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Journal Articles

Bcl11b -Edited Lymphoid Progenitors for the Generation of CAR-Engineered Natural Killer-like Cells with Potent Anti-Leukemic Activity

Franziska Baatz, Jessica Herbst, Johann Meyer, Axel Schambach, Tobias Maetzig, Michael Hust, Martin G. Sauer

Blood (2022) 140 (Supplement 1): 2862–2863.

https://doi.org/10.1182/blood-2022-157663

Published: 2022

Journal Articles

Co-Transplantation of CAR-Gene Engineered Precursor T Cells Leads to Suppressed T Cell Development and Increased NK Cell-Based CAR-Mediated Anti-Leukemic Activity

Marcel Maluski, Jessica Herbst, Vanessa Scholl, Rolf Baumann, MD, Niels Heinz, PhD, Robert Geffers, PhD, Johann Meyer, PhD, Andreas Krueger, PhD, Axel Schambach, MD PhD, Martin G. Sauer

Blood (2017) 130 (Supplement 1): 1916.

https://doi.org/10.1182/blood.V130.Suppl_1.1916.1916

Published: 2017

Journal Articles

Bortezomib inhibits STAT5-dependent degradation of LEF-1, inducing granulocytic differentiation in congenital neutropenia CD34 + cells

Kshama Gupta, Inna Kuznetsova, Olga Klimenkova, Maksim Klimiankou, Johann Meyer, Malcolm A. S. Moore, Cornelia Zeidler, Karl Welte, Julia Skokowa

Blood (2014) 123 (16): 2550–2561.

https://doi.org/10.1182/blood-2012-09-456889

Published: 2014

Includes: Supplemental data

Journal Articles

Mutant IDH1 promotes leukemogenesis in vivo and can be specifically targeted in human AML

Blood (2013) 122 (16): 2877–2887.

https://doi.org/10.1182/blood-2013-03-491571

Published: 2013

Includes: Supplemental data

Journal Articles

Mutated IDH1 Has 2-Hydroxyglutarate-Independent Functions in Leukemogenesis

Blood (2012) 120 (21): 770.

https://doi.org/10.1182/blood.V120.21.770.770

Published: 2012

Journal Articles

Receptor Tyrosine Kinases, Notch Mutations and PTEN Loss Converge On mTOR in T-ALL and Cause Addiction to Cap Dependent mRNA Translation.

Adrian Schwarzer, MD, Helmut Holtmann, PhD, Martijn Brugman, PhD, Johann Meyer, PhD, Doris Steinemann, PhD, Brigitte Schlegelberger, Zhixiong Li, MD, Christopher Baum, MD

Blood (2012) 120 (21): 2415.

https://doi.org/10.1182/blood.V120.21.2415.2415

Published: 2012

Journal Articles

Lentiviral Vector Induced Insertional Haploinsufficiency of Ebf1 Causes Leukemia in a Murine Bone Marrow Transplantation Model

Dirk Heckl, PhD, Adrian Schwarzer, MD, Reinhard Haemmerle, Johann Meyer, PhD, Doris Steinemann, PhD, Cornelia Rudolph, PhD, Britta Skawran, PhD, Brigitte Schlegelberger, MD, Christopher Baum, MD, Ute Modlich, DVM, PhD

Blood (2011) 118 (21): 671.

https://doi.org/10.1182/blood.V118.21.671.671

Published: 2011

Journal Articles

Use of the in Vitro Immortalization Assay to Quantify the Impact of Integration Spectrum and Vector Design on Insertional Mutagenesis

Ute Modlich, DVM, PhD, Julia Sürth, Daniela Zychlinski, PhD, Johann Meyer, PhD, Christian Brendel, Manuel Grez, PhD, Paritha Arumugam, PhD, Punam Malik, MD, Elke Grassman, PhD, Axel Schambach, MD PhD, Christopher Baum, MD

Blood (2011) 118 (21): 3123.

https://doi.org/10.1182/blood.V118.21.3123.3123

Published: 2011

Journal Articles

Evidence for Cooperation of Receptor Tyrosine Kinases and Activating NOTCH Mutations to Hyperactivate mTOR in T-Cell Leukemia: A Rationale Basis for Targeted Therapy

Adrian Schwarzer, MD, Johann Meyer, PhD, Martijn Brugman, PhD, Axel Schambach, MD PhD, Martin Stanulla, MD, MSc, Martin Schrappe, MD, Doris Steinemann, PhD, Brigitte Schlegelberger, M.D., Christopher Baum, MD, Zhixiong Li, MD

Blood (2011) 118 (21): 1381.

https://doi.org/10.1182/blood.V118.21.1381.1381

Published: 2011

Journal Articles

Lentiviral gene transfer regenerates hematopoietic stem cells in a mouse model for Mpl-deficient aplastic anemia

Dirk Heckl, Daniel C. Wicke, Martijn H. Brugman, Johann Meyer, Axel Schambach, Guntram Büsche, Matthias Ballmaier, Christopher Baum, Ute Modlich

Blood (2011) 117 (14): 3737–3747.

https://doi.org/10.1182/blood-2010-09-308262

Published: 2011

Includes: Supplemental data

Journal Articles

Bortezomib Induces G-CSF-Triggered Granulocytic Differentiation of CD34 + Cells From CN Patients by Rescue of STAT5-Dependent Degradation of LEF-1 Protein

Kshama Gupta, Johann Meyer, Julia Skokowa, Dr, Karl Welte, MD

Blood (2010) 116 (21): 388.

https://doi.org/10.1182/blood.V116.21.388.388

Published: 2010

Journal Articles

High-affinity neurotrophin receptors and ligands promote leukemogenesis

Zhixiong Li, Gernot Beutel, Mathias Rhein, Johann Meyer, Christian Koenecke, Thomas Neumann, Min Yang, Jürgen Krauter, Nils von Neuhoff, Michael Heuser, Helmut Diedrich, Gudrun Göhring, Ludwig Wilkens, Brigitte Schlegelberger, Arnold Ganser, Christopher Baum

Blood (2009) 113 (9): 2028–2037.

https://doi.org/10.1182/blood-2008-05-155200

Published: 2009

Includes: Supplemental data

Journal Articles

Leukemia Induced by Altered TRK-Signaling Is Sensitive to Rapamycin Treatment in a Preclinical Model

Mathias Rhein, Min Yang, Volkhard Kaever, PhD, Johann Meyer, PhD, Christopher Baum, MD, Zhixiong Li, MD

Blood (2008) 112 (11): 2851.

https://doi.org/10.1182/blood.V112.11.2851.2851

Published: 2008

Journal Articles

Ectopic Expression of the Extracellular Domain of Mpl Is Sufficient to Induce a Hematopoietic Population Crisis

Daniel C. Wicke, Johann Meyer, Guntram Büsche, MD, Hans Kreipe, MD, Zhixiong Li, MD, Karl Welte, Matthias Ballmaier, Christopher Baum, Ute Modlich

Blood (2008) 112 (11): 2886.

https://doi.org/10.1182/blood.V112.11.2886.2886

Published: 2008

Journal Articles

Resistance of mature T cells to oncogene transformation

Sebastian Newrzela, Kerstin Cornils, Zhixiong Li, Christopher Baum, Martijn H. Brugman, Marianne Hartmann, Johann Meyer, Sylvia Hartmann, Martin-Leo Hansmann, Boris Fehse, Dorothee von Laer

Blood (2008) 112 (6): 2278–2286.

https://doi.org/10.1182/blood-2007-12-128751

Published: 2008

Includes: Supplemental data

Journal Articles

Neurotrophin Receptors and Ligands Are Highly Expressed in Acute Leukemia and Promote Leukemogenesis.

Zhixiong Li, MD, Gernot Beutel, MD, Johann Meyer, PhD, Christian Koenecke, MD, Thomas Neumann, Min Yang, Juergen Krauter, MD, Mathias Rhein, Msc, Nils von Neuhoff, PhD, Michael Heuser, MD, Helmut Diedrich, MD, Ludwig Wilkens, MD, Brigitte Schlegelberger, MD, Arnold Ganser, MD, Christopher Baum, MD

Blood (2007) 110 (11): 696.

https://doi.org/10.1182/blood.V110.11.696.696

Published: 2007

Journal Articles

Constitutive Activation of STAT5a in Myeloid Progenitors of Severe Congenital Neutropenia Patients Leads to Downregulation of LEF-1.

Julia Skokowa, MD PhD, Kshama Gupta, M.Sc, Annette Mueller Brechlin, Johann Meyer, PhD, Malcolm A.S. Moore, PhD, Karl Welte, MD, PhD

Blood (2007) 110 (11): 663.

https://doi.org/10.1182/blood.V110.11.663.663

Published: 2007

Journal Articles

Leukemogenic Cascade Induced by a Constitutively Active Neurotrophin Receptor, ΔTrkA.

Zhixiong Li, MD, Johann Meyer, PhD, Mathias Rhein, Olga Kustikova, PhD, Cornelia Rudolph, PhD, Kenji Kamino, MD, Thomas Neumann, Min Yang, BSc, Anke Wahlers, PhD, Boris Fehse, PhD, Gary W. Reuther, PhD, Brigitte Schlegelberger, MD, Arnold Ganser, MD, Christopher Baum, MD

Blood (2006) 108 (11): 1442.

https://doi.org/10.1182/blood.V108.11.1442.1442

Published: 2006

Journal Articles

Leukemias following retroviral transfer of multidrug resistance 1 ( MDR1 ) are driven by combinatorial insertional mutagenesis

Ute Modlich, Olga S. Kustikova, Manfred Schmidt, Cornelia Rudolph, Johann Meyer, Zhixiong Li, Kenji Kamino, Nils von Neuhoff, Brigitte Schlegelberger, Klaus Kuehlcke, Kevin D. Bunting, Sonja Schmidt, Annette Deichmann, Christof von Kalle, Boris Fehse, Christopher Baum

Blood (2005) 105 (11): 4235–4246.

https://doi.org/10.1182/blood-2004-11-4535

Published: 2005

Journal Articles

Side effects of retroviral gene transfer into hematopoietic stem cells

Christopher Baum, Jochen Düllmann, Zhixiong Li, Boris Fehse, Johann Meyer, David A. Williams, Christof von Kalle

Blood (2003) 101 (6): 2099–2113.

https://doi.org/10.1182/blood-2002-07-2314

Published: 2003

NARROW

Bcl11b -Edited Lymphoid Progenitors for the Generation of CAR-Engineered Natural Killer-like Cells with Potent Anti-Leukemic Activity

Co-Transplantation of CAR-Gene Engineered Precursor T Cells Leads to Suppressed T Cell Development and Increased NK Cell-Based CAR-Mediated Anti-Leukemic Activity

Bortezomib inhibits STAT5-dependent degradation of LEF-1, inducing granulocytic differentiation in congenital neutropenia CD34 + cells

Mutant IDH1 promotes leukemogenesis in vivo and can be specifically targeted in human AML

Mutated IDH1 Has 2-Hydroxyglutarate-Independent Functions in Leukemogenesis

Receptor Tyrosine Kinases, Notch Mutations and PTEN Loss Converge On mTOR in T-ALL and Cause Addiction to Cap Dependent mRNA Translation.

Lentiviral Vector Induced Insertional Haploinsufficiency of Ebf1 Causes Leukemia in a Murine Bone Marrow Transplantation Model

Use of the in Vitro Immortalization Assay to Quantify the Impact of Integration Spectrum and Vector Design on Insertional Mutagenesis

Evidence for Cooperation of Receptor Tyrosine Kinases and Activating NOTCH Mutations to Hyperactivate mTOR in T-Cell Leukemia: A Rationale Basis for Targeted Therapy

Lentiviral gene transfer regenerates hematopoietic stem cells in a mouse model for Mpl-deficient aplastic anemia

Bortezomib Induces G-CSF-Triggered Granulocytic Differentiation of CD34 + Cells From CN Patients by Rescue of STAT5-Dependent Degradation of LEF-1 Protein

High-affinity neurotrophin receptors and ligands promote leukemogenesis

Leukemia Induced by Altered TRK-Signaling Is Sensitive to Rapamycin Treatment in a Preclinical Model

Ectopic Expression of the Extracellular Domain of Mpl Is Sufficient to Induce a Hematopoietic Population Crisis

Resistance of mature T cells to oncogene transformation

Neurotrophin Receptors and Ligands Are Highly Expressed in Acute Leukemia and Promote Leukemogenesis.

Constitutive Activation of STAT5a in Myeloid Progenitors of Severe Congenital Neutropenia Patients Leads to Downregulation of LEF-1.

Leukemogenic Cascade Induced by a Constitutively Active Neurotrophin Receptor, ΔTrkA.

Leukemias following retroviral transfer of multidrug resistance 1 ( MDR1 ) are driven by combinatorial insertional mutagenesis

Side effects of retroviral gene transfer into hematopoietic stem cells

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American Society of Hematology

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