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Journal Articles

Acute Influenza A Virus Infection Affects Cell Cycle and Lineage Output of Hematopoietic Stem Cells

Marcel E G Rommel, Lisa Walz, Dr., Saskia Kohlscheen, Dr., Franziska Schenk, Yvonne Krebs, Kevin Wittwer, M.Sc., Veronika von Messling, Prof. Dr., Ute Modlich, Prof. Dr. Dr.

Blood (2019) 134 (Supplement_1): 2467.

https://doi.org/10.1182/blood-2019-126482

Published: 2019

Journal Articles

Endothelial protein C receptor supports hematopoietic stem cell engraftment and expansion in Mpl-deficient mice

Saskia Kohlscheen, Franziska Schenk, Marcel G. E. Rommel, Katharina Cullmann, Ute Modlich

Blood (2019) 133 (13): 1465–1478.

https://doi.org/10.1182/blood-2018-03-837344

Published: 2019

Includes: Supplemental data

Journal Articles

New Molecular Surrogate Assay for Genotoxicity Assessment of Gene Therapy Vectors (SAGA)

Adrian Schwarzer, MD PhD, Steven R Talbot, PhD, Oliver Dittrich-Breiholz, PhD, Adrian J Thrasher, MD PhD, Bobby Gaspar, MD, Ute Modlich, Christopher Baum, MD, Axel Schambach, MD PhD, Michael Rothe, PhD

Blood (2016) 128 (22): 4710.

https://doi.org/10.1182/blood.V128.22.4710.4710

Published: 2016

Journal Articles

Hematopoietic Stem Cell Gene Therapy For Wiskott- Aldrich Syndrome

Blood (2013) 122 (21): 718.

https://doi.org/10.1182/blood.V122.21.718.718

Published: 2013

Journal Articles

Mutant IDH1 promotes leukemogenesis in vivo and can be specifically targeted in human AML

Blood (2013) 122 (16): 2877–2887.

https://doi.org/10.1182/blood-2013-03-491571

Published: 2013

Includes: Supplemental data

Journal Articles

Mutated IDH1 Has 2-Hydroxyglutarate-Independent Functions in Leukemogenesis

Blood (2012) 120 (21): 770.

https://doi.org/10.1182/blood.V120.21.770.770

Published: 2012

Journal Articles

Lentiviral Vector Induced Insertional Haploinsufficiency of Ebf1 Causes Leukemia in a Murine Bone Marrow Transplantation Model

Dirk Heckl, PhD, Adrian Schwarzer, MD, Reinhard Haemmerle, Johann Meyer, PhD, Doris Steinemann, PhD, Cornelia Rudolph, PhD, Britta Skawran, PhD, Brigitte Schlegelberger, MD, Christopher Baum, MD, Ute Modlich, DVM, PhD

Blood (2011) 118 (21): 671.

https://doi.org/10.1182/blood.V118.21.671.671

Published: 2011

Journal Articles

Telomere Attrition and Chromosomal Instability During Long-Term Cultivation of Hematopoietic Stem Cells,

Kathrin Lange, Dipl. Biochem., Beate Kuhlmann, PhD, Andrea Schienke, Axel Schambach, MD PhD, Ute Modlich, DVM, PhD, Christopher Baum, MD, Brigitte Schlegelberger, M.D., Gudrun Göhring, MD

Blood (2011) 118 (21): 4001.

https://doi.org/10.1182/blood.V118.21.4001.4001

Published: 2011

Journal Articles

Retroviral Ectopic Expression of a Signaling-Defective Thrombopoietin Receptor (Mpl) Induces a Systemic Loss of Hematopoietic Stem Cells in Mice,

Sabine Wintterle, MD, Dirk Heckl, PhD, Adrian Schwarzer, MD, Guntram Buesche, MD, Christopher Baum, MD, Ute Modlich, DVM, PhD

Blood (2011) 118 (21): 4175.

https://doi.org/10.1182/blood.V118.21.4175.4175

Published: 2011

Journal Articles

Use of the in Vitro Immortalization Assay to Quantify the Impact of Integration Spectrum and Vector Design on Insertional Mutagenesis

Ute Modlich, DVM, PhD, Julia Sürth, Daniela Zychlinski, PhD, Johann Meyer, PhD, Christian Brendel, Manuel Grez, PhD, Paritha Arumugam, PhD, Punam Malik, MD, Elke Grassman, PhD, Axel Schambach, MD PhD, Christopher Baum, MD

Blood (2011) 118 (21): 3123.

https://doi.org/10.1182/blood.V118.21.3123.3123

Published: 2011

Journal Articles

Somatic Gene Therapy for X-Linked Severe Combined Immunodeficiency Using a Self-Inactivating Modified Gammaretroviral Vector Results in An Improved Preclinical Safety Profile and Early Clinical Efficacy in a Human Patient

Blood (2011) 118 (21): 164.

https://doi.org/10.1182/blood.V118.21.164.164

Published: 2011

Journal Articles

Efficacy of Gene Therapy for Wiskott-Aldrich-Syndrome

Blood (2011) 118 (21): 165.

https://doi.org/10.1182/blood.V118.21.165.165

Published: 2011

Journal Articles

Lentiviral gene transfer regenerates hematopoietic stem cells in a mouse model for Mpl-deficient aplastic anemia

Dirk Heckl, Daniel C. Wicke, Martijn H. Brugman, Johann Meyer, Axel Schambach, Guntram Büsche, Matthias Ballmaier, Christopher Baum, Ute Modlich

Blood (2011) 117 (14): 3737–3747.

https://doi.org/10.1182/blood-2010-09-308262

Published: 2011

Includes: Supplemental data

Journal Articles

Polyclonal fluctuation of lentiviral vector–transduced and expanded murine hematopoietic stem cells

Tobias Maetzig, Martijn H. Brugman, Stefan Bartels, Niels Heinz, Olga S. Kustikova, Ute Modlich, Zhixiong Li, Melanie Galla, Bernhard Schiedlmeier, Axel Schambach, Christopher Baum

Blood (2011) 117 (11): 3053–3064.

https://doi.org/10.1182/blood-2010-08-303222

Published: 2011

Includes: Supplemental data

Journal Articles

Ectopic Expression of the Extracellular Domain of Mpl Is Sufficient to Induce a Hematopoietic Population Crisis

Daniel C. Wicke, Johann Meyer, Guntram Büsche, MD, Hans Kreipe, MD, Zhixiong Li, MD, Karl Welte, Matthias Ballmaier, Christopher Baum, Ute Modlich

Blood (2008) 112 (11): 2886.

https://doi.org/10.1182/blood.V112.11.2886.2886

Published: 2008

Journal Articles

Retroviral vector insertion sites associated with dominant hematopoietic clones mark “stemness” pathways

Olga S. Kustikova, Hartmut Geiger, Zhixiong Li, Martijn H. Brugman, Stuart M. Chambers, Chad A. Shaw, Karin Pike-Overzet, Dick de Ridder, Frank J. T. Staal, Gottfried von Keudell, Kerstin Cornils, Kalpana Jekumar Nattamai, Ute Modlich, Gerard Wagemaker, Margaret A. Goodell, Boris Fehse, Christopher Baum

Blood (2006) 109 (5): 1897–1907.

https://doi.org/10.1182/blood-2006-08-044156

Published: 2006

Includes: Supplemental data

Journal Articles

Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity

Ute Modlich, Jens Bohne, Manfred Schmidt, Christof von Kalle, Sabine Knöss, Axel Schambach, Christopher Baum

Blood (2006) 108 (8): 2545–2553.

https://doi.org/10.1182/blood-2005-08-024976

Published: 2006

Includes: Supplemental data

Journal Articles

Leukemias following retroviral transfer of multidrug resistance 1 ( MDR1 ) are driven by combinatorial insertional mutagenesis

Ute Modlich, Olga S. Kustikova, Manfred Schmidt, Cornelia Rudolph, Johann Meyer, Zhixiong Li, Kenji Kamino, Nils von Neuhoff, Brigitte Schlegelberger, Klaus Kuehlcke, Kevin D. Bunting, Sonja Schmidt, Annette Deichmann, Christof von Kalle, Boris Fehse, Christopher Baum

Blood (2005) 105 (11): 4235–4246.

https://doi.org/10.1182/blood-2004-11-4535

Published: 2005

Journal Articles

More Than One Mutation Is Required for Leukemia Development Following Retroviral Vector-Mediated Gene Transfer.

Olga Kustikova, PhD, Manfred Schmidt, PhD, Ute Modlich, PhD, Zhixiong Li, MD, Sonja Schmidt, Anette Deichmann, PhD, Cornelia Rudolph, Nils von Neuhoff, PhD, Brigitte Schlegelberger, MD, Boris Fehse, MD, Christof Kalle, MD, Christopher Baum, MD

Blood (2004) 104 (11): 294.

https://doi.org/10.1182/blood.V104.11.294.294

Published: 2004

NARROW

Acute Influenza A Virus Infection Affects Cell Cycle and Lineage Output of Hematopoietic Stem Cells

Endothelial protein C receptor supports hematopoietic stem cell engraftment and expansion in Mpl-deficient mice

New Molecular Surrogate Assay for Genotoxicity Assessment of Gene Therapy Vectors (SAGA)

Hematopoietic Stem Cell Gene Therapy For Wiskott- Aldrich Syndrome

Mutant IDH1 promotes leukemogenesis in vivo and can be specifically targeted in human AML

Mutated IDH1 Has 2-Hydroxyglutarate-Independent Functions in Leukemogenesis

Lentiviral Vector Induced Insertional Haploinsufficiency of Ebf1 Causes Leukemia in a Murine Bone Marrow Transplantation Model

Telomere Attrition and Chromosomal Instability During Long-Term Cultivation of Hematopoietic Stem Cells,

Retroviral Ectopic Expression of a Signaling-Defective Thrombopoietin Receptor (Mpl) Induces a Systemic Loss of Hematopoietic Stem Cells in Mice,

Use of the in Vitro Immortalization Assay to Quantify the Impact of Integration Spectrum and Vector Design on Insertional Mutagenesis

Somatic Gene Therapy for X-Linked Severe Combined Immunodeficiency Using a Self-Inactivating Modified Gammaretroviral Vector Results in An Improved Preclinical Safety Profile and Early Clinical Efficacy in a Human Patient

Efficacy of Gene Therapy for Wiskott-Aldrich-Syndrome

Lentiviral gene transfer regenerates hematopoietic stem cells in a mouse model for Mpl-deficient aplastic anemia

Polyclonal fluctuation of lentiviral vector–transduced and expanded murine hematopoietic stem cells

Ectopic Expression of the Extracellular Domain of Mpl Is Sufficient to Induce a Hematopoietic Population Crisis

Retroviral vector insertion sites associated with dominant hematopoietic clones mark “stemness” pathways

Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity

Leukemias following retroviral transfer of multidrug resistance 1 ( MDR1 ) are driven by combinatorial insertional mutagenesis

More Than One Mutation Is Required for Leukemia Development Following Retroviral Vector-Mediated Gene Transfer.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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