effects of combining nilotinib and imatinib in preclinical models of BCR-ABL⁺ leukemias

Ellen Weisberg,Laurie Catley,Renee D. Wright,Daisy Moreno,Lolita Banerji,Arghya Ray,Paul W. Manley,Juergen Mestan,Doriano Fabbro,Jingrui Jiang,Elizabeth Hall-Meyers,Linda Callahan,Jamie L. DellaGatta,Andrew L. Kung,James D. Griffin

View Articletitled, Beneficial effects of combining nilotinib and imatinib in preclinical models of BCR-ABL+ leukemias

Supplemental data

MEK blockade converts AML differentiating response to retinoids into extensive apoptosis

Michele Milella,Marina Konopleva,Cristina M. Precupanu,Yoko Tabe,Maria Rosaria Ricciardi,Chiara Gregorj,Steven J. Collins,Bing Z. Carter,Carmen D'Angelo,Maria Teresa Petrucci,Robin Foà,Francesco Cognetti,Agostino Tafuri,Michael Andreeff

View Articletitled, MEK blockade converts AML differentiating response to retinoids into extensive apoptosis

SDX-308, a nonsteroidal anti-inflammatory agent, inhibits NF-κB activity, resulting in strong inhibition of osteoclast formation/activity and multiple myeloma cell growth

Rentian Feng,Gülsüm Anderson,Guozhi Xiao,Gary Elliott,Lorenzo Leoni,Markus Y. Mapara,G. David Roodman,Suzanne Lentzsch

View Articletitled, SDX-308, a nonsteroidal anti-inflammatory agent, inhibits NF-κB activity, resulting in strong inhibition of osteoclast formation/activity and multiple myeloma cell growth

Supplemental data

Enhanced natural-killer cell and erythropoietic activities in VEGF-A–overexpressing mice delay F-MuLV–induced erythroleukemia

David Cervi,Yuval Shaked,Mehran Haeri,Tatiana Usenko,Christina R. Lee,Jody J. Haigh,Andras Nagy,Robert S. Kerbel,Eitan Yefenof,Yaacov Ben-David

View Articletitled, Enhanced natural-killer cell and erythropoietic activities in VEGF-A–overexpressing mice delay F-MuLV–induced erythroleukemia

Adaptive secretion of granulocyte-macrophage colony-stimulating factor (GM-CSF) mediates imatinib and nilotinib resistance in BCR/ABL⁺ progenitors via JAK-2/STAT-5 pathway activation

Ying Wang,Dali Cai,Cornelia Brendel,Christine Barett,Philipp Erben,Paul W. Manley,Andreas Hochhaus,Andreas Neubauer,Andreas Burchert

View Articletitled, Adaptive secretion of granulocyte-macrophage colony-stimulating factor (GM-CSF) mediates imatinib and nilotinib resistance in BCR/ABL+ progenitors via JAK-2/STAT-5 pathway activation

Supplemental data

Gene-expression profiling of systemic anaplastic large-cell lymphoma reveals differences based on ALK status and two distinct morphologic ALK⁺ subtypes

Laurence Lamant,Aurélien de Reyniès,Marie-Michèle Duplantier,David S. Rickman,Frédérique Sabourdy,Sylvie Giuriato,Laurence Brugières,Philippe Gaulard,Estelle Espinos,Georges Delsol

View Articletitled, Gene-expression profiling of systemic anaplastic large-cell lymphoma reveals differences based on ALK status and two distinct morphologic ALK+ subtypes

Supplemental data

Rapamycin is efficacious against primary effusion lymphoma (PEL) cell lines in vivo by inhibiting autocrine signaling

Sang-Hoon Sin,Debasmita Roy,Ling Wang,Michelle R. Staudt,Farnaz D. Fakhari,Dhavalkumar D. Patel,David Henry,William J. Harrington, Jr,Blossom A. Damania,Dirk P. Dittmer

View Articletitled, Rapamycin is efficacious against primary effusion lymphoma (PEL) cell lines in vivo by inhibiting autocrine signaling

Supplemental data

K1 protein of human herpesvirus 8 suppresses lymphoma cell Fas-mediated apoptosis

Suizhao Wang,Shu Wang,Hoyoung Maeng,Daniel P. Young,Om Prakash,Luis E. Fayad,Anas Younes,Felipe Samaniego

View Articletitled, K1 protein of human herpesvirus 8 suppresses lymphoma cell Fas-mediated apoptosis

Expression of the granzyme B inhibitor PI9 predicts outcome in nasal NK/T-cell lymphoma: results of a Western series of 48 patients treated with first-line polychemotherapy within the Groupe d'Etude des Lymphomes de l'Adulte (GELA) trials
Clinical Trials & Observations

Céline Bossard,Karim Belhadj,Felix Reyes,Nadine Martin-Garcia,Françoise Berger,Jean Alain Kummer,Josette Brière,Anne-Catherine Baglin,Stéphane Cheze,Jacques Bosq,Vincent Ribrag,Christian Gisselbrecht,Nicolas Mounier,Philippe Gaulard

View Articletitled, Expression of the granzyme B inhibitor PI9 predicts outcome in nasal NK/T-cell lymphoma: results of a Western series of 48 patients treated with first-line polychemotherapy within the Groupe d'Etude des Lymphomes de l'Adulte (GELA) trials

Expression of a non–DNA-binding isoform of Helios induces T-cell lymphoma in mice

Zheng Zhang,C. Scott Swindle,John T. Bates,Rose Ko,Claudiu V. Cotta,Christopher A. Klug

View Articletitled, Expression of a non–DNA-binding isoform of Helios induces T-cell lymphoma in mice

Respiratory tract infections and subsequent risk of chronic lymphocytic leukemia
Clinical Trials & Observations Brief Report

Ola Landgren,Joshua S. Rapkin,Neil E. Caporaso,Lene Mellemkjaer,Gloria Gridley,Lynn R. Goldin,Eric A. Engels

View Articletitled, Respiratory tract infections and subsequent risk of chronic lymphocytic leukemia

Novel activating JAK2 mutation in a patient with Down syndrome and B-cell precursor acute lymphoblastic leukemia
Clinical Trials & Observations Brief Report

Sebastien Malinge,Raouf Ben-Abdelali,Catherine Settegrana,Isabelle Radford-Weiss,Marianne Debre,Kheira Beldjord,Elizabeth A. Macintyre,Jean-Luc Villeval,William Vainchenker,Roland Berger,Olivier A. Bernard,Eric Delabesse,Virginie Penard-Lacronique

View Articletitled, Novel activating JAK2 mutation in a patient with Down syndrome and B-cell precursor acute lymphoblastic leukemia

Supplemental data

RED CELLS

Evidence for the multimeric structure of ferroportin

Ivana De Domenico,Diane McVey Ward,Giovanni Musci,Jerry Kaplan

View Articletitled, Evidence for the multimeric structure of ferroportin

Transcriptional interference among the murine β-like globin genes

Xiao Hu,Susan Eszterhas,Nicolas Pallazzi,Eric E. Bouhassira,Jennifer Fields,Osamu Tanabe,Scott A. Gerber,Michael Bulger,James Douglas Engel,Mark Groudine,Steven Fiering

View Articletitled, Transcriptional interference among the murine β-like globin genes

Supplemental data

Transport of the essential nutrient isoleucine in human erythrocytes infected with the malaria parasite Plasmodium falciparum

Rowena E. Martin,Kiaran Kirk

View Articletitled, Transport of the essential nutrient isoleucine in human erythrocytes infected with the malaria parasite Plasmodium falciparum

TRANSPLANTATION

Early CD30 signaling is critical for adoptively transferred CD4⁺CD25⁺ regulatory T cells in prevention of acute graft-versus-host disease

Robert Zeiser,Vu H. Nguyen,Jing-Zhou Hou,Andreas Beilhack,Elizabeth Zambricki,Martin Buess,Christopher H. Contag,Robert S. Negrin

View Articletitled, Early CD30 signaling is critical for adoptively transferred CD4+CD25+ regulatory T cells in prevention of acute graft-versus-host disease

A GMCSF and IL-15 fusokine leads to paradoxical immunosuppression in vivo via asymmetrical JAK/STAT signaling through the IL-15 receptor complex

Moutih Rafei,Jian Hui Wu,Borhane Annabi,Laurence Lejeune,Moïra François,Jacques Galipeau

View Articletitled, A GMCSF and IL-15 fusokine leads to paradoxical immunosuppression in vivo via asymmetrical JAK/STAT signaling through the IL-15 receptor complex

Supplemental data

Autologous hematopoietic stem cell transplantation in refractory celiac disease with aberrant T cells
Clinical Trials & Observations

Abdulbaqi Al-toma,Otto J. Visser,Hyacintha M. van Roessel,B. Mary E. von Blomberg,Wieke H. M. Verbeek,Petra E. T. Scholten,Gert J. Ossenkoppele,Peter C. Huijgens,Chris J. J. Mulder

View Articletitled, Autologous hematopoietic stem cell transplantation in refractory celiac disease with aberrant T cells

Low-power laser in the prevention of induced oral mucositis in bone marrow transplantation patients: a randomized trial
Clinical Trials & Observations

Héliton Spíndola Antunes,Alexandre Mello de Azevedo,Luiz Fernando da Silva Bouzas,Carlos Alberto Esteves Adão,Claudia Tereza Pinheiro,Renato Mayhe,Lucia Helena Pinheiro,Renato Azevedo,Valkiria D'Aiuto de Matos,Pedro Carvalho Rodrigues,Isabele Avila Small,Renato Amaro Zangaro,Carlos Gil Ferreira

View Articletitled, Low-power laser in the prevention of induced oral mucositis in bone marrow transplantation patients: a randomized trial

Unrelated donor bone marrow transplantation for the treatment of Fanconi anemia
Clinical Trials & Observations

John E. Wagner,Mary Eapen,Margaret L. MacMillan,Richard E. Harris,Ricardo Pasquini,Farid Boulad,Mei-Jie Zhang,Arleen D. Auerbach

View Articletitled, Unrelated donor bone marrow transplantation for the treatment of Fanconi anemia

CORRESPONDENCE

Optimizing fusion transcript monitoring in CML

Mark Hertzberg,David McDonald

View Articletitled, Optimizing fusion transcript monitoring in CML

Response: Reliability of PCR for BCR-ABL transcripts

Timothy Hughes,Susan Branford,John M. Goldman

View Articletitled, Response: Reliability of PCR for BCR-ABL transcripts

Improved outcome after stem-cell transplantation in FLT3/ITD-positive AML

Martin Bornhäuser,Thomas Illmer,Markus Schaich,Silke Soucek,Gerhard Ehninger,Christian Thiede,for the AML SHG 96 study group

View Articletitled, Improved outcome after stem-cell transplantation in FLT3/ITD-positive AML

Response: Still a need for more robust evidence that FLT3/ITD status should influence the decision to proceed to transplantation in AML patients

Rosemary E. Gale,Robert Hills,Keith Wheatley,Alan K. Burnett,David C. Linch

View Articletitled, Response: Still a need for more robust evidence that FLT3/ITD status should influence the decision to proceed to transplantation in AML patients

Metoclopramide treatment in DBA patients: no complete response in a French prospective study

Thierry M. Leblanc,Lydie Da Costa,Isabelle Marie,Pierre Demolis,Gilbert Tchernia

View Articletitled, Metoclopramide treatment in DBA patients: no complete response in a French prospective study

Correction of the bleeding time in von Willebrand factor (VWF)–deficient mice using murine VWF

Peter J. Lenting,Philip G. de Groot,Simon F. De Meyer,Karen Vanhoorelbeke,Cynthia Pruss,David Lillicrap,Isabelle Marx,Cécile V. Denis

View Articletitled, Correction of the bleeding time in von Willebrand factor (VWF)–deficient mice using murine VWF

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Table of Contents

INSIDE BLOOD

Acquired hemophilia A: is more better? Clinical Trials & Observations

BLOOD WORK

PLENARY PAPERS

PERSPECTIVE

End points to establish the efficacy of new agents in the treatment of acute leukemia Clinical Trials & Observations

ERRATUM

REVIEW ARTICLES

Neutrophil elastase in cyclic and severe congenital neutropenia Clinical Trials & Observations

CHEMOKINES, CYTOKINES, AND INTERLEUKINS

Postgenomic up-regulation of CCL3L1 expression in HTLV-2–infected persons curtails HIV-1 replication Clinical Trials & Observations

CLINICAL TRIALS AND OBSERVATIONS

The revised International Prognostic Index (R-IPI) is a better predictor of outcome than the standard IPI for patients with diffuse large B-cell lymphoma treated with R-CHOP Clinical Trials & Observations

Effect of genetic variations in platelet glycoproteins Ibα and VI on the risk for coronary heart disease events in postmenopausal women taking hormone therapy Clinical Trials & Observations

Acquired hemophilia A in the United Kingdom: a 2-year national surveillance study by the United Kingdom Haemophilia Centre Doctors' Organisation Clinical Trials & Observations

Late cardiotoxicity after treatment for Hodgkin lymphoma Clinical Trials & Observations

HEMATOPOIESIS

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

ADAMTS13 and von Willebrand factor and the risk of myocardial infarction in men Clinical Trials & Observations Brief Report

IMMUNOBIOLOGY

Cytotoxic CD4+ T cells use granulysin to kill Cryptococcus neoformans, and activation of this pathway is defective in HIV patients Clinical Trials & Observations

Gene expression patterns in blood leukocytes discriminate patients with acute infections Clinical Trials & Observations

Idiopathic CD4+ T lymphocytopenia is associated with increases in immature/transitional B cells and serum levels of IL-7 Brief Report

NEOPLASIA

Circulating proteasome levels are an independent prognostic factor for survival in multiple myeloma Clinical Trials & Observations

Expression of the granzyme B inhibitor PI9 predicts outcome in nasal NK/T-cell lymphoma: results of a Western series of 48 patients treated with first-line polychemotherapy within the Groupe d'Etude des Lymphomes de l'Adulte (GELA) trials Clinical Trials & Observations

Respiratory tract infections and subsequent risk of chronic lymphocytic leukemia Clinical Trials & Observations Brief Report

Novel activating JAK2 mutation in a patient with Down syndrome and B-cell precursor acute lymphoblastic leukemia Clinical Trials & Observations Brief Report

RED CELLS

TRANSPLANTATION

Autologous hematopoietic stem cell transplantation in refractory celiac disease with aberrant T cells Clinical Trials & Observations

Low-power laser in the prevention of induced oral mucositis in bone marrow transplantation patients: a randomized trial Clinical Trials & Observations

Unrelated donor bone marrow transplantation for the treatment of Fanconi anemia Clinical Trials & Observations

CORRESPONDENCE

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Acquired hemophilia A: is more better?
Clinical Trials & Observations

End points to establish the efficacy of new agents in the treatment of acute leukemia
Clinical Trials & Observations

Neutrophil elastase in cyclic and severe congenital neutropenia
Clinical Trials & Observations

Postgenomic up-regulation of CCL3L1 expression in HTLV-2–infected persons curtails HIV-1 replication
Clinical Trials & Observations

The revised International Prognostic Index (R-IPI) is a better predictor of outcome than the standard IPI for patients with diffuse large B-cell lymphoma treated with R-CHOP
Clinical Trials & Observations

Effect of genetic variations in platelet glycoproteins Ibα and VI on the risk for coronary heart disease events in postmenopausal women taking hormone therapy
Clinical Trials & Observations

Acquired hemophilia A in the United Kingdom: a 2-year national surveillance study by the United Kingdom Haemophilia Centre Doctors' Organisation
Clinical Trials & Observations

Late cardiotoxicity after treatment for Hodgkin lymphoma
Clinical Trials & Observations

ADAMTS13 and von Willebrand factor and the risk of myocardial infarction in men
Clinical Trials & Observations Brief Report

Cytotoxic CD4⁺ T cells use granulysin to kill Cryptococcus neoformans, and activation of this pathway is defective in HIV patients
Clinical Trials & Observations

Gene expression patterns in blood leukocytes discriminate patients with acute infections
Clinical Trials & Observations

Idiopathic CD4⁺ T lymphocytopenia is associated with increases in immature/transitional B cells and serum levels of IL-7
Brief Report

Circulating proteasome levels are an independent prognostic factor for survival in multiple myeloma
Clinical Trials & Observations

Expression of the granzyme B inhibitor PI9 predicts outcome in nasal NK/T-cell lymphoma: results of a Western series of 48 patients treated with first-line polychemotherapy within the Groupe d'Etude des Lymphomes de l'Adulte (GELA) trials
Clinical Trials & Observations

Respiratory tract infections and subsequent risk of chronic lymphocytic leukemia
Clinical Trials & Observations Brief Report

Novel activating JAK2 mutation in a patient with Down syndrome and B-cell precursor acute lymphoblastic leukemia
Clinical Trials & Observations Brief Report

Autologous hematopoietic stem cell transplantation in refractory celiac disease with aberrant T cells
Clinical Trials & Observations

Low-power laser in the prevention of induced oral mucositis in bone marrow transplantation patients: a randomized trial
Clinical Trials & Observations

Unrelated donor bone marrow transplantation for the treatment of Fanconi anemia
Clinical Trials & Observations