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Journal Articles

Understanding the Role of CSF3R and Runx1 Runt Homology Domain Missense Mutations in Leukemic Transformation of Hematopoietic Stem Cells

Malte U Ritter, Olga Klimenkova, Maksim Klimiankou, Amy E Schmidt, MDPhD, Carol Stocking, PhD, Lothar Kanz, Cornelia Zeidler, Daniel C. Link, MD, Karl Welte, Julia Skokowa, MDPhD

Blood (2018) 132 (Supplement 1): 1101.

https://doi.org/10.1182/blood-2018-99-118644

Published: 2018

Journal Articles

Two cases of cyclic neutropenia with acquired CSF3R mutations, with 1 developing AML

Maksim Klimiankou, Sabine Mellor-Heineke, Olga Klimenkova, Elisa Reinel, Murat Uenalan, Siarhei Kandabarau, Julia Skokowa, Karl Welte, Cornelia Zeidler

Blood (2016) 127 (21): 2638–2641.

https://doi.org/10.1182/blood-2015-12-685784

Published: 2016

Journal Articles

Inhibition of the NAMPT-Triggered Deacetylation of HCLS1 Protein: A New Therapeutic Option in Chronic Myeloid Leukemia

Bardia Samareh, PhD, Inna Zimmer, Andrew Zikic, Olga Klimenkova, PhD, Houra Loghmani-Khouzani, PhD, Meinolf Suttorp, Prof. Dr., Lothar Kanz, Prof. Dr. MD, Karl Welte, Prof. Dr. MD, Julia Skokowa, Prof. Dr.

Blood (2015) 126 (23): 1001.

https://doi.org/10.1182/blood.V126.23.1001.1001

Published: 2015

Journal Articles

Nicotinamidephosphoribosyltransferase (NAMPT) Induces Ubiquitination of LEF-1 Transcription Factor By Deacetylation

Inna Zimmer, Bardia Samareh, PhD, Olga Klimenkova, PhD, Maksim Klimiankou, PhD, Murat Ünalan, PhD, Lothar Kanz, Prof. Dr. MD, Karl Welte, Prof. Dr. MD, Julia Skokowa, Prof. Dr.

Blood (2015) 126 (23): 2206.

https://doi.org/10.1182/blood.V126.23.2206.2206

Published: 2015

Journal Articles

Differential Expression of Neutrophil Granule Protein Genes in Bone Marrow Myeloid Cells at the Peak and Nadir of Neutrophil Counts in Cyclic Neutropenia

Olga Klimenkova, PhD, Maksim Klimiankou, PhD, Lothar Kanz, MD, Cornelia Zeidler, MD, Karl Welte, MD, Julia Skokowa, Prof. Dr.

Blood (2015) 126 (23): 2194.

https://doi.org/10.1182/blood.V126.23.2194.2194

Published: 2015

Journal Articles

Activation of C/EBPa Myeloid-Specific Transcription Factor By NAMPT/SIRT1-Triggered Deacetylation

Bardia Samareh, PhD, Masoud Nasri, M.Sc, Inna Zimmer, Olga Klimenkova, PhD, Leonie Keller, Lothar Kanz, Prof. Dr. MD, Karl Welte, Prof. Dr. MD, Julia Skokowa, Prof. Dr.

Blood (2015) 126 (23): 2199.

https://doi.org/10.1182/blood.V126.23.2199.2199

Published: 2015

Journal Articles

Time Course of Acquisition of a CSF3R Mutation and Subsequent Development of AML in a Patient with Cyclic Neutropenia

Maksim Klimiankou, PhD, Olga Klimenkova, PhD, Lothar Kanz, Prof. Dr. MD, Cornelia Zeidler, MD, Karl Welte, Prof. Dr. MD, Julia Skokowa, Prof. Dr.

Blood (2015) 126 (23): 885.

https://doi.org/10.1182/blood.V126.23.885.885

Published: 2015

Journal Articles

GM-CSF stimulates granulopoiesis in a congenital neutropenia patient with loss-of-function biallelic heterozygous CSF3R mutations

Maksim Klimiankou, Olga Klimenkova, Murat Uenalan, Alexander Zeidler, Sabine Mellor-Heineke, Siarhei Kandabarau, Julia Skokowa, Cornelia Zeidler, Karl Welte

Blood (2015) 126 (15): 1865–1867.

https://doi.org/10.1182/blood-2015-07-661264

Published: 2015

Journal Articles

Co-Acquisition of RUNX1 and CSF3R Mutations Transforms Hematopoietic Progenitor Cells of CN Patients into More Primitive Highly Proliferative Blasts: Evidence in CN Patients and in a Mouse Model

Olga Klimenkova, PhD, Maksim Klimiankou, Amy Schmidt, Carol Stocking, Cornelia Zeidler, MD, Daniel C. Link, Karl Welte, Prof. Dr. MD, Julia Skokowa, MD PhD

Blood (2014) 124 (21): 223.

https://doi.org/10.1182/blood.V124.21.223.223

Published: 2014

Journal Articles

IL-3 Specifies Early Hematopoietic Development from Human iPSCs and Synergizes with M-CSF and G-CSF on Myeloid Differentiation

Nico Lachmann, PhD, Mania Ackermann, Eileen Frenzel, Christine Happle, MD PhD, Olga Klimenkova, PhD, Sebastian Brennig, Doreen Lüttge, Theresa Buchegger, Sabina Janciauskiene, MD, Julia Skokowa, MD PhD, Dagmar Dilloo, MD, Thomas Moritz, MD

Blood (2014) 124 (21): 4308.

https://doi.org/10.1182/blood.V124.21.4308.4308

Published: 2014

Journal Articles

Bortezomib inhibits STAT5-dependent degradation of LEF-1, inducing granulocytic differentiation in congenital neutropenia CD34 + cells

Kshama Gupta, Inna Kuznetsova, Olga Klimenkova, Maksim Klimiankou, Johann Meyer, Malcolm A. S. Moore, Cornelia Zeidler, Karl Welte, Julia Skokowa

Blood (2014) 123 (16): 2550–2561.

https://doi.org/10.1182/blood-2012-09-456889

Published: 2014

Includes: Supplemental data

Journal Articles

Cooperativity of RUNX1 and CSF3R mutations in severe congenital neutropenia: a unique pathway in myeloid leukemogenesis

Blood (2014) 123 (14): 2229–2237.

https://doi.org/10.1182/blood-2013-11-538025

Published: 2014

Includes: Supplemental data

Journal Articles

A lack of secretory leukocyte protease inhibitor (SLPI) causes defects in granulocytic differentiation

Olga Klimenkova, Wienke Ellerbeck, Maksim Klimiankou, Murat Ünalan, Siarhei Kandabarau, Anna Gigina, Kais Hussein, Cornelia Zeidler, Karl Welte, Julia Skokowa

Blood (2014) 123 (8): 1239–1249.

https://doi.org/10.1182/blood-2013-06-508887

Published: 2014

Includes: Supplemental data

Journal Articles

Stop-Codon Mutation In The Extracellular Part Of G-CSFR Leading To G-CSF Unresponsiveness Due To Defects In Erk1/2 Phopsphorylation In a Patient With Severe Congenital Neutropenia

Olga Klimenkova, Cornelia Zeidler, MD, Julia Skokowa, Karl Welte

Blood (2013) 122 (21): 3461.

https://doi.org/10.1182/blood.V122.21.3461.3461

Published: 2013

Journal Articles

Cooperativity Of RUNX1 and CSF3R Mutations In The Development Of Leukemia In Severe Congenital Neutropenia: A Unique Pathway In Myeloid Leukemogenesis

Blood (2013) 122 (21): 444.

https://doi.org/10.1182/blood.V122.21.444.444

Published: 2013

Journal Articles

Mutations in the TNFRSF1A, CEBPE and ELANE genes in a Congenital Cyclic Neutropenia Patient: A New Syndrome?

Julia Skokowa, MD, PhD, Olga Klimenkova, Maksim Klimiankou, Siarhei Kandabarau, Marlene Reuter, Anna-Lena Hagemann, Karl Welte, MD

Blood (2012) 120 (21): 11.

https://doi.org/10.1182/blood.V120.21.11.11

Published: 2012

Journal Articles

A Lack of Secretory Leukocyte Protease Inhibitor (SLPI) Causes Defects in Myeloid Differentiation

Olga Klimenkova, Wienke Ellerbeck, Ana Gigina, Karl Welte, MD, Julia Skokowa, MD, PhD

Blood (2012) 120 (21): 10.

https://doi.org/10.1182/blood.V120.21.10.10

Published: 2012

Journal Articles

mRNA and Protein Expression Levels of Secretory Leukocyte Protease Inhibitor (SLPI) Are Severely Reduced in Patients with Severe Congenital Neutropenia (CN)

Wienke Ellerbeck, Olga Klimenkova, Julia Skokowa, MD, PhD, Karl Welte, MD

Blood (2011) 118 (21): 2165.

https://doi.org/10.1182/blood.V118.21.2165.2165

Published: 2011

NARROW

Understanding the Role of CSF3R and Runx1 Runt Homology Domain Missense Mutations in Leukemic Transformation of Hematopoietic Stem Cells

Two cases of cyclic neutropenia with acquired CSF3R mutations, with 1 developing AML

Inhibition of the NAMPT-Triggered Deacetylation of HCLS1 Protein: A New Therapeutic Option in Chronic Myeloid Leukemia

Nicotinamidephosphoribosyltransferase (NAMPT) Induces Ubiquitination of LEF-1 Transcription Factor By Deacetylation

Differential Expression of Neutrophil Granule Protein Genes in Bone Marrow Myeloid Cells at the Peak and Nadir of Neutrophil Counts in Cyclic Neutropenia

Activation of C/EBPa Myeloid-Specific Transcription Factor By NAMPT/SIRT1-Triggered Deacetylation

Time Course of Acquisition of a CSF3R Mutation and Subsequent Development of AML in a Patient with Cyclic Neutropenia

GM-CSF stimulates granulopoiesis in a congenital neutropenia patient with loss-of-function biallelic heterozygous CSF3R mutations

Co-Acquisition of RUNX1 and CSF3R Mutations Transforms Hematopoietic Progenitor Cells of CN Patients into More Primitive Highly Proliferative Blasts: Evidence in CN Patients and in a Mouse Model

IL-3 Specifies Early Hematopoietic Development from Human iPSCs and Synergizes with M-CSF and G-CSF on Myeloid Differentiation

Bortezomib inhibits STAT5-dependent degradation of LEF-1, inducing granulocytic differentiation in congenital neutropenia CD34 + cells

Cooperativity of RUNX1 and CSF3R mutations in severe congenital neutropenia: a unique pathway in myeloid leukemogenesis

A lack of secretory leukocyte protease inhibitor (SLPI) causes defects in granulocytic differentiation

Stop-Codon Mutation In The Extracellular Part Of G-CSFR Leading To G-CSF Unresponsiveness Due To Defects In Erk1/2 Phopsphorylation In a Patient With Severe Congenital Neutropenia

Cooperativity Of RUNX1 and CSF3R Mutations In The Development Of Leukemia In Severe Congenital Neutropenia: A Unique Pathway In Myeloid Leukemogenesis

Mutations in the TNFRSF1A, CEBPE and ELANE genes in a Congenital Cyclic Neutropenia Patient: A New Syndrome?

A Lack of Secretory Leukocyte Protease Inhibitor (SLPI) Causes Defects in Myeloid Differentiation

mRNA and Protein Expression Levels of Secretory Leukocyte Protease Inhibitor (SLPI) Are Severely Reduced in Patients with Severe Congenital Neutropenia (CN)

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American Society of Hematology

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ASH Publications

American Society of Hematology

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