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Journal Articles

Targeted Inhibition of the NUP98-NSD1 Fusion Oncogene in AML

Sagarajit Mohanty, MSc, Nidhi Jyotsana, PhD, Amit Sharma, PhD, Basem Othman, Arnold Kloos, PhD, Madhvi Mandhania, MSc, Renate Schottmann, Euan Ramsay, PhD, Hans- Peter Vornlocher, PhD, Arnold Ganser, MD, Felicitas Thol, MD, Michael Heuser, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2545.
https://doi.org/10.1182/blood-2019-123709
Published: 2019
Journal Articles

Signaling Pathways of Mutant IDH1 Independent of R-2-Hydroxyglutarate

Charu Gupta, Michelle Maria Araujo Cruz, PhD, Nidhi Jyotsana, PhD, Amit Sharma, PhD, Ramya Goparaju, PhD, Kerstin Görlich, Renate Schottmann, Eduard Struys, PhD, Erwin E Jansen, Felicitas Thol, MD, Arnold Ganser, MD, Michael Heuser, MD, Anuhar Chaturvedi, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2617.
https://doi.org/10.1182/blood-2018-99-110159
Published: 2018
Journal Articles

Pan-Mutant-IDH1 Inhibitor Bay-1436032 Is Highly Effective Against Human IDH1 Mutant Acute Myeloid Leukemia In Vivo

Michael Heuser, MD, Lena Herbst, PhD, Stefan Pusch, Lara Klett, Ramya Goparaju, Damian Stichel, Stefan Kaulfuss, Olaf Panknin, Katja Zimmermann, Luisella Toschi, Roland Neuhaus, Andrea Haegebarth, Hartmut Rehwinkel, Holger Hess-Stumpp, Markus Bauser, Tilmann Bochtler, MD, Eduard A Struys, Amit Sharma, PhD MSc, BSc, Abdellatif Abdellatif, Robert Geffers, PhD, Michelle M Araujo Cruz, Felicitas Thol, MD, Razif Gabdoulline, Arnold Ganser, MD, Anthony D Ho, MD, Andreas von Deimling, Karsten Rippe, Anuhar Chaturvedi, PhD MS, BPharm, Alwin Kraemer, MD
Journal: Blood
Blood (2016) 128 (22): 745.
https://doi.org/10.1182/blood.V128.22.745.745
Published: 2016
Journal Articles

Effective Treatment of Human CML By RNAi In Vivo in a Xenotransplantation Mouse Model

Nidhi Jyotsana, PhD, Amit Sharma, PhD MSc, BSc, Anuhar Chaturvedi, PhD MS, BPharm, Colin Walsh, Anitha Thomas, Michaela Scherr, PhD, Matthias Eder, MD, Karin Battmer, Florian Kuchenbauer, MD PhD, Sajti Laszlo, Annette Barchanski, Kerstin Goerlich, Robert Lindner, Fatih Noyan, PhD, Suehs.Kurt Wolfram, Denis Grote-Koska, Korbinian Brand, Hans-Peter Vornlocher, Arnold Ganser, MD, Euan Ramsay, Pieter Cullis, Michael Heuser, MD
Journal: Blood
Blood (2015) 126 (23): 1261.
https://doi.org/10.1182/blood.V126.23.1261.1261
Published: 2015
Journal Articles

High-Throughput Drug Screening Identifies Pyrimethamine As a Potent and Selective Inhibitor of Acute Myeloid Leukemia

Amit Sharma, PhD, Nidhi Jyotsana, Courteney K. Lai, BSc, Anuhar Chaturvedi, PhD, Kerstin Görlich, Cecilia Murphy, Jan E. Blanchard, Arnold Ganser, Eric Brown, John A. Hassell, R. Keith Humphries, MD PhD, Michael A Morgan, PhD, Michael Heuser, MD
Journal: Blood
Blood (2014) 124 (21): 2304.
https://doi.org/10.1182/blood.V124.21.2304.2304
Published: 2014
Journal Articles

The Metabolite R-2-Hydroxyglutarate (R2HG) Collaborates with HoxA9 to Induce Monocytic Leukemia

Anuhar Chaturvedi, PhD, Michelle Maria Araujo Cruz, Nidhi Jyotsana, Amit Sharma, PhD, Ramya Goparaju, Vishwas Sharma, PhD, Adrian Schwarzer, MDPhD, Kerstin Goerlich, Renate Schottmann, Eduard A. Struys, PhD, Erwin E. Jansen, Robert Geffers, PhD, Gudrun Goehring, MD, Felicitas Thol, MD, Arnold Ganser, Michael Heuser, MD
Journal: Blood
Blood (2014) 124 (21): 366.
https://doi.org/10.1182/blood.V124.21.366.366
Published: 2014
Journal Articles

Mutant IDH1 promotes leukemogenesis in vivo and can be specifically targeted in human AML

Anuhar Chaturvedi, Michelle Maria Araujo Cruz, Nidhi Jyotsana, Amit Sharma, Haiyang Yun, Kerstin Görlich, Martin Wichmann, Adrian Schwarzer, Matthias Preller, Felicitas Thol, Johann Meyer, Reinhard Haemmerle, Eduard A. Struys, Erwin E. Jansen, Ute Modlich, Zhixiong Li, Laura M. Sly, Robert Geffers, Robert Lindner, Dietmar J. Manstein, Ulrich Lehmann, Jürgen Krauter, Arnold Ganser, Michael Heuser
Journal: Blood
Blood (2013) 122 (16): 2877–2887.
https://doi.org/10.1182/blood-2013-03-491571
Published: 2013
Includes: Supplemental data
Journal Articles

Mutated IDH1 Has 2-Hydroxyglutarate-Independent Functions in Leukemogenesis

Anuhar Chaturvedi, PhD, Michelle Maria Araujo Cruz, Nidhi Jyotsana, Amit Sharma, Haiyang Yun, Kerstin Görlich, Martin Wichmann, Adrian Schwarzer, MD, Matthias Preller, PhD, Felicitas Thol, MD, Johann Meyer, PhD, Reinhard Haemmerle, Eduard A. Struys, PhD, Erwin E. Jansen, Ute Modlich, DVM, PhD, Zhixiong Li, MD, Laura M. Sly, PhD, Robert Geffers, PhD, Robert Lindner, PhD, Dietmar J. Manstein, PhD, Urlich Lehmann, PhD, Jürgen Krauter, MD, Arnold Ganser, Michael Heuser, MD
Journal: Blood
Blood (2012) 120 (21): 770.
https://doi.org/10.1182/blood.V120.21.770.770
Published: 2012
Journal Articles

Receptor-binding residues lie in central regions of Duffy-binding–like domains involved in red cell invasion and cytoadherence by malaria parasites

Alfredo Mayor, Nivedita Bir, Ritica Sawhney, Shailja Singh, Priyabrata Pattnaik, Saurabh Kumar Singh, Amit Sharma, Chetan E. Chitnis
Journal: Blood
Blood (2005) 105 (6): 2557–2563.
https://doi.org/10.1182/blood-2004-05-1722
Published: 2005